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3625: Rehabilitation after gynaecological radiotherapy 3625:妇科放射治疗后的康复
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03476-5
Aoife Nolan
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引用次数: 0
3495: RTT perspective 3495:RTT 透视图
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03419-4
Emma Hallam
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引用次数: 0
18: Secondary analysis of JCOG1008: Frequency and risk factors associated with the hypothyroidism 18：JCOG1008 的二次分析：与甲状腺功能减退症相关的频率和风险因素
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03486-8
Hidetoshi Shimizu, Takeshi Kodaira, Naomi Kiyota, Ryuichi Hayashi, Hiroshi Nishino, Yukinori Asada, Hiroki Mitani, Yuuji Hirayama, Yusuke Onozawa, Naoki Nishio, Nobuhiro Hanai, Akira Ohkoshi, Hiroki Hara, Nobuya Monden, Masato Nagaoka, Shujiro Minami, Takashi Fujii, Kaoru Tanaka, Akihiro Homma, Keita Sasaki, Ryo Kitabayashi, Satoshi Ishikura, Yasumasa Nishimura, Makoto Tahara
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引用次数: 0
Clinical target volume design and dose in carbon-ion radiation therapy for sinonasal mucosal melanoma 鼻窦粘膜黑色素瘤碳离子放射治疗的临床靶体积设计和剂量。
IF 4.9 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/j.radonc.2024.110511

Background and purpose

No guidelines exist for the clinical target volume (CTV) and radiotherapy dose in sinonasal mucosal melanoma (SNMM). Thus, we aimed to determine the carbon-ion radiotherapy (CIRT) CTV and dose for SNMM.

Materials and methods

In total, 135 patients with SNMM who received CIRT were reviewed. The relative biological effectiveness-weighted dose was 57.6 or 64 Gy in 16 fractions. CTV was classified into small CTV, which included the gross tumor and visible melanosis with a certain margin, and extended CTV, which included the tumor site and adjacent anatomical structures. Local recurrence (LR) patterns were pattern I, II, and III, defined as recurrence over the gross tumor, visible melanosis and subclinical area, which would be covered if extended CTV was applied, and outside the extended CTV, respectively.

Results

The 5-year LR rate was 35.3 %. The prescribed dose was not a significant risk factor for pattern I LR; however, 57.6 Gy for a large tumor was insufficient for local control. Using an extended CTV was significantly associated with a lower risk of pattern II LR, and these recurrences did not occur in regions that received > 40 Gy. The 5-year pattern III LR rate was 6.4 %.

Conclusion

Utilizing an extended CTV in CIRT for SNMM is appropriate even for small tumors. Using a smaller CTV after an extended CTV of at least 40 Gy is recommended to reduce adverse events. Although the optimal dose for gross tumors remains unclear, the latest technology with 64 Gy showed good outcomes.

背景和目的：目前尚无鼻窦粘膜黑色素瘤（SNMM）临床靶体积（CTV）和放疗剂量的指南。因此，我们旨在确定鼻窦粘膜黑色素瘤的碳离子放疗（CIRT）CTV和剂量：材料和方法：共对 135 例接受过 CIRT 治疗的鼻窦粘膜黑色素瘤患者进行了回顾性研究。相对生物效应加权剂量为 57.6 或 64 Gy，分 16 次进行。CTV分为小CTV和大CTV，小CTV包括大肿瘤和一定边缘内可见的黑色素沉着，大CTV包括肿瘤部位和邻近的解剖结构。局部复发（LR）模式为模式Ⅰ、Ⅱ和Ⅲ，分别定义为复发于肿瘤毛发、可见黑色素沉着和亚临床区域（如果应用扩展 CTV 则会覆盖该区域）以及扩展 CTV 以外的区域：5年LR率为35.3%。处方剂量不是I型LR的重要风险因素；然而，57.6 Gy的大肿瘤剂量不足以实现局部控制。使用扩大的CTV与较低的II型LR风险明显相关，而在接受> 40 Gy治疗的区域则不会发生II型LR。5年的III型LR发生率为6.4%：结论：在SNMM的CIRT中使用扩展CTV是合适的，即使是小肿瘤也是如此。建议在使用至少 40 Gy 的扩展 CTV 后再使用较小的 CTV，以减少不良反应。尽管对巨大肿瘤的最佳剂量仍不明确，但最新技术的64 Gy显示了良好的疗效。
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引用次数: 0
3459: Postoperative radiotherapy in high-risk and advanced NMSC 3459： 高风险和晚期 NMSC 的术后放疗
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03396-6
Nikhil Joshi
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引用次数: 0
3628: Bridging the evidence gap: From physics and technology innovations to clinical practice 3628: 缩小证据差距：从物理学和技术创新到临床实践
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03478-9
David I. Thwaites
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引用次数: 0
3508: Targeting aerobic glycolysis and mitochondrial respiration to overcome radioresistance 3508:针对有氧糖酵解和线粒体呼吸克服放射抗药性
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03430-3
Paul N. Span
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引用次数: 0
3536: The role of proton radiotherapy in the treatment of oesophageal cancer 3536: 质子放射治疗在食道癌治疗中的作用
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03442-x
Christina Muijs
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引用次数: 0
3501: Social inequality and other socioeconomic factors affecting treatment in head and neck cancer care: Can we actually do something? 3501：影响头颈部癌症治疗的社会不平等和其他社会经济因素：我们能做些什么吗？
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03424-8
Maja Halgren Olsen
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引用次数: 0
3469: Quality checks that enable the clinical use of synthetic CT 3469:使合成 CT 能够用于临床的质量检查
IF 5.7 1区 医学 Q1 ONCOLOGY
Radiotherapy and Oncology
Pub Date : 2024-08-30 DOI: 10.1016/s0167-8140(24)03402-9
Fernanda Villegas-Navarro
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引用次数: 0
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