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Anomalous Single Pulmonary Venous Trunk. 异常单肺静脉主干
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.230261
Zhidong Yuan, Xuehan Hu, Guanxun Cheng
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引用次数: 0
Radiomics from Cardiovascular MR Cine Images for Identifying Patients with Hypertrophic Cardiomyopathy at High Risk for Heart Failure. 从心血管磁共振视频图像中提取放射组学信息,用于识别心衰高风险肥厚型心肌病患者。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.230323
Hongbo Zhang, Lei Zhao, Haoru Wang, Yuhan Yi, Keyao Hui, Chen Zhang, Xiaohai Ma

Purpose To develop a model integrating radiomics features from cardiac MR cine images with clinical and standard cardiac MRI predictors to identify patients with hypertrophic cardiomyopathy (HCM) at high risk for heart failure (HF). Materials and Methods In this retrospective study, 516 patients with HCM (median age, 51 years [IQR: 40-62]; 367 [71.1%] men) who underwent cardiac MRI from January 2015 to June 2021 were divided into training and validation sets (7:3 ratio). Radiomics features were extracted from cardiac cine images, and radiomics scores were calculated based on reproducible features using the least absolute shrinkage and selection operator Cox regression. Radiomics scores and clinical and standard cardiac MRI predictors that were significantly associated with HF events in univariable Cox regression analysis were incorporated into a multivariable analysis to construct a combined prediction model. Model performance was validated using time-dependent area under the receiver operating characteristic curve (AUC), and the optimal cutoff value of the combined model was determined for patient risk stratification. Results The radiomics score was the strongest predictor for HF events in both univariable (hazard ratio, 10.37; P < .001) and multivariable (hazard ratio, 10.25; P < .001) analyses. The combined model yielded the highest 1- and 3-year AUCs of 0.81 and 0.80, respectively, in the training set and 0.82 and 0.77 in the validation set. Patients stratified as high risk had more than sixfold increased risk of HF events compared with patients at low risk. Conclusion The combined model with radiomics features and clinical and standard cardiac MRI parameters accurately identified patients with HCM at high risk for HF. Keywords: Cardiomyopathies, Outcomes Analysis, Cardiovascular MRI, Hypertrophic Cardiomyopathy, Radiomics, Heart Failure Supplemental material is available for this article. © RSNA, 2024.

目的 建立一个模型,将心脏磁共振 cine 图像的放射组学特征与临床和标准心脏磁共振成像预测指标相结合,以识别心力衰竭(HF)高风险肥厚型心肌病(HCM)患者。材料与方法 在这项回顾性研究中,2015 年 1 月至 2021 年 6 月期间接受心脏 MRI 检查的 516 例 HCM 患者(中位年龄 51 岁 [IQR:40-62];367 例 [71.1%] 男性)被分为训练集和验证集(比例为 7:3)。从心脏ct图像中提取放射组学特征,并使用最小绝对收缩和选择算子Cox回归法根据可重复特征计算放射组学评分。在单变量考克斯回归分析中与高频事件显著相关的放射组学评分和临床及标准心脏磁共振成像预测因子被纳入多变量分析,以构建综合预测模型。利用随时间变化的接收者操作特征曲线下面积(AUC)验证了模型的性能,并确定了用于患者风险分层的组合模型的最佳临界值。结果 在单变量(危险比为 10.37;P < .001)和多变量(危险比为 10.25;P < .001)分析中,放射组学评分是预测高血压事件的最强指标。在训练集中,合并模型的 1 年和 3 年 AUC 分别为 0.81 和 0.80,在验证集中分别为 0.82 和 0.77,均为最高。与低风险患者相比,被分层为高风险的患者发生心房颤动事件的风险增加了六倍多。结论 结合放射组学特征、临床和标准心脏磁共振成像参数的综合模型能准确识别HCM高危患者。关键词心肌病、结果分析、心血管磁共振成像、肥厚型心肌病、放射组学、心力衰竭 本文有补充材料。© RSNA, 2024.
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引用次数: 0
Evaluation of Intracardiac Pressures Using Subharmonic-aided Pressure Estimation with Sonazoid Microbubbles. 利用 Sonazoid 微气泡的次谐波辅助压力估算评估心内压
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.230153
Cara Esposito, Priscilla Machado, Maureen E McDonald, Michael P Savage, David Fischman, Praveen Mehrotra, Ira S Cohen, Nicholas Ruggiero, Paul Walinsky, Alec Vishnevsky, Kristopher Dickie, Marguerite Davis, Flemming Forsberg, Jaydev K Dave

Purpose To investigate if the right ventricular (RV) systolic and left ventricular (LV) diastolic pressures can be obtained noninvasively using the subharmonic-aided pressure estimation (SHAPE) technique with Sonazoid microbubbles. Materials and Methods Individuals scheduled for a left and/or right heart catheterization were prospectively enrolled in this institutional review board-approved clinical trial from 2017 to 2020. A standard-of-care catheterization procedure was performed by advancing fluid-filled pressure catheters into the LV and aorta (n = 25) or RV (n = 22), and solid-state high-fidelity pressure catheters into the LV and aorta in a subset of participants (n = 18). Study participants received an infusion of Sonazoid microbubbles (GE HealthCare), and SHAPE data were acquired using a validated interface developed on a SonixTablet (BK Medical) US scanner, synchronously with the pressure catheter data. A conversion factor, derived using cuff-based pressure measurements with a SphygmoCor XCEL PWA (ATCOR) and subharmonic signal from the aorta, was used to convert the subharmonic signal into pressure values. Errors between the pressure measurements obtained using the SHAPE technique and pressure catheter were compared. Results The mean errors in pressure measurements obtained with the SHAPE technique relative to those of the fluid-filled pressure catheter were 1.6 mm Hg ± 1.5 [SD] (P = .85), 8.4 mm Hg ± 6.2 (P = .04), and 7.4 mm Hg ± 5.7 (P = .09) for RV systolic, LV minimum diastolic, and LV end-diastolic pressures, respectively. Relative to the measurements with the solid-state high-fidelity pressure catheter, the mean errors in LV minimum diastolic and LV end-diastolic pressures were 7.2 mm Hg ± 4.5 and 6.8 mm Hg ± 3.3 (P ≥ .44), respectively. Conclusion These results indicate that SHAPE with Sonazoid may have the potential to provide clinically relevant RV systolic and LV diastolic pressures. Keywords: Ultrasound-Contrast, Cardiac, Aorta, Left Ventricle, Right Ventricle ClinicalTrials.gov registration no.: NCT03245255 © RSNA, 2024.

目的 研究是否可以通过使用 Sonazoid 微气泡的次谐波辅助压力估算(SHAPE)技术无创获取右心室(RV)收缩压和左心室(LV)舒张压。材料与方法 2017 年至 2020 年期间,计划接受左心导管和/或右心导管检查的个人前瞻性地加入了这项经机构审查委员会批准的临床试验。通过将充液压力导管推进左心室和主动脉(n = 25)或右心室(n = 22),以及将固态高保真压力导管推进左心室和主动脉,对一部分参与者(n = 18)进行了标准护理导管检查。研究参与者输注 Sonazoid 微气泡(GE HealthCare),使用在 SonixTablet(BK Medical)US 扫描仪上开发的有效界面获取 SHAPE 数据,并与压力导管数据同步。使用 SphygmoCor XCEL PWA(ATCOR)和主动脉次谐波信号进行袖带压力测量,得出一个转换系数,用于将次谐波信号转换为压力值。比较了使用 SHAPE 技术和压力导管获得的压力测量值之间的误差。结果 相对于充液压力导管,SHAPE 技术获得的压力测量平均误差分别为 1.6 mm Hg ± 1.5 [SD] (P = .85)、8.4 mm Hg ± 6.2 (P = .04) 和 7.4 mm Hg ± 5.7 (P = .09)(左心室收缩压、左心室最低舒张压和左心室舒张末压)。相对于使用固态高保真压力导管进行的测量,左心室最小舒张压和左心室舒张末期压的平均误差分别为 7.2 mm Hg ± 4.5 和 6.8 mm Hg ± 3.3(P ≥ .44)。结论 这些结果表明,使用 Sonazoid 的 SHAPE 有可能提供与临床相关的 RV 收缩压和 LV 舒张压。关键词超声对比 心脏 主动脉 左心室 右心室 ClinicalTrials.gov 注册号:NCT03245255 © RSNA, 2024.
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引用次数: 0
CT Attenuation of Periaortic Adipose Tissue in Abdominal Aortic Aneurysms. 腹主动脉瘤主动脉周围脂肪组织的 CT 衰减。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.230250
Samuel Debono, Evangelos Tzolos, Maaz B J Syed, Jennifer Nash, Alexander J Fletcher, Marc R Dweck, David E Newby, Damini Dey, Rachael O Forsythe, Michelle C Williams

Purpose To assess periaortic adipose tissue attenuation at CT angiography in different abdominal aortic aneurysm disease states. Materials and Methods In a retrospective observational study from January 2018 to December 2022, periaortic adipose tissue attenuation was assessed at CT angiography in patients with asymptomatic or symptomatic (including rupture) abdominal aortic aneurysms and controls without aneurysms. Adipose tissue attenuation was measured using semiautomated software in periaortic aneurysmal and nonaneurysmal segments of the abdominal aorta and in subcutaneous and visceral adipose tissue. Periaortic adipose tissue attenuation values between the three groups were assessed using Student t tests and Wilcoxon rank sum tests followed by a multiregression model. Results Eighty-eight individuals (median age, 70 years [IQR, 65-78]; 78 male and 10 female patients) were included: 70 patients with abdominal aortic aneurysms (40 asymptomatic and 30 symptomatic, including 24 with rupture) and 18 controls. There was no evidence of differences in the periaortic adipose tissue attenuation in the aneurysmal segment in asymptomatic patients versus controls (-81.44 HU ± 7 [SD] vs -83.27 HU ± 9; P = .43) and attenuation in nonaneurysmal segments between asymptomatic patients versus controls (-75.43 HU ± 8 vs -78.81 HU ± 6; P = .08). However, symptomatic patients demonstrated higher periaortic adipose tissue attenuation in both aneurysmal (-57.85 HU ± 7; P < .0001) and nonaneurysmal segments (-58.16 HU ± 8; P < .0001) when compared with the other two groups. Conclusion Periaortic adipose tissue CT attenuation was not increased in stable abdominal aortic aneurysm disease. There was a generalized increase in attenuation in patients with symptomatic disease, likely reflecting the systemic consequences of acute rupture. Keywords: Abdominal Aortic Aneurysm, Periaortic Adipose Tissue Attenuation, CT Angiography ClinicalTrials.gov registration no. NCT02229006 © RSNA, 2024.

目的 评估不同腹主动脉瘤疾病状态下 CT 血管造影时主动脉周围脂肪组织的衰减情况。材料和方法 在 2018 年 1 月至 2022 年 12 月的一项回顾性观察研究中,对无症状或有症状(包括破裂)的腹主动脉瘤患者以及无动脉瘤的对照组在 CT 血管造影时的主动脉周围脂肪组织衰减进行了评估。使用半自动软件测量了腹主动脉瘤周围和非瘤段以及皮下和内脏脂肪组织的脂肪组织衰减。使用学生 t 检验和 Wilcoxon 秩和检验评估三组之间的主动脉周围脂肪组织衰减值,然后使用多元回归模型进行评估。结果 共纳入 88 名患者(中位年龄 70 岁 [IQR,65-78];男性 78 名,女性 10 名):其中包括 70 名腹主动脉瘤患者(40 名无症状,30 名有症状,包括 24 名破裂患者)和 18 名对照组患者。无症状患者与对照组动脉瘤节段的主动脉周围脂肪组织衰减(-81.44 HU ± 7 [SD] vs -83.27 HU ± 9;P = .43)以及无症状患者与对照组非动脉瘤节段的衰减(-75.43 HU ± 8 vs -78.81 HU ± 6;P = .08)无明显差异。然而,与其他两组相比,无症状患者的动脉瘤节段(-57.85 HU ± 7; P < .0001)和非动脉瘤节段(-58.16 HU ± 8; P < .0001)的主动脉周围脂肪组织衰减程度更高。结论 在稳定的腹主动脉瘤疾病中,主动脉周围脂肪组织 CT 衰减没有增加。有症状的患者的衰减普遍增加,这可能反映了急性破裂的全身性后果。关键词:腹主动脉瘤腹主动脉瘤 主动脉周围脂肪组织衰减 CT 血管造影 ClinicalTrials.gov registration no.NCT02229006 © RSNA, 2024.
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引用次数: 0
Echocardiography versus Cardiac MRI for Measurement of Left Ventricular Ejection Fraction in Individuals with Cancer and Suspected Cardiotoxicity. 超声心动图与心脏磁共振成像在测量癌症患者左心室射血分数和疑似心脏毒性方面的比较
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.230048
Muhummad Sohaib Nazir, Joseph Okafor, Theodore Murphy, Maria Sol Andres, Sivatharshini Ramalingham, Stuart D Rosen, Amedeo Chiribiri, Sven Plein, Sanjay Prasad, Raad Mohiaddin, Dudley J Pennell, A John Baksi, Rajdeep Khattar, Alexander R Lyon

Purpose To compare left ventricular ejection fraction (LVEF) measured with echocardiography and cardiac MRI in individuals with cancer and suspected cardiotoxicity and assess the potential effect on downstream clinical decision-making. Materials and Methods In this prospective, single-center observational cohort study, participants underwent same-day two-dimensional (2D) echocardiography and cardiac MRI between 2011 and 2021. Participants with suboptimal image quality were excluded. A subset of 74 participants also underwent three-dimensional (3D) echocardiography. The agreement of LVEF derived from each modality was assessed using Bland-Altman analysis and at relevant thresholds for cardiotoxicity. Results A total of 745 participants (mean age, 60 years ± 5 [SD]; 460 [61.7%] female participants) underwent same-day echocardiography and cardiac MRI. According to Bland-Altman analysis, the mean bias was -3.7% ± 7.6 (95% limits of agreement [LOA]: -18.5% to 11.1%) for 2D echocardiography versus cardiac MRI. In 74 participants who underwent cardiac MRI, 3D echocardiography, and 2D echocardiography, the mean LVEFs were 60.0% ± 10.4, 58.4% ± 9.4, and 57.2% ± 8.9, respectively (P < .001). At the 50% LVEF threshold for detection of cardiotoxicity, there was disagreement for 9.3% of participants with 2D echocardiography and cardiac MRI. Agreement was better with 3D echocardiography and cardiac MRI (mean bias, -1.6% ± 6.3 [95% LOA: -13.9% to 10.7%]) compared with 2D echocardiography and cardiac MRI (mean bias, -2.8% ± 6.3 [95% LOA: -15.2% to 9.6%]; P = .016). Conclusion Two-dimensional echocardiography had variations of ±15% for LVEF measurement compared with cardiac MRI in participants with cancer and led to misclassification of approximately 10% of participants for cardiotoxicity detection. Three-dimensional echocardiography had better agreement with cardiac MRI and should be used as first-line imaging. Keywords: Echocardiography, MR Functional Imaging, Cardiac Supplemental material is available for this article. © RSNA, 2024.

目的 比较通过超声心动图和心脏磁共振成像测量的癌症患者左心室射血分数(LVEF)和疑似心脏毒性患者左心室射血分数(LVEF),并评估其对下游临床决策的潜在影响。材料与方法 在这项前瞻性、单中心观察性队列研究中,2011 年至 2021 年间的参与者接受了当天的二维 (2D) 超声心动图和心脏核磁共振成像检查。排除了图像质量不佳的参与者。74名参与者还接受了三维(3D)超声心动图检查。采用布兰-阿尔特曼分析法和心脏毒性的相关阈值评估了每种模式得出的 LVEF 的一致性。结果 共有 745 名参与者(平均年龄为 60 岁 ± 5 [SD];460 名女性参与者 [61.7%])接受了当天的超声心动图和心脏磁共振成像检查。根据 Bland-Altman 分析,二维超声心动图与心脏磁共振成像的平均偏差为 -3.7% ± 7.6(95% 的一致性范围 [LOA]:-18.5% 至 11.1%)。在接受心脏核磁共振成像、三维超声心动图和二维超声心动图检查的 74 名参与者中,平均 LVEF 分别为 60.0% ± 10.4、58.4% ± 9.4 和 57.2% ± 8.9(P < .001)。在检测心脏毒性的50% LVEF阈值上,9.3%的参与者在二维超声心动图和心脏磁共振成像上存在分歧。与二维超声心动图和心脏磁共振成像(平均偏差为-2.8% ± 6.3 [95% LOA: -15.2%至9.6%];P = .016)相比,三维超声心动图和心脏磁共振成像的一致性更好(平均偏差为-1.6% ± 6.3 [95% LOA: -13.9%至10.7%])。结论 在癌症患者中,二维超声心动图与心脏磁共振成像相比,LVEF测量的偏差为±15%,导致约10%的患者在心脏毒性检测中被误诊。三维超声心动图与心脏磁共振成像的一致性更好,应作为一线成像。关键词超声心动图、磁共振功能成像、心脏 本文有补充材料。© RSNA, 2024.
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引用次数: 0
Unilateral Anomalous Pulmonary Venous Return into Coronary Sinus. 单侧异常肺静脉回流至冠状动脉窦
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.230359
Pavithra Subramanian, Sanjeev Hanumanthacharya Naganur, Arun Sharma, Manphool Singhal
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引用次数: 0
Comparison of Lung-RADS Version 1.1 and Lung-RADS Version 2022 in Classifying Airway Nodules Detected at Lung Cancer Screening CT. 比较 Lung-RADS 1.1 版和 Lung-RADS 2022 版对肺癌筛查 CT 检测到的气道结节的分类。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.230149
Ariadne K DeSimone, Suzanne C Byrne, Mark M Hammer

Purpose To compare the Lung Imaging Reporting and Data System (Lung-RADS) version 1.1 with version 2022 classification of airway nodules detected at lung cancer screening CT examinations. Materials and Methods This retrospective study included all patients who underwent a lung cancer screening CT examination in the authors' health care network between 2015 and 2021 with a reported airway or endobronchial nodule. A fellowship-trained cardiothoracic radiologist reviewed these CT images and characterized the airway nodules by size, location, multiplicity, morphology, dependent portions of airway, internal air, fluid attenuation, distal changes, outcome at follow-up, and final pathologic diagnosis, if malignant. Sensitivity and specificity of Lung-RADS version 1.1 in detecting malignant nodules were compared with those of Lung-RADS version 2022 using the McNemar test. Results A total of 174 patients were included. Of these, 163 (94%) had airway nodules that were deemed benign, while 11 (6%) had malignant nodules. Airway nodules in the trachea and mainstem bronchi were all benign, while lobar and segmental airway nodules had the highest risk for lung cancer (17.2% and 11.1%, respectively). Of the 12 subsegmental airway nodules that were obstructive, three (25%) were malignant and nine (75%) were benign. Nodules with nonobstructive morphologies, dependent portions of airway, internal air, or fluid attenuation were all benign. Only 10 of the 92 (10.9%) patients with positive Lung-RADS by clinical report had cancer. Lung-RADS version 2022 resulted in higher specificity than version 1.1 (82% vs 50%, P < .001), without sacrificing sensitivity (91% for both). Conclusion Compared with the previous version, Lung-RADS version 2022 reduced the number of false-positive screening CT examinations while still identifying malignant airway nodules. Keywords: CT, Lung, Primary Neoplasms, Pulmonary, Lung Cancer Screening, Lung-RADS, Nodule Risk, Airway Nodule, Endobronchial Nodule © RSNA, 2024.

目的 比较肺部影像报告和数据系统(Lung-RADS)1.1 版和 2022 版对肺癌筛查 CT 检查发现的气道结节的分类。材料和方法 这项回顾性研究纳入了作者所在医疗保健网络在 2015 年至 2021 年期间接受肺癌筛查 CT 检查并报告有气道或支气管内结节的所有患者。一位接受过研究员培训的心胸放射科医生对这些 CT 图像进行了审查,并根据气道结节的大小、位置、多发性、形态、气道依赖部分、内部空气、液体衰减、远端变化、随访结果以及最终病理诊断(如果是恶性的)对气道结节进行了定性。采用 McNemar 检验比较了 Lung-RADS 1.1 版与 Lung-RADS 2022 版在检测恶性结节方面的敏感性和特异性。结果 共纳入 174 名患者。其中 163 人(94%)的气道结节被认定为良性,11 人(6%)的结节为恶性。气管和支气管主干的气道结节均为良性,而叶状和节段性气道结节罹患肺癌的风险最高(分别为 17.2% 和 11.1%)。在 12 个阻塞性亚段气道结节中,3 个(25%)为恶性,9 个(75%)为良性。具有非阻塞性形态、气道依赖部分、内部空气或液体衰减的结节均为良性。在 92 名临床报告显示 Lung-RADS 呈阳性的患者中,只有 10 人(10.9%)罹患癌症。与 1.1 版相比,2022 版 Lung-RADS 的特异性更高(82% vs 50%,P < .001),但灵敏度并未降低(两者均为 91%)。结论 与之前的版本相比,Lung-RADS 2022 版本减少了假阳性筛查 CT 检查的数量,同时仍能识别恶性气道结节。关键词CT,肺,原发性肿瘤,肺,肺癌筛查,Lung-RADS,结节风险,气道结节,支气管内结节 © RSNA,2024。
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引用次数: 0
Evaluation of Prognosis in Patients with Lung Adenocarcinoma with Atypical Solid Nodules on Thin-Section CT Images. 通过薄层 CT 图像评估伴有非典型实性结节的肺腺癌患者的预后。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.220234
Mengwen Liu, Lin Yang, Xujie Sun, Xin Liang, Cong Li, Qianqian Feng, Meng Li, Li Zhang

Purpose To evaluate the clinicopathologic characteristics and prognosis of patients with clinical stage IA lung adenocarcinoma with atypical solid nodules (ASNs) on thin-section CT images. Materials and Methods Data from patients with clinical stage IA lung adenocarcinoma who underwent resection between January 2005 and December 2012 were retrospectively reviewed. According to their manifestations on thin-section CT images, nodules were classified as ASNs, subsolid nodules (SSNs), and typical solid nodules (TSNs). The clinicopathologic characteristics of the ASNs were investigated, and the differences across the three groups were analyzed. The Kaplan-Meier method and multivariable Cox analysis were used to evaluate survival differences among patients with ASNs, SSNs, and TSNs. Results Of the 254 patients (median age, 58 years [IQR, 53-66]; 152 women) evaluated, 49 had ASNs, 123 had SSNs, and 82 had TSNs. Compared with patients with SSNs, those with ASNs were more likely to have nonsmall adenocarcinoma (P < .001), advanced-stage adenocarcinoma (P = .004), nonlepidic growth adenocarcinoma (P < .001), and middle- or low-grade differentiation tumors (P < .001). Compared with patients with TSNs, those with ASNs were more likely to have no lymph node involvement (P = .009) and epidermal growth factor receptor mutation positivity (P = .018). Average disease-free survival in patients with ASNs was significantly longer than that in patients with TSNs (P < .001) but was not distinguishable from that in patients with SSNs (P = .051). Conclusion ASNs were associated with better clinical outcomes than TSNs in patients with clinical stage IA lung adenocarcinoma. Keywords: Adenocarcinoma, Atypical Solid Nodules, CT, Disease-free Survival, Lung, Prognosis, Pulmonary Supplemental material is available for this article. Published under a CC BY 4.0 license.

目的 评价在薄层 CT 图像上显示非典型实性结节(ASN)的临床 IA 期肺腺癌患者的临床病理特征和预后。材料和方法 对 2005 年 1 月至 2012 年 12 月间接受切除术的临床 IA 期肺腺癌患者的数据进行了回顾性研究。根据结节在薄层 CT 图像上的表现,将其分为 ASN、亚实性结节(SSN)和典型实性结节(TSN)。研究了 ASN 的临床病理特征,并分析了三组之间的差异。采用 Kaplan-Meier 法和多变量 Cox 分析法评估 ASN、SSN 和 TSN 患者的生存率差异。结果 在接受评估的 254 名患者(中位年龄 58 岁 [IQR,53-66];152 名女性)中,49 人患有 ASN,123 人患有 SSN,82 人患有 TSN。与 SSN 患者相比,ASN 患者更有可能患有非小腺癌(P < .001)、晚期腺癌(P = .004)、非鳞状生长腺癌(P < .001)以及中低分化肿瘤(P < .001)。与TSN患者相比,ASN患者更可能没有淋巴结受累(P = .009)和表皮生长因子受体突变阳性(P = .018)。ASN患者的平均无病生存期明显长于TSN患者(P < .001),但与SSN患者无明显差异(P = .051)。结论 在临床分期为 IA 期的肺腺癌患者中,ASN 的临床疗效优于 TSN。关键词腺癌 非典型实性结节 CT 无病生存期 肺 预后 肺 本文有补充材料。以 CC BY 4.0 许可发布。
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引用次数: 0
Ultra-rapid, Free-breathing, Real-time Cardiac Cine MRI Using GRASP Amplified with View Sharing and KWIC Filtering. 利用视图共享和 KWIC 滤波的 GRASP 放大技术实现超快速、自由呼吸、实时心脏 Cine MRI。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.230107
Lexiaozi Fan, KyungPyo Hong, Bradley D Allen, Rupsa Paul, James C Carr, Sarah Zhang, Rod Passman, Joshua D Robinson, Daniel C Lee, Cynthia K Rigsby, Daniel Kim

Purpose To achieve ultra-high temporal resolution (approximately 20 msec) in free-breathing, real-time cardiac cine MRI using golden-angle radial sparse parallel (GRASP) reconstruction amplified with view sharing (VS) and k-space-weighted image contrast (KWIC) filtering. Materials and Methods Fourteen pediatric patients with congenital heart disease (mean age [SD], 9 years ± 2; 13 male) and 10 adult patients with arrhythmia (mean age, 62 years ± 8; nine male) who underwent both standard breath-hold cine and free-breathing real-time cine using GRASP were retrospectively identified. To achieve high temporal resolution, each time frame was reconstructed using six radial spokes, corresponding to acceleration factors ranging from 24 to 32. To compensate for loss in spatial resolution resulting from over-regularization in GRASP, VS and KWIC filtering were incorporated. The blur metric, visual image quality scores, and biventricular parameters were compared between clinical and real-time cine images. Results In pediatric patients, the incorporation of VS and KWIC into GRASP (ie, GRASP + VS + KWIC) produced significantly (P < .05) sharper x-y-t (blur metric: 0.36 ± 0.03, 0.41 ± 0.03, 0.48 ± 0.03, respectively) and x-y-f (blur metric: 0.28 ± 0.02, 0.31 ± 0.03, 0.37 ± 0.03, respectively) component images compared with GRASP + VS and conventional GRASP. Only the noise score differed significantly between GRASP + VS + KWIC and clinical cine; all visual scores were above the clinically acceptable (3.0) cutoff point. Biventricular volumetric parameters strongly correlated (R2 > 0.85) between clinical and real-time cine images reconstructed with GRASP + VS + KWIC and were in good agreement (relative error < 6% for all parameters). In adult patients, the visual scores of all categories were significantly lower (P < .05) for clinical cine compared with real-time cine with GRASP + VS + KWIC, except for noise (P = .08). Conclusion Incorporating VS and KWIC filtering into GRASP reconstruction enables ultra-high temporal resolution (approximately 20 msec) without significant loss in spatial resolution. Keywords: Cine, View Sharing, k-Space-weighted Image Contrast Filtering, Radial k-Space, Pediatrics, Arrhythmia, GRASP, Compressed Sensing, Real-Time, Free-Breathing Supplemental material is available for this article. © RSNA, 2024.

目的 使用黄金角径向稀疏并行(GRASP)重建,放大视图共享(VS)和 k 空间加权图像对比度(KWIC)滤波,在自由呼吸的实时心脏椎体磁共振成像中实现超高时间分辨率(约 20 毫秒)。材料与方法 对 14 名患有先天性心脏病的儿童患者(平均年龄 [SD],9 岁 ± 2;13 名男性)和 10 名患有心律失常的成人患者(平均年龄 62 岁 ± 8;9 名男性)进行了回顾性鉴定,他们都接受了标准屏气 cine 和使用 GRASP 的自由呼吸实时 cine。为了实现高时间分辨率,每个时间帧都使用六个径向辐条进行重建,对应的加速因子范围为 24 到 32。为了弥补 GRASP 过度规则化造成的空间分辨率损失,采用了 VS 和 KWIC 滤波技术。比较了临床和实时 cine 图像的模糊度量、视觉图像质量评分和双心室参数。结果 在儿科患者中,与 GRASP + VS 和传统 GRASP 相比,在 GRASP 中加入 VS 和 KWIC(即 GRASP + VS + KWIC)后,x-y-t(模糊度:分别为 0.36 ± 0.03、0.41 ± 0.03、0.48 ± 0.03)和 x-y-f(模糊度:分别为 0.28 ± 0.02、0.31 ± 0.03、0.37 ± 0.03)分量图像明显更清晰(P < .05)。只有噪声评分在 GRASP + VS + KWIC 和临床 cine 之间存在明显差异;所有视觉评分均高于临床可接受的临界点(3.0)。使用 GRASP + VS + KWIC 重建的临床和实时 cine 图像之间的双心室容积参数具有很强的相关性(R2 > 0.85),且一致性很好(所有参数的相对误差均小于 6%)。在成年患者中,与使用 GRASP + VS + KWIC 的实时电影图像相比,临床电影图像的所有类别的视觉评分都明显较低(P < .05),噪声除外(P = .08)。结论 在 GRASP 重建中加入 VS 和 KWIC 滤波可实现超高时间分辨率(约 20 毫秒),而不会明显降低空间分辨率。关键词Cine、视图共享、k-空间加权图像对比度过滤、径向 k-空间、儿科、心律失常、GRASP、压缩传感、实时、自由呼吸 本文有补充材料。© RSNA, 2024.
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引用次数: 0
Erratum for: Clinical Validation of the Accuracy of Absolute Myocardial Blood Flow Quantification with Dual-Source CT Using 15O-Water PET. 勘误:使用 15O 水 PET 的双源 CT 绝对心肌血流定量准确性的临床验证。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-02-01 DOI: 10.1148/ryct.249001
Masafumi Takafuji, Kakuya Kitagawa, Masaki Ishida, Yasutaka Ichikawa, Satoshi Nakamura, Shiro Nakamori, Tairo Kurita, Kaoru Dohi, Hajime Sakuma
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引用次数: 0
期刊
Radiology. Cardiothoracic imaging
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