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Establishment of a two-stage limb ischemia in diabetic rats 糖尿病大鼠两期肢体缺血模型的建立
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2023-01-01 DOI: 10.4103/rcm.rcm_43_23
Liangrong Wang, Yu Cao, Shuyu Hu, Hongbo Wang, Xiaoyao Li, Jun Ma
Background: This study aimed to establish a clinically relevant animal model for peripheral arterial disease (PAD) that better replicates the complexity observed in human patients. Materials and Methods: Thirty male rats were randomly assigned into the sham (SM), femoral artery resection (FE), constrictor-induced ischemia (CI), two-stage ischemia (TS), or diabetic two-stage ischemia (DT) groups. In the FE group, rats underwent femoral artery resection, whereas the SM group had sham surgery. The CI group received progressive ischemia using two ameroid constrictors, and the TS and DT groups underwent a two-stage ischemia procedure involving initial gradual narrowing with two ameroid constrictors and subsequent femoral artery resection in healthy and diabetic rats, respectively. Perfusion evaluation and functional assessment were conducted at postoperative days 14, 28, and 42. On day 42, hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) protein expression were measured, along with histological examination and immunofluorescence analysis. Results: Motor function deficits and reduced limb reperfusion were most prominent in the TS and DT groups on days 28 and 42 (P < 0.05), exacerbated by type 2 diabetes. Gastrocnemius exhibited upregulated HIF-1α and VEGF protein expression, as well as increased capillary density in response to ischemia. However, the DT group showed significantly lower protein expression and capillary density, along with more severe structural damage compared to other groups (P < 0.05). Conclusion: A clinically relevant rat model of PAD was established by implementing a two-stage ischemia procedure involving initial progressive narrowing and subsequent femoral artery excision in the context of diabetes.
背景:本研究旨在建立一种与临床相关的外周动脉疾病(PAD)动物模型,以更好地复制在人类患者中观察到的复杂性。材料与方法:将30只雄性大鼠随机分为假手术组(SM)、股动脉切除组(FE)、收缩性缺血组(CI)、两期缺血组(TS)和糖尿病两期缺血组(DT)。FE组大鼠行股动脉切除术,SM组大鼠行假手术。CI组使用两种ameroid缩窄器进行渐进式缺血,TS组和DT组分别在健康和糖尿病大鼠中进行两阶段缺血过程,包括最初使用两种ameroid缩窄器逐渐缩小,随后切除股动脉。术后第14、28、42天进行灌注评价和功能评价。第42天,检测缺氧诱导因子(HIF)-1α和血管内皮生长因子(VEGF)蛋白表达,并进行组织学检查和免疫荧光分析。结果:TS组和DT组运动功能缺损和肢体再灌注减少在第28天和第42天最为明显(P < 0.05),并因2型糖尿病加重。腓肠肌缺血后HIF-1α和VEGF蛋白表达上调,毛细血管密度增加。但DT组蛋白表达和毛细血管密度显著低于其他组,且结构损伤较其他组严重(P < 0.05)。结论:在糖尿病的情况下,通过两阶段的缺血过程,包括最初的进行性狭窄和随后的股动脉切除术,建立了具有临床意义的大鼠PAD模型。
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引用次数: 0
Lifetime predicted risk of atherosclerotic cardiovascular disease among an urban cohort: A cross-sectional study 城市队列中动脉粥样硬化性心血管疾病的终生预测风险:一项横断面研究
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-10-01 DOI: 10.4103/rcm.rcm_26_22
Nikita Savani, R. Chauhan, Rajesh Chudasama
Introduction: Although atherosclerotic cardiovascular disease (ASCVD) results have significantly improved in recent years, ASCVD continues to be the world's leading cause of morbidity and mortality. Therefore, in the present study, lifetime risk of ASCVD was calculated in an urban cohort. White-collar employees have higher risk of developing cardiovascular disease events because of their work profile. Aim and Objectives: To calculate lifetime predicted risk of ASCVD among study cohort and to explore factors contributing to the disparities of cardiovascular risks. Materials and Methods: This was community-based cross-sectional study. The baseline data were collected during the period 2016–2019 from Rajkot city, and their lifetime predicted risk of ASCVD was calculated using ASCVD risk calculator. Crude and adjusted prevalence ratio was calculated. Results: The study revealed that 69.25% and 6.37% of participants had low and intermediate lifetime predicted risk of ASCVD, respectively, while the remaining 16.12% and 8.25% had borderline and high risk, respectively. Conclusion: This study indicates that increased lifetime predicted risk of ASCVD was associated with increasing age, male, stress, elevated blood pressure, high level of body mass index, and central obesity among participants.
引言:尽管近年来动脉粥样硬化性心血管疾病(ASCVD)的结果有了显著改善,但ASCVD仍然是世界上发病率和死亡率的主要原因。因此,在本研究中,在城市队列中计算了ASCVD的终生风险。白领员工由于其工作特点,患心血管疾病的风险更高。目的和目的:计算研究队列中ASCVD的终生预测风险,并探讨导致心血管风险差异的因素。材料和方法:这是一项基于社区的横断面研究。基线数据是在2016年至2019年期间从Rajkot市收集的,并使用ASCVD风险计算器计算其一生预测的ASCVD风险。计算粗略和调整后的患病率。结果:研究显示,69.25%和6.37%的参与者分别具有ASCVD的低寿命和中寿命预测风险,其余16.12%和8.25%分别具有临界风险和高风险。结论:本研究表明,ASCVD的寿命预测风险增加与参与者年龄、男性、压力、血压升高、高体重指数和中心性肥胖的增加有关。
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引用次数: 1
A rare case of williams–Beuren syndrome with presence of fibrocalcific supravalvular aortic stenosis and supravalvular pulmonary stenosis: Genetic disorder that bites the gene and bites the heart 一例罕见的williams–Beuren综合征伴纤维钙化性瓣上主动脉瓣狭窄和瓣上肺动脉瓣狭窄:基因和心脏的遗传性疾病
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-10-01 DOI: 10.4103/rcm.rcm_9_22
Debasish Das, A. Banerjee, Abhinav Kumar, S. Singh, Tutan Das, Manaranjan Dixit
We report an extremely rare case of Williams–Beuren (WB) syndrome in a 10-year-old boy with supravalvular aortic stenosis (SVAS) secondary to a large fibrocalcific eccentric shelf in the ascending aorta with fibrocalcific severe supravalvular pulmonary stenosis, which has not yet been described in the literature. Although the presence of peripheral pulmonary stenosis is well described in Williams syndrome (WS), our case is the unique and first to demonstrate fibrocalcific severe supravalvular pulmonary stenosis in WS without the presence of peripheral pulmonary artery stenosis. Although regarded as a strong genetic insult with 27 gene deletions (almost like biting the gene), it has also bitten the heart in this index child and left a large chunk of supravalvular fibrocalcific mass in the ascending aorta causing SVAS.
我们报告了一例极为罕见的Williams–Beuren(WB)综合征病例,该病例发生在一名10岁男孩的主动脉瓣上狭窄(SVAS),继发于升主动脉中的一个巨大的纤维钙化偏心架,并伴有纤维钙化的严重瓣上肺动脉狭窄,这在文献中尚未描述。尽管Williams综合征(WS)中很好地描述了外周肺动脉狭窄的存在,但我们的病例是唯一的,也是第一个在没有外周肺血管狭窄的情况下证明WS中存在纤维钙化严重瓣上肺动脉狭窄。尽管它被认为是一种强烈的遗传损伤,有27个基因缺失(几乎就像咬了基因一样),但它也咬了这个指数儿童的心脏,并在升主动脉中留下了大块瓣上纤维钙化块,导致SVAS。
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引用次数: 0
What is the Prevalence of Pulmonary Hypertension in Thalassemic Patients in Guilan? A Retrospective Analytic Study 桂兰地中海贫血患者肺动脉高压的患病率是多少?回顾性分析研究
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-10-01 DOI: 10.4103/rcm.rcm_18_22
Seyyed Fakhr-Moosavi, A. Salari, Yasaman‐Sadat Borghei, T. Hasandokht, A. Haghdoost, S. Mousavi, Sajad Ramezani
Introduction: Pulmonary hypertension (PH) is quite common among patients with thalassemia, and it can lead to cardiac failure and even death in those patients. Methods: This current cross-sectional study was conducted with 155 patients with β-thalassemia major and thalassemia intermedia referring to Razi Hospital Rasht, Iran in a recent year. All patients underwent echocardiography and the data (including age, sex, thalassemia type, splenectomy history, deferoxamine usage, hydroxyurea usage, hemoglobin, and ferritin level) were collected by a researcher-made checklist. Data analysis was performed using SPSS software. Results: The prevalence of PH was 13.7% in this study. There was a correlation between sex, thalassemia type, deferoxamine usage, and ferritin level with a prevalence of PH. However, there was not a significant relationship between splenectomy history, hydroxyurea usage, and hemoglobin level with PH prevalence (P = 0.187, P = 0.035, and P = 0.178, respectively). Conclusions: The findings of the study represented that the proposed variables can cause and exacerbate cardiac complications and may have a correlation with the disease's side effects. By conducting more studies and designing a more promising interventional study with a higher sample size, using the results of this study and similar studies, a step could be taken to identify patients susceptible to exacerbation of cardiac complications earlier. By treating them, we may be able to increase their chance of survival in the long run.
引言:肺动脉高压(PH)在地中海贫血患者中很常见,可导致心力衰竭甚至死亡。方法:这项横断面研究是对近年来在伊朗拉什特拉齐医院就诊的155名β-地中海贫血重度和中间型地中海贫血患者进行的。所有患者都接受了超声心动图检查,数据(包括年龄、性别、地中海贫血类型、脾切除术史、去铁胺使用情况、羟基脲使用情况、血红蛋白和铁蛋白水平)由研究人员编制的检查表收集。数据分析采用SPSS软件进行。结果:本研究中PH的患病率为13.7%。性别、地中海贫血类型、去铁胺使用量和铁蛋白水平与PH患病率之间存在相关性。然而,脾切除术史、羟基脲使用量和血红蛋白水平与PH发病率之间没有显著关系(分别为P=0.187、P=0.035和P=0.178)。结论:研究结果表明,所提出的变量会导致和加剧心脏并发症,并可能与疾病的副作用有关。利用这项研究和类似研究的结果,通过进行更多的研究并设计一项更具前景的更高样本量的介入研究,可以采取措施更早地识别易受心脏并发症恶化影响的患者。通过治疗他们,从长远来看,我们可能能够增加他们的生存机会。
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引用次数: 0
Practical use of dual-lumen catheter-facilitated reverse wire technique for nonhighly angulated side branch 双腔导管辅助反导丝技术在非高角度侧支中的实际应用
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-10-01 DOI: 10.4103/rcm.rcm_29_22
Issei Ota, T. Nomura, K. Ono, Yu Sakaue, Keisuke Shoji, Naotoshi Wada, N. Keira, T. Tatsumi
Dual-lumen catheter (DLC)-facilitated reverse wire technique is considered a method of last resort for inserting a guidewire into a markedly angulated side branch. Moreover, this technique can be practically applied to other types of anatomical variations around the bifurcation. Case 1 was that of a 53-year-old man with a tight stenosis of the proximal left anterior descending artery at the diagonal bifurcation with angiographically apparent coronary dissection. We successfully achieved guidewire insertion into the targeted branch using the DLC-facilitated reverse wire technique. Case 2 involved a 78-year-old man with total occlusion of the mid-portion of the right coronary artery. The guidewire reentry point in the atrioventricular branch was slightly distant from the true distal end of the occlusion. We successfully used the DLC-facilitated reverse wire technique to pass a second guidewire to the posterodescending artery. Case 3 was that of an 80-year-old man whose coronary artery had an aneurysm with severe stenoses at both entry and exit of the aneurysm. We adopted the DLC-facilitated reverse wire technique and easily advanced the guidewire by matching the guidewire advancing path with the direction of the sequential conduit constituted by the coronary aneurysm and stenosis. The timing of decision-making to try the DLC-facilitated reverse wire technique is important. The lesion for which reverse wiring is suitable is usually difficult to be treated with conventional guidewire crossing. We have to promptly judge the validity of applying this technique based on the angiographic findings of targeted lesions and take immediate action to implement this procedure to reduce the procedural time and irradiation dose.
双腔导管(DLC)辅助反导丝技术被认为是将导丝插入明显倾斜的侧支的最后手段。此外,这项技术可以实际应用于分叉周围的其他类型的解剖变异。病例1为一名53岁男性,左前降支近端斜分叉处狭窄,血管造影可见冠状动脉夹层。我们使用DLC促进的反向导丝技术成功地将导丝插入目标分支。病例2涉及一名78岁的男性,右冠状动脉中部完全闭塞。房室支中的导丝折返点距离闭塞的真正远端稍远。我们成功地使用DLC促进的反向导丝技术将第二根导丝传递到后验动脉。病例3是一名80岁的男性,他的冠状动脉有一个动脉瘤,在动脉瘤的入口和出口都有严重的狭窄。我们采用了DLC促进的反向导丝技术,通过将导丝前进路径与冠状动脉瘤和狭窄构成的顺序导管的方向相匹配,可以轻松地推进导丝。尝试DLC促进的反向布线技术的决策时机很重要。适合反向布线的病变通常很难用传统的导丝交叉进行治疗。我们必须根据靶向病变的血管造影结果及时判断应用该技术的有效性,并立即采取行动实施该程序,以减少手术时间和照射剂量。
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引用次数: 0
The short outcomes and in-hospital complications in patients with STEMI revascularized with primary PCI: A prospective registry from India STEMI血管重建术患者的短期预后和院内并发症:来自印度的前瞻性登记
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-10-01 DOI: 10.4103/rcm.rcm_25_22
Ambukeshwar Singh, V. Narain, Jayesh Sharma, G. Chaudhary, P. Vishwakarma, S. Yadav, S. Dwivedi
Context: Primary percutaneous coronary intervention (PCI) is the most effective reperfusion therapy with low complication rate in comparison to thrombolysis. Aims: We aimed to study the short-term outcomes of primary PCI at a large tertiary care center in India. Settings and Design: A prospective cohort of patients with ST-elevation myocardial infarction (STEMI) who underwent primary PCI was enrolled between December 2015 and November 2016. Subjects and Methods: The demographic profile, risk factors, clinical characteristics, inhospital complications, and outcomes at 30 days were assessed. The primary outcome was a composite of death, reinfarction, and repeat revascularization. Acute left ventricular failure (LVF), complete heart block (CHB) or bradyarrhythmia, ventricular tachycardia (VT) or ventricular fibrillation, stroke, and major thrombolysis in myocardial infarction bleeding were the inhospital complications that were considered the secondary outcomes. Results: A total of 237 STEMI patients with primary PCI were enrolled, accounting for 7.5% of all PCI procedures performed during this period. The mean age was 55.4 ± 11.9 years, and 86.5% were male. The mean window period was 5.1 ± 3.18 h, and the mean door-to-balloon time was 58.4 ± 11.5 min. Prior to PCI, the most often administered antiplatelets were clopidogrel in 54.4% of patients and prasugrel in 55.6%. The aspiration thrombectomy was done in 70.8% of patients. Predilatation with balloon was required in 41.8% of patients. Drug-eluting stents were implanted in 98.3% of patients. The primary outcome was found in 3.3% of patients (deaths – 2.9% and reinfarction – 0.4%) and the secondary outcomes were observed in 13%. The common inhospital complication was CHB or bradyarrhythmia in 5.0% followed by acute LVF in 4.6% and then VT in 2.1%. Conclusions: The primary outcome rate is as good as reported in developed Western countries in contemporary treatment practices of STEMI. CHB and acute LVF were the major inhospital complications among patients of STEMI treated with primary PCI.
背景:与溶栓相比,经皮冠状动脉介入治疗(PCI)是最有效的再灌注治疗,并发症发生率低。目的:我们旨在研究在印度一家大型三级医疗中心进行初级PCI的短期结果。设置和设计:在2015年12月至2016年11月期间,纳入了一个接受初次PCI的ST段抬高型心肌梗死(STEMI)患者的前瞻性队列。受试者和方法:评估人口统计学特征、危险因素、临床特征、住院并发症和30天时的结果。主要结果是死亡、再梗死和重复血运重建的复合结果。急性左心室衰竭(LVF)、完全性心脏传导阻滞(CHB)或缓慢性心律失常、室性心动过速(VT)或室颤、中风和心肌梗死出血的主要溶栓是被认为是次要结果的住院并发症。结果:共有237名经皮冠状动脉介入治疗的STEMI患者入选,占在此期间进行的所有PCI手术的7.5%。平均年龄55.4±11.9岁,男性占86.5%。平均窗口期为5.1±3.18小时,平均门到球囊时间为58.4±11.5分钟。PCI前,最常用的抗血小板药物是氯吡格雷(54.4%)和普拉格雷(55.6%)。抽吸血栓切除术(70.8%)。41.8%的患者需要球囊扩张术。98.3%的患者植入了药物洗脱支架。3.3%的患者出现了主要转归(死亡2.9%,再梗死0.4%),13%的患者出现次要转归。常见的住院并发症是慢性乙型肝炎或缓慢性心律失常(5.0%),其次是急性LVF(4.6%),然后是室性心动过速(2.1%)。CHB和急性LVF是经皮冠状动脉介入治疗STEMI患者的主要住院并发症。
{"title":"The short outcomes and in-hospital complications in patients with STEMI revascularized with primary PCI: A prospective registry from India","authors":"Ambukeshwar Singh, V. Narain, Jayesh Sharma, G. Chaudhary, P. Vishwakarma, S. Yadav, S. Dwivedi","doi":"10.4103/rcm.rcm_25_22","DOIUrl":"https://doi.org/10.4103/rcm.rcm_25_22","url":null,"abstract":"Context: Primary percutaneous coronary intervention (PCI) is the most effective reperfusion therapy with low complication rate in comparison to thrombolysis. Aims: We aimed to study the short-term outcomes of primary PCI at a large tertiary care center in India. Settings and Design: A prospective cohort of patients with ST-elevation myocardial infarction (STEMI) who underwent primary PCI was enrolled between December 2015 and November 2016. Subjects and Methods: The demographic profile, risk factors, clinical characteristics, inhospital complications, and outcomes at 30 days were assessed. The primary outcome was a composite of death, reinfarction, and repeat revascularization. Acute left ventricular failure (LVF), complete heart block (CHB) or bradyarrhythmia, ventricular tachycardia (VT) or ventricular fibrillation, stroke, and major thrombolysis in myocardial infarction bleeding were the inhospital complications that were considered the secondary outcomes. Results: A total of 237 STEMI patients with primary PCI were enrolled, accounting for 7.5% of all PCI procedures performed during this period. The mean age was 55.4 ± 11.9 years, and 86.5% were male. The mean window period was 5.1 ± 3.18 h, and the mean door-to-balloon time was 58.4 ± 11.5 min. Prior to PCI, the most often administered antiplatelets were clopidogrel in 54.4% of patients and prasugrel in 55.6%. The aspiration thrombectomy was done in 70.8% of patients. Predilatation with balloon was required in 41.8% of patients. Drug-eluting stents were implanted in 98.3% of patients. The primary outcome was found in 3.3% of patients (deaths – 2.9% and reinfarction – 0.4%) and the secondary outcomes were observed in 13%. The common inhospital complication was CHB or bradyarrhythmia in 5.0% followed by acute LVF in 4.6% and then VT in 2.1%. Conclusions: The primary outcome rate is as good as reported in developed Western countries in contemporary treatment practices of STEMI. CHB and acute LVF were the major inhospital complications among patients of STEMI treated with primary PCI.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":"11 1","pages":"96 - 101"},"PeriodicalIF":0.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46314810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiopathic radial artery true aneurysm: A rare entity 特发性桡动脉真动脉瘤:一种罕见的实体瘤
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-07-01 DOI: 10.4103/rcm.rcm_17_22
Anshuman Darbari, Ruhi Sharma, Rahul Sharma, Ajay Kumar
True idiopathic radial artery aneurysm is a rare entity. There are only a few cases reported in the literature. Asymptomatic radial arterial aneurysm in young patients is even rarer. Here, we present a successfully managed case report of a left radial artery aneurysm in a young female who presented to us with a painless, pulsatile swelling at the wrist.
真正的特发性桡动脉瘤是一种罕见的实体瘤。文献中只报道了少数病例。年轻患者的无症状桡动脉瘤更为罕见。在这里,我们介绍了一例成功治疗的年轻女性左桡动脉瘤的病例报告,她向我们介绍了手腕处无痛、搏动性肿胀。
{"title":"Idiopathic radial artery true aneurysm: A rare entity","authors":"Anshuman Darbari, Ruhi Sharma, Rahul Sharma, Ajay Kumar","doi":"10.4103/rcm.rcm_17_22","DOIUrl":"https://doi.org/10.4103/rcm.rcm_17_22","url":null,"abstract":"True idiopathic radial artery aneurysm is a rare entity. There are only a few cases reported in the literature. Asymptomatic radial arterial aneurysm in young patients is even rarer. Here, we present a successfully managed case report of a left radial artery aneurysm in a young female who presented to us with a painless, pulsatile swelling at the wrist.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":"11 1","pages":"86 - 88"},"PeriodicalIF":0.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48659358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of aortic root dilation in adult patients after repair of tetralogy of Fallot 成人法洛四联症修复后主动脉根部扩张的评价
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-07-01 DOI: 10.4103/rcm.rcm_3_22
Mozhgan Parsaee, A. Rezaeefar, Z. Khajali, Hamideh Khesali, Mohammad Bidkhori, A. Soleimani
Background and Aim: Aortic root dilation is one of the common complications in patients with a history of tetralogy of Fallot total correction (TFTC). We evaluate the frequency of aortic root dilation in adult TFTC patients and analyze probable risk factors related to the dilated aortic root. Materials and Methods and Results: We reviewed echocardiography images of 146 adult TFTC patients who admitted at Rajaie Cardiovascular Medical and Research Center from 1383 to 1399 in an observational retrospective cohort study. Sinus of Valsalva (SOV) was measured in parasternal long-axis view. Aortic root dilation was determined by two definitions. When we adjusted SOV diameter for body surface area and sex, the frequency of aortic root dilation was 68%, with a mean SOV diameter of 3.5 ± 0.7 cm and when we used absolute diameter ≥4 cm for dilated SOV, 22% showed aortic root dilation. By multivariate logistic regression analysis, male sex (odds ratio (OR) = 3.47, P = 0.003), age at the time of TFTC (OR = 1.06, P = 0.009), and aortic regurgitation (OR = 3.97, P = 0.003) were associated with increased adds of dilated aortic root. Three patients underwent aortic surgery, including one case of type A aortic dissection. Conclusion: Although aortic root dilation was common, aneurysmal dilation and adverse events were not so frequent. Serial evaluation of all segments of the ascending aorta, including the aortic root, is important but not more frequent than previously suggested.
背景与目的:主动脉根部扩张是法洛四联症患者的常见并发症之一。我们评估成人TFTC患者主动脉根部扩张的频率,并分析与主动脉根部扩张相关的可能危险因素。材料、方法和结果:我们回顾了1383年至1399年在Rajaie心血管医学和研究中心入院的146例成年TFTC患者的超声心动图。胸骨旁长轴位测量Valsalva窦(SOV)。主动脉根部扩张由两种定义确定。当我们根据体表面积和性别调整SOV直径时,主动脉根部扩张的频率为68%,平均SOV直径为3.5±0.7 cm,当我们使用绝对直径≥4 cm的SOV扩张时,22%的SOV出现主动脉根部扩张。通过多因素logistic回归分析,男性(优势比(OR) = 3.47, P = 0.003)、TFTC时的年龄(OR = 1.06, P = 0.009)、主动脉反流(OR = 3.97, P = 0.003)与主动脉根扩张的增加相关。3例患者接受了主动脉手术,其中1例为A型主动脉夹层。结论:虽然主动脉根部扩张是常见的,但动脉瘤扩张和不良事件并不常见。对升主动脉的所有节段(包括主动脉根)进行连续评估很重要,但并不比以前建议的更频繁。
{"title":"Evaluation of aortic root dilation in adult patients after repair of tetralogy of Fallot","authors":"Mozhgan Parsaee, A. Rezaeefar, Z. Khajali, Hamideh Khesali, Mohammad Bidkhori, A. Soleimani","doi":"10.4103/rcm.rcm_3_22","DOIUrl":"https://doi.org/10.4103/rcm.rcm_3_22","url":null,"abstract":"Background and Aim: Aortic root dilation is one of the common complications in patients with a history of tetralogy of Fallot total correction (TFTC). We evaluate the frequency of aortic root dilation in adult TFTC patients and analyze probable risk factors related to the dilated aortic root. Materials and Methods and Results: We reviewed echocardiography images of 146 adult TFTC patients who admitted at Rajaie Cardiovascular Medical and Research Center from 1383 to 1399 in an observational retrospective cohort study. Sinus of Valsalva (SOV) was measured in parasternal long-axis view. Aortic root dilation was determined by two definitions. When we adjusted SOV diameter for body surface area and sex, the frequency of aortic root dilation was 68%, with a mean SOV diameter of 3.5 ± 0.7 cm and when we used absolute diameter ≥4 cm for dilated SOV, 22% showed aortic root dilation. By multivariate logistic regression analysis, male sex (odds ratio (OR) = 3.47, P = 0.003), age at the time of TFTC (OR = 1.06, P = 0.009), and aortic regurgitation (OR = 3.97, P = 0.003) were associated with increased adds of dilated aortic root. Three patients underwent aortic surgery, including one case of type A aortic dissection. Conclusion: Although aortic root dilation was common, aneurysmal dilation and adverse events were not so frequent. Serial evaluation of all segments of the ascending aorta, including the aortic root, is important but not more frequent than previously suggested.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":"11 1","pages":"59 - 65"},"PeriodicalIF":0.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41505425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demographic characteristics, predisposing factors, clinical presentations, echocardiographic findings, complications, and outcomes of patients with viridans streptococcal endocarditis 病毒性链球菌性心内膜炎患者的人口学特征、易感因素、临床表现、超声心动图检查结果、并发症和转归
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-07-01 DOI: 10.4103/rcm.rcm_23_22
P. Moradnejad, S. Boudagh
Background: Several microorganisms are associated with infective endocarditis (IE), but the most common IE causes are staphylococci and streptococci. Among streptococci, the viridans group streptococci are responsible for a considerable percentage of all IE cases. Methods: Since 2006, the Iranian Registry of Infective Endocarditis has recorded information regarding all adult patients with a definite or possible IE diagnosis according to the modified Duke criteria. Patients with viridans streptococcal endocarditis were detected through three blood culture sets. The patients' demographic characteristics, predisposing factors, clinical presentations, and echocardiographic findings were recorded. Results: Of 731 patients diagnosed with endocarditis, viridans streptococci were found in 46 (6.3%) patients, consisting of 28 (60.9%) men and 18 (39.1%) women at a mean age of 42.56 ± 15.46 years, who were subsequently included in the study. Among the 46 patients with viridans streptococcal endocarditis, 26 had a subacute course, whereas 20 had an acute course. Vegetation was detected in 35 patients. All the patients were treated with the standard antibiotic regimen for viridans streptococcal endocarditis, and cardiac surgery was performed on 16 patients. Conclusions: Clinicians should pay sufficient heed to the following points in all cases of viridans streptococcal endocarditis: firstly, an appropriate antibiotic regimen must be based on a precise minimal inhibitory concentration determination for the usual antibiotics. Secondly, since prolonged antibiotic therapy is crucial to the eradication of microorganisms within vegetation, all patients with viridans streptococcal endocarditis must receive an adequate therapy course.
背景:几种微生物与感染性心内膜炎(IE)有关,但最常见的IE病因是葡萄球菌和链球菌。在链球菌中,翠绿链球菌群在所有IE病例中占相当大的比例。方法:自2006年以来,伊朗感染性心内膜炎登记处记录了所有根据修改的Duke标准确定或可能诊断为IE的成年患者的信息。采用三组血培养检测翠绿链球菌心内膜炎患者。记录患者的人口学特征、易感因素、临床表现和超声心动图结果。结果:在诊断为心内膜炎的731例患者中,46例(6.3%)患者中发现了绿绿链球菌,其中男性28例(60.9%),女性18例(39.1%),平均年龄为42.56±15.46岁。46例翠绿链球菌心内膜炎患者中,亚急性病程26例,急性病程20例。35例患者检出植被。所有患者均采用标准抗生素方案治疗翠绿链球菌心内膜炎,并对16例患者进行心脏手术。结论:临床医生在所有翠绿链球菌性心内膜炎病例中应充分注意以下几点:首先,适当的抗生素治疗方案必须基于对常用抗生素精确的最低抑菌浓度测定。其次,由于长期的抗生素治疗对于根除植被内的微生物至关重要,所有患有翠绿链球菌心内膜炎的患者都必须接受适当的治疗疗程。
{"title":"Demographic characteristics, predisposing factors, clinical presentations, echocardiographic findings, complications, and outcomes of patients with viridans streptococcal endocarditis","authors":"P. Moradnejad, S. Boudagh","doi":"10.4103/rcm.rcm_23_22","DOIUrl":"https://doi.org/10.4103/rcm.rcm_23_22","url":null,"abstract":"Background: Several microorganisms are associated with infective endocarditis (IE), but the most common IE causes are staphylococci and streptococci. Among streptococci, the viridans group streptococci are responsible for a considerable percentage of all IE cases. Methods: Since 2006, the Iranian Registry of Infective Endocarditis has recorded information regarding all adult patients with a definite or possible IE diagnosis according to the modified Duke criteria. Patients with viridans streptococcal endocarditis were detected through three blood culture sets. The patients' demographic characteristics, predisposing factors, clinical presentations, and echocardiographic findings were recorded. Results: Of 731 patients diagnosed with endocarditis, viridans streptococci were found in 46 (6.3%) patients, consisting of 28 (60.9%) men and 18 (39.1%) women at a mean age of 42.56 ± 15.46 years, who were subsequently included in the study. Among the 46 patients with viridans streptococcal endocarditis, 26 had a subacute course, whereas 20 had an acute course. Vegetation was detected in 35 patients. All the patients were treated with the standard antibiotic regimen for viridans streptococcal endocarditis, and cardiac surgery was performed on 16 patients. Conclusions: Clinicians should pay sufficient heed to the following points in all cases of viridans streptococcal endocarditis: firstly, an appropriate antibiotic regimen must be based on a precise minimal inhibitory concentration determination for the usual antibiotics. Secondly, since prolonged antibiotic therapy is crucial to the eradication of microorganisms within vegetation, all patients with viridans streptococcal endocarditis must receive an adequate therapy course.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":"11 1","pages":"71 - 75"},"PeriodicalIF":0.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41892384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Familial hypercholesterolemia within cardiology practice – single-center experience during 2-year period 心脏病学实践中的家族性高胆固醇血症- 2年期间的单中心经验
IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-07-01 DOI: 10.1016/j.atherosclerosis.2022.06.462
E. Begić, Ada Djozic, Emina Karavelic, Nadira Zatric, Adela Sinancevic, A. Džubur, A. Durak-Nalbantić, A. Begić, N. Begić, Amina Šahbaz, Esma Hasanagić, Ena Gogić, N. Naser, F. Zukić, Edin Medjedović, A. Iglica, M. Halilčević, Z. Begić
{"title":"Familial hypercholesterolemia within cardiology practice – single-center experience during 2-year period","authors":"E. Begić, Ada Djozic, Emina Karavelic, Nadira Zatric, Adela Sinancevic, A. Džubur, A. Durak-Nalbantić, A. Begić, N. Begić, Amina Šahbaz, Esma Hasanagić, Ena Gogić, N. Naser, F. Zukić, Edin Medjedović, A. Iglica, M. Halilčević, Z. Begić","doi":"10.1016/j.atherosclerosis.2022.06.462","DOIUrl":"https://doi.org/10.1016/j.atherosclerosis.2022.06.462","url":null,"abstract":"","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":"11 1","pages":"81 - 85"},"PeriodicalIF":0.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48915727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Research in Cardiovascular Medicine
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