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Heart Failure with Normal Natriuretic Peptide Levels and Preserved Ejection Fraction: A Prospective Clinical and Cardiac MRI Study. 钠尿肽水平正常而射血分数保留的心力衰竭:一项前瞻性临床和心脏磁共振成像研究
IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-01 DOI: 10.1148/ryct.230281
Jian He, Wenjing Yang, Weichun Wu, Gang Yin, Baiyan Zhuang, Jing Xu, Di Zhou, Jian Zhang, Yining Wang, Leyi Zhu, Xiaoxin Sun, Arlene Sirajuddin, Zhongzhao Teng, Faraz Kureshi, Andrew E Arai, Shihua Zhao, Minjie Lu

Purpose To describe the clinical presentation, comprehensive cardiac MRI characteristics, and prognosis of individuals with predisposed heart failure with preserved ejection fraction (HFpEF). Materials and Methods This prospective cohort study (part of MISSION-HFpEF [Multimodality Imaging in the Screening, Diagnosis, and Risk Stratification of HFpEF]; NCT04603404) was conducted from January 1, 2019, to September 30, 2021, and included individuals with suspected HFpEF who underwent cardiac MRI. Participants who had primary cardiomyopathy and primary valvular heart disease were excluded. Participants were split into a predisposed HFpEF group, defined as HFpEF with normal natriuretic peptide levels based on an HFA-PEFF (Heart Failure Association Pretest Assessment, Echocardiography and Natriuretic Peptide, Functional Testing, and Final Etiology) score of 4 from the latest European Society of Cardiology guidelines, and an HFpEF group (HFA-PEFF score of ≥ 5). An asymptomatic control group without heart failure was also included. Clinical and cardiac MRI-based characteristics and outcomes were compared between groups. The primary end points were death, heart failure hospitalization, or stroke. Results A total of 213 participants with HFpEF, 151 participants with predisposed HFpEF, and 100 participants in the control group were analyzed. Compared with the control group, participants with predisposed HFpEF had worse left ventricular remodeling and function and higher systemic inflammation. Compared with participants with HFpEF, those with predisposed HFpEF, whether obese or not, were younger and had higher plasma volume, lower prevalence of atrial fibrillation, lower left atrial volume index, and less impaired left ventricular global longitudinal strain (-12.2% ± 2.8 vs -13.9% ± 3.1; P < .001) and early-diastolic global longitudinal strain rate (eGLSR, 0.52/sec ± 0.20 vs 0.57/sec ± 0.15; P = .03) but similar prognosis. Atrial fibrillation occurrence (hazard ratio [HR] = 3.90; P = .009), hemoglobin level (HR = 0.94; P = .001), and eGLSR (per 0.2-per-second increase, HR = 0.28; P = .002) were independently associated with occurrence of primary end points in participants with predisposed HFpEF. Conclusion Participants with predisposed HFpEF showed relatively unique clinical and cardiac MRI features, warranting greater clinical attention. eGLSR should be considered as a prognostic factor in participants with predisposed HFpEF. Keywords: Heart Failure with Preserved Ejection Fraction, Normal Natriuretic Peptide Levels, Cardiovascular Magnetic Resonance, Myocardial Strain, Prognosis Clinical trial registration no. NCT04603404 Supplemental material is available for this article. © RSNA, 2024.

目的 描述射血分数保留型心力衰竭(HFpEF)患者的临床表现、心脏磁共振成像综合特征和预后。材料与方法 该前瞻性队列研究(MISSION-HFpEF [多模态成像在 HFpEF 筛查、诊断和风险分层中的应用] 的一部分;NCT04603404)于 2019 年 1 月 1 日至 2021 年 9 月 30 日进行,纳入了接受心脏 MRI 检查的疑似 HFpEF 患者。患有原发性心肌病和原发性瓣膜性心脏病的参与者被排除在外。参试者被分为易患 HFpEF 组和 HFpEF 组(HFA-PEFF(心衰协会试验前评估、超声心动图和钠尿肽、功能测试和最终病因学)评分为 4 分),前者的定义是钠尿肽水平正常的 HFpEF,后者的定义是最新欧洲心脏病学会指南中的 HFA-PEFF(心衰协会试验前评估、超声心动图和钠尿肽、功能测试和最终病因学)评分为 4 分。此外还包括一个无症状、无心衰的对照组。对各组的临床特征和基于心脏磁共振成像的特征及结果进行了比较。主要终点为死亡、心衰住院或中风。结果 共分析了 213 名高频心衰患者、151 名易患高频心衰的患者和 100 名对照组患者。与对照组相比,易患 HFpEF 的参与者左心室重塑和功能较差,全身炎症较高。与 HFpEF 患者相比,易患 HFpEF 的患者,无论是否肥胖,都更年轻,血浆容量更高,心房颤动发生率更低,左心房容积指数更低,左心室整体纵向应变受损程度更轻(-12.2% ± 2.8 vs -13.9% ± 3.1;P < .001)和舒张早期整体纵向应变率(eGLSR,0.52/秒 ± 0.20 vs 0.57/秒 ± 0.15;P = .03)受损较轻,但预后相似。心房颤动发生率(危险比 [HR] = 3.90;P = .009)、血红蛋白水平(HR = 0.94;P = .001)和 eGLSR(每增加 0.2 秒,HR = 0.28;P = .002)与易患高频心房颤动患者的主要终点发生率独立相关。结论 易患 HFpEF 的参试者表现出相对独特的临床和心脏磁共振成像特征,值得临床进一步关注。关键词射血分数保留型心力衰竭 正常钠尿肽水平 心血管磁共振 心肌应变 预后 临床试验注册号:NCT04603404本文有补充材料。© RSNA, 2024.
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引用次数: 0
Maximizing the Prognostic Utility of 13N-Ammonia PET: Featuring Right Ventricular Strain. 最大限度地发挥 13N-Ammonia PET 的预后作用:显示右心室应变。
IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-01 DOI: 10.1148/ryct.240187
Gaurav S Gulsin, Kate Hanneman
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引用次数: 0
Sequential MRI Evaluation of Lymphatic Abnormalities over the Course of Fontan Completion. 对丰坦手术完成过程中淋巴异常的顺序 MRI 评估。
IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-01 DOI: 10.1148/ryct.230315
Benjamin Kelly, Sheyanth Mohanakumar, Brooke Ford, Christopher L Smith, Erin Pinto, David M Biko, Vibeke E Hjortdal, Yoav Dori

Purpose To evaluate lymphatic abnormalities before and after Fontan completion using noncontrast lymphatic imaging and relate findings with postoperative outcomes. Materials and Methods This study is a retrospective review of noncontrast T2-weighted lymphatic imaging performed at The Children's Hospital of Philadelphia from June 2012 to February 2023 in patients with single ventricle physiology. All individuals with imaging at both pre-Fontan and Fontan stages were eligible. Lymphatic abnormalities were classified into four types based on severity and location of lymphatic vessels. Classifications were compared between images and related to clinical outcomes such as postoperative drainage and hospitalization, lymphatic complications, heart transplant, and death. Results Forty-three patients (median age, 10 years [IQR, 8-11]; 20 [47%] boys, 23 [53%] girls) were included in the study. Lymphatic abnormalities progressed in 19 individuals after Fontan completion (distribution of lymphatic classifications: type 1, 23; type 2, 11; type 3, 6; type 4, 3 vs type 1, 10; type 2, 18; type 3, 10; type 4, 5; P = .04). Compared with individuals showing no progression of lymphatic abnormalities, those progressing to a high-grade lymphatic classification had longer postoperative drainage (median time, 9 days [IQR, 6-14] vs 17 days [IQR, 10-23]; P = .04) and hospitalization (median time, 13 days [IQR, 9-25] vs 26 days [IQR, 18-30]; P = .03) after Fontan completion and were more likely to develop chylothorax (12% [three of 24] vs 75% [six of eight]; P < .01) and/or protein-losing enteropathy (0% [0 of 24] vs 38% [three of eight]; P < .01) during a median follow-up of 8 years (IQR, 5-9). Progression to any type was not associated with an increased risk of adverse events. Conclusion The study demonstrated that lymphatic structural abnormalities may progress in select individuals with single ventricle physiology after Fontan completion, and progression of abnormalities to a high-grade classification was associated with worse postoperative outcomes. Keywords: Congenital Heart Disease, Glenn, Fontan, Lymphatic Imaging, Cardiovascular MRI Supplemental material is available for this article. Published under a CC BY 4.0 license.

目的 使用非对比淋巴成像评估丰坦手术完成前后的淋巴异常,并将结果与术后预后联系起来。材料和方法 本研究是对费城儿童医院自2012年6月至2023年2月对单心室生理学患者进行的非对比T2加权淋巴成像的回顾性研究。所有在Fontan前期和Fontan阶段进行成像的患者均符合条件。根据淋巴管的严重程度和位置,淋巴异常被分为四种类型。对不同图像的分类进行比较,并将其与术后引流和住院、淋巴并发症、心脏移植和死亡等临床结果联系起来。结果 研究共纳入 43 名患者(中位年龄 10 岁 [IQR,8-11];20 [47%] 男孩,23 [53%] 女孩)。19名患者在丰坦手术完成后出现淋巴异常(淋巴分类分布:1型,23人;2型,11人;3型,6人;4型,3人 vs 1型,10人;2型,18人;3型,10人;4型,5人;P = .04)。与淋巴异常没有进展的患者相比,淋巴异常进展为高级别的患者术后引流时间(中位时间,9 天 [IQR, 6-14] vs 17 天 [IQR, 10-23];P = .04)和住院时间(中位时间,13 天 [IQR, 9-25] vs 26 天 [IQR, 18-30];P = .在中位随访8年(IQR,5-9年)期间,患者在丰坦手术完成后更容易出现乳糜胸(12% [24例中的3例] vs 75% [8例中的6例];P < .01)和/或蛋白丢失性肠病(0% [24例中的0例] vs 38% [8例中的3例];P < .01)。进展为任何类型的肠病与不良事件风险增加无关。结论 该研究表明,单心室生理学的特定个体在完成丰坦手术后淋巴结构异常可能会进展,异常进展到高级别分类与术后预后较差有关。关键词:先天性心脏病先天性心脏病 格伦 Fontan 淋巴成像 心血管磁共振成像 本文有补充材料。以 CC BY 4.0 许可发布。
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引用次数: 0
Heart Rate Lowering for Coronary CTA with Ivabradine in End-Stage Liver Disease. 使用伊伐布雷定降低终末期肝病患者冠状动脉 CTA 的心率
IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-01 DOI: 10.1148/ryct.230402
Rishabh Tandon, Dzhalal Agakishiev, Rebecca L Freese, Julie Thompson, Prabhjot S Nijjar
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引用次数: 0
MRI in Patients with Cardiovascular Implantable Electronic Devices and Fractured or Abandoned Leads. 心血管植入式电子设备和导线断裂或脱落患者的核磁共振成像。
IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-01 DOI: 10.1148/ryct.230303
Mark J Greenhill, Pooja Rangan, Wilber Su, J Peter Weiss, Michael Zawaneh, Samuel Unzek, Balaji Tamarappoo, Julia Indik, Roderick Tung, Michael F Morris

Purpose To examine the clinical effect of lead length and lead orientation in patients with cardiac implantable electronic devices (CIEDs) and lead fragments or abandoned leads undergoing 1.5-T MRI. Materials and Methods This Health Insurance Portability and Accountability Act-compliant retrospective study included patients with CIEDs and abandoned leads or lead fragments undergoing 1.5-T MRI from March 2014 through July 2020. CIED settings before and after MRI were reviewed, with clinically significant variations defined as a composite of the change in capture threshold of at least 50%, in sensing of at least 40%, or in lead impedance of at least 30% between before MRI and after MRI interrogation. Adverse clinical events were assessed at MRI and up to 30 days after. Univariable and multivariable analysis was performed. Results Eighty patients with 126 abandoned CIED leads or lead fragments underwent 107 1.5-T MRI examinations. Sixty-seven patients (median age, 74 years; IQR, 66-78 years; 44 male patients, 23 female patients) had abandoned leads, and 13 (median age, 66 years; IQR, 52-74 years; nine male patients, four female patients) had lead fragments. There were no reported deaths, clinically significant arrhythmias, or adverse clinical events within 30 days of MRI. Three patients with abandoned leads had a significant change in the composite of capture threshold, sensing, or lead impedance. In a multivariable generalized estimating equation analysis, lead orientation, lead length, MRI type, and MRI duration were not associated with a significant change in the composite outcome. Conclusion Use of 1.5-T MRI in patients with abandoned CIED leads or lead fragments of varying length and orientation was not associated with adverse clinical events. Keywords: Cardiac Assist Devices, MRI, Cardiac Implantable Electronic Device Supplemental material is available for this article. © RSNA, 2024.

目的 研究在接受 1.5-T 磁共振成像检查的心脏植入式电子装置(CIED)和导联碎片或废弃导联患者中,导联长度和导联方向的临床影响。材料和方法 这项符合《健康保险可携性和责任法案》的回顾性研究纳入了从 2014 年 3 月到 2020 年 7 月接受 1.5-T 磁共振成像检查的 CIED 和废弃导线或导线碎片患者。对磁共振成像前后的 CIED 设置进行了审查,具有临床意义的变化是指磁共振成像前和磁共振成像检查后捕获阈值变化至少 50%、传感变化至少 40% 或导联阻抗变化至少 30% 的综合结果。不良临床事件在核磁共振成像时和成像后 30 天内进行评估。进行了单变量和多变量分析。结果 80名患者共接受了107次1.5 T磁共振成像检查,其中有126个被遗弃的CIED导线或导线碎片。67名患者(中位年龄 74 岁;IQR 66-78 岁;44 名男性患者,23 名女性患者)有废弃导线,13 名患者(中位年龄 66 岁;IQR 52-74 岁;9 名男性患者,4 名女性患者)有导线碎片。在核磁共振成像后的 30 天内,没有死亡病例、有临床意义的心律失常或不良临床事件的报告。三位有弃导联的患者在捕获阈值、传感或导联阻抗的综合指标上有显著变化。在多变量广义估计方程分析中,导联方向、导联长度、磁共振成像类型和磁共振成像持续时间与综合结果的显著变化无关。结论 在有废弃CIED导联或不同长度和方向的导联碎片的患者中使用1.5T磁共振成像与不良临床事件无关。关键词心脏辅助装置、核磁共振成像、心脏植入式电子装置 本文有补充材料。© RSNA, 2024.
{"title":"MRI in Patients with Cardiovascular Implantable Electronic Devices and Fractured or Abandoned Leads.","authors":"Mark J Greenhill, Pooja Rangan, Wilber Su, J Peter Weiss, Michael Zawaneh, Samuel Unzek, Balaji Tamarappoo, Julia Indik, Roderick Tung, Michael F Morris","doi":"10.1148/ryct.230303","DOIUrl":"10.1148/ryct.230303","url":null,"abstract":"<p><p>Purpose To examine the clinical effect of lead length and lead orientation in patients with cardiac implantable electronic devices (CIEDs) and lead fragments or abandoned leads undergoing 1.5-T MRI. Materials and Methods This Health Insurance Portability and Accountability Act-compliant retrospective study included patients with CIEDs and abandoned leads or lead fragments undergoing 1.5-T MRI from March 2014 through July 2020. CIED settings before and after MRI were reviewed, with clinically significant variations defined as a composite of the change in capture threshold of at least 50%, in sensing of at least 40%, or in lead impedance of at least 30% between before MRI and after MRI interrogation. Adverse clinical events were assessed at MRI and up to 30 days after. Univariable and multivariable analysis was performed. Results Eighty patients with 126 abandoned CIED leads or lead fragments underwent 107 1.5-T MRI examinations. Sixty-seven patients (median age, 74 years; IQR, 66-78 years; 44 male patients, 23 female patients) had abandoned leads, and 13 (median age, 66 years; IQR, 52-74 years; nine male patients, four female patients) had lead fragments. There were no reported deaths, clinically significant arrhythmias, or adverse clinical events within 30 days of MRI. Three patients with abandoned leads had a significant change in the composite of capture threshold, sensing, or lead impedance. In a multivariable generalized estimating equation analysis, lead orientation, lead length, MRI type, and MRI duration were not associated with a significant change in the composite outcome. Conclusion Use of 1.5-T MRI in patients with abandoned CIED leads or lead fragments of varying length and orientation was not associated with adverse clinical events. <b>Keywords:</b> Cardiac Assist Devices, MRI, Cardiac Implantable Electronic Device <i>Supplemental material is available for this article.</i> © RSNA, 2024.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contrast-enhanced Imaging in Peripheral Pulmonary Lesions: The Role in US-guided Biopsies. 外周肺部病变的对比增强成像:在 US 引导活检中的作用。
IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-01 DOI: 10.1148/ryct.230234
Xue-Yan Wang, Zhi-Fan Yuan, Ke-Hong Gan, Yuan Zhong, Jia-Xin Huang, Wei-Jun Huang, Yu-Huan Xie, Xiao-Qing Pei

Purpose To compare the tissue adequacy and diagnostic accuracy of US-guided biopsies of peripheral pulmonary lesions (PPLs) with and without contrast agents. Materials and Methods A retrospective study was conducted at four medical centers in patients with PPLs who underwent US-guided percutaneous transthoracic needle biopsy (PTNB) between January 2017 and October 2022. The patients were divided into contrast-enhanced US (CEUS) and US groups based on whether prebiopsy CEUS evaluation was performed. Tissue adequacy and the diagnostic accuracy of PTNB, stratified by lesion size, were analyzed and compared between groups. A propensity score matching (PSM) analysis was conducted using the nearest-neighbor matching method. Results A total of 1027 lesions were analyzed, with 634 patients (mean age, 59.4 years ± 13.0 [SD]; 413 male) in the US group and 393 patients (mean age, 61.2 years ± 12.5; 270 male) in the CEUS group. The CEUS group produced more acceptable samples than the US group (98.2% vs 95.7%; P = .03) and achieved higher diagnostic accuracy (96.9% vs 94.2%; P = .04), with no evidence of a difference in sensitivity (96.7% vs 94.0%; P = .06). PSM and stratified analyses (n = 358 per group) indicated higher tissue adequacy (99.0% vs 95.7%; P = .04) and diagnostic accuracy (98.5% vs 92.9%; P = .006) in the CEUS group compared with the US group for 2-7-cm PPLs but not for lesions larger than 7 cm. Conclusion PTNB with prebiopsy CEUS evaluation demonstrated significantly better tissue adequacy and diagnostic accuracy compared with US guidance alone for PPLs ranging from 2 to 7 cm, with similar biopsy performance achieved between groups for lesions larger than 7 cm. Keywords: Contrast Material, Thoracic Diseases, Ultrasonography, Image-Guided Biopsy © RSNA, 2024.

目的 比较使用和不使用造影剂进行 US 引导下肺外周病变 (PPL) 活检的组织充分性和诊断准确性。材料与方法 在四个医疗中心对 2017 年 1 月至 2022 年 10 月期间接受 US 引导下经皮经胸穿刺活检(PTNB)的 PPL 患者进行了回顾性研究。根据是否进行活检前CEUS评估,将患者分为对比增强US(CEUS)组和US组。根据病变大小进行分层,分析并比较各组间的组织充分性和PTNB的诊断准确性。采用最近邻匹配法进行倾向得分匹配(PSM)分析。结果 共分析了 1027 个病灶,其中 US 组有 634 名患者(平均年龄为 59.4 岁 ± 13.0 [SD];413 名男性),CEUS 组有 393 名患者(平均年龄为 61.2 岁 ± 12.5;270 名男性)。CEUS 组比 US 组产生了更多可接受的样本(98.2% vs 95.7%;P = .03),并获得了更高的诊断准确性(96.9% vs 94.2%;P = .04),但没有证据表明灵敏度存在差异(96.7% vs 94.0%;P = .06)。PSM 和分层分析(每组 n = 358)表明,与 US 组相比,CEUS 组对 2-7 厘米 PPL 的组织充分性(99.0% vs 95.7%;P = .04)和诊断准确性(98.5% vs 92.9%;P = .006)更高,但对大于 7 厘米的病变则没有差异。结论 对于 2-7 厘米的 PPL,CEUS 评估活检前 PTNB 的组织充分性和诊断准确性明显优于单纯 US 引导,而对于大于 7 厘米的病变,两组的活检效果相似。关键词造影剂、胸腔疾病、超声、图像引导活检 © RSNA, 2024.
{"title":"Contrast-enhanced Imaging in Peripheral Pulmonary Lesions: The Role in US-guided Biopsies.","authors":"Xue-Yan Wang, Zhi-Fan Yuan, Ke-Hong Gan, Yuan Zhong, Jia-Xin Huang, Wei-Jun Huang, Yu-Huan Xie, Xiao-Qing Pei","doi":"10.1148/ryct.230234","DOIUrl":"10.1148/ryct.230234","url":null,"abstract":"<p><p>Purpose To compare the tissue adequacy and diagnostic accuracy of US-guided biopsies of peripheral pulmonary lesions (PPLs) with and without contrast agents. Materials and Methods A retrospective study was conducted at four medical centers in patients with PPLs who underwent US-guided percutaneous transthoracic needle biopsy (PTNB) between January 2017 and October 2022. The patients were divided into contrast-enhanced US (CEUS) and US groups based on whether prebiopsy CEUS evaluation was performed. Tissue adequacy and the diagnostic accuracy of PTNB, stratified by lesion size, were analyzed and compared between groups. A propensity score matching (PSM) analysis was conducted using the nearest-neighbor matching method. Results A total of 1027 lesions were analyzed, with 634 patients (mean age, 59.4 years ± 13.0 [SD]; 413 male) in the US group and 393 patients (mean age, 61.2 years ± 12.5; 270 male) in the CEUS group. The CEUS group produced more acceptable samples than the US group (98.2% vs 95.7%; <i>P</i> = .03) and achieved higher diagnostic accuracy (96.9% vs 94.2%; <i>P</i> = .04), with no evidence of a difference in sensitivity (96.7% vs 94.0%; <i>P</i> = .06). PSM and stratified analyses (<i>n</i> = 358 per group) indicated higher tissue adequacy (99.0% vs 95.7%; <i>P</i> = .04) and diagnostic accuracy (98.5% vs 92.9%; <i>P</i> = .006) in the CEUS group compared with the US group for 2-7-cm PPLs but not for lesions larger than 7 cm. Conclusion PTNB with prebiopsy CEUS evaluation demonstrated significantly better tissue adequacy and diagnostic accuracy compared with US guidance alone for PPLs ranging from 2 to 7 cm, with similar biopsy performance achieved between groups for lesions larger than 7 cm. <b>Keywords:</b> Contrast Material, Thoracic Diseases, Ultrasonography, Image-Guided Biopsy © RSNA, 2024.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deformation-encoding Deep Learning Transformer for High-Frame-Rate Cardiac Cine MRI. 用于高帧频心脏显像 MRI 的变形编码深度学习变换器
IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-01 DOI: 10.1148/ryct.230177
Manuel A Morales, Fahime Ghanbari, Shiro Nakamori, Salah Assana, Amine Amyar, Siyeop Yoon, Jennifer Rodriguez, Martin S Maron, Ethan J Rowin, Jiwon Kim, Robert M Judd, Jonathan W Weinsaft, Reza Nezafat

Purpose To develop a deep learning model for increasing cardiac cine frame rate while maintaining spatial resolution and scan time. Materials and Methods A transformer-based model was trained and tested on a retrospective sample of cine images from 5840 patients (mean age, 55 years ± 19 [SD]; 3527 male patients) referred for clinical cardiac MRI from 2003 to 2021 at nine centers; images were acquired using 1.5- and 3-T scanners from three vendors. Data from three centers were used for training and testing (4:1 ratio). The remaining data were used for external testing. Cines with downsampled frame rates were restored using linear, bicubic, and model-based interpolation. The root mean square error between interpolated and original cine images was modeled using ordinary least squares regression. In a prospective study of 49 participants referred for clinical cardiac MRI (mean age, 56 years ± 13; 25 male participants) and 12 healthy participants (mean age, 51 years ± 16; eight male participants), the model was applied to cines acquired at 25 frames per second (fps), thereby doubling the frame rate, and these interpolated cines were compared with actual 50-fps cines. The preference of two readers based on perceived temporal smoothness and image quality was evaluated using a noninferiority margin of 10%. Results The model generated artifact-free interpolated images. Ordinary least squares regression analysis accounting for vendor and field strength showed lower error (P < .001) with model-based interpolation compared with linear and bicubic interpolation in internal and external test sets. The highest proportion of reader choices was "no preference" (84 of 122) between actual and interpolated 50-fps cines. The 90% CI for the difference between reader proportions favoring collected (15 of 122) and interpolated (23 of 122) high-frame-rate cines was -0.01 to 0.14, indicating noninferiority. Conclusion A transformer-based deep learning model increased cardiac cine frame rates while preserving both spatial resolution and scan time, resulting in images with quality comparable to that of images obtained at actual high frame rates. Keywords: Functional MRI, Heart, Cardiac, Deep Learning, High Frame Rate Supplemental material is available for this article. © RSNA, 2024.

目的 开发一种深度学习模型,在保持空间分辨率和扫描时间的同时提高心脏显像帧频。材料与方法 在九个中心 2003 年至 2021 年期间转诊的 5840 名临床心脏 MRI 患者(平均年龄 55 岁 ± 19 [SD];3527 名男性患者)的回顾性电影图像样本上训练和测试了一个基于变压器的模型;图像是使用三个供应商的 1.5-T 和 3-T 扫描仪采集的。三个中心的数据用于培训和测试(4:1 比例)。其余数据用于外部测试。使用线性插值、双三次插值和基于模型的插值还原了降采样帧率的正片。插值图像与原始电影图像之间的均方根误差采用普通最小二乘法回归建模。在一项针对 49 名转诊至临床心脏磁共振成像的患者(平均年龄 56 岁 ± 13 岁;25 名男性患者)和 12 名健康患者(平均年龄 51 岁 ± 16 岁;8 名男性患者)进行的前瞻性研究中,该模型被应用于以每秒 25 帧(fps)获取的动态影像,从而将帧频提高了一倍,并将这些插值动态影像与实际的 50 帧/秒动态影像进行了比较。两位读者根据所感知的时间平滑度和图像质量的偏好进行了评估,非劣效差为 10%。结果 该模型生成了无伪影的插值图像。考虑到供应商和场强的普通最小二乘法回归分析表明,在内部和外部测试集中,基于模型的插值与线性插值和双三次插值相比,误差更小(P < .001)。在读者的选择中,"无偏好 "的比例最高(122 人中有 84 人)。读者对收集的(122 人中的 15 人)和插值的(122 人中的 23 人)高帧率电影的偏好比例差异的 90% CI 为-0.01 到 0.14,表明两者之间不存在劣势。结论 基于变压器的深度学习模型在保持空间分辨率和扫描时间的同时提高了心脏超声帧率,从而获得了与实际高帧率下获得的图像质量相当的图像。关键词功能磁共振成像 心脏 深度学习 高帧率 本文有补充材料。© RSNA, 2024.
{"title":"Deformation-encoding Deep Learning Transformer for High-Frame-Rate Cardiac Cine MRI.","authors":"Manuel A Morales, Fahime Ghanbari, Shiro Nakamori, Salah Assana, Amine Amyar, Siyeop Yoon, Jennifer Rodriguez, Martin S Maron, Ethan J Rowin, Jiwon Kim, Robert M Judd, Jonathan W Weinsaft, Reza Nezafat","doi":"10.1148/ryct.230177","DOIUrl":"10.1148/ryct.230177","url":null,"abstract":"<p><p>Purpose To develop a deep learning model for increasing cardiac cine frame rate while maintaining spatial resolution and scan time. Materials and Methods A transformer-based model was trained and tested on a retrospective sample of cine images from 5840 patients (mean age, 55 years ± 19 [SD]; 3527 male patients) referred for clinical cardiac MRI from 2003 to 2021 at nine centers; images were acquired using 1.5- and 3-T scanners from three vendors. Data from three centers were used for training and testing (4:1 ratio). The remaining data were used for external testing. Cines with downsampled frame rates were restored using linear, bicubic, and model-based interpolation. The root mean square error between interpolated and original cine images was modeled using ordinary least squares regression. In a prospective study of 49 participants referred for clinical cardiac MRI (mean age, 56 years ± 13; 25 male participants) and 12 healthy participants (mean age, 51 years ± 16; eight male participants), the model was applied to cines acquired at 25 frames per second (fps), thereby doubling the frame rate, and these interpolated cines were compared with actual 50-fps cines. The preference of two readers based on perceived temporal smoothness and image quality was evaluated using a noninferiority margin of 10%. Results The model generated artifact-free interpolated images. Ordinary least squares regression analysis accounting for vendor and field strength showed lower error (<i>P</i> < .001) with model-based interpolation compared with linear and bicubic interpolation in internal and external test sets. The highest proportion of reader choices was \"no preference\" (84 of 122) between actual and interpolated 50-fps cines. The 90% CI for the difference between reader proportions favoring collected (15 of 122) and interpolated (23 of 122) high-frame-rate cines was -0.01 to 0.14, indicating noninferiority. Conclusion A transformer-based deep learning model increased cardiac cine frame rates while preserving both spatial resolution and scan time, resulting in images with quality comparable to that of images obtained at actual high frame rates. <b>Keywords:</b> Functional MRI, Heart, Cardiac, Deep Learning, High Frame Rate <i>Supplemental material is available for this article.</i> © RSNA, 2024.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling Subclinical Cardiovascular Disease in HIV with Advanced Cardiovascular Imaging. 用先进的心血管成像技术揭示艾滋病毒亚临床心血管疾病。
IF 7 Pub Date : 2024-04-01 DOI: 10.1148/ryct.240076
J. Luetkens, Leon M Bischoff
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引用次数: 0
Molecular Imaging of Diffuse Cardiac Fibrosis with a Radiotracer That Targets Proteolyzed Collagen IV. 利用针对蛋白水解胶原 IV 的放射性示踪剂对弥漫性心脏纤维化进行分子成像。
IF 7 Pub Date : 2024-04-01 DOI: 10.1148/ryct.230098
Be'eri Niego, Bianca Jupp, Nicholas A Zia, Rong Xu, Edwina Jap, Martin Ezeani, Asif Noor, Paul S Donnelly, Christoph E Hagemeyer, Karen Alt

Purpose To develop an approach for in vivo detection of interstitial cardiac fibrosis using PET with a peptide tracer targeting proteolyzed collagen IV (T-peptide). Materials and Methods T-peptide was conjugated to the copper chelator MeCOSar (chemical name, 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic acid) and radiolabeled with copper 64 (64Cu). PET/CT scans were acquired following intravenous delivery of 64Cu-T-peptide-MeCOSar (0.25 mg/kg; 18 MBq ± 2.7 [SD]) to male transgenic mice overexpressing β2-adrenergic receptors with intermediate (7 months of age; n = 4 per group) to severe (10 months of age; n = 11 per group) cardiac fibrosis and their wild-type controls. PET scans were also performed following coadministration of the radiolabeled probe with nonlabeled T-peptide in excess to confirm binding specificity. PET data were analyzed by t tests for static scans and analysis of variance tests (one- or two-way) for dynamic scans. Results PET/CT scans revealed significantly elevated (2.24-4.26-fold; P < .05) 64Cu-T-peptide-MeCOSar binding in the fibrotic hearts of aged transgenic β2-adrenergic receptor mice across the entire 45-minute acquisition period compared with healthy controls. The cardiac tracer accumulation and presence of diffuse cardiac fibrosis in older animals were confirmed by gamma counting (P < .05) and histologic evaluation, respectively. Coadministration of a nonradiolabeled probe in excess abolished the elevated radiotracer binding in the aged transgenic hearts. Importantly, PET tracer accumulation was also detected in younger (7 months of age) transgenic mice with intermediate cardiac fibrosis, although this was only apparent from 20 minutes following injection (1.6-2.2-fold binding increase; P < .05). Conclusion The T-peptide PET tracer targeting proteolyzed collagen IV provided a sensitive and specific approach of detecting diffuse cardiac fibrosis at varying degrees of severity in a transgenic mouse model. Keywords: Diffuse Cardiac Fibrosis, Molecular Peptide Probe, Molecular Imaging, PET/CT © RSNA, 2024.

目的 开发一种利用正电子发射计算机断层显像技术(PET)检测体内心脏间质纤维化的方法,该方法使用的多肽示踪剂靶向蛋白水解胶原 IV(T-肽)。材料与方法 将 T 肽与铜螯合剂 MeCOSar(化学名称:5-(8-甲基-3,6,10,13,16,19-六氮杂双环[6.6.6]伊可新-1-氨基)-5-氧代戊酸)共轭,并用铜 64 (64Cu) 进行放射性标记。在静脉注射 64Cu-T-peptide-MeCOSar (0.25 mg/kg; 18 MBq ± 2.7 [SD])给中度(7 个月大;每组 n = 4)至重度(10 个月大;每组 n = 11)心脏纤维化的过表达 β2-肾上腺素能受体雄性转基因小鼠及其野生型对照组后,进行 PET/CT 扫描。为了确认结合的特异性,还在放射性标记探针与过量的非标记T肽共同给药后进行了PET扫描。静态扫描的 PET 数据采用 t 检验,动态扫描的 PET 数据采用方差分析检验(单因素或双因素)。结果 PET/CT 扫描显示,与健康对照组相比,在整个 45 分钟的采集期间,老龄转基因 β2-肾上腺素能受体小鼠纤维化心脏中的 64Cu-T 肽-MeCOSar 结合率明显升高(2.24-4.26 倍;P < .05)。伽马计数(P < .05)和组织学评估分别证实了老年动物的心脏示踪剂积累和弥漫性心脏纤维化的存在。同时过量使用非放射性标记探针可消除老年转基因心脏中升高的放射性示踪剂结合。重要的是,在较年轻(7 个月大)的中度心脏纤维化转基因小鼠中也检测到了 PET 示踪剂的积累,尽管这只在注射后 20 分钟才显现出来(结合增加 1.6-2.2 倍;P < .05)。结论 以蛋白水解胶原 IV 为靶点的 T 肽 PET 示踪剂为检测转基因小鼠模型中不同严重程度的弥漫性心脏纤维化提供了一种灵敏而特异的方法。关键词:弥漫性心脏纤维化弥漫性心脏纤维化 分子肽探针 分子成像 PET/CT © RSNA, 2024.
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引用次数: 0
Measurement Variability of Same-Day CT Quantification of Interstitial Lung Disease: A Multicenter Prospective Study. 间质性肺病当天 CT 定量的测量变异性:一项多中心前瞻性研究
IF 7 Pub Date : 2024-04-01 DOI: 10.1148/ryct.230287
Jong Hyuk Lee, Kum Ju Chae, Jimyung Park, Sun Mi Choi, Myoung-Jin Jang, Eui Jin Hwang, Gong Yong Jin, Jin Mo Goo

Purpose To investigate quantitative CT (QCT) measurement variability in interstitial lung disease (ILD) on the basis of two same-day CT scans. Materials and Methods Participants with ILD were enrolled in this multicenter prospective study between March and October 2022. Participants underwent two same-day CT scans at an interval of a few minutes. Deep learning-based texture analysis software was used to segment ILD features. Fibrosis extent was defined as the sum of reticular opacity and honeycombing cysts. Measurement variability between scans was assessed with Bland-Altman analyses for absolute and relative differences with 95% limits of agreement (LOA). The contribution of fibrosis extent to variability was analyzed using a multivariable linear mixed-effects model while adjusting for lung volume. Eight readers assessed ILD fibrosis stability with and without QCT information for 30 randomly selected samples. Results Sixty-five participants were enrolled in this study (mean age, 68.7 years ± 10 [SD]; 47 [72%] men, 18 [28%] women). Between two same-day CT scans, the 95% LOA for the mean absolute and relative differences of quantitative fibrosis extent were -0.9% to 1.0% and -14.8% to 16.1%, respectively. However, these variabilities increased to 95% LOA of -11.3% to 3.9% and -123.1% to 18.4% between CT scans with different reconstruction parameters. Multivariable analysis showed that absolute differences were not associated with the baseline extent of fibrosis (P = .09), but the relative differences were negatively associated (β = -0.252, P < .001). The QCT results increased readers' specificity in interpreting ILD fibrosis stability (91.7% vs 94.6%, P = .02). Conclusion The absolute QCT measurement variability of fibrosis extent in ILD was 1% in same-day CT scans. Keywords: CT, CT-Quantitative, Thorax, Lung, Lung Diseases, Interstitial, Pulmonary Fibrosis, Diagnosis, Computer Assisted, Diagnostic Imaging Supplemental material is available for this article. © RSNA, 2024.

目的 根据两次当天的 CT 扫描结果,研究间质性肺病(ILD)的定量 CT(QCT)测量变异性。材料和方法 在 2022 年 3 月至 10 月期间,这项多中心前瞻性研究招募了患有 ILD 的参与者。参与者在几分钟内接受了两次当天的 CT 扫描。基于深度学习的纹理分析软件用于分割 ILD 特征。纤维化程度被定义为网状不透明和蜂窝状囊肿的总和。扫描之间的测量变异性通过布兰-阿尔特曼(Bland-Altman)分析法进行评估,以确定绝对和相对差异以及 95% 的一致性限(LOA)。使用多变量线性混合效应模型分析了纤维化程度对变异性的影响,同时对肺容积进行了调整。八位读者对随机抽取的 30 个样本进行了有 QCT 信息和无 QCT 信息的 ILD 纤维化稳定性评估。结果 65 名参与者参加了这项研究(平均年龄为 68.7 岁 ± 10 [SD];男性 47 [72%],女性 18 [28%])。在两次当天的 CT 扫描之间,定量纤维化程度的平均绝对值和相对值差异的 95% LOA 分别为 -0.9% 至 1.0% 和 -14.8% 至 16.1%。然而,在不同重建参数的CT扫描之间,这些变异性增加到95% LOA,分别为-11.3%至3.9%和-123.1%至18.4%。多变量分析显示,绝对差异与基线纤维化程度无关(P = .09),但相对差异呈负相关(β = -0.252,P < .001)。QCT 结果提高了读者解读 ILD 纤维化稳定性的特异性(91.7% vs 94.6%,P = .02)。结论 在当天的 CT 扫描中,QCT 测量 ILD 纤维化程度的绝对变异性为 1%。关键词CT,CT-定量,胸部,肺,肺部疾病,间质性,肺纤维化,诊断,计算机辅助,诊断成像 本文有补充材料。© RSNA, 2024.
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引用次数: 0
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Radiology. Cardiothoracic imaging
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