Pub Date : 2024-01-08DOI: 10.56016/dahudermj.1391630
Nazif Yalçin, Aysegul ERTINMAZ OZKAN, N. Koca
Abstract Hypereosinophilic Syndrome (HES) is caused by the uncontrolled proliferation of eosinophils generally associated with conditions such as allergic reactions or parasitic infections. This syndrome is characterized by excessive eosinophil production (>1500/mm3) that persists for more than six months and cannot be explained by secondary causes. HES symptoms can affect different body organs, and usually, nonspecific symptoms include fever, malaise, fatigue, rash, shortness of breath, and myalgia. HES is a rare disease with multiorgan involvement, including the skin, joints, kidneys, vascular system, gastrointestinal tract, cardiac and pulmonary systems. The main feature of this disease is that overproduced eosinophils accumulate in organs and cause organ damage. Cardiac involvement plays a critical role in determining morbidity and mortality, and cardiac and large vessel thrombosis with severe clinical manifestations can also be observed. Treatment aims to reduce the absolute eosinophil count, improve symptoms, and prevent disease progression. Pharmacologic therapy aims to maintain targeted eosinophil levels below 1.5 x 10^9/L (1500 cells/mcL) to reduce the symptoms of eosinophilic disease and prevent organ damage. Furthermore, indications for emergency treatment should be rapidly assessed and initiated promptly in appropriate patients. This paper will discuss the diagnosis, clinical manifestations, treatment modalities, and management challenges of HES in detail through two rare case examples.
摘要 嗜酸性粒细胞过多综合征（HES）是由嗜酸性粒细胞不受控制的增殖引起的，通常与过敏反应或寄生虫感染等情况有关。该综合征的特征是嗜酸性粒细胞过度增生（>1500/mm3），且持续时间超过六个月，无法用继发性原因解释。嗜酸性粒细胞增多症的症状可影响不同的身体器官，通常的非特异性症状包括发热、乏力、疲劳、皮疹、气短和肌痛。HES 是一种多器官受累的罕见疾病，包括皮肤、关节、肾脏、血管系统、胃肠道、心脏和肺部系统。这种疾病的主要特征是过量产生的嗜酸性粒细胞积聚在器官中，造成器官损伤。心脏受累在决定发病率和死亡率方面起着关键作用，还可观察到具有严重临床表现的心脏和大血管血栓形成。治疗的目的是减少嗜酸性粒细胞的绝对数量、改善症状并防止疾病进展。药物治疗的目的是将嗜酸性粒细胞的目标水平维持在 1.5 x 10^9/L （1500 个细胞/毫升）以下，以减轻嗜酸性粒细胞疾病的症状，防止器官损伤。此外，应迅速评估紧急治疗的指征，并在适当的患者中及时启动紧急治疗。本文将通过两个罕见病例详细讨论 HES 的诊断、临床表现、治疗方法和管理难题。
{"title":"Hypereosinophilic syndrome: Case series and review of the literature","authors":"Nazif Yalçin, Aysegul ERTINMAZ OZKAN, N. Koca","doi":"10.56016/dahudermj.1391630","DOIUrl":"https://doi.org/10.56016/dahudermj.1391630","url":null,"abstract":"Abstract \u0000Hypereosinophilic Syndrome (HES) is caused by the uncontrolled proliferation of eosinophils generally associated with conditions such as allergic reactions or parasitic infections. This syndrome is characterized by excessive eosinophil production (>1500/mm3) that persists for more than six months and cannot be explained by secondary causes. HES symptoms can affect different body organs, and usually, nonspecific symptoms include fever, malaise, fatigue, rash, shortness of breath, and myalgia. \u0000HES is a rare disease with multiorgan involvement, including the skin, joints, kidneys, vascular system, gastrointestinal tract, cardiac and pulmonary systems. The main feature of this disease is that overproduced eosinophils accumulate in organs and cause organ damage. Cardiac involvement plays a critical role in determining morbidity and mortality, and cardiac and large vessel thrombosis with severe clinical manifestations can also be observed. \u0000Treatment aims to reduce the absolute eosinophil count, improve symptoms, and prevent disease progression. Pharmacologic therapy aims to maintain targeted eosinophil levels below 1.5 x 10^9/L (1500 cells/mcL) to reduce the symptoms of eosinophilic disease and prevent organ damage. Furthermore, indications for emergency treatment should be rapidly assessed and initiated promptly in appropriate patients. \u0000This paper will discuss the diagnosis, clinical manifestations, treatment modalities, and management challenges of HES in detail through two rare case examples.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-03DOI: 10.56016/dahudermj.1357040
Mustafa Çeti̇n, E. Eroglu, Ç. Karakükçü, Gökmen Zararsız, Ayşenur ÇIRAK GÜRSOY, İsmail Koçyi̇ği̇t
Objective: We aimed to evaluate the relationship between serum perilipin-2 / adipophilin (PLIN-2 / ADRP) levels and clinical course in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Methods: 80 ADPKD patients with Chronic Kidney Disease (CKD) G1-G4 status, among the patients who were regularly followed up in the nephrology outpatient clinic between 2012 and 2019, were included in the study. CKD-G5 patients were excluded from the study. Baseline PLIN-2/ADRP levels were measured. Patients were divided into 2 groups according to the median serum PLIN-2/ADRP level. During the follow-up period, data such as blood pressure, height-adjusted total kidney volume (HtTKV), proteinuria, complete blood count, and biochemical tests were recorded. Results: In the patients with serum PLIN-2 / ADRP level above the median value (11.675 ng / mL), BMI was significantly higher than the other group (p
{"title":"The association between serum Perilipin-2 and kidney disease progression of patients with autosomal dominant polycystic kidney disease","authors":"Mustafa Çeti̇n, E. Eroglu, Ç. Karakükçü, Gökmen Zararsız, Ayşenur ÇIRAK GÜRSOY, İsmail Koçyi̇ği̇t","doi":"10.56016/dahudermj.1357040","DOIUrl":"https://doi.org/10.56016/dahudermj.1357040","url":null,"abstract":"Objective: We aimed to evaluate the relationship between serum perilipin-2 / adipophilin (PLIN-2 / ADRP) levels and clinical course in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). \u0000Methods: 80 ADPKD patients with Chronic Kidney Disease (CKD) G1-G4 status, among the patients who were regularly followed up in the nephrology outpatient clinic between 2012 and 2019, were included in the study. CKD-G5 patients were excluded from the study. Baseline PLIN-2/ADRP levels were measured. Patients were divided into 2 groups according to the median serum PLIN-2/ADRP level. During the follow-up period, data such as blood pressure, height-adjusted total kidney volume (HtTKV), proteinuria, complete blood count, and biochemical tests were recorded. \u0000Results: In the patients with serum PLIN-2 / ADRP level above the median value (11.675 ng / mL), BMI was significantly higher than the other group (p","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139630647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.56016/dahudermj.1326075
A. Kırık, C. Erci̇n, Hasan Gürel, A. Çiçek, Ali Cem Yekdeş, Sultan Türel, S. Tapan, T. Doğru
Objectives: Non-alcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease and is known as a part of metabolic syndrome (MetS), and the role of bilirubin in the pathogenesis of NAFLD is unclear. This study aimed to evaluate the relationship between bilirubin levels and histopathological findings in patients with NAFLD having no confounding factors such as morbid obesity, diabetes mellitus (DM), and hypertension. Methods: A retrospective analysis of clinical and laboratory data of patients with biopsy-proven NAFLD was performed. The relationship between the bilirubin levels and histopathologic findings was evaluated. Results: The subjects in the nonalcoholic steatohepatitis (NASH) group had greater AST (p < 0.001) and ALT (p < 0.001) levels than the non-NASH group. We found no difference between NASH and non-NASH groups regarding bilirubin levels. The levels of AST (p = 0.001), ALT (p = 0.011), insulin (p = 0.029), and HOMA-IR index (p = 0.027) were higher in fibrosis group comparing non-fibrosis group. However, bilirubin levels were not different comparing the fibrosis and non-fibrosis group. We couldn’t find any relation between bilirubin levels and other parameters in correlation analysis. Conclusion: We couldn’t find any relation between the bilirubin levels and histopathological findings of the patient with NAFLD having no confounding factors such as morbid obesity, DM, and hypertension. The difference, shown in the other studies, may be the effect of other diseases related to MetS.
{"title":"The relationship of serum bilirubin level with histopathological parameters in patients with nonalcoholic fatty liver disease","authors":"A. Kırık, C. Erci̇n, Hasan Gürel, A. Çiçek, Ali Cem Yekdeş, Sultan Türel, S. Tapan, T. Doğru","doi":"10.56016/dahudermj.1326075","DOIUrl":"https://doi.org/10.56016/dahudermj.1326075","url":null,"abstract":"Objectives: Non-alcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease and is known as a part of metabolic syndrome (MetS), and the role of bilirubin in the pathogenesis of NAFLD is unclear. This study aimed to evaluate the relationship between bilirubin levels and histopathological findings in patients with NAFLD having no confounding factors such as morbid obesity, diabetes mellitus (DM), and hypertension. \u0000Methods: A retrospective analysis of clinical and laboratory data of patients with biopsy-proven NAFLD was performed. The relationship between the bilirubin levels and histopathologic findings was evaluated. \u0000Results: The subjects in the nonalcoholic steatohepatitis (NASH) group had greater AST (p < 0.001) and ALT (p < 0.001) levels than the non-NASH group. We found no difference between NASH and non-NASH groups regarding bilirubin levels. The levels of AST (p = 0.001), ALT (p = 0.011), insulin (p = 0.029), and HOMA-IR index (p = 0.027) were higher in fibrosis group comparing non-fibrosis group. However, bilirubin levels were not different comparing the fibrosis and non-fibrosis group. We couldn’t find any relation between bilirubin levels and other parameters in correlation analysis. \u0000Conclusion: We couldn’t find any relation between the bilirubin levels and histopathological findings of the patient with NAFLD having no confounding factors such as morbid obesity, DM, and hypertension. The difference, shown in the other studies, may be the effect of other diseases related to MetS.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129373868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25DOI: 10.56016/dahudermj.1312590
A. Güven, Rüya Özelsancak
Rhabdomyolysis is the breakdown of the muscle cells with the resultant leakage of intracellular components. Hyperkalemia and hyperphosphatemia may occur during the disease course, as well as acute kidney injury due to blockade of the tubules by myoglobin released from the muscle cells. Electrolyte disturbances are generally more severe than acute kidney injuries. We would like to report a patient who was diagnosed with exertional rhabdomyolysis-induced acute kidney injury due to vigorous swimming and who required hemodialysis but lacked hyperkalemia. The discrepancy between the severe acute kidney injury and lack of hyperkalemia was remarkable. A brief literature search also revealed several patient reports with hypo- and normokalemia despite experiencing acute kidney injury. Pathophysiologic explanations for this discrepancy include exercise-induced increased kaliuresis and intracellular shifting of potassium.
{"title":"Exertional rhabdomyolysis-induced “normokalemic” severe acute kidney injury. A case report and a brief literature review","authors":"A. Güven, Rüya Özelsancak","doi":"10.56016/dahudermj.1312590","DOIUrl":"https://doi.org/10.56016/dahudermj.1312590","url":null,"abstract":"Rhabdomyolysis is the breakdown of the muscle cells with the resultant leakage of intracellular components. Hyperkalemia and hyperphosphatemia may occur during the disease course, as well as acute kidney injury due to blockade of the tubules by myoglobin released from the muscle cells. Electrolyte disturbances are generally more severe than acute kidney injuries. We would like to report a patient who was diagnosed with exertional rhabdomyolysis-induced acute kidney injury due to vigorous swimming and who required hemodialysis but lacked hyperkalemia. The discrepancy between the severe acute kidney injury and lack of hyperkalemia was remarkable. A brief literature search also revealed several patient reports with hypo- and normokalemia despite experiencing acute kidney injury. Pathophysiologic explanations for this discrepancy include exercise-induced increased kaliuresis and intracellular shifting of potassium.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122231026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.56016/dahudermj.1279501
Ali Zeynetti̇n, I. Demir, H. S. Akay
Objectives: Many markers and indication systems are being used to indicate the prognosis of acute pancreatitis. Our study was planned to investigate the importance of procalcitonin(PCT) in patients with severe pancreatitis in terms of predicting prognosis by comparing C-reactive protein , modified CT severity index, and duration of hospitalization. Methods: In our cross-sectional retrospective study, 30 patients who were hospitalized with a diagnosis of A. pancreatitis were included in the study. Our study was conducted from January 2013 to January 2019 at Katip Çelebi University. PCT, CRP, duration of hospitalization, gender, age, CRE, CA, pleural effusion, and modified CT severity scores were recorded in all patients. Results: Of the 30 patients included in the study,13 (43.33%) were male and 17(56.66%) were female. The presence of stones in 80% of patients was detected in 6.7% of patients due to hypertriglestrimia. The PCT value was found to be a minimum of 0.0 ng/ml, a maximum of 39.68 ng/ml, and an average of 1.97 ng/ml. There is a significant relationship between the PCT value and the length of hospitalization for the patients. The hospitalization period was a minimum of 3 days, a maximum of 23 days, and an average of 10.13 days in the 30 patients studied. It was determined that there was a statistically significant relationship between PCT and length of stay (r = 0.437; p 0.016). Conclusion: In patients with A. pancreatitis, the evaluation of PCT, CRP, and modified CT severity index can be used to estimate the duration of hospitalization.
{"title":"The value of procalsitonin in determining the severity acute pancreatitis cases","authors":"Ali Zeynetti̇n, I. Demir, H. S. Akay","doi":"10.56016/dahudermj.1279501","DOIUrl":"https://doi.org/10.56016/dahudermj.1279501","url":null,"abstract":"Objectives: Many markers and indication systems are being used to indicate the prognosis of acute pancreatitis. Our study was planned to investigate the importance of procalcitonin(PCT) in patients with severe pancreatitis in terms of predicting prognosis by comparing C-reactive protein , modified CT severity index, and duration of hospitalization. \u0000Methods: In our cross-sectional retrospective study, 30 patients who were hospitalized with a diagnosis of A. pancreatitis were included in the study. Our study was conducted from January 2013 to January 2019 at Katip Çelebi University. PCT, CRP, duration of hospitalization, gender, age, CRE, CA, pleural effusion, and modified CT severity scores were recorded in all patients. \u0000Results: Of the 30 patients included in the study,13 (43.33%) were male and 17(56.66%) were female. The presence of stones in 80% of patients was detected in 6.7% of patients due to hypertriglestrimia. The PCT value was found to be a minimum of 0.0 ng/ml, a maximum of 39.68 ng/ml, and an average of 1.97 ng/ml. There is a significant relationship between the PCT value and the length of hospitalization for the patients. The hospitalization period was a minimum of 3 days, a maximum of 23 days, and an average of 10.13 days in the 30 patients studied. It was determined that there was a statistically significant relationship between PCT and length of stay (r = 0.437; p 0.016). \u0000Conclusion: In patients with A. pancreatitis, the evaluation of PCT, CRP, and modified CT severity index can be used to estimate the duration of hospitalization.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127599023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although pancreatic pathologies are primarily and mostly manifested by abdominal complaints, they can also occur with other organ systems. Erythema nodosum is the most common variant of panniculitis. In this study, we present a patient with acute pancreatitis who developed erythema nodosum. Although this phenomenon was reported by Chiari in the past, extra-abdominal findings can be ignored today.
{"title":"Erythema nodosum: a clinical sign of acute pancreatitis","authors":"Yasemin Çöl, Dilara Turan Gökçe, Meral Akdoğan Kayhan","doi":"10.56016/dahudermj.1263226","DOIUrl":"https://doi.org/10.56016/dahudermj.1263226","url":null,"abstract":"Although pancreatic pathologies are primarily and mostly manifested by abdominal complaints, they can also occur with other organ systems. Erythema nodosum is the most common variant of panniculitis. In this study, we present a patient with acute pancreatitis who developed erythema nodosum. Although this phenomenon was reported by Chiari in the past, extra-abdominal findings can be ignored today.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125907544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.56016/dahudermj.1253273
Ismail Demir, Gokhan Sahin, B. Pamuk
Background: This study aims to assess the validation and reliability of the Turkish adaptation of the Hypoglycemic Confident Scale and to investigate its relationship between the Hypoglycemia Fear survey, WHO Well-Being Index, Hba1c, sociodemographic characteristics and variables. Methods: The survey consists of a total of 81 questions concerning the sociodemographic status, clinic status variables, and the Hypoglycemic Confidence Scale formed by 35 standard questions and 46 scale questions. Result: In this study, assessment of the reliability of the scale was achieved by internal consistency and test-retest methods, and the Cronbach alpha internal consistency reliability coefficients were 0.814 in the first test and 0.885 in the second test. It was observed that the responses given to the items of the Hypoglycemic Confidence Scale at two separate times were consistent with one another. The overall correlation of the scale (r = 0.927, p < 0.0001) was positive and highly significant (p < 0001). A significant, inverse, and moderate correlation was found between HbA1c values and Hypoglycemic Confidence Scale total scores (p < 0,0001, r = -0,479). Similarly, a higher hypoglycemic confidence score was observed to be associated with higher WHO Well-Being Index score and lower hypoglycemic fear. Conclusion: This study shows that the Hypoglycemia Confidence Scale created by Polonsky et al. is a valid and reliable scale that can be put into use in our country.1 The Hypoglycemic Confidence Scale may be beneficial in diabetic patient follow-up and achieving treatment goals in diabetic patients.
背景:本研究旨在评估土耳其人对低血糖自信量表的适应性的有效性和可靠性，并探讨其与低血糖恐惧调查、WHO幸福指数、Hba1c、社会人口学特征和变量之间的关系。方法:调查共81个问题，涉及社会人口学状况、临床状态变量和由35个标准问题和46个量表组成的低血糖置信度量表。结果:本研究采用内部一致性法和重测法对量表进行信度评价，第一次检验的Cronbach alpha内部一致性信度系数为0.814，第二次检验的Cronbach alpha内部一致性信度系数为0.885。我们观察到，在两个不同的时间对低血糖置信度量表项目的回答是一致的。量表的总体相关性(r = 0.927, p < 0.0001)为正且高度显著(p < 0001)。HbA1c值与低血糖置信度评分之间存在显著、负相关和中度相关(p < 0,0001, r = -0,479)。同样，观察到较高的低血糖信心得分与较高的世卫组织幸福指数得分和较低的低血糖恐惧相关。结论:本研究表明Polonsky等人编制的低血糖置信度量表是一种有效、可靠的量表，可在我国推广使用低血糖置信度量表可能有助于糖尿病患者的随访和治疗目标的实现。
{"title":"Validity and reliability of the hypoglycemia confidence scale for patients with type 1 diabetes","authors":"Ismail Demir, Gokhan Sahin, B. Pamuk","doi":"10.56016/dahudermj.1253273","DOIUrl":"https://doi.org/10.56016/dahudermj.1253273","url":null,"abstract":"Background: This study aims to assess the validation and reliability of the Turkish adaptation of the Hypoglycemic Confident Scale and to investigate its relationship between the Hypoglycemia Fear survey, WHO Well-Being Index, Hba1c, sociodemographic characteristics and variables. \u0000Methods: The survey consists of a total of 81 questions concerning the sociodemographic status, clinic status variables, and the Hypoglycemic Confidence Scale formed by 35 standard questions and 46 scale questions. \u0000Result: In this study, assessment of the reliability of the scale was achieved by internal consistency and test-retest methods, and the Cronbach alpha internal consistency reliability coefficients were 0.814 in the first test and 0.885 in the second test. It was observed that the responses given to the items of the Hypoglycemic Confidence Scale at two separate times were consistent with one another. The overall correlation of the scale (r = 0.927, p < 0.0001) was positive and highly significant (p < 0001). A significant, inverse, and moderate correlation was found between HbA1c values and Hypoglycemic Confidence Scale total scores (p < 0,0001, r = -0,479). Similarly, a higher hypoglycemic confidence score was observed to be associated with higher WHO Well-Being Index score and lower hypoglycemic fear. \u0000Conclusion: This study shows that the Hypoglycemia Confidence Scale created by Polonsky et al. is a valid and reliable scale that can be put into use in our country.1 The Hypoglycemic Confidence Scale may be beneficial in diabetic patient follow-up and achieving treatment goals in diabetic patients.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126432975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-26DOI: 10.56016/dahudermj.1249255
M. Karadeniz, Ozge Ozcan Abacioglu, Ü. Malkan, İ. C. Haznedaroğlu
Objectives: Chronic myeloproliferative diseases (CMPD) are neoplastic disorders leading to hypercoagulability and thrombosis. The critical hemostatic abnormalities include alterations in the blood viscosity and a history of recent thrombus. The aim of this study is to assess the interrelationships among the atherogenic index of plasma (AIP) and thromboembolism of CMPD with JAK2 V617F mutation. Methods: Ninety-two patients diagnosed as CMPD with JAK2 V617F mutation and 73 controls were included into the study. The patients were evaluated for the presence of any venous or arterial thromboembolic events. AIP was calculated by using the formula log (Tg/HDL) from serum triglyceride and high-density lipoprotein values. Results: The study group consisted of 30 patients (33%) with myelofibrosis (MF), 42 patients (46%) with polycythemia vera (PV) and 20 patients (21%) with essential thrombocythemia (ET). Two study groups were similar in terms of sex, age and other comorbidities (p > 0.05). CMPD group had higher levels of right blood cell count (RBC), red blood cell distribution width (RDW), platelets (PLT), hemotocrit (Hct) and AIP. Univariate and multivariate logistic regression analysis revealed that platelet count, RBC and AIP were independent predictors for thrombosis in both groups. The comparison of ROC curve analysis disclosed that AIP was superior to platelet count and RBC in predicting thrombosis. Conclusion: AIP can be used to determinate higher risk of thromboembolism in patients with CMPD. As a reliable and ‘easy-to-assess’ diagnostic tool, AIP could be useful for the determination of thrombotic events in CMPD clinicobiological disease course.
{"title":"The atherogenic index of plasma complicates the thrombotic tendency of chronic myeloproliferative disorders: A retrospective cohort study","authors":"M. Karadeniz, Ozge Ozcan Abacioglu, Ü. Malkan, İ. C. Haznedaroğlu","doi":"10.56016/dahudermj.1249255","DOIUrl":"https://doi.org/10.56016/dahudermj.1249255","url":null,"abstract":"Objectives: Chronic myeloproliferative diseases (CMPD) are neoplastic disorders leading to hypercoagulability and thrombosis. The critical hemostatic abnormalities include alterations in the blood viscosity and a history of recent thrombus. The aim of this study is to assess the interrelationships among the atherogenic index of plasma (AIP) and thromboembolism of CMPD with JAK2 V617F mutation. \u0000Methods: Ninety-two patients diagnosed as CMPD with JAK2 V617F mutation and 73 controls were included into the study. The patients were evaluated for the presence of any venous or arterial thromboembolic events. AIP was calculated by using the formula log (Tg/HDL) from serum triglyceride and high-density lipoprotein values. \u0000Results: The study group consisted of 30 patients (33%) with myelofibrosis (MF), 42 patients (46%) with polycythemia vera (PV) and 20 patients (21%) with essential thrombocythemia (ET). Two study groups were similar in terms of sex, age and other comorbidities (p > 0.05). CMPD group had higher levels of right blood cell count (RBC), red blood cell distribution width (RDW), platelets (PLT), hemotocrit (Hct) and AIP. Univariate and multivariate logistic regression analysis revealed that platelet count, RBC and AIP were independent predictors for thrombosis in both groups. The comparison of ROC curve analysis disclosed that AIP was superior to platelet count and RBC in predicting thrombosis. \u0000Conclusion: AIP can be used to determinate higher risk of thromboembolism in patients with CMPD. As a reliable and ‘easy-to-assess’ diagnostic tool, AIP could be useful for the determination of thrombotic events in CMPD clinicobiological disease course.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126078783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-22DOI: 10.56016/dahudermj.1271677
Pelin Ti̇ryaki̇oğlu, H. Yilmaz, İsmail Yilmaz, Ismail Demir
Obesity is a complex disorder and affected by so many factors in which the balance between food consumption and calorie usage is disrupted. Drugs that act on appetite, food intake, calorie absorption or calorie consumption, or a combination of these, are basically central or peripheral agents. Diethylpropion and phentermine are preferred for short-term obesity treatment. Orlistat, lorcaserin, topiramate/phentermine, naltrexone/bupropion, and liraglutide are preferred for long-term obesity treatment. The main drugs whose experimental and clinical phase studies are still ongoing are cemelanotide, zonisamide/bupropion, neuropeptide Y antagonists, semaglutide and oral glucagon-like peptide (GLP)-1 agonists, cannabinoid type-1 receptor inhibitors, amylin mimetics, amylin/calcitonin activators. receptor, glucose-linked insulin-like acting peptide analogues, dual-acting GLP-1/glucagon receptor agonists, peptide YY, leptin analogues, beloranib, cetilistat, tenofensin, fibroblast growth factor-21 and obesity vaccines. While managing the treatment of an obese patient, considering the large costs of the disease and the high incidence of disorder, pharmacotherapeutic agents are not enough to meet the clinic spectrum like adverse effects and contraindications, but new drugs and studies in this field offer hope to the medical world in terms of efficacy and safety profile. However, it would not be rational to expect miracles from drugs without a change in lifestyle in the magement of this disorder.
{"title":"Current pharmacological approaches in obesity treatment","authors":"Pelin Ti̇ryaki̇oğlu, H. Yilmaz, İsmail Yilmaz, Ismail Demir","doi":"10.56016/dahudermj.1271677","DOIUrl":"https://doi.org/10.56016/dahudermj.1271677","url":null,"abstract":"Obesity is a complex disorder and affected by so many factors in which the balance between food consumption and calorie usage is disrupted. Drugs that act on appetite, food intake, calorie absorption or calorie consumption, or a combination of these, are basically central or peripheral agents. Diethylpropion and phentermine are preferred for short-term obesity treatment. Orlistat, lorcaserin, topiramate/phentermine, naltrexone/bupropion, and liraglutide are preferred for long-term obesity treatment. The main drugs whose experimental and clinical phase studies are still ongoing are cemelanotide, zonisamide/bupropion, neuropeptide Y antagonists, semaglutide and oral glucagon-like peptide (GLP)-1 agonists, cannabinoid type-1 receptor inhibitors, amylin mimetics, amylin/calcitonin activators. receptor, glucose-linked insulin-like acting peptide analogues, dual-acting GLP-1/glucagon receptor agonists, peptide YY, leptin analogues, beloranib, cetilistat, tenofensin, fibroblast growth factor-21 and obesity vaccines. While managing the treatment of an obese patient, considering the large costs of the disease and the high incidence of disorder, pharmacotherapeutic agents are not enough to meet the clinic spectrum like adverse effects and contraindications, but new drugs and studies in this field offer hope to the medical world in terms of efficacy and safety profile. However, it would not be rational to expect miracles from drugs without a change in lifestyle in the magement of this disorder.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133650005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-12DOI: 10.56016/dahudermj.1246248
A. Isiklar, T. Y. Kuzan
Objective: Predicting the clinical course of acute pancreatitis has been discussed previously on the basis of visceral adipose tissue. This study was conducted to determine the relationship between clinical outcomes of acute pancreatitis and changes in skeletal muscle parameters. Method: This is a single-center, cross-sectional, retrospective study. Patients who were diagnosed with acute pancreatitis between 01-28 February 2019 and had abdominal computed tomography (CT) taken in the first week of their hospitalization were included in the study. L3 level of abdominal CT images were used to evaluate skeletal muscle parameters. Results: During the hospital database scanning, 127 patients newly diagnosed with acute pancreatitis were included in the study. The median age was 50 (18-88) years, 47% were male, and 53% were female. The median body mass index (BMI) was 26,42 (19.4-46.8) kg/m2. Fifty-one % of patients were diagnosed with biliary acute pancreatitis, and 48.8% were diagnosed with non-biliary acute pancreatitis. At the same time, acute pancreatitis severity was classified according to revised Atlanta criteria, 67.7% were mild (n = 86), 28.3% were moderate (n = 36) and 5 (3.9%) patients were severe. Skeletal muscle mass was evaluated using the total psoas index (TPI) and, skeletal muscle density calculated by HU. Median TPI was 6.3 (2.5-13.7). The median of Hounsfield Unit (HU) average calculation was 18.9 (3.8-28.5) (Table 1). There were no statistically significant differences on sex, age, BMI, skeletal muscle parameters, and acute pancreatitis clinical outcome (Table 2). Conclusion: Skeletal muscle parameters determined by TPI and HU were not a predictor of the clinical course, and viewing them always cannot effectively investigate their effect on acute pathologies. So, this way couldn't be proposed as a perfect method for predicting the clinical outcome of acute pancreatitis.
目的:根据内脏脂肪组织预测急性胰腺炎的临床病程已有讨论。本研究旨在确定急性胰腺炎临床结果与骨骼肌参数变化之间的关系。方法:这是一项单中心、横断面、回顾性研究。2019年2月1日至28日期间被诊断为急性胰腺炎并在住院第一周接受腹部计算机断层扫描(CT)的患者被纳入研究。采用L3层腹部CT图像评价骨骼肌参数。结果:在医院数据库扫描期间，127例新诊断为急性胰腺炎的患者被纳入研究。中位年龄50岁(18-88岁)，男性占47%，女性占53%。中位体重指数(BMI)为26.42 (19.4-46.8)kg/m2。51%的患者诊断为胆道性急性胰腺炎，48.8%的患者诊断为非胆道性急性胰腺炎。同时，根据修订后的亚特兰大标准对急性胰腺炎的严重程度进行分类，其中轻度占67.7% (n = 86)，中度占28.3% (n = 36)，重度占5例(3.9%)。用总腰肌指数(TPI)评估骨骼肌质量，用HU计算骨骼肌密度。TPI中位数为6.3(2.5-13.7)。Hounsfield Unit (HU)平均计算的中位数为18.9(3.8-28.5)(表1)。性别、年龄、BMI、骨骼肌参数、急性胰腺炎临床转归差异无统计学意义(表2)。结论:TPI和HU测定的骨骼肌参数不能作为临床病程的预测因子，观察骨骼肌参数往往不能有效探讨其对急性病理的影响。因此，这种方法不能作为预测急性胰腺炎临床预后的完美方法。
{"title":"Initial values of skeletal muscle parameters in patients presenting with acute pancreatitis","authors":"A. Isiklar, T. Y. Kuzan","doi":"10.56016/dahudermj.1246248","DOIUrl":"https://doi.org/10.56016/dahudermj.1246248","url":null,"abstract":"Objective: Predicting the clinical course of acute pancreatitis has been discussed previously on the basis of visceral adipose tissue. This study was conducted to determine the relationship between clinical outcomes of acute pancreatitis and changes in skeletal muscle parameters. \u0000Method: This is a single-center, cross-sectional, retrospective study. Patients who were diagnosed with acute pancreatitis between 01-28 February 2019 and had abdominal computed tomography (CT) taken in the first week of their hospitalization were included in the study. L3 level of abdominal CT images were used to evaluate skeletal muscle parameters. \u0000Results: During the hospital database scanning, 127 patients newly diagnosed with acute pancreatitis were included in the study. The median age was 50 (18-88) years, 47% were male, and 53% were female. The median body mass index (BMI) was 26,42 (19.4-46.8) kg/m2. Fifty-one % of patients were diagnosed with biliary acute pancreatitis, and 48.8% were diagnosed with non-biliary acute pancreatitis. At the same time, acute pancreatitis severity was classified according to revised Atlanta criteria, 67.7% were mild (n = 86), 28.3% were moderate (n = 36) and 5 (3.9%) patients were severe. Skeletal muscle mass was evaluated using the total psoas index (TPI) and, skeletal muscle density calculated by HU. Median TPI was 6.3 (2.5-13.7). The median of Hounsfield Unit (HU) average calculation was 18.9 (3.8-28.5) (Table 1). There were no statistically significant differences on sex, age, BMI, skeletal muscle parameters, and acute pancreatitis clinical outcome (Table 2). \u0000Conclusion: Skeletal muscle parameters determined by TPI and HU were not a predictor of the clinical course, and viewing them always cannot effectively investigate their effect on acute pathologies. So, this way couldn't be proposed as a perfect method for predicting the clinical outcome of acute pancreatitis.","PeriodicalId":210697,"journal":{"name":"DAHUDER Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116977747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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