Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1631757
M. M. Jagadale, M. R. Asabe, V.T. Vader, S. V. Rajmane, V. P. Ubale
The newfangled Schiff base ligand 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}-phenol [HL 1 ], 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}- naphthalene-2-ol [HL 2 ], 2-{[4-(4’- amino-phenoxy)- phenylimino]- methyl}- 4 - bromophenol [HL 3 ] and 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}-6- methoxyphenol [HL 4 ] and it’s In(III) metal complexes had been synthesized. The ligand and metal complexes have been characterized with elemental analysis, UV-visible, IR, 1 H NMR spectroscopy, thermal studies, and magnetic susceptibility measurement. The crystallographic investigation reveals the tetragonal geometry of In (III) complexes of Schiff bases HL 1 to HL 4 . Also, the magnetic moment and electronic spectral studies supported the tetrahedral structure In (III) complexes of Schiff bases. The antibacterial and antifungal activity of the Schiff base was accentuated while being coordinated with metal ions. Ligand [HL 1-4 ] is immune to both human cancer cell lines, comprehensive of breast (MCF7) and colon (HT29) with GI50 of 62.2 μM, 65.2 μM, 72.2 μM, and 84 μM respectively. In (III) metal complexes confirm adequate activity in the breast (MCF7) cellular cell line with IC50 values of 31.1 μM.
{"title":"SYNTHESIS, CHARACTERIZATION AND ANTICANCER STUDIES OF NEWFANGLED INDIUM (III) SCHIFF BASE METAL COMPLEXES","authors":"M. M. Jagadale, M. R. Asabe, V.T. Vader, S. V. Rajmane, V. P. Ubale","doi":"10.31788/rjc.2023.1631757","DOIUrl":"https://doi.org/10.31788/rjc.2023.1631757","url":null,"abstract":"The newfangled Schiff base ligand 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}-phenol [HL 1 ], 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}- naphthalene-2-ol [HL 2 ], 2-{[4-(4’- amino-phenoxy)- phenylimino]- methyl}- 4 - bromophenol [HL 3 ] and 2-{[4-(4’- amino-phenoxy)- phenylimino]-methyl}-6- methoxyphenol [HL 4 ] and it’s In(III) metal complexes had been synthesized. The ligand and metal complexes have been characterized with elemental analysis, UV-visible, IR, 1 H NMR spectroscopy, thermal studies, and magnetic susceptibility measurement. The crystallographic investigation reveals the tetragonal geometry of In (III) complexes of Schiff bases HL 1 to HL 4 . Also, the magnetic moment and electronic spectral studies supported the tetrahedral structure In (III) complexes of Schiff bases. The antibacterial and antifungal activity of the Schiff base was accentuated while being coordinated with metal ions. Ligand [HL 1-4 ] is immune to both human cancer cell lines, comprehensive of breast (MCF7) and colon (HT29) with GI50 of 62.2 μM, 65.2 μM, 72.2 μM, and 84 μM respectively. In (III) metal complexes confirm adequate activity in the breast (MCF7) cellular cell line with IC50 values of 31.1 μM.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1638272
Umar Kalmar Nizar, Rizki Gunawan, Taufiq Yap Yun Hin, Rita Sundari, Surahim Bin Mahmud, Siti Fadhilah Binti Ibrahim, Nawirus Sazali, Amelia Sintia, Arrum Lazuardi, Niza Lian Pernadi
A series of sulfonated avocado seed carbon catalysts for biodiesel production was successfully synthesized. The carbonization of avocado seed has been varied at 300 o C, 400 o C, 500 o C, and 600 o C using nitrogen gas purging followed by sulfonation applying HSO 3 Cl (chlorosulfonic acid) in chloroform solvent. The designed catalyst has been characterized using FTIR, XRD, and TPD-NH 3 . The results show strong absorption peaks in FTIR spectra at the wave numbers of 1140 and 1030 cm -1 , which indicates an O-S-O bonding vibration in asymmetric and symmetric stretching. Meanwhile, the XRD patterns show two main peaks, namely the broad peak at 2 10 o -30 o corresponding with the C (002) plane and the sharp peak at 2 40 o -45 o corresponding with the C (101) plane. The TPD-NH 3 reveals that the catalyst with the highest acid site number showed for sulfonated avocado seed carbon calcined at 400 o C (AS400-S) sample. The catalytic activity shows the designed catalyst can convert PFAD to form biodiesel until 64.6061%.
{"title":"UTILIZATION OF AVOCADO SEED WASTE IN THE SYNTHESIS OF SULFONATED CARBON CATALYSTS USING CHLOROSULFONIC ACID FOR BIODIESEL PRODUCTION","authors":"Umar Kalmar Nizar, Rizki Gunawan, Taufiq Yap Yun Hin, Rita Sundari, Surahim Bin Mahmud, Siti Fadhilah Binti Ibrahim, Nawirus Sazali, Amelia Sintia, Arrum Lazuardi, Niza Lian Pernadi","doi":"10.31788/rjc.2023.1638272","DOIUrl":"https://doi.org/10.31788/rjc.2023.1638272","url":null,"abstract":"A series of sulfonated avocado seed carbon catalysts for biodiesel production was successfully synthesized. The carbonization of avocado seed has been varied at 300 o C, 400 o C, 500 o C, and 600 o C using nitrogen gas purging followed by sulfonation applying HSO 3 Cl (chlorosulfonic acid) in chloroform solvent. The designed catalyst has been characterized using FTIR, XRD, and TPD-NH 3 . The results show strong absorption peaks in FTIR spectra at the wave numbers of 1140 and 1030 cm -1 , which indicates an O-S-O bonding vibration in asymmetric and symmetric stretching. Meanwhile, the XRD patterns show two main peaks, namely the broad peak at 2 10 o -30 o corresponding with the C (002) plane and the sharp peak at 2 40 o -45 o corresponding with the C (101) plane. The TPD-NH 3 reveals that the catalyst with the highest acid site number showed for sulfonated avocado seed carbon calcined at 400 o C (AS400-S) sample. The catalytic activity shows the designed catalyst can convert PFAD to form biodiesel until 64.6061%.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1617052
Ritmaleni, Dong-Hwi Kim
PC-2 is one of the active compounds isolated from Indonesian red betel leaf. The structure of the compound is named 2-allyl-4-(1'-hydroxy-1'-(3",4",5"-trimethoxyphenyl)propan-2'-yl)-3,5-dimethoxycyclohexa-3,5-dienone and included in the neolignan’s structure category. This compound was reported to have very good biological activity in giving antiproliferative effects on human breast (T47D) cells. From 2.12 g of its leaf methanolic extract, only 12.1 mg of Pc-2 was collected. This amount is too small to do more studies about its biological activities. The synthetic work should be applied to get a sufficient amount. This paper is aimed to explain the synthetic study and design of the Pc2 compound. The first approach is by involving the aldol reaction in the synthetic pathway through the disconnection approach. The result showed that this attempt did not work very well. The second approach is to design the new synthetic pathway by using the synthia Organic Retrosynthesis Software by Merck. This software gave a reasonable result to be tried. The result proposed the use of the Suzuki coupling reaction for the new synthetic pathway of Pc-2.
{"title":"SYNTHETIC STUDY OF Pc-2, AN ACTIVE COMPOUND FROM INDONESIAN RED BETEL LEAF","authors":"Ritmaleni, Dong-Hwi Kim","doi":"10.31788/rjc.2023.1617052","DOIUrl":"https://doi.org/10.31788/rjc.2023.1617052","url":null,"abstract":"PC-2 is one of the active compounds isolated from Indonesian red betel leaf. The structure of the compound is named 2-allyl-4-(1'-hydroxy-1'-(3\",4\",5\"-trimethoxyphenyl)propan-2'-yl)-3,5-dimethoxycyclohexa-3,5-dienone and included in the neolignan’s structure category. This compound was reported to have very good biological activity in giving antiproliferative effects on human breast (T47D) cells. From 2.12 g of its leaf methanolic extract, only 12.1 mg of Pc-2 was collected. This amount is too small to do more studies about its biological activities. The synthetic work should be applied to get a sufficient amount. This paper is aimed to explain the synthetic study and design of the Pc2 compound. The first approach is by involving the aldol reaction in the synthetic pathway through the disconnection approach. The result showed that this attempt did not work very well. The second approach is to design the new synthetic pathway by using the synthia Organic Retrosynthesis Software by Merck. This software gave a reasonable result to be tried. The result proposed the use of the Suzuki coupling reaction for the new synthetic pathway of Pc-2.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69409787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1618088
K. M. Nagarsha, T. Sharanakumar, D. Ramesh, N. Kumar, M. N. Kumarswamy, D. Ramesh, K. P. Latha
The novel derivatives of naphtho-furan such N-(5bromo-2-(5-phenyl-1,3,4-oxadiazol-2-yl)naphtha[2,1-b]furan-1- yl)acetamide (8), N-(5-bromo-2-(hydrazinecarbonyl)naphtha[2,1-b]furan-1-yl]acetamide (7), ethyl-1-acetamido-5- bromonaphtho[2,1-b]furan-2-carboxylate (6), N-(5-nitro-2-(5-phenyl-1,3,4-oxadiazol-2-yl)naphtha[2,1-bfuran-1- yl]acetamide (5),N-(2-(hydrazinecarbonyl)-5-nitronaphtho[2,1-b]furan-1-yl)acetamide (4), ethyl-1-acetamido-5- nitrpnaphtho[2,1-b]furan-2-carboxylate (3), are prepared by ethyl-1-acetamidonaphtho[2,1-b]furan-2-carboxyate and ethyl 1-aminonaphtho[2,1-b]furan-2-carboxylate. All newly synthesized compounds were confirmed by Mass, NMR, and FTIR spectroscopic techniques. Those compounds were used for antimicrobial activity it exhibits good antibacterial and anti-functional activity.
这部小说衍生品等naphtho-furan N - (5 bromo-2 - (5-phenyl-1 3 4-oxadiazol-2-yl)石脑油(2,1 b) furan-1 - yl)乙酰胺(8)、N - (5-bromo-2——(hydrazinecarbonyl)石脑油(2,1 b) furan-1-yl)乙酰胺(7),ethyl-1-acetamido-5——bromonaphtho (2, 1 b) furan-2-carboxylate(6)、N - (5-nitro-2——(5-phenyl-1 3 4-oxadiazol-2-yl)石脑油(2,1-bfuran-1 - yl)乙酰胺(5),N - (2 - (hydrazinecarbonyl) 5-nitronaphtho [2, 1 b] furan-1-yl)乙酰胺(4),ethyl-1-acetamido-5——nitrpnaphtho (2, 1 b) furan-2-carboxylate (3),由1-乙酰氨基萘[2,1-b]呋喃-2-羧酸乙酯和1-氨基萘[2,1-b]呋喃-2-羧酸乙酯制备。所有新合成的化合物均经质谱、核磁共振和红外光谱技术证实。这些化合物具有良好的抑菌活性和抗功能活性。
{"title":"NOVEL SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF N-(5BROMO-2-(5-PHENYL1,3,4-OXADIAZOL-2-YL)NAPHTHA[2,1-B]FURAN-1- YL)ACETAMIDE AND N-(5-NITRO-2-(5-PHENYL-1,3,4- OXADIAZOL-2-YL)NAPHTHA[2,1-BFURAN-1-YL]ACETAMIDE AND THEIR DERIVATIVES","authors":"K. M. Nagarsha, T. Sharanakumar, D. Ramesh, N. Kumar, M. N. Kumarswamy, D. Ramesh, K. P. Latha","doi":"10.31788/rjc.2023.1618088","DOIUrl":"https://doi.org/10.31788/rjc.2023.1618088","url":null,"abstract":"The novel derivatives of naphtho-furan such N-(5bromo-2-(5-phenyl-1,3,4-oxadiazol-2-yl)naphtha[2,1-b]furan-1- yl)acetamide (8), N-(5-bromo-2-(hydrazinecarbonyl)naphtha[2,1-b]furan-1-yl]acetamide (7), ethyl-1-acetamido-5- bromonaphtho[2,1-b]furan-2-carboxylate (6), N-(5-nitro-2-(5-phenyl-1,3,4-oxadiazol-2-yl)naphtha[2,1-bfuran-1- yl]acetamide (5),N-(2-(hydrazinecarbonyl)-5-nitronaphtho[2,1-b]furan-1-yl)acetamide (4), ethyl-1-acetamido-5- nitrpnaphtho[2,1-b]furan-2-carboxylate (3), are prepared by ethyl-1-acetamidonaphtho[2,1-b]furan-2-carboxyate and ethyl 1-aminonaphtho[2,1-b]furan-2-carboxylate. All newly synthesized compounds were confirmed by Mass, NMR, and FTIR spectroscopic techniques. Those compounds were used for antimicrobial activity it exhibits good antibacterial and anti-functional activity.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69410202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1618075
R. Mini, V. Prabhu, K. Poonkodi, K. Vimaladevi, K. Revathi
Silver oxide nanoparticles exhibit distinctive material and biotic properties that contain passionate research impact as vital applications in the pharmaceutical, biomedical, paper and textile industries. The goal of the current task is to synthesize AgNPs through a facile, low-cost, environmentally friendly route. In this method, we use the aqueous leaf extract of Scoparia dulcis Linn, found in the Western Ghats region, because the use of an aqueous medium is critical for reducing time and minimizing the possibility of side effects. The synthesized Ag nanoparticles were evaluated using UV-Visible, FTIR technique, scanning electron microscopy (SEM) with EADX, transmission electron microscopy (TEM), X-ray powder diffraction (XRD). Results confirmed that UV-visible spectroscopic analysis showed the absorbance peak at 460 nm, which implies the formation of silver nanoparticles. The FTIR spectrum aimed to such that biomolecules involved in wrapping and binding AgNPs synthesized by the plant extract. SEM and TEM are used to visualize the size and shape of nanoparticles. The XRD analysis revealed spherical structures with an average grain size of 21nm and a diameter range of 2 to 20nm. The EDAX study also exhibits the presence of 86.34 % Silver and 13.6 % Oxygen. Alzheimer's disease symptoms were controlled with a drug known as an acetylcholinesterase inhibitor. The in vitro acetylcholinesterase inhibitory activity of the AgNPs from Scoparia dulcis plant extract was evaluated using an Ellman's test with an IC50 value of 149µg/ml. The generated nanoparticles significantly inhibit AChE. The SD-AgNPs were examined for antioxidant activity via the DPPH and ABTS assays having IC50 values of 73.29µg/ml and 55.29µg/ml, respectively
{"title":"GREEN SYNTHESIS OF SILVER NANOPARTICLES FROM Scoparia dulcis L. PLANT EXTRACT AND ITS In-vitro ACETYLCHOLINESTERASE, ANTIOXIDANT ACTIVITY","authors":"R. Mini, V. Prabhu, K. Poonkodi, K. Vimaladevi, K. Revathi","doi":"10.31788/rjc.2023.1618075","DOIUrl":"https://doi.org/10.31788/rjc.2023.1618075","url":null,"abstract":"Silver oxide nanoparticles exhibit distinctive material and biotic properties that contain passionate research impact as vital applications in the pharmaceutical, biomedical, paper and textile industries. The goal of the current task is to synthesize AgNPs through a facile, low-cost, environmentally friendly route. In this method, we use the aqueous leaf extract of Scoparia dulcis Linn, found in the Western Ghats region, because the use of an aqueous medium is critical for reducing time and minimizing the possibility of side effects. The synthesized Ag nanoparticles were evaluated using UV-Visible, FTIR technique, scanning electron microscopy (SEM) with EADX, transmission electron microscopy (TEM), X-ray powder diffraction (XRD). Results confirmed that UV-visible spectroscopic analysis showed the absorbance peak at 460 nm, which implies the formation of silver nanoparticles. The FTIR spectrum aimed to such that biomolecules involved in wrapping and binding AgNPs synthesized by the plant extract. SEM and TEM are used to visualize the size and shape of nanoparticles. The XRD analysis revealed spherical structures with an average grain size of 21nm and a diameter range of 2 to 20nm. The EDAX study also exhibits the presence of 86.34 % Silver and 13.6 % Oxygen. Alzheimer's disease symptoms were controlled with a drug known as an acetylcholinesterase inhibitor. The in vitro acetylcholinesterase inhibitory activity of the AgNPs from Scoparia dulcis plant extract was evaluated using an Ellman's test with an IC50 value of 149µg/ml. The generated nanoparticles significantly inhibit AChE. The SD-AgNPs were examined for antioxidant activity via the DPPH and ABTS assays having IC50 values of 73.29µg/ml and 55.29µg/ml, respectively","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69410564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1626810
Susilawati, D. Pangga, M. Zainuri, A. Doyan, S. Prayogi, M. R. Bilad
Barium hexaferrite (BaFe12O19) has attracted research attention due to its diverse applications. This study reports the synthesis of barium M-hexaferrite (BaFe12-2xCoxZnxO19) powder using co-precipitation of BaCO3 and FeCl3.6H2O powder, Co and Zn powder as a dopant material on the variation of x = 0, 0.2, 0.4, 0.6, 0.8, and 1. Results show that co-precipitation is an effective method for the synthesis of nanomaterial barium M-hexaferrites (BaFe12-2xCoxZnxO19) containing >89% of Fe elements and an average particle size of 50 nm. The DTA/TGA analyses show phase transformation at T ≤ 285°C and T = 750-840°C. The results of refinement using the Rietveld method show that the barium M-hexaferrite phase begins to form at low temperatures, with the best yield at x = 0.4. At high temperatures T > 740°C, it tends to form single-phase α-Fe2O3 (hematite). Substitution ion dopant Co/Zn only slightly changes the lattice parameters of the hexagonal basic crystal structure
{"title":"SYNTHESIS AND CHARACTERIZATION OF BARIUM MHEXAFERRITE BaFe12-2xCoxZnxO19 (0 ≤ X ≤ 1) PREPARED FROM CO-PRECIPITATION","authors":"Susilawati, D. Pangga, M. Zainuri, A. Doyan, S. Prayogi, M. R. Bilad","doi":"10.31788/rjc.2023.1626810","DOIUrl":"https://doi.org/10.31788/rjc.2023.1626810","url":null,"abstract":"Barium hexaferrite (BaFe12O19) has attracted research attention due to its diverse applications. This study reports the synthesis of barium M-hexaferrite (BaFe12-2xCoxZnxO19) powder using co-precipitation of BaCO3 and FeCl3.6H2O powder, Co and Zn powder as a dopant material on the variation of x = 0, 0.2, 0.4, 0.6, 0.8, and 1. Results show that co-precipitation is an effective method for the synthesis of nanomaterial barium M-hexaferrites (BaFe12-2xCoxZnxO19) containing >89% of Fe elements and an average particle size of 50 nm. The DTA/TGA analyses show phase transformation at T ≤ 285°C and T = 750-840°C. The results of refinement using the Rietveld method show that the barium M-hexaferrite phase begins to form at low temperatures, with the best yield at x = 0.4. At high temperatures T > 740°C, it tends to form single-phase α-Fe2O3 (hematite). Substitution ion dopant Co/Zn only slightly changes the lattice parameters of the hexagonal basic crystal structure","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69410788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1618207
An attempt is made to design, synthesize and pharmacologically evaluate novel bis-intercalators as possible anticancer agents. According to a literature study on bis-intercalators, 4-substituted bis-benzamides are widely recognized for their medicinal uses and may be effective anticancer and antioxidant agents. Synthetic studies revealed that the yield of Chain linkers L1-L14, 4-substituted bis benzamides, and L-proline derivatives were in the 50-70% range. The 4-substituted bis benzamides compounds have been evaluated for anticancer and antioxidant activity studies. Among the 4-substituted bis benzamides compounds, Compound IIIc, IIIf, and IIIg have revealed promising anticancer and antioxidant activity. Compounds III7 and III12 have good cytotoxicity and antioxidant activity among L-proline derivatives. As a result, the current study emphasizes the significance of 4-substituted bis benzamides and L-proline derivatives with various heterocyclic moiety features responsible for cytotoxicity and antioxidant activity. It might be a starting point for further alterations to create new entities with therapeutically useful properties.
{"title":"DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL BIS-INTERCALATORS AS POSSIBLE ANTICANCER AGENTS","authors":"","doi":"10.31788/rjc.2023.1618207","DOIUrl":"https://doi.org/10.31788/rjc.2023.1618207","url":null,"abstract":"An attempt is made to design, synthesize and pharmacologically evaluate novel bis-intercalators as possible anticancer agents. According to a literature study on bis-intercalators, 4-substituted bis-benzamides are widely recognized for their medicinal uses and may be effective anticancer and antioxidant agents. Synthetic studies revealed that the yield of Chain linkers L1-L14, 4-substituted bis benzamides, and L-proline derivatives were in the 50-70% range. The 4-substituted bis benzamides compounds have been evaluated for anticancer and antioxidant activity studies. Among the 4-substituted bis benzamides compounds, Compound IIIc, IIIf, and IIIg have revealed promising anticancer and antioxidant activity. Compounds III7 and III12 have good cytotoxicity and antioxidant activity among L-proline derivatives. As a result, the current study emphasizes the significance of 4-substituted bis benzamides and L-proline derivatives with various heterocyclic moiety features responsible for cytotoxicity and antioxidant activity. It might be a starting point for further alterations to create new entities with therapeutically useful properties.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69411174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1628287
H. Parbuntari, F. Azra, O. Suryani, M. Melati
The protection of active compounds such as flavonoids as candidate drug compounds has been the focus of several studies in recent years. This is due to the different physicochemical properties of flavonoids. Furthermore, the function of these flavonoid compounds can be maximized from the initial process of separating them from the plant of origin known as extraction. This study compared the effectiveness and efficiency of using microwave extraction and maceration of Gedi leaves (Abelmoschus manihot L.). Then, the extract was encapsulated to protect the unstable flavonoids. There were two methods to encapsulate the extract in this study. They were the coprecipitation and kneading methods. The result shows that microwave extraction assisted has higher product in less solvent and was time-consuming. The coprecipitation also shows better performance in encapsulating the extract. The calculation of the efficiency of encapsulation was done for 3 different volumes of both methods. The addition of 1 mL extract by coprecipitation showed approximately 92.12%. It was also supported by the data of FTIR and UV VIS.
{"title":"MICROENCAPSULATION OF FLAVONOIDS FROM GEDI LEAVES (Abelmoschus manihot L.) IN β-CYCLODEXTRIN USING COPRECIPITATION AND KNEADING METHODS","authors":"H. Parbuntari, F. Azra, O. Suryani, M. Melati","doi":"10.31788/rjc.2023.1628287","DOIUrl":"https://doi.org/10.31788/rjc.2023.1628287","url":null,"abstract":"The protection of active compounds such as flavonoids as candidate drug compounds has been the focus of several studies in recent years. This is due to the different physicochemical properties of flavonoids. Furthermore, the function of these flavonoid compounds can be maximized from the initial process of separating them from the plant of origin known as extraction. This study compared the effectiveness and efficiency of using microwave extraction and maceration of Gedi leaves (Abelmoschus manihot L.). Then, the extract was encapsulated to protect the unstable flavonoids. There were two methods to encapsulate the extract in this study. They were the coprecipitation and kneading methods. The result shows that microwave extraction assisted has higher product in less solvent and was time-consuming. The coprecipitation also shows better performance in encapsulating the extract. The calculation of the efficiency of encapsulation was done for 3 different volumes of both methods. The addition of 1 mL extract by coprecipitation showed approximately 92.12%. It was also supported by the data of FTIR and UV VIS.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69411219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1638335
Mohit Ananda, Abhishek Ghosh, Hridhya Mohandas, Rudranil Karmakar, Belagala Nagesh, S. Jubie, Sanal Dev K. T., Jeyaprakash M. R.
Abacavir Sulfate is a nucleoside analog and reverse transcriptase inhibitor which is used in combination with Lamivudine and Zidovudine for the treatment of HIV and AIDS. Abacavir has higher toxicity levels and is least stable in heat. The specified temperature for the drug was proposed to be not more than 25°C. The present study focuses on the stability-related problem of the ABC. The new synthetic moiety will help to stabilize the drug, it can be used as a pro-drug formulation and can take the present scenario of the market which supplies any anti-retroviral drug. The aim of the current study is to synthesize a novel drug using Schiff base synthesis and perform its structural elucidation by different modes of Instrumental Analysis and perform in silico studies. From the above study, we can conclude that the novel moiety is safe to use as a drug and could be explored furthermore for its use.
{"title":"SYNTHESIS, MOLECULAR DOCKING, IN-SILICO ADMET SCREENING, STRUCTURAL SAFETY EVALUATION OF ABACAVIR SULFATE AND ITS NOVEL MODIFIED SUBSTANCE","authors":"Mohit Ananda, Abhishek Ghosh, Hridhya Mohandas, Rudranil Karmakar, Belagala Nagesh, S. Jubie, Sanal Dev K. T., Jeyaprakash M. R.","doi":"10.31788/rjc.2023.1638335","DOIUrl":"https://doi.org/10.31788/rjc.2023.1638335","url":null,"abstract":"Abacavir Sulfate is a nucleoside analog and reverse transcriptase inhibitor which is used in combination with Lamivudine and Zidovudine for the treatment of HIV and AIDS. Abacavir has higher toxicity levels and is least stable in heat. The specified temperature for the drug was proposed to be not more than 25°C. The present study focuses on the stability-related problem of the ABC. The new synthetic moiety will help to stabilize the drug, it can be used as a pro-drug formulation and can take the present scenario of the market which supplies any anti-retroviral drug. The aim of the current study is to synthesize a novel drug using Schiff base synthesis and perform its structural elucidation by different modes of Instrumental Analysis and perform in silico studies. From the above study, we can conclude that the novel moiety is safe to use as a drug and could be explored furthermore for its use.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69412454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.31788/rjc.2023.1618097
A. Immaculate, J. Vimala, D. Takuwa
Medicinal plants play an important role in our life. Worldwide modern drugs used in healthcare are derived from plants. Several Rhizomes and tubers are important for people due to their edible as well as medicinal properties. The Rhizome and tuberous plants namely Solanum aculeastrum dunal, Elephantorrhiza elephentina, Cadaba aphylla (Thunb), and Adenia glauca which are indigenous plants of Botswana have been so far employed in the treatment of cutaneous, subcutaneous parasitic infection, wounds, dermatological diseases, gastrointestinal system disorders, sexual dysfunction, and sexually transmitted infections. This study was conducted to identify the phytoconstituents by subjecting them to Ultrasound-Assisted Extraction (UAE) with distilled water, methanol, ethanol, chloroform, and hexane, each extract of which was further applied to the phytochemical screening through qualitative and quantitative tests. The extracting yields of Solanum aculeastrum dunal with different solvents gave the values of 13.0% (hexane), 13.0% (chloroform), 66.6% (ethanol), 66.6% (methanol) and 46.6% (aqueous), Elephantorrhiza elephentina 13.0% (hexane), 20.0% (chloroform), 66.6% (ethanol), 80.0% (methanol) and 86.0% (aqueous), Cadaba aphylla 60% (ethanol), 66.6% (methanol) and 53.3% (aqueous), Adenia glauca 40% (ethanol), 40.0% (methanol) and 46.6% (aqueous). Standards were used to determine the total content of alkaloid, flavonoid, phenol, saponin, and tannin (Atropine, Quercetin, Gallic acid, Tannic acid, and Quillaja). The regression coefficient (R2 ) was calculated and for Alkaloids, it is 0.9925, flavonoid (0.9953), phenol (0.9978), tannin (0.9955), and saponin (0.9912) respectively. These medicinal plants have produced many phytochemical substances in quantitative analysis, which will be applied in future drug analysis research
{"title":"PHYTOCHEMICAL ANALYSIS IN ROOTS AND TUBERS OF BOTSWANA MEDICINAL PLANTS- Solanum Aculeastrum dunal, Elephantorrhiza elephentina, Cadaba aphylla (Thunb) AND Adenia glauca","authors":"A. Immaculate, J. Vimala, D. Takuwa","doi":"10.31788/rjc.2023.1618097","DOIUrl":"https://doi.org/10.31788/rjc.2023.1618097","url":null,"abstract":"Medicinal plants play an important role in our life. Worldwide modern drugs used in healthcare are derived from plants. Several Rhizomes and tubers are important for people due to their edible as well as medicinal properties. The Rhizome and tuberous plants namely Solanum aculeastrum dunal, Elephantorrhiza elephentina, Cadaba aphylla (Thunb), and Adenia glauca which are indigenous plants of Botswana have been so far employed in the treatment of cutaneous, subcutaneous parasitic infection, wounds, dermatological diseases, gastrointestinal system disorders, sexual dysfunction, and sexually transmitted infections. This study was conducted to identify the phytoconstituents by subjecting them to Ultrasound-Assisted Extraction (UAE) with distilled water, methanol, ethanol, chloroform, and hexane, each extract of which was further applied to the phytochemical screening through qualitative and quantitative tests. The extracting yields of Solanum aculeastrum dunal with different solvents gave the values of 13.0% (hexane), 13.0% (chloroform), 66.6% (ethanol), 66.6% (methanol) and 46.6% (aqueous), Elephantorrhiza elephentina 13.0% (hexane), 20.0% (chloroform), 66.6% (ethanol), 80.0% (methanol) and 86.0% (aqueous), Cadaba aphylla 60% (ethanol), 66.6% (methanol) and 53.3% (aqueous), Adenia glauca 40% (ethanol), 40.0% (methanol) and 46.6% (aqueous). Standards were used to determine the total content of alkaloid, flavonoid, phenol, saponin, and tannin (Atropine, Quercetin, Gallic acid, Tannic acid, and Quillaja). The regression coefficient (R2 ) was calculated and for Alkaloids, it is 0.9925, flavonoid (0.9953), phenol (0.9978), tannin (0.9955), and saponin (0.9912) respectively. These medicinal plants have produced many phytochemical substances in quantitative analysis, which will be applied in future drug analysis research","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69410315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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