RESEARCH RESULTS IN BIOMEDICINE最新文献

{"title":"Validity of a brief screener for environmental risk factors of age-related diseases using type 2 diabetes and coronary artery disease as examples","authors":"I. Azarova, O. A. Sunyaykina","doi":"10.18413/2658-6533-2022-8-1-0-10","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-1-0-10","url":null,"abstract":"Background: Numerous epidemiological studies have shown the role of unhealthy diet, smoking, low physical activity, and psycho-emotional stress in the development of multifactorial diseases, most of which are age-related. In this regard, the development of a brief screener to identify environmental risk factors in patients with age-related diseases is an urgent task. The aim of the study was to evaluate the reproducibility and validity of a brief screener to estimate environmental risk factors in agerelated diseases using type 2 diabetes mellitus (T2D) and coronary artery disease (CAD) as examples. Materials and methods: The study included 1024 patients with T2D and 448 patients with CAD. All participants in the study completed a double questionnaire survey along with two 24-hour dietary recalls. The reproducibility of the questionnaire was assessed by Spearman's correlation coefficients between the results obtained from patients at both admission and discharge. Validity was assessed by Spearman's correlation coefficients between the results obtained using a brief screener and dietary recalls of patients. Results: Spearman's correlation coefficients for all parameters of the questionnaire at admission and discharge of patients with T2D and CAD were above 0.6, which allows characterizing the questionnaire as reproducible. At the same time, the maximum correlation with respect to nutrients was found for quantitative protein intake in T2D patients (r=0.83, P=0.001) and carbohydrates in CAD patients (r=0.86, P=0.02), whereas the minimum correlation was observed for the amount of fresh fruits and vegetables consumed in both groups of patients (r=0.65 and 0.71, Краткое сообщение Short communication Клёсова ЕЮ, и др. Валидация краткого опросника для оценки ... Klyosova EYu, et al. Validity of a brief screener for environmental ... 132 P<0.05, respectively). Comparison of the results of the survey with the dietary recall data also showed a statistically significant agreement for all items, with the maximum correlation coefficient for the number of consumed proteins in patients with T2D (r=0.71, P=0.0012) and the amount of dietary fiber in patients with CAD (r=0.72, P=0.0012). The minimum correlation was noted for the amount of refined sugar in T2D patients (r=0.61, P=0.03), as well as for the number of fresh vegetables and fruits in CAD patients (r=0.62, P=0.0017). Conclusion: The brief screener designed to estimate environmental risk factors showed statistically significant reproducibility and validity, hence can be used for epidemiological studies of age-related diseases.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76655220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic and genomic mechanisms in the pathogenesis of posttraumatic stress disorder (review)","authors":"А.Г. Фаустова, И. Ю. Юров","doi":"10.18413/2658-6533-2022-8-1-0-2","DOIUrl":"https://doi.org/10.18413/2658-6533-2022-8-1-0-2","url":null,"abstract":"Background: Posttraumatic stress disorder is one of the most prominent examples of gene-environment interactions. Psychological traumatization is a dominant, but not the only etiological factor. Over the past 20 years, sufficient data have been accumulated to confirm the role of the hereditary component in the formation of the so-called \"vulnerable phenotype”. Epigenetic modifications are considered as a mechanism for environmental (traumatic) exposure provoking changes in gene expression and genome stability, which can lead to specific symptoms. The aim of the study: To summarize and to compare the essential results of studies of epigenetic mechanisms of genome regulation in posttraumatic stress disorder. Materials and methods: A theoretical analysis of the published studies dedicated to epigenetic markers of posttraumatic stress disorder was carried out. The PubMed database was browsed in the aforementioned context. Results: The studies published during the last decades have a number of common characteristics (reliance on retrospective data about a traumatic event obtained by the self-report method; use of available tissues for analysis; use of a retrospective cross-sectional design). The systematics of research is based on both the dominant methodology (search and study of candidate genes; methods of whole-genome or epigenome associations) and the analysis of DNA methylation, posttranslational modifications of histones, and chromatin structural organization. The pathogenesis of posttraumatic stress disorder is also explained in the context of cytogenomic hypothesis (changes in genome instability levels modulate behavior). The limitations and prospects of studying epigenetic mechanisms in the pathogenesis of posttraumatic stress disorder are outlined. Conclusion: Epigenetic and genomic analyses of the molecular basis of PTSD offer the Обзор Review Научные результаты биомедицинских исследований. 2022;8(1):15-35 Research Results in Biomedicine. 2022:8(1):15-35 17 most holistic approach to understanding the interaction between genotype and environment presenting as a traumatic event. The study of epigenetic modifications and genome instability, which are potentially reversible, will contribute to the improvement of the prevention and the provision of clinical and psychological assistance to individuals who have experienced traumatic events.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75432591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allostatic load as a method of objectification of age-related viability of patients with ophthalmopathology","authors":"O. Fabrikantov, N. Agarkov, I. Lev, T. Gurko, M. Yablokov, E. Moskaleva, Aleksandr A. Moskalev","doi":"10.18413/2658-6533-2021-7-4-0-10","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-4-0-10","url":null,"abstract":"Background: In recent years, the elderly have seen an increase in the prevalence of combined ophthalmic diseases that change their functional activity in everyday life and society. In gerontological practice, tests and scales that differ significantly in the subjective perception of patients are mainly used to assess age-related viability. Allostatic load, which is an objective reflection of age-related viability, has not been practically studied in patients of older age groups in the presence of ophthalmic diseases. The aim of the study: To analyze the age-related viability in elderly patients with ophthalmic pathology based on allostatic load. Materials and methods: The study of age-related viability was conducted in the Tambov Branch of the Academician S.N. Fedorov Eye Microsurgery in 2018-2020 in 45 60-74-year-old patients with primary angle-closure glaucoma, 52 60-74-year-old patients with diabetic retinopathy, and 68 60-74-year-old Оригинальная статья Original article Научные результаты биомедицинских исследований. 2021;7(4):451-460 Research Results in Biomedicine. 2021:7(4):451-460 453 patients with combined angle-closure glaucoma and diabetic retinopathy. To assess the age-related viability, the allostatic load was determined by a set of indicators: body mass index, blood content of C-reactive protein, homocysteine, total cholesterol, triglycerides, blood albumin level, glomerular filtration rate, diastolic and systolic blood pressure. Results: There are significant differences in the indicators of allostatic load in elderly patients with comorbid ophthalmic pathology, compared with the control. In comorbid primary angle-closure glaucoma and diabetic retinopathy, the allostatic load is 3.4±0.3 points, which is statistically significantly higher than in patients of the same age with primary angle-closure glaucoma (1.8±0.2 points) and diabetic retinopathy (2.4±0.2 points). All components of allostatic load in patients aged 60-74 years with combined primary angle-closure glaucoma and diabetic retinopathy differ significantly and have deviations from the reference values, with the exception of glomerular filtration rate. The level of albumins is 51.2±0.8% vs. 57.8±0.6 in primary angle-closure glaucoma, body mass index 28.8±0.5 kg / m2 vs. 24.7±0.3 kg / m2, C-reactive protein 13.1±0.3 mg / l vs. 6.7±0.2 mg / L, glycated hemoglobin 6.8±0.4 % vs. 4.1±0.2 %, systolic blood pressure 151.6±2.0 mmHg vs. 142.8±1.9 mmHg. Conclusion: Allostatic load in elderly patients with ophthalmic diseases can serve as an objective method for assessing the age-related viability of elderly patients with visual organ pathology.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75818373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restructuring of erythrocytes in persons of mature and elderly age on the background of diabetes mellitus","authors":"T. Pavlova, I. B. Bukhvalov, A. Kaplin, Irina I. Povalyaeva, I. Goncharov, L. A. Pavlova","doi":"10.18413/2658-6533-2021-7-4-0-6","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-4-0-6","url":null,"abstract":"Background: The high incidence of diabetes mellitus in modern conditions dictates the need to search for new, including microscopic, opportunities to identify pathological changes in the course of various physiological processes. The aim of the study: To study the peculiarities of changes in the properties and parameters of erythrocytes in various types of diabetes mellitus (types 1 and 2) in women of mature and elderly age. Materials and methods: Venous blood of 55 women aged 30 to 70 years, divided into study groups (women with type DM, women with type II DM, control without endocrinopathy) was examined using atomic force and scanning probe microscopy. Results: The authors found an increase in the percentage of pathological forms of erythrocytes in patients with diabetes mellitus. An increase in the number of macrocytic forms of erythrocytes was observed not only when compared with the control group (DM I 12.20±2.14, DM II 10.00±1.20, control 4.40±0.15), but and when comparing two age groups of patients with type 2 DM (30-45 years old 10.00±1.20, 60-70 years old 13.20±1.90). The same tendency is typical for microcytes. Geriatric changes in the geometric parameters of erythrocytes in the group of patients with type 2 DM were characterized by an increase in the volume, as well as the maximum height of erythrocytes with increasing age of the patients. Conclusion: The use of atomic force microscopy in the study of the biophysical parameters of erythrocytes makes it possible to identify paОригинальная статья Original article Научные результаты биомедицинских исследований. 2021;7(4:400-409 Research Results in Biomedicine. 2021:7(4):400-409 401 tients from high-risk groups by determining such changes as an increase in the number of macrocytes, microcytes and pathologically altered forms of erythrocytes, a decrease in the average volume and area of erythrocytes.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90468669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essentially pure partial trisomy 6(p21.31-p25) (case report and literature review)","authors":"O. Molina-Gamboa, A. Barrios-Martínez, A. García-García, Luanda Maceira, L. Méndez-Rosado","doi":"10.18413/2658-6533-2021-7-4-0-1","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-4-0-1","url":null,"abstract":"Background: In reviewed literature, several patients with duplication or partial trisomy of the 6p region have been described. Most of these cases are associated with a partial monosomy of another chromosome. It has been suggested that partial trisomy 6p constitutes a well-defined syndrome. The aim of the study: To achieve a better clinical delineation of the 6p syndrome through the description of a patient with partial trisomy 6(p21.31-p25) comparing his characteristics with international reports and to discuss aspects of the phenotype of this syndrome. Materials and methods: A detailed clinical analysis of the patient’s condition was performed. The chromosomes were studied through the GTG-banding analysis. Results: On clinical examination we observed: a small anterior fontanel; fine, sparse and very pale hair, almost white hair; very white, translucent and thin skin; pale and sparse eyebrows and eyelashes; very narrow palpebral fissures with palpebral ptosis (blepharophimosis); a high nasal bridge, and straight nose with tiny nostrils; low implantation of the ears; microcephaly, neurodevelopmental and psychomotor delay; long philtrum, thin lips, the upper lip almost inverted and the mouth is small. From the neurological point of view there was evidence of trunk hypotonia and limb hypertonia. These are all typical features of trisomy 6p syndrome. A cytogenetic study of the patient and his father showed that trisomy 6p was due to an adjacent segregation I in paternal gametogenesis as the father is a 6,16-translocation carrier. Conclusion: The possible critical region is difficult to determine due to the clinical heterogeneity present in this syndrome. However, this case should be analyzed by molecular methods to determine more precisely the extent of the area involved in the trisomy.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77550662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the level of population endogamia as the basis of population-genetic and medical-genetic studies","authors":"Sergei N. Sokorev, O. Efremova, I. Sorokina","doi":"10.18413/2658-6533-2021-7-4-0-4","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-4-0-4","url":null,"abstract":"Background: When conducting population-genetic and genetic-epidemiological studies, the endogamy index should be taken into account to assess the level of the elementary population, characteristics of the migration activity of the population and the degree of isolation of the population. The aim of the study: To assess the level of endogamy among the entire population of the Belgorod region in the modern period of time. Materials and methods: Based on 11052 marriage records of the Registry Office in the Belgorod region for 2016-2018, the endogamy index was studied among the entire population in all administrative units of the Belgorod region – 21 districts. The endogamy index was calculated on the basis of data on the place of birth of spouses, as the proportion of husbands and wives born in a given population. Results: It was found that in the district populations of the Belgorod region, the endogamy index at the district level varied from 0.33 to 0.68 with an average value for the region of 0.46, which is within the range of variability of this indicator among the Russian populations of the Russian Federation. At present, the endogamy of regional populations, which include big and large cities, exceeds this indicator among the rural population. For highly urbanized districts of the region, the size of the elementary population corresponds to the administrative boundaries of the district, while for the rural population, the size of the elementary population exceeds the boundaries of the district. It should be noted that the reduced values of this indicator for the rural population correspond to general migration trends. An increase in the inflow of migrants to the regional populations of the Belgorod region leads to a decrease in the endogamy index, as evidenced by the established inverse correlations between the number of migrants per 1000 inhabitants over three time periods (1990, 2000, and 2019) and the endogamy index. Conclusion: The populations of the Belgorod region are characterized by high migration activity, which leads to a decrease in the level of endogamy among the population. At present, the size of the elementary population in the Belgorod region corresponds to the area or slightly exceeds it.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85485347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Rosuvastatin in elderly patients with coronary heart disease on the background of acute respiratory viral infection with various polymorphic variants of interleukin genes","authors":"I. A. Gribovskaya, M. Solodilova, G. Mal","doi":"10.18413/2658-6533-2021-7-4-0-7","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-4-0-7","url":null,"abstract":"Background: Coronary heart disease (CHD) is the leading pathology among all cardiovascular diseases. Elderly patients with concomitant diseases represent a special risk group. Acute respiratory viral infections (ARVI) in old age tend to be more severe due to age-related immunodeficiency. There are known facts of the negative influence of viruses and bacteria on the course of atherosclerosis, manifested increase in the frequency of angina attacks, changes in the level of inflammatory markers. At the same time, lipid metabolism disorders in the elderly category of patients require a change in the approaches to therapy. The aim of the study: To analyze the association of interleukin genes with a dose choice of rosuvastatin in patients with CHD and ARVI in comparison with patients without an infectious process. Materials and methods: The study included 118 men and women aged 61-74 years with coronary artery disease, among them 63 people were in comorbidity with ARVI and 55 were without ARVI. The lipid spectrum and immune profile were determined (interleukins (IL-1β, IL-6, IL-4, IL-10)), genotyping of interleukin genes (IL-1β, IL-4, IL-6, IL-10). We used Microsoft Excel 2010 and Statistika 7 for Windows, SNPStats. Results: The selection of the correct dose of rosuvastatin for plaque protection in acute infection is based on correlation with the genotypes of interleukin genes. The association of the genotypes of proinflammatory IL-1β manifested itself in the achievement of the target LDL cholesterol by patients with the – 511CT genotype for the –511C>T (rs16944) polymorphism when taking rosuvastatin 20 Оригинальная статья Original article Грибовская ИА, и др. Эффективность розувастатина у пожилых ... Gribovskaya IA, et al. The efficacy of Rosuvastatin in elderly patients ... 412 mg/day in comparison with other genotypes. Homozygotes C/C-T/T showed a pronounced drug response, manifested by the achievement of the target level of LDL cholesterol with the appointment of 10 mg rosuvastatin. For carriers of other variants of genotypes for polymorphism –174G/C (rs1800795) IL-6, –589C>T (rs2243250) IL-4 and –1082G>A (rs1800896) IL-10, there was a statistically significant relationship with the dose regimen of rosuvastatin in patients with coronary artery disease in conditions of viral infection were not observed. There were no associations between the statin therapy regimen with interleukin genotypes (IL-1β, IL-6, IL-4, IL-10) in elderly patients with coronary artery disease without an infectious process (p>0.05). Conclusion: Genotyping of interleukin genes can be used for a personalized approach to the pharmacotherapy of hyperlipidemia (GLP) in elderly patients with CHD, provided concomitant ARVI.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76244348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal microbiome in patients with menstrual cycle disorders (review)","authors":"П. Лебедева, М. В. Грязнова, О. Н. Козаренко, Михаил Ю. Сыромятников, Владимир Никитович Попов","doi":"10.18413/2658-6533-2021-7-4-0-9","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-4-0-9","url":null,"abstract":"Background: In the last two decades, because of the usage of non-cultural methods, new data on the female genital tract microbiome have been accumulated. However, the causes determining the predominance of certain microorganisms, and, consequently, the formation of microbiome composition, have not been finally determined. The major changes in the microbiome of the reproductive tract of women occur in response to the influence of hormones. The aim of the study: To assess the influence of menstrual cycle disorders on the vaginal microbiome composition. Materials and methods: The articles describing the role of menstrual cycle disorders in the formation of the vaginal microbiome composition, published over the past 20 years and deposited in the Pubmed, Google Academy, Scopus, Elibrary, ResearchGate, and EBSCO databases, were analyzed. Results: The data on the role of the human microbiome in the pathogenesis of somatic diseases are presented. The main characteristics of the vaginal microbiome are given, its classification is presented, the main functions of Lactobacillus in the female reproductive tract and their influence on local immunity are discussed. The vaginal microbiome during the normal menstrual cycle and in patients with menstrual cycle disorders is described. Conclusion: Despite the critical importance of the female genital tract microbiome for human reproduction, data on the role of menstrual cycle disorders in the formation of the microbiome are sporadic and are mainly concerned with the vaginal microbiome in polycystic ovary syndrome (PCOS). There are no data on the role of hyperprolactinemia, congenital adrenal hyperplasia, and other causes of menstrual cycle disorders in vaginal microbiome formation. Further studies of the microbiome in patients with menstrual cycle disorders, as well as its correction, are needed.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83874845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological efficiency of combined eye drug films based on Levofloxacin and Dexpanthenol, and also Dexamethazone and Dexpanthenol in the treatment of infected corneal injury","authors":"M. Medvedeva, V. Lipatov, M. Zatolokina, Oksana M. Yarmamedova","doi":"10.18413/2658-6533-2021-7-4-0-5","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-4-0-5","url":null,"abstract":"Background: When treating infected corneal burns, some patients are not able to comply with the schedule of frequent instillations of drugs, which entails a persistent irreversible decrease in visual acuity due to the formation of corneal opacities. The aim of the study: To increase the effectiveness of treatment of infected corneal burns using combined ophthalmic medicinal films based on Levofloxacin and Dexpanthenol, as well as Dexamethasone and Dexpanthenol. Materials and methods: 1 hour after the formation of a standard infected corneal burn, the comparison group was treated according to the classical method using instillations, and the experimental group was treated with combined ophthalmic medicinal films based on Levofloxacin and Dexpanthenol, as well as Dexamethasone and Dexpanthenol. The area of the defect in the corneal epithelium was recorded. Morphological examination with hematoxylin-eosin staining was carried out according to the standard technique at different periods of observation. Results: A pronounced cellular reaction was recorded already 1 hour after the formation of a standard infected corneal burn. The defect area of the corneal epithelium decreased faster in the group treated with combined ophthalmic drug films. The thickness of the outer corОригинальная статья Original article Ярмамедов ДМ, и др. Фармакологическая эффективность ... Yarmamedov DM, et al. Pharmacological efficiency of combined eye ... 390 neal epithelium, as well as the number of cells in its layers, returned to normal on the 3rd day in the experimental group, and in the comparison group with treatment according to the standard method on the 5th day of the experiment. When examining the thickness of the corneal endothelium, there were no statistically significant differences from the normal cornea. Conclusion: In the treatment of a standard infected corneal burn, the use of combined ophthalmic medicinal films can reduce the process of morphological restoration of the cornea to 3 days, in comparison with treatment using instillations, where the cornea is restored to the parameters of an intact eye on the 5th day.","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80447345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian cancer as part of hereditary cancer syndromes (review)","authors":"","doi":"10.18413/2658-6533-2021-7-4-0-2","DOIUrl":"https://doi.org/10.18413/2658-6533-2021-7-4-0-2","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91186467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}