Recent advances in drug delivery and formulation最新文献

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An Overview of Recent Patents and Patented Technology Platforms Based on Co-Processed Excipients. 基于共加工赋形剂的最新专利和专利技术平台综述。

Recent advances in drug delivery and formulation

Pub Date : 2021-01-01 DOI: 10.2174/1872211314999210104211125

Deepak Kaushik, Etisha Goel, Ravinder Verma, Parijat Pandey, Deepika Purohit, Vineet Mittal, Kuldeep Kumar, Md Habibur Rahman

Background: There is no single-component excipient that fulfills all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. Co-processing is a novel concept that incorporates a combination of two or more excipients, that is advantageous and cannot be achieved using a physical admixture.

Objective: This review provides an overview of co-processed excipients, recent patents granted and filed in this field and the commercial patented technology platforms based on these excipients.

Methods: Various online patent databases were used for collecting the information on recent patents and patented co-processed excipient technologies. The recent patents such as single-step coprocessing by dry coating, novel co-processed excipients for oily drugs and novel silica-coated compositions have been discussed.

Results: Co-processed excipients are evolving as a current and future trend of excipient technology in pharmaceutical manufacturing, which is evident by the increasing number of patents based on these excipients. Among various techniques, the maximum number of patents is based on the spray drying technique.

Conclusion: In this work, the authors have focussed on recent patents and commercial technologies on co-processed excipient. A better understanding of this will help researchers and pharmaceutical industries to select the appropriate platform, or to develop new innovative co-processed excipients with improved tableting characteristics.

背景:没有一种单组分赋形剂能够满足所有必需的性能，使活性药物成分能够被配制成特定的剂型。协同加工是一个新概念，包含两种或两种以上赋形剂的组合，这是有利的，不能使用物理混合物来实现。目的:综述共加工辅料、该领域近期授权和申请的专利以及基于这些辅料的商业化专利技术平台。方法:利用各种在线专利数据库，收集最新专利和共加工辅料技术专利信息。介绍了干包衣单步共加工、新型油类药物共加工赋形剂和新型二氧化硅包覆组合物等最新专利。结果:协同加工辅料是当前和未来制药辅料技术的发展趋势，这一点从基于这些辅料的专利数量的增加可以看出。在各种技术中，专利数量最多的是喷雾干燥技术。结论:本文对近年来共加工赋形剂的专利和商业技术进行了综述。更好地了解这一点将有助于研究人员和制药行业选择合适的平台，或开发具有改进片剂特性的新的创新共加工辅料。

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引用次数: 2

Preface. 前言。

Recent advances in drug delivery and formulation

Pub Date : 2021-01-01 DOI: 10.2174/266738781501210816122827

Stefano Giovagnoli

引用次数: 0

Systematic Patent Review of Nanoparticles in Drug Delivery and Cancer Therapy in the Last Decade. 近十年来纳米颗粒在药物传递和癌症治疗中的系统专利综述。

Recent advances in drug delivery and formulation

Pub Date : 2021-01-01 DOI: 10.2174/1872211314666210521105534

Nur Umairah Ali Hazis, Nagender Aneja, Rajan Rajabalaya, Sheba Rani David

Background: The application of nanotechnology has been considered a powerful platform in improving the current situation in drug delivery and cancer therapy, especially in targeting the desired site of action.

Objective: The main objective of the patent review is to survey and review patents from the past ten years that are related to the two particular areas of nanomedicines.

Methods: The patents related to the nanoparticle-based inventions utilized in drug delivery and cancer treatment from 2010 onwards were browsed in databases like USPTO, WIPO, Google Patents, and Free Patents Online. After conducting numerous screening processes, a total of 40 patents were included in the patent analysis. See the PRISMA checklist 2020 checklist.

Results: Amongst the selected patents, an overview of various types of nanoparticles is presented in this paper, including polymeric, metallic, silica, lipid-based nanoparticles, quantum dots, carbon nanotubes, and albumin-based nanomedicines.

Conclusion: Nanomedicines' advantages include improvements in terms of drug delivery, bioavailability, solubility, penetration, and stability of drugs. It is concluded that the utilization of nanoparticles in medicines is essential in the pursuit of better clinical practice.

背景:纳米技术的应用被认为是改善药物传递和癌症治疗现状的一个强大平台，特别是在靶向作用部位方面。目的:专利审查的主要目的是调查和审查近十年来与纳米药物两个特定领域相关的专利。方法:检索美国专利商标局(USPTO)、世界知识产权组织(WIPO)、Google patents和Free patents Online等数据库，检索2010年以来用于药物输送和癌症治疗的基于纳米颗粒的发明专利。经过多次筛选，共有40项专利被纳入专利分析。参见PRISMA检查表2020检查表。结果:在选定的专利中，本文概述了各种类型的纳米颗粒，包括聚合物，金属，二氧化硅，脂基纳米颗粒，量子点，碳纳米管和白蛋白基纳米药物。结论:纳米药物在给药、生物利用度、溶解度、穿透性、稳定性等方面具有优势。结论是纳米颗粒在药物中的应用对于追求更好的临床实践至关重要。

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引用次数: 3

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