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An Overview of COVID-19 Stigma: India’s perspective “Pain of rejection is more severe than infection” “被拒绝的痛苦比感染更严重”的印度视角
Pub Date : 2021-10-20 DOI: 10.22038/RCM.2021.60368.1377
Ashutosh Kumar Singh, N. Khargekar, D. Khanna, Ashish Sharma
Stigma and disease have an ancient relation. Since disease is being considered as the curse of God and patients of contagious diseases is considered as disease spreader facing the social rejection. Wreak havoc of COVID-19 across the globe has desolated the mindset of common man, fear, anxiety and ignorance of community fuelling the social discrimination. The patient can recover the physical wound or diseases but stigma strikes the soul of victim that debilitates the will for survival. Stigma does not only affect the patients only but also the front line warriors excruciating the global emergency. Psychological distress mitigation is still missing in COVID-19 coping strategies. This article is intended to provide an overview of social-stigmatization faced by different sets of population as well as to draw attention over mental health component assimilation in therapeutic measures of COVID-19. To ensure the physical, mental and social wellbeing of the individual and society as whole.
耻辱和疾病有着古老的关系。由于疾病被认为是上帝的诅咒,传染病患者被认为是面临社会排斥的疾病传播者。新冠肺炎在全球范围内的灾难摧毁了普通人的心态,恐惧、焦虑和对社区的无知助长了社会歧视。患者可以恢复身体创伤或疾病,但污名会打击受害者的灵魂,削弱其生存意愿。耻辱不仅影响到病人,也影响到在全球紧急情况下受苦受难的前线战士。在新冠肺炎应对策略中,心理压力缓解仍然缺失。本文旨在概述不同人群面临的社会污名化,并提请注意新冠肺炎治疗措施中的心理健康成分同化。确保个人和整个社会的身心健康和社会福祉。
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引用次数: 0
Functional outcome of tibial plateau fractures treated by Locking Compression Plates- A Prospective Study. 锁定加压钢板治疗胫骨平台骨折的功能结果——一项前瞻性研究。
Pub Date : 2021-10-17 DOI: 10.22038/RCM.2021.57833.1368
Narendra Kumar, B. Sahu, D. Sharma
Introduction: Tibial plateau fractures represent the fractures involving the articular surface of proximal part of the tibia bone i.e. lateral or medial condyle or both, and with varying degrees of articular depression and displacement.Fixation by locking plates has led to dramatic improvement in the treatment of tibial plateau fractures.Method: It was a prospective study conducted on 30 patients with tibial plateau fractures at a tertiary care hospital in New Delhi, India. Patients were operated with locking compression plates and followed up for 18 months. Union was checked with serial radiographs and functional outcome was assessed with Rasmussen Functional Knee Score.Result:Twentynine patients achieved union at a mean time of 13.65 weeks, one patient had infective nonunion. Overall mean Rasmussen Functional Knee Score was 27 which is graded as excellent.Conclusion: Treatment of tibial plateau fractures with open reduction and plating with locking compression plates provides anatomical reduction and desirable functional outcome. Union is earlier and functional results are better for Schatzker type 1-3 when compared to type 4-6. Return to work with greater capacity largely depends on motivation.
引言:胫骨平台骨折是指涉及胫骨近端关节面,即外侧髁或内侧髁或两者兼有的骨折,并伴有不同程度的关节凹陷和移位。锁定钢板固定治疗胫骨平台骨折的疗效显著提高。方法:在印度新德里的一家三级护理医院对30名胫骨平台骨折患者进行了前瞻性研究。患者采用锁定加压钢板进行手术,随访18个月。用连续的X光片检查愈合情况,并用Rasmussen膝关节功能评分评估功能结果。结果:29例患者平均愈合13.65周,其中1例发生感染性骨不连。拉斯穆森膝关节功能评分的总体平均值为27分,被评为优秀。结论:开放复位加锁定加压钢板内固定治疗胫骨平台骨折具有良好的解剖复位效果和良好的功能效果。与4-6型相比,Schatzker 1-3型的并集更早,功能结果更好。以更大的能力重返工作岗位在很大程度上取决于动机。
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引用次数: 0
Evaluation of Interleukin 33 and ST2 serum concentration in active tuberculosis patients 活动性肺结核患者血清白细胞介素33和ST2浓度的评估
Pub Date : 2021-09-30 DOI: 10.22038/RCM.2021.59643.1373
M. Youssefi, Golsa Teimouri, Farnaaz Zahedi-avval, K. Ghazvini, M. Keikha
The aim of this study was to determine the serum levels of ST2 protein and interleukin-33 in patients affected to tuberculosis and compare them with the control group. In the present study, at first 30 patients affected to TB were randomly selected and 52 healthy individuals, who were matched with respect to their age and gender, included in the study as the control group. After that, the serum levels of sST2 and IL33 were measured by ELISA sandwich method using commercial Quantikine Human ELISA kit (R&D Systems). The data were finally analyzed by SPSS software. IL-33 levels in the TB group were higher than the healthy controls and a statistically significant difference was observed in the IL-33 levels between the two groups (P = 0.021). Moreover, IL-33R (ST2) was slightly increased in the TB patients compared to the healthy controls, although statistical analysis showed no significant difference between the two groups (P = 0.083). Regarding the high normal variation of sST2 and the limitations of the present study, it is recommended that future studies of sST2 be performed in with higher number of TB patients.
本研究的目的是测定结核患者血清中ST2蛋白和白细胞介素-33的水平,并与对照组进行比较。在本研究中,首先随机选择30名结核病患者和52名年龄和性别相匹配的健康个体作为对照组。随后,采用商用Quantikine Human ELISA kit (R&D Systems),采用ELISA夹心法检测血清sST2和IL33水平。最后用SPSS软件对数据进行分析。结核组IL-33水平高于正常对照组,两组间IL-33水平差异有统计学意义(P = 0.021)。结核患者IL-33R (ST2)较健康对照组略有升高,但两组间差异无统计学意义(P = 0.083)。考虑到sST2的高正常变异和本研究的局限性,建议在更多的结核病患者中进行sST2的进一步研究。
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引用次数: 0
Estrogen on Candida spp. of the vagina: Is there any effect? 雌激素对阴道念珠菌有影响吗?
Pub Date : 2021-08-30 DOI: 10.22038/RCM.2021.59562.1371
A. Al-Janabi, R. K. M. Jawad
A variety of Candida spp. as the most common fungi in the human body can normally be found in the vagina competing with other microbotes. Their presence is influenced by a variety of conditions in the vaginal environment. The proliferation of Candida spp. in the vagina under specific conditions can result in a fungal disease known as vaginal candidiasis. More than 17 species of Candida out of 200 members of this genus are capable of causing diseases within the human body. Estrogen, along with other steroidal hormones, has been shown to have direct multifunctional effects on various pathogenic microorganisms by numerous activities. Its production as well as other factors such as disturbance of microbial balance and immune activity may alter the vaginal physical environment and promote the development of vaginal fungal infection. The vaginal functions can be affected by the level of circulation of estrogens in the blood according to the stage of the menstrual cycle in women. It also has many other functional actions on the vaginal structure. Estrogen and several other factors play an important role in determining the vaginal content of Candida species. Its effect could be a direct action on the cells of Candida or through an indirect effect on the immunity defenses of the vagina.
作为人体中最常见的真菌,各种念珠菌通常可以在阴道中与其他微生物竞争。它们的存在受到阴道环境各种条件的影响。念珠菌在特定条件下在阴道内的增殖可导致一种称为阴道念珠菌病的真菌疾病。念珠菌属的200个成员中有超过17个种类能够在人体内引起疾病。雌激素与其他甾体激素一起,已被证明通过多种活动对各种病原微生物具有直接的多功能作用。它的产生与其他因素如微生物平衡和免疫活性的紊乱可能改变阴道物理环境,促进阴道真菌感染的发展。根据女性月经周期的不同阶段,血液中雌激素的循环水平会影响阴道功能。它对阴道结构也有许多其他的功能作用。雌激素和其他几个因素在决定阴道念珠菌种类的内容中起重要作用。它的作用可能是对念珠菌细胞的直接作用或通过对阴道免疫防御的间接作用。
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引用次数: 1
Trend and use of Complementary and Alternative Medicine in Gastroenterology patients. 补充和替代医学在胃肠病患者中的趋势和应用。
Pub Date : 2021-08-30 DOI: 10.22038/RCM.2021.59641.1372
Hesaneh Izadyar, M. Ahadi, A. Khorashad, H. Saadatnia, H. Vosoghinia, Mohamadreza Farzanehfar, A. Namdar, E. Amirmajdi, Sahar Khorasani, Hamideh Akbari, Foad Faroughi Bojd
Objective: This study was conducted to evaluate the prevalence of complementary and alternative medicine in patients referring to the gastroentrology clinics in Mashhad. Methods: Patients responded to the questionnaire and study checklist through interviews. The collected data were analyzed by SPSS-16 statistical software.Results: This study was conducted on 751 patients referring to gastroenterologists; of whom, 274 (48.36%) were male and 476 (38.63) were female. According to the results, the most popular complementary and alternative medicine treatments were respectively herbal medicine, cupping therapy and acupuncture. A significant difference was observed in the means at is faction with complementary and alternative medicine between those who believed in it and those who did not (p=0.001); but, no significant difference was detected in mean satisfaction with complementary and alternative medicine between patients with different occupations (p=0.193). There was also a significant difference in the number of patients between the group of patients receiving chemical medication and the group of patients receiving complementary and alternative medicine therapies (p=0.005). No significant difference was found in the level of satisfaction with complementary and alternative medicine between participants referring to the gastroenterology clinics for different causes (p=0.431); nonetheless, the highest satisfaction was observed in patients with malignancy, and the lowest satisfaction was detected in patients with oesophagal disorders.Conclusion: This study indicated the high prevalence of complementary and alternative medicine in Iran. The worldwide popularity of complementary and alternative medicine should not be overlooked, therefore; current medical treatment systems need to be revised and modified.
目的:本研究旨在评估马什哈德胃肠病诊所患者补充和替代药物的患病率。方法:患者通过访谈对问卷和研究检查表进行回答。采用SPSS-16统计软件对收集到的数据进行分析。结果:本研究共对751例胃肠病患者进行了研究;其中男性274例(48.36%),女性476例(38.63)。根据研究结果,最流行的补充和替代药物治疗分别是草药、拔罐和针灸。在那些相信补充和替代药物的人和那些不相信的人之间,观察到补充和替代医学的平均值有显著差异(p=0.001);但是不同职业的患者对补充和替代药物的平均满意度没有显著差异(p=0.193)。接受化学药物治疗的患者组和接受补充和替代治疗的患者之间的患者人数也有显著差异(p=0.005)由于不同原因到胃肠病诊所就诊的参与者对补充药物和替代药物的满意度存在差异(p=0.431);尽管如此,恶性肿瘤患者的满意度最高,食道疾病患者的满意度最低。结论:本研究表明,伊朗的补充医学和替代医学的患病率很高。因此,补充医学和替代医学在世界范围内的普及不应被忽视;目前的医疗制度需要修改。
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引用次数: 0
Blood culture positive for gram-positive rods: Contamination or a true infection-A literature review 革兰氏阳性杆菌血培养阳性:污染还是真正的感染——文献综述
Pub Date : 2021-07-11 DOI: 10.22038/RCM.2021.58032.1369
K. S. Rizi, Hadi Farsiani, Mohammad Momen Ghalibaf
Today, human bloodstream infections (BSIs) are recognized as a major cause of morbidity and mortality worldwide. The bacteria, responsible for bacteremia, are usually identified in diagnostic clinical laboratories, using blood cultures. True bacteremia is defined as a positive blood culture (>15 CFU/mL), with signs and symptoms of infection (e.g., fever and chills). A wide range of bacteria can cause true bacteremia and some bacterial isolates from BSIs may be responsible for contamination. Gram-positive bacilli, such as Bacillus species, and coryneform bacteria are suspected sources of contamination in blood cultures. However, in certain patients, such as immunocompromised patients and intravenous drug users, gram-positive bacilli can act as a true pathogen. Therefore, it is important to know when gram positive bacilli act as a true pathogen and when they act as contamination. So, the rapidly diagnosis of true pathogens and appropriate treatment play a very important role in controlling infection with these bacteria. Effective measures are especially important in patients with an underlying disease or an immunocompromised status. In this article, we reviewed the literature on common Gram-positive rod-shaped bacteria, which were isolated from blood cultures and were suspected to be true pathogens or contaminants.
今天,人类血液感染(bsi)被认为是世界范围内发病率和死亡率的主要原因。导致菌血症的细菌通常在诊断性临床实验室中通过血液培养来确定。真正的菌血症定义为血培养阳性(> - 15 CFU/mL),伴有感染的体征和症状(如发热和发冷)。广泛的细菌可引起真正的菌血症,从bsi分离的一些细菌可能造成污染。革兰氏阳性杆菌,如芽孢杆菌种和棒状细菌是血液培养中可疑的污染源。然而,在某些患者中,如免疫功能低下患者和静脉注射吸毒者,革兰氏阳性杆菌可以作为真正的病原体。因此,了解革兰氏阳性杆菌何时作为真正的病原体,何时作为污染是很重要的。因此,快速诊断真正的病原体并进行适当的治疗对控制这些细菌的感染起着非常重要的作用。有效的措施对有基础疾病或免疫功能低下的患者尤为重要。在本文中,我们回顾了常见的革兰氏阳性杆状细菌的文献,这些细菌是从血液培养中分离出来的,被怀疑是真正的病原体或污染物。
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引用次数: 1
Effect of Hyperbaric Oxygen Therapy on Diabetic Foot Ulcer; a Clinical Study 目的探讨高压氧治疗糖尿病足溃疡的疗效;临床研究
Pub Date : 2021-06-01 DOI: 10.22038/RCM.2021.55444.1353
S. Babaniamansour, Nooshin Najari, Ehsan Aliniagerdroudbari, Amirmohammad Babaniamansour, Saeed Pezeshki
Introduction:One of the most common diabetes complications is diabetic foot ulcer (DFU). Besides conventional treatments, hyperbaric oxygen therapy (HBOT) is known as an adjunctive therapy for DFU. This study aimed to investigate the efficacy of HBOT and possible risk factors. Methods:This study was conducted in two hyperbaric clinics of Bahar and Khatam, respectively in Isfahan and Tehran, Iran, between September 2016 and September 2017. Eligible participants underwent 100% oxygen at 2 to 2.5 atmosphere absolute for 90 to 120 minutes daily (five days per week). Data were analyzed with SPSS version 24.0. Results: The recovery rate was 69% in 58 enrolled patients and had a significant direct association with good glycemic control status, before (p <0.01) and during HBOT (P < 0.01), and low-grade ulcers (P= 0.04). The mean number of HBOT sessions of the cured patients (21.5±17.1) was significantly higher than that of the not cured patients (11.3 ± 7.9) (P= 0.02). However, the recovery rate had no significant association with the type of ulcer (P= 0.1). Conclusion: HBOT had good efficacy and a high recovery rate in DFU treatment. Given the fact that good glycemic control status reduces the incidence of ulcers, this study showed that it increased the DFU recovery rate under HBOT.
引言:糖尿病足溃疡是糖尿病最常见的并发症之一。除了常规治疗外,高压氧治疗(HBOT)是DFU的一种辅助治疗方法。本研究旨在调查HBOT的疗效和可能的危险因素。方法:本研究于2016年9月至2017年9月在伊朗伊斯法罕和德黑兰的Bahar和Khatam两家高压诊所进行。符合条件的参与者每天(每周五天)在2至2.5个绝对大气压下接受100%氧气治疗90至120分钟。数据采用SPSS 24.0版软件进行分析。结果:58名入选患者的恢复率为69%,与良好的血糖控制状态、HBOT前(p<0.01)和期间(p<0.01)以及低度溃疡(p=0.04)有显著的直接关系。治愈患者的平均HBOT疗程数(21.5±17.1)显著高于未治愈患者的(11.3±7.9)(p=0.02)。然而,结论:HBOT治疗DFU疗效好,恢复率高。鉴于良好的血糖控制状态可以降低溃疡的发生率,这项研究表明,它提高了HBOT下DFU的恢复率。
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引用次数: 0
Effect of Melatonin on the Sleep Quality: A Systematic Review 褪黑素对睡眠质量的影响:一项系统综述
Pub Date : 2021-06-01 DOI: 10.22038/RCM.2021.55887.1356
Khadijeh Alizadeh Feremi, L. Alipoor, R. Esmaeili
Introduction:Sleep is one of the most important human needs affected by many factors. Sleep disorders, such as insomnia and delayed sleep, are very common and can affect the quality and quantity of sleep. The current systematic review aimed to evaluate the evidence on the effectiveness of melatonin treatment on sleep quality. Methods:The data on the effect of melatonin on sleep were collected using seven English databases, including Scopus, PubMed, Ovid, ProQuest, and Science Direct, as well as six Persian databases, including Iran Medex, SID, IRANDOC, Magiran, MEDLIB, and Noormags, from their inception up to the end of January 2020. English language, randomized clinical trials, human samples, and age of higher than 18 years were the main eligibility criteria. Nonrandomized clinical trials or those without a control group were excluded from the present study. Results: Seven articles met the eligibility criteria for being included in this review. In the aforementioned studies, the effect of melatonin therapy on sleep quality was assessed in 343 subjects. The majority (86%) of the studies confirmed the effectiveness of melatonin treatment on sleep quality. Conclusion: Melatonin as an orally administered drug had beneficial effects on sleep quality. These effects of melatonin attributed to more efficient healthier sleep, deeper sleep, longer sleep duration without causing fatigue and early morning drowsiness, and faster sleeping. One of the limitations of the present study was considered reviewing articles without the consideration of the medical conditions of the subjects. Moreover, the type of sleep disorder was not investigated in this review.
睡眠是人类最重要的需求之一,受许多因素的影响。睡眠障碍,如失眠和睡眠延迟,是非常常见的,会影响睡眠的质量和数量。本系统综述旨在评估褪黑激素治疗对睡眠质量的有效性。方法:使用Scopus、PubMed、Ovid、ProQuest、Science Direct等7个英文数据库和Iran Medex、SID、IRANDOC、Magiran、MEDLIB、Noormags等6个波斯语数据库,从其建立至2020年1月底收集褪黑激素对睡眠的影响数据。英语、随机临床试验、人体样本和年龄大于18岁是主要的入选标准。非随机临床试验或没有对照组的临床试验被排除在本研究之外。结果:7篇文章符合纳入本综述的资格标准。在上述研究中,对343名受试者进行了褪黑素治疗对睡眠质量的影响评估。大多数(86%)的研究证实了褪黑激素治疗对睡眠质量的有效性。结论:口服褪黑素可改善睡眠质量。褪黑素的这些作用有助于提高睡眠效率、改善睡眠深度、延长睡眠时间而不会引起疲劳和清晨困倦,以及加快睡眠速度。本研究的局限性之一是在审查文章时没有考虑受试者的医疗状况。此外,本综述未对睡眠障碍的类型进行调查。
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引用次数: 0
Prevalence of Child Abuse and its Related Factors in Iran: A Systematic Review 伊朗儿童虐待流行及其相关因素:系统回顾
Pub Date : 2021-06-01 DOI: 10.22038/RCM.2021.57344.1366
M. Salehian, N. Maleki-saghooni, F. Karimi
Introduction:Child abuse is a global problem that is deeply rooted in the cultural, social, and economic performance of society. It is a behavior that occurs in various forms of physical, mental, emotional, or sexual, which can cause harm to the health, welfare, and education of the child. The present study was conducted to estimate the prevalence of child abuse and its related factors in Iran.Methods:In the present systematic review study, to find articles related to the prevalence of child abuse in Iran, valid databases such as Scopus, PubMed, Cochrane, SID, Magiran, IranDoc, and Google Scholar was were searched using the keywords of “child abuse”, “physical abuse” “emotional abuse”,” neglect”, “prevalence” and “Iran”.Results: In this study, 22 articles were analyzed. Based on this review about 4.5%-58.2% of children reported physical abuse, 7.3%-91.6% emotional abuse, and 5.5%-85.3% neglect. Factors associated with child abuse were hyperactivity anxiety and mental status disorder. All studies showed a significant relationship of abuses with education, occupation, addiction, and divorce of parents. Moreover, depression and anxiety of parents and poor parental relationships were related to abuse of children. Conclusion: Child abuse has many negative effects on childish and adolescent health. It seems that child abuse in Iran is in critical condition; therefore, policymakers must take action to solve this problem and prevent it by designing special programs and effective policies in Iran.
儿童虐待是一个全球性问题,深深植根于社会的文化、社会和经济表现。它是一种发生在身体、精神、情感或性方面的各种形式的行为,可能对儿童的健康、福利和教育造成损害。本研究旨在估计伊朗虐待儿童的普遍程度及其相关因素。方法:本系统综述研究以“儿童虐待”、“身体虐待”、“情感虐待”、“忽视”、“患病率”和“伊朗”为关键词,对Scopus、PubMed、Cochrane、SID、Magiran、IranDoc和谷歌Scholar等有效数据库进行检索,查找与伊朗儿童虐待发生率相关的文章。结果:本研究共分析了22篇文献。根据这篇综述,大约4.5%-58.2%的儿童报告身体虐待,7.3%-91.6%的儿童报告精神虐待,5.5%-85.3%的儿童报告忽视。与儿童虐待相关的因素是多动、焦虑和精神状态障碍。所有的研究都表明,虐待与教育、职业、成瘾和父母离婚有显著的关系。此外,父母的抑郁、焦虑和父母关系不佳与虐待儿童有关。结论:虐待儿童对儿童和青少年健康有诸多负面影响。伊朗的虐待儿童问题似乎处于危急状态;因此,决策者必须采取行动解决这一问题,并通过在伊朗设计特殊方案和有效政策来防止这一问题的发生。
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引用次数: 0
The Effect of Chamomile Extract on Coronavirus 洋甘菊提取物对冠状病毒的作用
Pub Date : 2021-06-01 DOI: 10.22038/RCM.2021.58399.1370
Mohaddeseh Sadat Moghaddam, Niyusha Torabzadeh Khorasani, R. Darban, H. Rahimi
Acute respiratory Syndrome (SARS) is an uncommon respiratory illness that is transmitted primarily by respiratory droplets or direct contact with an infected person. The COVID-19 initially appeared in late 2019 in Wuhan, China, and spread everywhere around the globe. Earlier in 2003, the coronavirus was known due to the human SARS-CoV virus, which infected 8,000 people and caused 800 deaths in southeast Asia and Canada. It should be mentioned that in 2012, another coronavirus, called Middle East respiratory syndrome coronavirus, infected Saudi Arabia and 27 other countries. The SARS-CoV2 belongs to a family of viruses called Coronaviruses that can infect bats, birds, pigs, cows, and different mammals. Some plant extracts are shown to inhibit microorganism replication and may be utilized in medication to treat infectious and non-infectious diseases, one of which is chamomile. chamomile medicinal plant, that has 120 biologically active compounds, the most necessary of which are flavonoids, like apigenin and luteolin, that are shown to possess antiviral activity.
急性呼吸系统综合症(SARS)是一种罕见的呼吸道疾病,主要通过呼吸道飞沫或与感染者直接接触传播。COVID-19最初于2019年底在中国武汉出现,并蔓延到全球各地。2003年早些时候,这种冠状病毒因人类sars冠状病毒而为人所知,sars冠状病毒在东南亚和加拿大感染了8000人,造成800人死亡。值得一提的是,2012年,另一种名为中东呼吸综合征冠状病毒的冠状病毒感染了沙特阿拉伯等27个国家。SARS-CoV2属于冠状病毒家族,可以感染蝙蝠、鸟类、猪、牛和不同的哺乳动物。一些植物提取物被证明可以抑制微生物复制,并可用于治疗感染性和非感染性疾病的药物,其中一种是洋甘菊。洋甘菊是一种药用植物,含有120种生物活性化合物,其中最重要的是类黄酮,如芹菜素和木犀草素,它们具有抗病毒活性。
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引用次数: 3
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