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Genetic polymorphism in drug oxidation. 药物氧化中的基因多态性。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_16
W Kalow

Of the two clearly established drug oxidation polymorphisms, only the one referred to as debrisoquine polymorphism affects many drugs. The only known polymorphic substrates of mephenytoin hydroxylase are mephenytoin and mephobarbital. Relatively recently discovered drug substrates of debrisoquine hydroxylase are propafenone, diltiazem, and codeine. The list of substrates contains 28 items. The fate of slightly less than half of these is clinically affected in poor metabolizers, and several of the latter drugs are no longer marketed. There are many reasons why a failure of metabolism may not alter the fate of a drug sufficiently to affect its clinical use. Of interest and clinical importance is the inhibition of debrisoquine hydroxylase by inhibitors such as quinidine and by some neuroleptics; also the simultaneous use of two substrates has led to serious toxicity by mutual metabolic inhibition. The study of these oxidation polymorphisms has been instructive not only for formal pharmacogenetics but also for the understanding of problems of therapy in patients without genetic defects.

在两种明确建立的药物氧化多态性中，只有一种称为碎片喹多态性影响许多药物。唯一已知的甲苯妥英羟化酶的多态底物是甲苯妥英和甲比妥。最近发现的碎片喹羟化酶的底物有普罗帕酮、地尔硫卓和可待因。基材清单包含28个项目。这些药物中不到一半的命运在临床上受到代谢不良者的影响，而后者中的一些药物已不再上市。有很多原因可以解释为什么新陈代谢的失败并不足以改变药物的命运，从而影响其临床应用。令人感兴趣的和具有临床重要性的是抑制剂如奎尼丁和一些抗精神病药对碎片喹羟化酶的抑制作用;同时使用两种底物也会因相互代谢抑制而导致严重的毒性。这些氧化多态性的研究不仅对正式的药物遗传学有指导意义，而且对理解无遗传缺陷患者的治疗问题也有指导意义。
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引用次数: 9
Effects of serotonergic agonists on neuroendocrine responses of rhesus monkeys and patients with depression and anxiety disorders. 血清素激动剂对恒河猴及抑郁焦虑障碍患者神经内分泌反应的影响。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_10
G R Heninger, D S Charney, L H Price, P Delgado, S Woods, W Goodman
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引用次数: 7
The use of human liver banks in pharmacogenetic research. 人肝库在药物遗传学研究中的应用。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_17
C von Bahr, F P Guengerich, G Movin, C Nordin
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引用次数: 13
Role of pharmacogenetics in drug development. 药物遗传学在药物开发中的作用。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_23
L P Balant, A E Balant-Gorgia
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引用次数: 0
Theoretical and practical implications of a controlled trial of an alpha 2-adrenoceptor antagonist in the treatment of depression. α 2-肾上腺素受体拮抗剂治疗抑郁症的对照试验的理论和实践意义。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_11
S A Montgomery
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引用次数: 2
Benzodiazepine receptor subtypes and their possible clinical significance. 苯二氮卓受体亚型及其可能的临床意义。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_14
W Sieghart
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引用次数: 3
Targets for neurotransmitter receptor research using PET scan: the neuroleptic binding site. PET扫描研究神经递质受体的靶点:抗精神病药结合部位。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_3
J C Baron, J L Martinot, H Cambon, J P Boulenger, M F Poirier, V Caillard, J Blin, J D Huret, C Loc'h, B Maziere
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引用次数: 1
Neurotransmitter interactions as a target of drug action. 神经递质相互作用作为药物作用的靶标。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_5
W Z Potter, J K Hsiao, H Agren
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引用次数: 3
Animal pharmacology of raclopride, a selective dopamine D2 antagonist. 选择性多巴胺D2拮抗剂raclopride的动物药理作用。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_13
H Hall, S O Ogren, C Köhler, O Magnusson
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引用次数: 18
From animal experiments to clinical dosing: some aspects of preclinical development of antidepressants. 从动物实验到临床给药:抗抑郁药临床前开发的一些方面。
Psychopharmacology series
Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_33
A Delini-Stula
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引用次数: 3
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