Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-3
Alexander S. Moskalev
{"title":"Association of L432V (rs1056836) polymorphism of the CYP1B1 gene with the increased risk of colorectal cancer in the population of Central Russia","authors":"Alexander S. Moskalev","doi":"10.18413/2658-6533-2020-6-3-0-3","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-3","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80367346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-2
Karina Melo, F. Santiago, S. B. D. de Lucena, R. T. Silvestre, Maryah Bravo, U. Otero, Adenilson de Souza Fonseca, L. P. da Silva Sergio, L. Scherrer, Gilda Alves, M. H. Ornellas
{"title":"Aplastic anemia, clinical implications and DNA damage in workers with occupational exposure to aromatic hydrocarbons in Rio de Janeiro","authors":"Karina Melo, F. Santiago, S. B. D. de Lucena, R. T. Silvestre, Maryah Bravo, U. Otero, Adenilson de Souza Fonseca, L. P. da Silva Sergio, L. Scherrer, Gilda Alves, M. H. Ornellas","doi":"10.18413/2658-6533-2020-6-3-0-2","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-2","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84890716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-8
S. Skachilova, A. Agarkova
{"title":"Investigation of cerebroprotective properties of the drug «Mexidol» on the model of pneumococcal bacterial meningitis in experimental conditions","authors":"S. Skachilova, A. Agarkova","doi":"10.18413/2658-6533-2020-6-3-0-8","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-8","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77629882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-10
O. Osipova, Vladislav V. Bukatov
{"title":"Features of myocardial infarction with ST segment elevation in patients of the older age group","authors":"O. Osipova, Vladislav V. Bukatov","doi":"10.18413/2658-6533-2020-6-3-0-10","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-10","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88124408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-9
Vitautas Rubikas, Tatsiana Piatryshcha, O. Rozhdestvenskaya, Elena Voronina, Alena Gerois
Background: Premature ageing is a common process. According to various authors, at least 10-20% of middle-aged people have unfavorable levels of discrepancy be-tween biological and passport age. That is why the preventive direction is actively developing in gerontology. Various substances like the proresilients, for example, are actively studied for their geroprotective properties in terms of their impact on cellular mechanisms of premature ageing. The aim of the study: To study the properties of the proresilients in multimodal programs for the prevention of premature ageing. Materials and methods: We studied literary figures for 2015-2020 in computer databases, PubMed, Medical-Science, Elibrary, Ceeol, JSTOR, Web of Science, Sco-pus. Results: The proresilients are used in various programs for improving the body and reducing the aging process of cells, reducing oxidative stress and other pathological mechanisms. They act at the level of the cell so they can slow down the destruction of organs and balance systems. This is due to their positive effect on the entire body and the patient's well-being. The proresilients have the criteria of a good pharmaceutical practices and quality criteria of 4G. The application of the proresilients is important in three areas of medicine like cosmetology, anti-ageing and preventive medicine. Age-related skin changes are inevitable, but it is important to take measures to prevent premature ageing. That‘s why it`s important to use the proresili-ents to prevent skin changes and premature ageing. Conclusion: In conclusion, the proresilients is a new, actively developed group of nutraceutical drugs that can be successfully used in modern health management technologies in multi-modal prevention and rehabilitation programs
背景:早衰是一个普遍的过程。根据不同作者的说法，至少有10-20%的中年人在生理年龄和护照年龄之间存在不利的差异。这就是为什么老年学的预防方向正在积极发展。例如，人们正在积极研究各种物质，如抗衰老剂，它们对过早衰老的细胞机制的影响，从而具有保护衰老的特性。本研究的目的:研究多模式预防早衰方案中促弹性剂的特性。材料和方法:我们在计算机数据库、PubMed、Medical-Science、library、Ceeol、JSTOR、Web of Science、Sco-pus中研究了2015-2020年的文献数据。结果:proresilients在各种项目中用于改善身体，减缓细胞老化过程，减少氧化应激和其他病理机制。它们在细胞水平上起作用，因此它们可以减缓对器官和平衡系统的破坏。这是由于它们对整个身体和病人的健康有积极的影响。proresilients具有良好的制药规范和4G质量标准的标准。抗衰老剂的应用在美容、抗衰老和预防医学等医学领域具有重要意义。与年龄相关的皮肤变化是不可避免的，但重要的是采取措施防止过早衰老。这就是为什么使用促弹性剂来防止皮肤变化和过早衰老是很重要的。结论:proresilients是一种新型的、积极开发的营养保健品，可成功地应用于现代健康管理技术的多模式预防和康复项目中
{"title":"The proresilients in multimodal programmes for the prevention of premature ageing","authors":"Vitautas Rubikas, Tatsiana Piatryshcha, O. Rozhdestvenskaya, Elena Voronina, Alena Gerois","doi":"10.18413/2658-6533-2020-6-3-0-9","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-9","url":null,"abstract":"Background: Premature ageing is a common process. According to various authors, at least 10-20% of middle-aged people have unfavorable levels of discrepancy be-tween biological and passport age. That is why the preventive direction is actively developing in gerontology. Various substances like the proresilients, for example, are actively studied for their geroprotective properties in terms of their impact on cellular mechanisms of premature ageing. The aim of the study: To study the properties of the proresilients in multimodal programs for the prevention of premature ageing. Materials and methods: We studied literary figures for 2015-2020 in computer databases, PubMed, Medical-Science, Elibrary, Ceeol, JSTOR, Web of Science, Sco-pus. Results: The proresilients are used in various programs for improving the body and reducing the aging process of cells, reducing oxidative stress and other pathological mechanisms. They act at the level of the cell so they can slow down the destruction of organs and balance systems. This is due to their positive effect on the entire body and the patient's well-being. The proresilients have the criteria of a good pharmaceutical practices and quality criteria of 4G. The application of the proresilients is important in three areas of medicine like cosmetology, anti-ageing and preventive medicine. Age-related skin changes are inevitable, but it is important to take measures to prevent premature ageing. That‘s why it`s important to use the proresili-ents to prevent skin changes and premature ageing. Conclusion: In conclusion, the proresilients is a new, actively developed group of nutraceutical drugs that can be successfully used in modern health management technologies in multi-modal prevention and rehabilitation programs","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91525047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-4
L. Osipova, D. Lichman, B. Hallmark, T. Karafet, Ping Hsun Hsieh, Joseph Watkins, M. F. Hammer
{"title":"Modern genomics in studying the problems of human adaptation to climate in north Siberia","authors":"L. Osipova, D. Lichman, B. Hallmark, T. Karafet, Ping Hsun Hsieh, Joseph Watkins, M. F. Hammer","doi":"10.18413/2658-6533-2020-6-3-0-4","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-4","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84879503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-7
R. Bontsevich, Olga I. Zemlyanskaya, A. Mikhno, G. Prozorova, E. Ebzeeva, I. F. Krotkova, O. Kompaniets, Elena V. Myronenko, E. Luchinina, G. Ketova, V. Barysheva, I. Galkina, M. L. Maximov
{"title":"The final results of the ASSA-II study: the knowledge of therapeutic doctors on the subject of bronchial asthma","authors":"R. Bontsevich, Olga I. Zemlyanskaya, A. Mikhno, G. Prozorova, E. Ebzeeva, I. F. Krotkova, O. Kompaniets, Elena V. Myronenko, E. Luchinina, G. Ketova, V. Barysheva, I. Galkina, M. L. Maximov","doi":"10.18413/2658-6533-2020-6-3-0-7","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-7","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91391364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-6
M. Solodilova, M. Medvedeva, M. Bykanova, O. Vasilyeva, V. Ivanov
{"title":"Polymorphism of the VEGFA gene, smoking and coronary heart disease: the significance of gene-environmental interactions for disease susceptibility","authors":"M. Solodilova, M. Medvedeva, M. Bykanova, O. Vasilyeva, V. Ivanov","doi":"10.18413/2658-6533-2020-6-3-0-6","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-6","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83553530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-1
Yomisisleidy B. Alvarez, A. García, L. M. Rosales, L. Méndez-Rosado
Background: Neurodevelopmental disorders have a prevalence of approximately 3% in the population, the genetic factor is involved in this condition. Microdeletions that comprise the 2q14.1q14.3 region are rare events. The aim of the study: To describe a girl with an interstitial deletion of the 2q14 region with a severely affected phenotype and to compare her with reports from the international literature. Materials and methods: Cell culture and the obtaining of chromosomes were carried out according to the standardized techniques in our laboratory. Results: Girl evaluated for dismorphias and brain malformation (corpus callosum agenesis). The chromosomal study with a resolution of 565 bands showed an interstitial deletion in the long arm of chromosome 2. Karyotype: 46, XX, del (2) (q14.1q14.2). Conclusion: The correct clinical analysis of the patient and the high-resolution cytogenetic technique has been successful for detection of the microdeletion in this case helping in genetic counseling and in elucidating the genetic origin of the patient's neurodevelopmental disorder.
背景:神经发育障碍在人群中的患病率约为3%，遗传因素与此有关。包含2q14.1q14.3区域的微缺失是罕见的事件。本研究的目的:描述一名患有严重影响表型的2q14区域间质缺失的女孩，并将其与国际文献的报道进行比较。材料和方法:细胞培养和染色体获取按实验室标准化技术进行。结果:女孩被评估为畸形和脑畸形(胼胝体发育不全)。565条带分辨率的染色体研究显示2号染色体长臂存在间质缺失。核型:46,XX, del (2) (q14.1q14.2)。结论:正确的患者临床分析和高分辨率细胞遗传学技术成功地检测了本病例的微缺失，有助于遗传咨询和阐明患者神经发育障碍的遗传起源。
{"title":"2q14 de novo interstitial deletion in a girl with intellectual disabilities and malformations","authors":"Yomisisleidy B. Alvarez, A. García, L. M. Rosales, L. Méndez-Rosado","doi":"10.18413/2658-6533-2020-6-3-0-1","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-1","url":null,"abstract":"Background: Neurodevelopmental disorders have a prevalence of approximately 3% in the population, the genetic factor is involved in this condition. Microdeletions that comprise the 2q14.1q14.3 region are rare events. The aim of the study: To describe a girl with an interstitial deletion of the 2q14 region with a severely affected phenotype and to compare her with reports from the international literature. Materials and methods: Cell culture and the obtaining of chromosomes were carried out according to the standardized techniques in our laboratory. Results: Girl evaluated for dismorphias and brain malformation (corpus callosum agenesis). The chromosomal study with a resolution of 565 bands showed an interstitial deletion in the long arm of chromosome 2. Karyotype: 46, XX, del (2) (q14.1q14.2). Conclusion: The correct clinical analysis of the patient and the high-resolution cytogenetic technique has been successful for detection of the microdeletion in this case helping in genetic counseling and in elucidating the genetic origin of the patient's neurodevelopmental disorder.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74029093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-20DOI: 10.18413/2658-6533-2020-6-3-0-12
Anna S. Fomina
{"title":"Premature birth modern realities","authors":"Anna S. Fomina","doi":"10.18413/2658-6533-2020-6-3-0-12","DOIUrl":"https://doi.org/10.18413/2658-6533-2020-6-3-0-12","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76240661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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