Pub Date : 2023-04-11DOI: 10.56016/dahudermj.1260289
Serap Cetiner, Özgür Okuturlar
Objective: We aimed to evaluate triglyceride (TG) level correlation with hemogram and biochemical parameters in non-diabetic but insulin-resistant and non-insulin-resistant obese patients. Methods: Patients with diabetes, neurological, cardiac, and rheumatological diseases were excluded from the study. Statistical analysis was performed by recording the patients' hemogram and all biochemical parameters. The patients were divided into two groups. Patients with a HOMA-IR level below 2.7 in group 1 and patients with a HOMA-IR level above 2.7 in group 2. Results: 70 patients were selected for our study. Twenty-four were assigned as those without insulin resistance and were named Group 1, and 46 of these patients were assigned as those with insulin resistance and were named Group 2. TG level was found to be lower in Group 1(80.05+32.17) compared to Group 2 (176.67+16.21) (p = 0.0001). There was no significant correlation between TG level and hemogram parameters in group 1. In Group 2, TG level and hematocrit (r = 0.475; p = 0.001) showed a significant positive correlation, while platelet lymphocyte ratio (r = 0.474; p = 0.001) showed a significant negative correlation. In Group 2, TG and ferritin (r = 0.421; p = 0.004) showed a significant positive correlation. Conclusion: In obese patients without diabetes, triglyceride levels were high in those with high insulin resistance. The significant correlation of triglyceride level with hct, PLR, and ferritin in insulin resistance reveals the importance of these parameters in the atherosclerotic process.
{"title":"Is there any relationship between triglyceride and hemogram indicesin insulin resistance ?","authors":"Serap Cetiner, Özgür Okuturlar","doi":"10.56016/dahudermj.1260289","DOIUrl":"https://doi.org/10.56016/dahudermj.1260289","url":null,"abstract":"Objective: We aimed to evaluate triglyceride (TG) level correlation with hemogram and biochemical parameters in non-diabetic but insulin-resistant and non-insulin-resistant obese patients. \u0000Methods: Patients with diabetes, neurological, cardiac, and rheumatological diseases were excluded from the study. Statistical analysis was performed by recording the patients' hemogram and all biochemical parameters. The patients were divided into two groups. Patients with a HOMA-IR level below 2.7 in group 1 and patients with a HOMA-IR level above 2.7 in group 2. \u0000Results: 70 patients were selected for our study. Twenty-four were assigned as those without insulin resistance and were named Group 1, and 46 of these patients were assigned as those with insulin resistance and were named Group 2. TG level was found to be lower in Group 1(80.05+32.17) compared to Group 2 (176.67+16.21) (p = 0.0001). \u0000There was no significant correlation between TG level and hemogram parameters in group 1. In Group 2, TG level and hematocrit (r = 0.475; p = 0.001) showed a significant positive correlation, while platelet lymphocyte ratio (r = 0.474; p = 0.001) showed a significant negative correlation. In Group 2, TG and ferritin (r = 0.421; p = 0.004) showed a significant positive correlation. \u0000Conclusion: In obese patients without diabetes, triglyceride levels were high in those with high insulin resistance. The significant correlation of triglyceride level with hct, PLR, and ferritin in insulin resistance reveals the importance of these parameters in the atherosclerotic process.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120844512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-27DOI: 10.56016/dahudermj.1216031
M. C. Şenoymak, İ. Engin, N. H. Erbatur, Sezin Canbek, F. Deniz, A. Yönem
Sex reversal syndromes can be summarized as an incompatibility of chromosomal sex and gonadal characteristics. A very rare syndrome. 46 XX testicular disorder was first described by De La Chapelle in 1964 in 46 XX karyotype male individuals. Generally, patients whose phenotype is male apply to the health center with infertility, impotence, loss of libido, or gynecomastia. Translating the part of the Y chromosome, including the SRY (sex-determining region Y) gene, to the X chromosome during paternal meiosis is responsible for etiopathogenesis. In our case, a 38-year-old male patient applied to our outpatient clinic complaining of enlargement in both breasts. His beard-mustache and body hair distribution was expected, he had bilateral grade 2 gynecomastia, his penis length was 7 cm, and his testicles were small and palpable in the scrotum. Laboratory values were compatible with hypogonadotropic hypogonadism, and in the sperm analysis, azoospermia was detected. Karyotype analysis was 46 XX, SRY was also studied with the FISH (Fluorescence in Situ Hybridization) technique. The patient was diagnosed with 46 XX Testicular Disorder (de la Chapelle Syndrome), and testosterone replacement therapy was started. We aimed to present the diagnosis and management of De La Chapelle Syndrome in our case.
性反转综合征可以概括为染色体性别和性腺特征的不相容。一种非常罕见的综合症。1964年，De La Chapelle首次在46例XX核型男性个体中描述了XX睾丸疾病。一般来说，表现型为男性的患者以不孕症、阳痿、性欲减退或男性乳房发育症来就诊。在父亲减数分裂期间，将Y染色体的一部分，包括SRY(性别决定区Y)基因翻译到X染色体上是致病的原因。在我们的病例中，一位38岁的男性患者到我们的门诊就诊，抱怨双乳肿大。胡子、体毛分布正常，双侧2级男性乳房发育，阴茎长7cm，阴囊内睾丸小，可触及。实验室值与促性腺功能减退症相一致，在精子分析中发现无精子症。核型分析为46 × XX，并用FISH(荧光原位杂交)技术进行SRY检测。患者被诊断为46 XX睾丸障碍(de la Chapelle综合征)，并开始睾酮替代治疗。我们的目的是提出诊断和管理德拉夏贝尔综合征在我们的情况。
{"title":"A rare disorder of sex development; de la chapelle syndrome","authors":"M. C. Şenoymak, İ. Engin, N. H. Erbatur, Sezin Canbek, F. Deniz, A. Yönem","doi":"10.56016/dahudermj.1216031","DOIUrl":"https://doi.org/10.56016/dahudermj.1216031","url":null,"abstract":"Sex reversal syndromes can be summarized as an incompatibility of chromosomal sex and gonadal characteristics. A very rare syndrome. 46 XX testicular disorder was first described by De La Chapelle in 1964 in 46 XX karyotype male individuals. Generally, patients whose phenotype is male apply to the health center with infertility, impotence, loss of libido, or gynecomastia. Translating the part of the Y chromosome, including the SRY (sex-determining region Y) gene, to the X chromosome during paternal meiosis is responsible for etiopathogenesis. \u0000In our case, a 38-year-old male patient applied to our outpatient clinic complaining of enlargement in both breasts. His beard-mustache and body hair distribution was expected, he had bilateral grade 2 gynecomastia, his penis length was 7 cm, and his testicles were small and palpable in the scrotum. Laboratory values were compatible with hypogonadotropic hypogonadism, and in the sperm analysis, azoospermia was detected. Karyotype analysis was 46 XX, SRY was also studied with the FISH (Fluorescence in Situ Hybridization) technique. The patient was diagnosed with 46 XX Testicular Disorder (de la Chapelle Syndrome), and testosterone replacement therapy was started. \u0000We aimed to present the diagnosis and management of De La Chapelle Syndrome in our case.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124854478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-25DOI: 10.56016/dahudermj.1220959
Y. Okuturlar, İ. Köksal, Yasemin Gündoğdu, Arzu Yüksel, Özgür Okuturlar, Fadıl Havas, Cem Gun
Objectives: Interleukin 6 (IL-6) plays a leading role in the proliferation and differentiation of immune cells. Level of IL-6 is manifestly increased under many inflammatory conditions, including cytokine release syndrome. We evaluated the IL-6 levels of patients who were hospitalized with the diagnosis of COVID-19. Methods: In the study, the test results of 19 cases whose IL-6 levels were measured between March 11, 2020 and May 31, 2020 retrospectively. The inpatients in the covid service (Group 1) and the patients admitted to the Intensive Care Unit (ICU) of our hospital (Group 2) were compared and evaluated. In addition, patients with positive and negative RT-PCR test results were checked for IL-6. Results: While 8 (Group 1) of 19 patients observed in the clinic were transferred to the ICU, 11 patients (Group 2) were observed in the covid service until their discharge. Group 1 IL-6 levels (median 34 pg/mL) and Group 2 IL-6 levels (median 116 pg/mL) were found to be high in both groups (p = 0,099). However, it was found to be significantly higher in patients with positive COVID-19 RT-PCR test (median 90.60 pg/mL) than in negative patients (median 29.90 pg/mL) (p = 0.018). Conclusion: No significant difference in IL-6 levels between the patients who were monitored in the clinic and transferred to the ICU was found in this study. The significant difference between IL-6 levels among COVID-19 RT-PCR positive and negative patients reveals the importance of IL-6 level with regard to tocilizumab treatment in COVID-19 patients in cytokine storm. Keywords: COVID-19, Interleukin 6, Cytokine Storm, Macrophage Activation Syndrome
{"title":"Evaluation of Interleukin 6 Levels in Severe COVID-19 Patients","authors":"Y. Okuturlar, İ. Köksal, Yasemin Gündoğdu, Arzu Yüksel, Özgür Okuturlar, Fadıl Havas, Cem Gun","doi":"10.56016/dahudermj.1220959","DOIUrl":"https://doi.org/10.56016/dahudermj.1220959","url":null,"abstract":"Objectives: Interleukin 6 (IL-6) plays a leading role in the proliferation and differentiation of immune cells. Level of IL-6 is manifestly increased under many inflammatory conditions, including cytokine release syndrome. We evaluated the IL-6 levels of patients who were hospitalized with the diagnosis of COVID-19. \u0000Methods: In the study, the test results of 19 cases whose IL-6 levels were measured between March 11, 2020 and May 31, 2020 retrospectively. The inpatients in the covid service (Group 1) and the patients admitted to the Intensive Care Unit (ICU) of our hospital (Group 2) were compared and evaluated. In addition, patients with positive and negative RT-PCR test results were checked for IL-6. \u0000Results: While 8 (Group 1) of 19 patients observed in the clinic were transferred to the ICU, 11 patients (Group 2) were observed in the covid service until their discharge. Group 1 IL-6 levels (median 34 pg/mL) and Group 2 IL-6 levels (median 116 pg/mL) were found to be high in both groups (p = 0,099). However, it was found to be significantly higher in patients with positive COVID-19 RT-PCR test (median 90.60 pg/mL) than in negative patients (median 29.90 pg/mL) (p = 0.018). \u0000Conclusion: No significant difference in IL-6 levels between the patients who were monitored in the clinic and transferred to the ICU was found in this study. The significant difference between IL-6 levels among COVID-19 RT-PCR positive and negative patients reveals the importance of IL-6 level with regard to tocilizumab treatment in COVID-19 patients in cytokine storm. \u0000Keywords: COVID-19, Interleukin 6, Cytokine Storm, Macrophage Activation Syndrome","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122956580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-08DOI: 10.56016/dahudermj.1201319
Hilal Heybeli̇, O. Gokdemir
A woman, 51 years old with known hypothyroidism, was admitted to the emergency service because of postoperative complaints of nausea, vomiting, and jaundice. The patient's imaging revealed pleural effusion, compression atelectasis in the right lung, and lesions compatible with type 2 hydatid cysts in the liver; therefore, PAIR (Puncture, Aspiration, Injection, Reaspiration) was planned, and she was admitted to the internal medicine service. After this, the routine COVID PCR, taken before the interventional procedure, was found positive. During the patient's follow-up, there were no indications of respiratory failure brought on by a COVID infection. Although her vitals were steady, it was noted that she had an intense headache, and frequent and severe hair loss from night to morning on the third day of hospitalisation due to a contagious infection. There are few photos about similar cases. This case also important to be recognized as a symptom/complication of COVID-19 to be managed.
{"title":"Sudden Hairloss and COVID-19","authors":"Hilal Heybeli̇, O. Gokdemir","doi":"10.56016/dahudermj.1201319","DOIUrl":"https://doi.org/10.56016/dahudermj.1201319","url":null,"abstract":"A woman, 51 years old with known hypothyroidism, was admitted to the emergency service because of postoperative complaints of nausea, vomiting, and jaundice. The patient's imaging revealed pleural effusion, compression atelectasis in the right lung, and lesions compatible with type 2 hydatid cysts in the liver; therefore, PAIR (Puncture, Aspiration, Injection, Reaspiration) was planned, and she was admitted to the internal medicine service. After this, the routine COVID PCR, taken before the interventional procedure, was found positive. During the patient's follow-up, there were no indications of respiratory failure brought on by a COVID infection. Although her vitals were steady, it was noted that she had an intense headache, and frequent and severe hair loss from night to morning on the third day of hospitalisation due to a contagious infection. \u0000There are few photos about similar cases. This case also important to be recognized as a symptom/complication of COVID-19 to be managed.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131656434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-07DOI: 10.56016/dahudermj.1225606
Zeynep Yüksel, A. Çalışkaner
Objectives: Common Variable Immunodeficiency (CVID) is a primary immunodeficiency characterized by immunoglobulin production defect. Our study aimed to create awareness of primary immunodeficiency in adult patients, establish standard approaches for clinical follow-up of CVID patients, and reveal the clinical characteristics of CVID patients in our region. Method: The study was conducted in patients with diagnosed and newly diagnosed CVID. The demographic and clinical characteristics of the patients and their treatment data were analyzed retrospectively and prospectively. Results: Thirteen of our patients were female and 12 were male. The mean age at diagnosis of the patients was 30.32 (2-57) and the mean delay in diagnosis was 9.32 months (0-30). The most common clinical finding of our patients at the time of admission was an infection. Among the infections identified, 3 patients had URTI, 19 had LRTI, and 2 had gastroenteritis. In 16 of our patients, bronchiectasis was detected at the time of diagnosis, and in 1 during the follow-up period. In the examinations performed in terms of organomegaly, splenomegaly was found in 11 patients and hepatomegaly was found in 8 patients. When patients were screened for autoimmune disease, ITP and celiac were found in 2 patients at the beginning, while autoimmune thyroiditis was developed in 1 patient and SLE in 1 patient during follow-up. Our patients were given IVIG treatment at regular intervals. The number of reactions seen in a total of 421 IVIG infusions was two. Conclusion: Primary immunodeficiencies should definitely be considered in patients with recurrent infections and resistance to antibiotic therapy. Patients should be followed according to established follow-up and treatment protocols in order to reduce and diagnose complications.
{"title":"Follow-up and treatment of patients with Common Variable Immune Deficiency: A single-center experience","authors":"Zeynep Yüksel, A. Çalışkaner","doi":"10.56016/dahudermj.1225606","DOIUrl":"https://doi.org/10.56016/dahudermj.1225606","url":null,"abstract":"Objectives: Common Variable Immunodeficiency (CVID) is a primary immunodeficiency characterized by immunoglobulin production defect. Our study aimed to create awareness of primary immunodeficiency in adult patients, establish standard approaches for clinical follow-up of CVID patients, and reveal the clinical characteristics of CVID patients in our region. \u0000Method: The study was conducted in patients with diagnosed and newly diagnosed CVID. The demographic and clinical characteristics of the patients and their treatment data were analyzed retrospectively and prospectively. \u0000Results: Thirteen of our patients were female and 12 were male. The mean age at diagnosis of the patients was 30.32 (2-57) and the mean delay in diagnosis was 9.32 months (0-30). The most common clinical finding of our patients at the time of admission was an infection. Among the infections identified, 3 patients had URTI, 19 had LRTI, and 2 had gastroenteritis. In 16 of our patients, bronchiectasis was detected at the time of diagnosis, and in 1 during the follow-up period. In the examinations performed in terms of organomegaly, splenomegaly was found in 11 patients and hepatomegaly was found in 8 patients. When patients were screened for autoimmune disease, ITP and celiac were found in 2 patients at the beginning, while autoimmune thyroiditis was developed in 1 patient and SLE in 1 patient during follow-up. Our patients were given IVIG treatment at regular intervals. The number of reactions seen in a total of 421 IVIG infusions was two. \u0000Conclusion: Primary immunodeficiencies should definitely be considered in patients with recurrent infections and resistance to antibiotic therapy. Patients should be followed according to established follow-up and treatment protocols in order to reduce and diagnose complications.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116876125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-05DOI: 10.56016/dahudermj.1194231
Genco Görgü, O. Gokdemir
The World Health Organization has produced a series of publications to create the general framework of mental health services. One of the main data sources is the WHO guide on community mental health services and the document promoting person-centered and human rights-based approaches. It includes the regulation of service providers' relations with the housing, education and employment sectors at the point of implementation of regional and national policies and the promotion of actions that are respectful of human rights and focused on recovery. It is a guide that offers various technical packages for the establishment and successful implementation of community-oriented mental health services. Various international framework agreements, including the United Nations Convention on the Rights of Persons with Disabilities, also suggest the establishment of community-oriented mental health services. The common goal of up-to-date medical evidence-based information and international policymakers is to make the community-based mental health service model permanent on a global scale, especially in low-income and developing countries.
{"title":"Right time for the community based mental health care","authors":"Genco Görgü, O. Gokdemir","doi":"10.56016/dahudermj.1194231","DOIUrl":"https://doi.org/10.56016/dahudermj.1194231","url":null,"abstract":"The World Health Organization has produced a series of publications to create the general framework of mental health services. One of the main data sources is the WHO guide on community mental health services and the document promoting person-centered and human rights-based approaches. It includes the regulation of service providers' relations with the housing, education and employment sectors at the point of implementation of regional and national policies and the promotion of actions that are respectful of human rights and focused on recovery. It is a guide that offers various technical packages for the establishment and successful implementation of community-oriented mental health services. Various international framework agreements, including the United Nations Convention on the Rights of Persons with Disabilities, also suggest the establishment of community-oriented mental health services. The common goal of up-to-date medical evidence-based information and international policymakers is to make the community-based mental health service model permanent on a global scale, especially in low-income and developing countries.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120933746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-02DOI: 10.56016/dahudermj.1193872
Ihsan Solmaz, Ömer Faruk Alakuş, Yusuf Yakut, Yunus Tekin, Sedrettin Koyun, Eşref Araç
Objectives: Chronic kidney disease (CKD) is an increasing public health problem. It is very important to know the definition of CKD, its risk factors and to predict the progression of its stages. Recently, the monocyte/HDL ratio (MHR) has been thought to be a new marker of inflammation and oxidative stress. In this study, it was aimed to investigate the relationship between stages and MHR in patients with stage 3A, stage 3B and stage 4 CKD. Methods: A total of 632 patients with CKD, aged 18 years and older, with stage 3A, stage 3B and stage 4 (eGFR) according to CKD stage were included in our study. Our study is retrospective and the data of the patients were obtained from the hospital system. Kruskal-Wallis and post hoc Tukey HSD tests were used for statistics. p < 0.05 was considered statistically significant. Results: The mean age of the patients included in the study was 63.4 ± 14.91(min:18max:98), and 305 (48.25%) of these patients were male and 327 (51.75%) were female. According to eGFR, 155 (24.5%) of the patients were stage 3A, 150 (23.8%) were stage 3B, and 327 (51.7%) were stage 4. In the statistical study of the groups divided into CKD stages with MHR, there was no significant difference between the groups (p: 0.245), while there was statistical significance for gender and hypertension (p: 0.004 and p: 0.044, respectively). Conclusion: As a result of this study, we concluded that MHR is not affected by CKD stages.
{"title":"The relationship between monocyte/HDL cholesterol ratio and chronic kidney disease stages, single center study","authors":"Ihsan Solmaz, Ömer Faruk Alakuş, Yusuf Yakut, Yunus Tekin, Sedrettin Koyun, Eşref Araç","doi":"10.56016/dahudermj.1193872","DOIUrl":"https://doi.org/10.56016/dahudermj.1193872","url":null,"abstract":"Objectives: Chronic kidney disease (CKD) is an increasing public health problem. It is very important to know the definition of CKD, its risk factors and to predict the progression of its stages. Recently, the monocyte/HDL ratio (MHR) has been thought to be a new marker of inflammation and oxidative stress. In this study, it was aimed to investigate the relationship between stages and MHR in patients with stage 3A, stage 3B and stage 4 CKD. \u0000Methods: A total of 632 patients with CKD, aged 18 years and older, with stage 3A, stage 3B and stage 4 (eGFR) according to CKD stage were included in our study. Our study is retrospective and the data of the patients were obtained from the hospital system. Kruskal-Wallis and post hoc Tukey HSD tests were used for statistics. p < 0.05 was considered statistically significant. \u0000Results: The mean age of the patients included in the study was 63.4 ± 14.91(min:18max:98), and 305 (48.25%) of these patients were male and 327 (51.75%) were female. According to eGFR, 155 (24.5%) of the patients were stage 3A, 150 (23.8%) were stage 3B, and 327 (51.7%) were stage 4. In the statistical study of the groups divided into CKD stages with MHR, there was no significant difference between the groups (p: 0.245), while there was statistical significance for gender and hypertension (p: 0.004 and p: 0.044, respectively). \u0000Conclusion: As a result of this study, we concluded that MHR is not affected by CKD stages.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123756422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-27DOI: 10.56016/dahudermj.1195167
Kübra Çerçi, İmge Bortay Teki̇n, S. Uyar
Familial hyperlipidemia (FH) is an autosomal dominant inherited disease characterized by genetic disorders with severe high blood cholesterol levels. There are two forms of the disease which are homozygous and heterozygous FH. FH cases are generally caused by hereditorial mutations in the LDL receptor (LDL-R) gene and less commonly in genes encoding apolipoprotein B (Apo B) and pro-protein convertase subtilisin/kexin 9 (PCSK9) proteins. The risk of early-onset coronary artery disease (CAD) in FH patients is 20 times higher than the normal population. Early diagnosis and treatment of FH will greatly reduce the morbidity and mortality associated with CAD.
{"title":"Approach To Diagnosis And Treatment Of Familial Hyperlipidemia","authors":"Kübra Çerçi, İmge Bortay Teki̇n, S. Uyar","doi":"10.56016/dahudermj.1195167","DOIUrl":"https://doi.org/10.56016/dahudermj.1195167","url":null,"abstract":"Familial hyperlipidemia (FH) is an autosomal dominant inherited disease characterized by genetic disorders with severe high blood cholesterol levels. There are two forms of the disease which are homozygous and heterozygous FH. FH cases are generally caused by hereditorial mutations in the LDL receptor (LDL-R) gene and less commonly in genes encoding apolipoprotein B (Apo B) and pro-protein convertase subtilisin/kexin 9 (PCSK9) proteins. The risk of early-onset coronary artery disease (CAD) in FH patients is 20 times higher than the normal population. Early diagnosis and treatment of FH will greatly reduce the morbidity and mortality associated with CAD.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114475649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-29DOI: 10.56016/dahudermj.1185131
Muharrem Köse, Y. Okuturlar, İ. Köksal, Özlem Çelik
Objectives: The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus, was identified as the cause of a severe respiratory illness in Wuhan, China three years ago. The COVID-19 infection, which was declared a pandemic in March 2020, caused more than 600 million people to get sick and close to 7 million people to die. Which people have the disease more severely and who have higher mortality are still the subject of research. We investigated whether vitamin D, whose role in immunity has been known for a long time, also affects the prognosis of COVID-19 infection. COVID-19 is currently the leading cause of death worldwide. Vitamin D is an important micronutrient and has been reported to protect against respiratory diseases by improving immunity. In this study, we aimed to reveal whether the 25-hydroxyvitamin D (25 (OH) D) concentration is associated with the risk and severity of COVID-19 by evaluating vitamin D levels in outpatients or hospitalized patients with the diagnosis of COVID-19. Methods: In the study, vitamin D levels in 124 COVID-19 cases and clinical course and laboratory findings were analyzed retrospectively between March 11-May 31 2020. Statistical analysis was done using IBM SPSS 23. Kolmogorov Smirnov, Man Whitney U, Kruskal Wallis Test, Chi-square, and fisher extract and risk analysis tests were used. Categorical variables were expressed as %. P value < 0.05 was considered significant. Results: Vitamin 25 (OH) D level in 32 patients (median 10.2) who were given antiviral treatment and needed oxygen. It was found to be significantly lower than the other 92 patients (median 16.25). When patients who needed oxygen treatment during COVID-19 treatment were examined in terms of vitamin D levels; It was observed that patients with 25 (OH) vitamin D level < 10 needed more O2 (OR: 2,833 CI 95% 1,230-6,528, p = 0.013). In patients with 25 (OH) vitamin D < 10, more patients had pulmonary involvement with thorax CT (OR: 2.225 CI 95% 0.999-4.952 p = 0.048) and these patients had more back pain symptoms (OR: 4,765 CI 95% 1,126-20,163 p = 0.022). Patients with 25 (OH) vitamin D
目的:严重急性呼吸综合征-冠状病毒-2 (SARS-CoV-2)病毒在三年前被确定为中国武汉严重呼吸道疾病的病因。2019冠状病毒病感染于2020年3月被宣布为大流行，造成6亿多人患病，近700万人死亡。哪些人的病情更严重，哪些人的死亡率更高，这仍是研究的主题。我们研究了维生素D是否也会影响COVID-19感染的预后，维生素D在免疫中的作用早已为人所知。COVID-19目前是全世界的主要死亡原因。维生素D是一种重要的微量营养素，据报道可以通过提高免疫力来预防呼吸系统疾病。在本研究中，我们旨在通过评估诊断为COVID-19的门诊或住院患者的维生素D水平，揭示25 (OH) D浓度是否与COVID-19的风险和严重程度相关。方法:回顾性分析2020年3月11日至5月31日124例COVID-19患者的维生素D水平、临床病程和实验室结果。采用IBM SPSS 23进行统计学分析。采用Kolmogorov Smirnov、Man Whitney U、Kruskal Wallis检验、卡方检验、fisher提取检验和风险分析检验。分类变量用%表示。P值< 0.05为显著性。结果:32例接受抗病毒治疗并需要氧气的患者(中位数10.2)出现维生素25 (OH) D水平。与其他92例患者(中位16.25)相比，该患者明显降低。当对COVID-19治疗期间需要氧气治疗的患者进行维生素D水平检查时;观察到25 (OH)维生素D水平< 10的患者需要更多的氧气(OR: 2,833 CI 95% 1,230-6,528, p = 0.013)。在25 (OH)维生素D < 10的患者中，更多的患者胸部CT有肺部受累(OR: 2.225 CI 95% 0.999-4.952 p = 0.048)，这些患者有更多的背部疼痛症状(OR: 4,765 CI 95% 1,126-20,163 p = 0.022)。25 (OH)维生素D患者
{"title":"Importance of Vitamin D in COVID-19 Patients","authors":"Muharrem Köse, Y. Okuturlar, İ. Köksal, Özlem Çelik","doi":"10.56016/dahudermj.1185131","DOIUrl":"https://doi.org/10.56016/dahudermj.1185131","url":null,"abstract":"Objectives: The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus, was identified as the cause of a severe respiratory illness in Wuhan, China three years ago. The COVID-19 infection, which was declared a pandemic in March 2020, caused more than 600 million people to get sick and close to 7 million people to die. Which people have the disease more severely and who have higher mortality are still the subject of research. We investigated whether vitamin D, whose role in immunity has been known for a long time, also affects the prognosis of COVID-19 infection. COVID-19 is currently the leading cause of death worldwide. Vitamin D is an important micronutrient and has been reported to protect against respiratory diseases by improving immunity. In this study, we aimed to reveal whether the 25-hydroxyvitamin D (25 (OH) D) concentration is associated with the risk and severity of COVID-19 by evaluating vitamin D levels in outpatients or hospitalized patients with the diagnosis of COVID-19. \u0000Methods: In the study, vitamin D levels in 124 COVID-19 cases and clinical course and laboratory findings were analyzed retrospectively between March 11-May 31 2020. Statistical analysis was done using IBM SPSS 23. Kolmogorov Smirnov, Man Whitney U, Kruskal Wallis Test, Chi-square, and fisher extract and risk analysis tests were used. Categorical variables were expressed as %. P value < 0.05 was considered significant. \u0000Results: Vitamin 25 (OH) D level in 32 patients (median 10.2) who were given antiviral treatment and needed oxygen. It was found to be significantly lower than the other 92 patients (median 16.25). When patients who needed oxygen treatment during COVID-19 treatment were examined in terms of vitamin D levels; It was observed that patients with 25 (OH) vitamin D level < 10 needed more O2 (OR: 2,833 CI 95% 1,230-6,528, p = 0.013). In patients with 25 (OH) vitamin D < 10, more patients had pulmonary involvement with thorax CT (OR: 2.225 CI 95% 0.999-4.952 p = 0.048) and these patients had more back pain symptoms (OR: 4,765 CI 95% 1,126-20,163 p = 0.022). Patients with 25 (OH) vitamin D","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129892487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-28DOI: 10.56016/dahudermj.1186140
A. Girgin, M. Yavuz
Objectives: The number of end-stage renal failure patients undergoing dialysis is increasing in our country and all over the world. Many patients continue with hemodialysis or peritoneal dialysis lifelong though kidney transplantation is the gold standard renal replacement therapy. The purpose of this study is to compare depression, anxiety, self-esteem and social adaptation in hemodialysis and peritoneal dialysis patients. Methods: The research consists of 30 hemodialysis and 30 peritoneal dialysis patients who are undergoing dialysis treatment in Uludag University Medical Faculty Hemodialysis and Peritoneal Dialysis Unit. Demographic Data Form, Beck Depression Inventory, Coopersmith Self-Esteem Scale, Social Adaptation Self-evaluation Scale, and State and Trait Anxiety Scale were administered to patients. Conclusion: The self-esteem score of peritoneal dialysis group is significantly high from the hemodialysis group. Peritoneal dialysis group average point was 21.0, hemodialysis group average point was 17.5 on Coopersmith Self-Esteem Scale. There was no significant difference in depression, anxiety and social adaptation scale scores.
{"title":"Evaluation and comparison of depression, anxiety, self-esteem, and social adaptation in hemodialysis and peritoneal dialysis patients","authors":"A. Girgin, M. Yavuz","doi":"10.56016/dahudermj.1186140","DOIUrl":"https://doi.org/10.56016/dahudermj.1186140","url":null,"abstract":"Objectives: The number of end-stage renal failure patients undergoing dialysis is increasing in our country and all over the world. Many patients continue with hemodialysis or peritoneal dialysis lifelong though kidney transplantation is the gold standard renal replacement therapy. The purpose of this study is to compare depression, anxiety, self-esteem and social adaptation in hemodialysis and peritoneal dialysis patients. \u0000Methods: The research consists of 30 hemodialysis and 30 peritoneal dialysis patients who are undergoing dialysis treatment in Uludag University Medical Faculty Hemodialysis and Peritoneal Dialysis Unit. Demographic Data Form, Beck Depression Inventory, Coopersmith Self-Esteem Scale, Social Adaptation Self-evaluation Scale, and State and Trait Anxiety Scale were administered to patients. \u0000Conclusion: The self-esteem score of peritoneal dialysis group is significantly high from the hemodialysis group. Peritoneal dialysis group average point was 21.0, hemodialysis group average point was 17.5 on Coopersmith Self-Esteem Scale. There was no significant difference in depression, anxiety and social adaptation scale scores.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125077277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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