Revista da Associacao Medica Brasileira最新文献_第5页

Comment on "Serum prealbumin: a potential predictor of right ventricular dysfunction in patients receiving programmed hemodialysis". 对“血清前白蛋白:程序性血液透析患者右心室功能障碍的潜在预测因子”的评论。

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.20221673

Longcai Fang, Xiaofang Wang

We read with great interest a recent study 1 investigating the relationship between serum prealbumin concentration and right ventricular dysfunction (RVD) in patients undergoing programmed hemodiaelysis. In this study 1 , the results found that patients with RVD had lower prealbumin concentration compared with patients without RVD (23.83 ± 8.50 mg/dL versus 31.38 ± 6.81 mg/dL, p=0.001), and prealbumin concentration had an important role in predicting RVD. However, after reading this study carefully

引用次数: 0

Lung and physical function in post COVID-19. COVID-19后肺和身体功能的变化。

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.20230487

Rujittika Mungmunpuntipantip, Viroj Wiwanitkit

Dear Editor, We would like to share our ideas on the article entitled “Lung and physical function in post COVID-19 and clinical and functional associations: a cross-sectional study in Brazil1”. Nascimento et al.1 investigated the relationship between lesionlevel characteristics assessed by chest computed tomography, probable sarcopenia, and the percentage of diffusing capacity of the lung for carbon monoxide with clinical and functional variables in COVID-19 survivors1. Muscle impairment and lung dysfunction are widespread in COVID-19 survivors, according to Nascimento et al.1 and hospitalization was related to the worst muscle force and carbon monoxide diffusing capacity of the lung1. According to Nascimento et al.1 the findings underscore the need for long-term follow-up of such patients as well as rehabilitation programs1. The long-term consequences of COVID-19 have a concern that must be addressed immediately. There are significant issues that need to be resolved. Despite the likelihood that the patient had undiscovered co-morbid conditions, COVID-19 supported the patient’s first apparent clinical diagnosis. The patient might also get a second COVID192. It is important to discuss about prior vaccines as well. To draw a conclusion on how the disease influences health issues, there must be enough data and adequate knowledge. In many instances, the patient’s symptoms are most likely not the primary cause of extended COVID-19, also known as prolonged COVID.

{"title":"Lung and physical function in post COVID-19.","authors":"Rujittika Mungmunpuntipantip, Viroj Wiwanitkit","doi":"10.1590/1806-9282.20230487","DOIUrl":"https://doi.org/10.1590/1806-9282.20230487","url":null,"abstract":"Dear Editor, We would like to share our ideas on the article entitled “Lung and physical function in post COVID-19 and clinical and functional associations: a cross-sectional study in Brazil1”. Nascimento et al.1 investigated the relationship between lesionlevel characteristics assessed by chest computed tomography, probable sarcopenia, and the percentage of diffusing capacity of the lung for carbon monoxide with clinical and functional variables in COVID-19 survivors1. Muscle impairment and lung dysfunction are widespread in COVID-19 survivors, according to Nascimento et al.1 and hospitalization was related to the worst muscle force and carbon monoxide diffusing capacity of the lung1. According to Nascimento et al.1 the findings underscore the need for long-term follow-up of such patients as well as rehabilitation programs1. The long-term consequences of COVID-19 have a concern that must be addressed immediately. There are significant issues that need to be resolved. Despite the likelihood that the patient had undiscovered co-morbid conditions, COVID-19 supported the patient’s first apparent clinical diagnosis. The patient might also get a second COVID192. It is important to discuss about prior vaccines as well. To draw a conclusion on how the disease influences health issues, there must be enough data and adequate knowledge. In many instances, the patient’s symptoms are most likely not the primary cause of extended COVID-19, also known as prolonged COVID.","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/49/1806-9282-ramb-69-07-e20230487.PMC10351995.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9893118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anesthesia and women's peculiarities. 麻醉和女人的特性。

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.2023S103

Luis Antonio Dos Santos Diego

INTRODUCTION An important issue is the establishment of concepts when the topic of discussion involves sex and gender. So, sex is a term used for the biological determinant (chromosomal), and gender is a social construct with a broad spectrum (cis, trans, etc.). Both genderand sex-related peculiarities may influence many aspects of anesthetic planning, although the different concepts of sex and gender are precious, as well as pregnancy status; gender and pregnancy are beyond the scope of this article. The physiological and pharmacological aspects are extensive and, by themselves, deserve special attention. From the preoperative evaluation to the postoperative management, the anesthesiologists must know these differences and how they may influence the outcome. However, only the main factors influencing anesthetic management and its results will be highlighted.

引用次数: 0

Acupuncture for pregnancy-related pain in the lower back and posterior pelvic girdle. 针刺治疗腰背部及骨盆后带妊娠相关疼痛。

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.2023S101

Marcus Yu Bin Pai, Adriano Hohl, Luciano Ricardo Curuci de Souza, Mara Valeria Mendes, Luiz Carlos Souza Sampaio, Andre Wan Wen Tsai

INTRODUCTION Low back pain and pelvic pain are common conditions during pregnancy, and they can persist even after delivery1. The etiology of this phenomenon is complex, likely involving mechanical, circulatory, hormonal, and psychosocial factors2. Although there are no organic or specific diseases in most cases, the effects of pain can be considerable, negatively affecting sleep quality, physical condition, work performance, social life, and leisure activities, as well as leading to economic losses due to absenteeism1,3. The experience of pain during pregnancy is widespread, and its treatment poses significant challenges4. Some pain-relieving medications can pose dangers to both the fetus and the mother, while inadequate pain management can lead to severe maternal consequences such as depression and high blood pressure4. Due to limitations concerning pain management, acupuncture becomes an important treatment5. Acupuncture has been increasingly integrated into Western medicine as a complementary therapy for various conditions, especially pain, and has been shown to have analgesic, anti-inflammatory, and neuromodulatory effects6. Several studies have suggested that acupuncture can relieve pregnancy-related pain in the lower back and posterior pelvic girdle by improving blood circulation, relaxing muscles, reducing inflammation, and regulating hormones7–9.

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引用次数: 0

Video-based digital platforms as an educational resource for the surgical preparation of orthopedic surgeons. 基于视频的数字平台作为骨科医生手术准备的教育资源。

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.20230205

Hakan Zeybek, Hakan Cici, Ali Ihsan Kilic

Objective: The aim of the study was to research the video-based digital platforms that orthopedic specialists in Turkey use as an educational resource in their surgical preparations that they have not seen or done before, the frequency of their use of these platforms, and their trust in these platforms, with a survey study.

Methods: The importance of video-based digital platforms in surgical preparations that surgeons have not seen or done before was measured using the data obtained from 181 orthopedic specialists using a survey prepared on an Internet-based server (docs.google.com).

Results: Orthopedists used video-based digital platforms with a ratio of 38.7% among the educational resources in their surgical preparations that they have not seen or done before. There was no significant difference between the specialists with a surgical experience of 1-10 years and more than 10 years of experience in terms of using video-based digital platforms in surgical preparation (p>0.05). A total of 81.2% of the participants used only video-based digital platforms in the preparation of a surgical procedure they have never seen before. The most frequently used digital platform was YouTube, and 62% of the participants considered these platforms reliable.

Conclusion: Orthopedic specialists in Turkey primarily and frequently use video-based digital platforms as a training resource in their preparations for surgery that they have not seen or done before. The establishment or support of platforms with evidence-based content with references from official orthopedic institutions and organizations can increase the trust of orthopedic specialists in these platforms.

目的:本研究的目的是通过一项调查研究，研究土耳其骨科专家在他们以前从未见过或做过的手术准备中使用的基于视频的数字平台作为教育资源，他们使用这些平台的频率，以及他们对这些平台的信任。方法:利用互联网服务器(docs.google.com)对181名骨科专家进行调查，分析视频数字平台在外科医生未见过或未做过的手术准备中的重要性。结果:骨科医生在未见过或未做过的手术准备教育资源中使用视频数字平台的比例为38.7%。手术经验1-10年与10年以上专科医生在手术准备中使用视频数字平台的情况比较，差异无统计学意义(p>0.05)。总共有81.2%的参与者只使用基于视频的数字平台来准备他们从未见过的外科手术。最常使用的数字平台是YouTube, 62%的参与者认为这些平台是可靠的。结论:土耳其的骨科专家主要并经常使用基于视频的数字平台作为他们以前从未见过或做过的手术准备的培训资源。建立或支持有官方骨科机构和组织引用的循证内容平台，可以增加骨科专家对这些平台的信任。

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引用次数: 0

Vascular endothelial growth factor gene insertion/deletion polymorphism is associated with Vitamin D level in Turkish patients with coronavirus disease 2019. 2019年土耳其冠状病毒病患者血管内皮生长因子基因插入/缺失多态性与维生素D水平相关

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.20221713

Serbulent Yigit, Sengul Tural, Recai Aci, Ozlem Sezer

Objective: Coronavirus disease 2019 emerges as a disease caused by severe acute respiratory syndrome coronavirus 2. It is a systemic disease associated with vascular inflammation and endothelial damage. In this study, we aimed to investigate whether vascular endothelial growth factor gene insertion/deletion polymorphism is associated with coronavirus disease 2019 in the Turkish population.

Methods: The study included 179 participants (79 patients with coronavirus disease 2019 and 100 controls). DNA isolation was made from peripheral blood, and then the polymerase chain reaction analysis was performed.

Results: When we analyze vascular endothelial growth factor gene insertion/deletion polymorphism in the study group, we found that the DD genotype and D allele were found to be statistically significantly different when compared to coronavirus disease 2019 patients with high vitamin D value (p=0.005 for DD genotype and p=0.006 for D allele) in the control group. In this high-level control group, when we analyze II+ID genotype versus DD, a statistically significant difference was also detected (p=0.007).

Conclusion: As a result of the study, we found that DD genotype and D allele were associated with vitamin D level in Turkish patients with coronavirus disease 2019.

目的:2019冠状病毒病是一种由严重急性呼吸综合征冠状病毒2引起的疾病。它是一种与血管炎症和内皮损伤相关的全身性疾病。在本研究中，我们旨在调查土耳其人群中血管内皮生长因子基因插入/缺失多态性是否与2019冠状病毒病相关。方法:本研究纳入179名参与者(79名2019冠状病毒病患者和100名对照组)。从外周血中分离DNA，进行聚合酶链反应分析。结果:在分析研究组血管内皮生长因子基因插入/缺失多态性时，我们发现与对照组高维生素D值的冠状病毒病2019患者(DD基因型p=0.005, D等位基因p=0.006)相比，DD基因型和D等位基因差异有统计学意义。在这个高水平的对照组中，当我们分析II+ID基因型与DD基因型时，也发现有统计学意义的差异(p=0.007)。结论:通过研究，我们发现土耳其2019冠状病毒病患者的DD基因型和D等位基因与维生素D水平相关。

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引用次数: 0

Sclerostin and TNF-related weak inducer of apoptosis: can they be important in the patients with glomerulonephritis? 硬化蛋白和tnf相关的细胞凋亡弱诱导剂:在肾小球肾炎患者中是否重要?

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.20230239

Hakan Ozer, İsmail Baloglu, Talat Aykut, Mehmet Ali Demirci, Fatma Humeyra Yerlikaya Aydemir, Kultigin Turkmen

Objective: Sclerostin is a protein produced by osteocytes, kidneys, and vascular cells and has many effects on kidney and vascular structures. Soluble TNF-related weak inducer of apoptosis is a proinflammatory cytokine that may cause glomerular and tubular injury and increase sclerostin expression. This study aimed to investigate serum sclerostin and soluble TNF-related weak inducer of apoptosis levels in patients with glomerulonephritis and the effects they may be associated with.

Methods: This cross-sectional study included 93 patients, 63 of whom were glomerulonephritis and 30 were healthy controls. Serum sclerostin, soluble TNF-related weak inducer of apoptosis, and 24-h urinary protein excretion were measured, and pulse wave velocity was calculated for arterial stiffness.

Results: Serum sclerostin and soluble TNF-related weak inducer of apoptosis were higher in glomerulonephritis patients than in the control group, and serum sclerostin and soluble TNF-related weak inducer of apoptosis levels were correlated with both proteinuria and pulse wave velocity. In addition, in the regression analysis, serum sclerostin and soluble TNF-related weak inducer of apoptosis levels were found to be independent predictors of proteinuria in patients with glomerulonephritis.

Conclusion: This is the first study to show that serum sclerostin and soluble TNF-related weak inducer of apoptosis are elevated in glomerulonephritis patients, and these two markers correlate with arterial stiffness and proteinuria in these patients. Considering the effects of sclerostin and soluble TNF-related weak inducer of apoptosis in patients with glomerulonephritis, we think these mechanisms will be the target of both diagnosis and new therapies.

目的:硬化蛋白是一种由骨细胞、肾脏和血管细胞产生的蛋白质，对肾脏和血管结构有许多影响。可溶性tnf相关的细胞凋亡弱诱导剂是一种促炎细胞因子，可引起肾小球和小管损伤，增加硬化蛋白的表达。本研究旨在探讨肾小球肾炎患者血清硬化蛋白和可溶性tnf相关的弱诱导细胞凋亡水平及其可能的影响。方法:本横断面研究纳入93例患者，其中63例为肾小球肾炎，30例为健康对照。测定血清硬化蛋白、可溶性tnf相关的细胞凋亡弱诱导剂、24 h尿蛋白排泄量，计算脉搏波速度测定动脉僵硬度。结果:肾小球肾炎患者血清硬化蛋白及可溶性tnf相关的凋亡弱诱导剂水平高于对照组，且血清硬化蛋白及可溶性tnf相关的凋亡弱诱导剂水平与蛋白尿及脉波速度相关。此外，在回归分析中发现血清硬化蛋白和可溶性tnf相关的细胞凋亡弱诱导剂水平是肾小球肾炎患者蛋白尿的独立预测因子。结论:本研究首次发现肾小球肾炎患者血清硬化蛋白和可溶性tnf相关的细胞凋亡弱诱导剂升高，这两项标志物与肾小球肾炎患者动脉硬化和蛋白尿相关。考虑到硬化蛋白和可溶性tnf相关的弱凋亡诱导剂在肾小球肾炎患者中的作用，我们认为这些机制将成为诊断和新疗法的目标。

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引用次数: 0

Accuracy of intrapartum cardiotocography in identifying fetal acidemia by umbilical cord blood analysis in low-risk pregnancies. 在低危妊娠中通过脐带血分析鉴定胎儿酸血症的产时心脏造影的准确性。

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.20221182

Michaela Franco Tomich, Renato Silva Leoni, Pedro Teixeira Meireles, Caetano Galvão Petrini, Edward Araujo Júnior, Alberto Borges Peixoto

Objective: The aim of this study was to evaluate the accuracy of intrapartum cardiotocography in identifying fetal acidemia by umbilical cord blood analysis in low-risk pregnancies.

Methods: This is a retrospective cohort study of low-risk singleton pregnancies in labor after performing intrapartum cardiotocography categories I, II, and III. The presence of fetal acidemia at birth was identified by analyzing the pH of umbilical cord arterial blood (pH<7.1).

Results: No significant effect of the cardiotocography category on the arterial (p=0.543) and venous (p=0.770) pH of umbilical cord blood was observed. No significant association was observed between the cardiotocography category and the presence of fetal acidemia (p=0.706), 1-min Apgar score <7 (p=0.260), hospitalization in the neonatal intensive care unit (p=0.605), newborn death within the first 48 h, need for neonatal resuscitation (p=0.637), and adverse perinatal outcomes (p=0.373). Sensitivities of 62, 31, and 6.0%; positive predictive values of 11.0, 16.0, and 10.0%; and negative predictive values of 85, 89.0, and 87.0% were observed for cardiotocography categories I, II, and III, respectively.

Conclusion: The three categories of intrapartum cardiotocography presented low sensitivities and high negative predictive values to identify fetal acidemia at birth in low-risk pregnancies.

目的:本研究的目的是评估在低危妊娠中通过脐带血分析鉴定胎儿酸血症的产时心脏造影的准确性。方法:这是一项回顾性队列研究，在分娩时进行I、II和III类心脏造影后进行低风险单胎妊娠。通过分析脐血动脉血pH值(pH)来判断胎儿出生时是否存在酸血症。结果:不同心脏造影类别对脐血动脉血pH值(p=0.543)和静脉血pH值(p=0.770)无显著影响。结论:在低危妊娠中，产时3种类型的心摄影对胎儿产时酸血症的诊断敏感性较低，阴性预测值较高。

{"title":"Accuracy of intrapartum cardiotocography in identifying fetal acidemia by umbilical cord blood analysis in low-risk pregnancies.","authors":"Michaela Franco Tomich, Renato Silva Leoni, Pedro Teixeira Meireles, Caetano Galvão Petrini, Edward Araujo Júnior, Alberto Borges Peixoto","doi":"10.1590/1806-9282.20221182","DOIUrl":"https://doi.org/10.1590/1806-9282.20221182","url":null,"abstract":"Objective: The aim of this study was to evaluate the accuracy of intrapartum cardiotocography in identifying fetal acidemia by umbilical cord blood analysis in low-risk pregnancies.Methods: This is a retrospective cohort study of low-risk singleton pregnancies in labor after performing intrapartum cardiotocography categories I, II, and III. The presence of fetal acidemia at birth was identified by analyzing the pH of umbilical cord arterial blood (pH<7.1).Results: No significant effect of the cardiotocography category on the arterial (p=0.543) and venous (p=0.770) pH of umbilical cord blood was observed. No significant association was observed between the cardiotocography category and the presence of fetal acidemia (p=0.706), 1-min Apgar score <7 (p=0.260), hospitalization in the neonatal intensive care unit (p=0.605), newborn death within the first 48 h, need for neonatal resuscitation (p=0.637), and adverse perinatal outcomes (p=0.373). Sensitivities of 62, 31, and 6.0%; positive predictive values of 11.0, 16.0, and 10.0%; and negative predictive values of 85, 89.0, and 87.0% were observed for cardiotocography categories I, II, and III, respectively.Conclusion: The three categories of intrapartum cardiotocography presented low sensitivities and high negative predictive values to identify fetal acidemia at birth in low-risk pregnancies.","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/3e/1806-9282-ramb-69-06-e20221182.PMC10185048.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9850729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional study on the Nesfatin-1 serum levels of Vietnamese patients with pre-diabetes. 越南糖尿病前期患者血清Nesfatin-1水平的横断面研究。

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.20221388

Nguyen Minh Duc, Minh Ngoc Nghiem, Thuy Thi Bich Vo, Minh Thi Nguyen, Sinh Thi Dao

Over the past few years, the number of diabetes patients in the world has increased rapidly, with many serious complications, making it one of the most pressing concerns in society. According to the International Diabetes Federation (IDF), there were 537 million people worldwide (aged 20–79) suffering from diabetes in 2021. This number is expected to rise to 783 million in 20451. Vietnam is among the top 10 countries with the highest increase rate of diabetes cases, at 5.5% per year. As reported by the Vietnamese Association of Diabetes and Endocrinology (VADE), there are currently 5 million Vietnamese people living with diabetes, accounting for 6% of the population. This number is predicted to increase to 7 or 8 million by 20252. Diabetes is estimated to be the cause of death for at least 80 people each day. The percentage of undiagnosed diabetes cases in Vietnam is nearly 62.6%3. If left undetected and untreated in the early stages, pre-diabetes can increase the risk of dangerous complications and severely affect the patient’s health. In recent years, Nesfatin-1 has been identified as one of the cytokines associated with diabetes4,5. Peripheral Nesfatin-1 was linked to several clinical laboratory parameters that influenced nutrition and metabolism6. Therefore, determining the concentration of Nesfatin-1 serum is important for assessing the disease progression, predicting the damage to target organs, and evaluating the impact of treatment measures. A cross-sectional study was carried out on 524 patients diagnosed with prediabetes and 205 healthy people serving as the control group. These participants were taken from periodic health check-up groups at general hospitals in northern Vietnam. Pre-diabetes was diagnosed for those with fasting blood glucose (FBG) ≥126 mg/dL, hemoglobin A1c (HbA1c) ≥6.5%, or with classic symptoms of hyperglycemia7. The concentration of Nesfatin-1 serum, anthropometry, and clinical parameters associated with the cardiovascular, hepatic, and renal organs were determined and analyzed. Nesfatin-1 has the effects of suppressing appetite, reducing gastric motility, reducing cholesterol, triglycerides, and white adipose mass, as well as lowering lipid production and glucose in the blood. The Nesfatin-1 serum level of pre-diabetes patients was 1.5 times lower than in the control group (0.66 vs. 1.12 ng/mL) (Table 1). Blood glucose-related indices of pre-diabetes, such as HbA1c and

{"title":"A cross-sectional study on the Nesfatin-1 serum levels of Vietnamese patients with pre-diabetes.","authors":"Nguyen Minh Duc, Minh Ngoc Nghiem, Thuy Thi Bich Vo, Minh Thi Nguyen, Sinh Thi Dao","doi":"10.1590/1806-9282.20221388","DOIUrl":"https://doi.org/10.1590/1806-9282.20221388","url":null,"abstract":"Over the past few years, the number of diabetes patients in the world has increased rapidly, with many serious complications, making it one of the most pressing concerns in society. According to the International Diabetes Federation (IDF), there were 537 million people worldwide (aged 20–79) suffering from diabetes in 2021. This number is expected to rise to 783 million in 20451. Vietnam is among the top 10 countries with the highest increase rate of diabetes cases, at 5.5% per year. As reported by the Vietnamese Association of Diabetes and Endocrinology (VADE), there are currently 5 million Vietnamese people living with diabetes, accounting for 6% of the population. This number is predicted to increase to 7 or 8 million by 20252. Diabetes is estimated to be the cause of death for at least 80 people each day. The percentage of undiagnosed diabetes cases in Vietnam is nearly 62.6%3. If left undetected and untreated in the early stages, pre-diabetes can increase the risk of dangerous complications and severely affect the patient’s health. In recent years, Nesfatin-1 has been identified as one of the cytokines associated with diabetes4,5. Peripheral Nesfatin-1 was linked to several clinical laboratory parameters that influenced nutrition and metabolism6. Therefore, determining the concentration of Nesfatin-1 serum is important for assessing the disease progression, predicting the damage to target organs, and evaluating the impact of treatment measures. A cross-sectional study was carried out on 524 patients diagnosed with prediabetes and 205 healthy people serving as the control group. These participants were taken from periodic health check-up groups at general hospitals in northern Vietnam. Pre-diabetes was diagnosed for those with fasting blood glucose (FBG) ≥126 mg/dL, hemoglobin A1c (HbA1c) ≥6.5%, or with classic symptoms of hyperglycemia7. The concentration of Nesfatin-1 serum, anthropometry, and clinical parameters associated with the cardiovascular, hepatic, and renal organs were determined and analyzed. Nesfatin-1 has the effects of suppressing appetite, reducing gastric motility, reducing cholesterol, triglycerides, and white adipose mass, as well as lowering lipid production and glucose in the blood. The Nesfatin-1 serum level of pre-diabetes patients was 1.5 times lower than in the control group (0.66 vs. 1.12 ng/mL) (Table 1). Blood glucose-related indices of pre-diabetes, such as HbA1c and","PeriodicalId":21234,"journal":{"name":"Revista da Associacao Medica Brasileira","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/04/d2/1806-9282-ramb-69-05-e20221388.PMC10204833.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9895351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of hepatitis B surface antigen, anti-hepatitis B surface, and anti-hepatitis C virus prevalence in Syrian refugee pregnant women and Turkish pregnant women. 叙利亚难民孕妇和土耳其孕妇乙型肝炎表面抗原、抗乙型肝炎表面和抗丙型肝炎病毒流行率的比较

IF 1.4 4区医学 Q2 Medicine

Revista da Associacao Medica Brasileira

Pub Date : 2023-01-01 DOI: 10.1590/1806-9282.20221446

Kemal Hansu, Ismail Gurkan Cikim

Objective: In this study, we aimed to determine and compare hepatitis B surface antigen level, anti-hepatitis B surface, and anti-hepatitis C virus positivity in Turkish pregnant women and Syrian refugee pregnant women residing in Turkey.

Methods: The study was conducted on Syrian refugee pregnant women aged 15-45 years and Turkish pregnant women who applied to state hospital's gynecology and obstetrics outpatient clinics between April 30, 2012, and April 30, 2022. In our study, 136,376 pregnant women (104,629 Turkish and 31,747 Syrian) tested for hepatitis B surface antigen, 72,035 pregnant women (53,070 Turkish and 18,965 Syrian) tested for anti-hepatitis B surface, and 120,611 pregnant women (92,514 Turkish and 28,097 Syrian) tested for anti-hepatitis C virus were included. The patients were divided into six groups for hepatitis B surface antigen, anti-hepatitis B surface, and anti-hepatitis C virus results based on their age: <20 years, 20-24 years, 25-29 years, 30-34 years, 35-39 years, and >40 years. For each age group, the results of Syrian refugee pregnant women and Turkish pregnant women were compared.

Results: Hepatitis B surface antigen positivity and anti-hepatitis B surface positivity were significantly higher in Turkish pregnant women compared to Syrian refugee pregnant women. Anti-hepatitis C virus positivity was significantly higher in Syrian refugee pregnant women compared to Turkish pregnant women.

Conclusion: Based on the available data, we think that hepatitis B surface antigen, anti-hepatitis B surface, and anti-hepatitis C virus tests should be done routinely for pregnant women. Raising awareness among Syrian refugees about the hepatitis B virus vaccine as well as encouraging them to be vaccinated may reduce the negative impact of migration.

目的:在本研究中，我们旨在测定和比较土耳其孕妇和居住在土耳其的叙利亚难民孕妇的乙型肝炎表面抗原水平、抗乙型肝炎表面和抗丙型肝炎病毒阳性。方法:选取2012年4月30日至2022年4月30日在国立医院妇产科门诊就诊的15-45岁叙利亚难民孕妇和土耳其孕妇为研究对象。在我们的研究中，136,376名孕妇(104,629名土耳其人和31,747名叙利亚人)接受了乙型肝炎表面抗原检测，72,035名孕妇(53,070名土耳其人和18,965名叙利亚人)接受了乙型肝炎表面抗体检测，120,611名孕妇(92,514名土耳其人和28,097名叙利亚人)接受了丙型肝炎抗病毒检测。按年龄40岁将患者分为6组，分别进行乙型肝炎表面抗原、抗乙型肝炎表面和抗丙型肝炎病毒检测。对于每个年龄组，比较了叙利亚难民孕妇和土耳其孕妇的结果。结果:土耳其孕妇乙型肝炎表面抗原阳性和抗乙型肝炎表面阳性明显高于叙利亚难民孕妇。与土耳其孕妇相比，叙利亚难民孕妇的丙型肝炎病毒抗体阳性明显更高。结论:根据现有资料，我们认为孕妇应常规进行乙型肝炎表面抗原、抗乙型肝炎表面和抗丙型肝炎病毒检测。提高叙利亚难民对乙型肝炎病毒疫苗的认识，并鼓励他们接种疫苗，可减少移徙的负面影响。

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引用次数: 0