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Imagen de fusión ecocardiográfica-fluoroscópica con la minisonda transesofágica 3D en cardiopatías congénitas pediátricas 在儿科先天性心脏病中使用经食管微型3D超声心动图-荧光融合成像
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-21 DOI: 10.1016/j.recesp.2025.03.011
Ramona Ghenghea , Khaled Hadeed , Paul Vignaud-Marighetto , Nicolas Combes , Philippe Acar , Clement Karsenty
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引用次数: 0
Efectos interactivos de la obesidad abdominal y la resistencia a la insulina sobre el riesgo cardiometabólico 腹部肥胖和胰岛素抵抗对心脏代谢风险的相互影响
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-17 DOI: 10.1016/j.recesp.2025.03.006
Mengyue Lin , Xiaocong Chen , Muli Wu , Jiaxin Xiao , Shaobin Li , Haoxian Tang , Xuerui Tan , Yequn Chen

Introduction and objectives

Both abdominal obesity (AO) and insulin resistance (IR) are predictors of cardiometabolic disease (CMD). We aimed to evaluate the temporal relationship between AO and IR and their combined effect on CMD risk.

Methods

A nationally representative cohort of 9234 participants was included, with a maximum follow-up of 9 years. The triglyceride-glucose (TyG) index was calculated as an indicator of IR, and AO was measured by waist circumference (WC). Cox regression was applied to evaluate the combined effect of AO and TyG on CMD risk, including hypertension, diabetes, heart disease, and stroke. A cross-lagged panel model was used to examine the temporal relationship. Multiplicative and additive interactions between AO and insulin resistance, as well as the mediating effect of TyG, were assessed.

Results

Individuals concurrently with AO and higher TyG (≥ 8.6 [median]) had the highest risk of hypertension (HR,1.46; 95%CI, 1.25-1.69), diabetes (HR, 1.99; 95%CI, 1.65-2.41), and stroke (HR, 1.76; 95%CI, 1.22-1.94). A biological interaction between AO and IR on diabetes was observed, with the attributable proportion due to interaction being 29%. There was a bidirectional temporal relationship between WC and TyG, and the effect of WC on TyG was more prominent than vice versa. High TyG had a mediating effect on the association of AO with hypertension (19%), diabetes (25%), and stroke (24%).

Conclusions

The findings reveal a temporal relationship between AO and IR, their combined effect on hypertension, diabetes, and stroke, and the mediating role of IR. Strategies simultaneously targeting both factors should be emphasized for the primary prevention of CMD.
简介与目的腹部肥胖(AO)和胰岛素抵抗(IR)都是心血管代谢疾病(CMD)的预测因子。我们的目的是评估AO和IR之间的时间关系以及它们对CMD风险的综合影响。方法纳入9234例具有全国代表性的队列,最长随访时间为9年。计算甘油三酯-葡萄糖(TyG)指数作为IR指标,以腰围(WC)测量AO。采用Cox回归评价AO和TyG对高血压、糖尿病、心脏病、脑卒中等CMD风险的联合影响。一个交叉滞后面板模型被用来检验时间关系。评估了AO与胰岛素抵抗之间的乘法和加法相互作用,以及TyG的中介作用。结果AO和TyG较高(≥8.6[中位数])的患者发生高血压(HR,1.46; 95%CI, 1.25 ~ 1.69)、糖尿病(HR, 1.99; 95%CI, 1.65 ~ 2.41)和脑卒中(HR, 1.76; 95%CI, 1.22 ~ 1.94)的风险最高。观察到AO和IR对糖尿病的生物学相互作用,相互作用的归因比例为29%。WC与TyG在时间上呈双向关系,且WC对TyG的影响比TyG对WC的影响更显著。高TyG对AO与高血压(19%)、糖尿病(25%)和中风(24%)的关联具有中介作用。结论研究结果揭示了AO与IR之间的时间关系,它们在高血压、糖尿病和脑卒中中的联合作用,以及IR的中介作用。应强调同时针对这两个因素的策略,以进行CMD的一级预防。
{"title":"Efectos interactivos de la obesidad abdominal y la resistencia a la insulina sobre el riesgo cardiometabólico","authors":"Mengyue Lin ,&nbsp;Xiaocong Chen ,&nbsp;Muli Wu ,&nbsp;Jiaxin Xiao ,&nbsp;Shaobin Li ,&nbsp;Haoxian Tang ,&nbsp;Xuerui Tan ,&nbsp;Yequn Chen","doi":"10.1016/j.recesp.2025.03.006","DOIUrl":"10.1016/j.recesp.2025.03.006","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Both abdominal obesity (AO) and insulin resistance (IR) are predictors of cardiometabolic disease (CMD). We aimed to evaluate the temporal relationship between AO and IR and their combined effect on CMD risk.</div></div><div><h3>Methods</h3><div>A nationally representative cohort of 9234 participants was included, with a maximum follow-up of 9 years. The triglyceride-glucose (TyG) index was calculated as an indicator of IR, and AO was measured by waist circumference (WC). Cox regression was applied to evaluate the combined effect of AO and TyG on CMD risk, including hypertension, diabetes, heart disease, and stroke. A cross-lagged panel model was used to examine the temporal relationship. Multiplicative and additive interactions between AO and insulin resistance, as well as the mediating effect of TyG, were assessed.</div></div><div><h3>Results</h3><div>Individuals concurrently with AO and higher TyG (≥<!--> <!-->8.6 [median]) had the highest risk of hypertension (HR,1.46; 95%CI, 1.25-1.69), diabetes (HR, 1.99; 95%CI, 1.65-2.41), and stroke (HR, 1.76; 95%CI, 1.22-1.94). A biological interaction between AO and IR on diabetes was observed, with the attributable proportion due to interaction being 29%. There was a bidirectional temporal relationship between WC and TyG, and the effect of WC on TyG was more prominent than vice versa. High TyG had a mediating effect on the association of AO with hypertension (19%), diabetes (25%), and stroke (24%).</div></div><div><h3>Conclusions</h3><div>The findings reveal a temporal relationship between AO and IR, their combined effect on hypertension, diabetes, and stroke, and the mediating role of IR. Strategies simultaneously targeting both factors should be emphasized for the primary prevention of CMD.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 11","pages":"Pages 967-976"},"PeriodicalIF":5.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nódulos calcificados en las arterias coronarias: revisión sistemática sobre incidencia y resultados del intervencionismo coronario percutáneo 冠状动脉钙化结节:经皮冠状动脉干预的发生率和结果系统综述
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-17 DOI: 10.1016/j.recesp.2025.03.003
Clara Fernández-Cordón , Emmanouil S. Brilakis , Mario García-Gómez , Akash Jain , Marcelo Rodríguez , Carlos Cortés-Villar , Alberto Campo-Prieto , Ana Serrador , Hipólito Gutiérrez , Sara Blasco-Turrión , Luca Scorpiglione , Luis Llamas-Fernández , J. Alberto San Román , Ignacio Jesús Amat Santos

Introduction and objectives

Calcified nodules (CN) have been associated with higher complexity and worse outcomes after percutaneous coronary intervention (PCI) in both stable and unstable coronary disease. The aim of this systematic review was to summarize the current evidence on CN.

Methods

Systematic review of published studies on the prevalence, clinical associations, and impact of CN on outcomes after PCI up to November 2024.

Results

We identified 474 publications, of which 87 were included (all observational). CN were divided into 2 types: noneruptive CN (NECN), with an intact fibrous cap; and eruptive CN (ECN), with disruption of the fibrous cap with or without thrombus. The most common location was the right coronary artery (28%-71%). Angiography-based diagnostic sensitivity was low (18%-38%). Optical coherence tomography was preferred for type differentiation. The main clinical factors associated with CN were older age, diabetes mellitus, and chronic kidney disease. CN were considered the culprit lesion in 3% to 18% of acute coronary syndromes but were also present in up to 30% of nonculprit arteries. ECN were associated with more events at follow-up than NECN (20% vs 3.3% at 1 year). Post-PCI, CN were associated with lower minimum lumen area (MLA), higher rates of stent-edge dissection (44%-73%), malapposition (71%-96%), and underexpansion (60%-77%). ECN were associated with better acute results but worse long-term outcomes compared with NECN.

Conclusions

CN are often present in acute coronary syndrome culprit and stable coronary lesions. Intracoronary imaging is essential for the diagnosis and differentiation of CN. CN are associated with worse outcomes after PCI, acutely and during follow-up.
介绍和目的在稳定和不稳定冠状动脉疾病中,钙化结节(CN)与经皮冠状动脉介入治疗(PCI)后更高的复杂性和更差的结果相关。本系统综述的目的是总结目前关于CN的证据。方法系统回顾截至2024年11月已发表的关于PCI术后CN的患病率、临床关联和影响的研究。结果共纳入474篇文献,其中87篇(均为观察性文献)。CN分为2种类型:非爆发型CN (NECN),纤维帽完整;和爆发性CN (ECN),纤维帽破裂,伴或不伴血栓。最常见的部位是右冠状动脉(28%-71%)。基于血管造影的诊断敏感性较低(18%-38%)。光学相干断层扫描是鉴别类型的首选方法。与CN相关的主要临床因素为老年、糖尿病和慢性肾脏疾病。在3%至18%的急性冠状动脉综合征中,CN被认为是罪魁祸首病变,但在高达30%的非罪魁祸首动脉中也存在CN。随访时,ECN比NECN与更多事件相关(1年时分别为20%和3.3%)。pci后,CN与最小管腔面积(MLA)降低、支架边缘剥离率升高(44%-73%)、错位(71%-96%)和扩张不足(60%-77%)相关。与NECN相比,ECN的急性预后较好,但长期预后较差。结论scn常见于急性冠状动脉综合征和稳定型冠状动脉病变。冠状动脉内显像对CN的诊断和鉴别至关重要。CN与PCI术后、急性期和随访期间较差的预后相关。
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引用次数: 0
Recanalización transfemoral del arco aórtico atrésico mediante guía de radiofrecuencia 使用射频导引对后主动脉弓进行股横截
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-16 DOI: 10.1016/j.recesp.2025.04.001
Stefano Svab , Alain Fraisse , Konstantinos Dimopoulos , Isma Rafiq , Harith Alam , Alexander Kempny
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引用次数: 0
Efecto del bloqueo de rama izquierda sobre la capacidad funcional máxima en individuos asintomáticos sin enfermedad estructural cardiaca 无症状无结构性心脏疾病患者左支阻滞对最大功能能力的影响
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-16 DOI: 10.1016/j.recesp.2025.03.001
Patricia Palau , Eloy Domínguez , Silvia Mínguez , Gonzalo Núñez , Enrique Santas , Celia García-Conejo , Iván de Amo , Paloma Marín , Cristina Flor , Laura López , Lucía Ortega , Isabel Gabaldón-Sánchez , Rafael de la Espriella , Juan Sanchis , Julio Núñez

Introduction and objectives

In asymptomatic individuals, left bundle branch block (LBBB) is associated with an increased risk of cardiovascular events, but its impact on maximal functional capacity remains unclear. This study aimed to evaluate maximal aerobic capacity (peakVO2) in asymptomatic adults with LBBB without structural heart disease and compare it to an age-, physical activity-, and sex-matched control population.

Methods

This prospective case-control study included asymptomatic adults with isolated LBBB and matched controls. All participants underwent maximal cardiopulmonary exercise testing and echocardiography. The primary outcome was to compare peakVO2 and percent predicted peakVO2 (pp-peakVO2) between LBBB and matched controls. Secondary outcomes included differences in left ventricular indexed end-diastolic volumes (iLVEDV) and left ventricular ejection fraction (LVEF). Multivariate linear mixed models were used to analyze primary and secondary outcomes.

Results

A total of 162 participants (81 with LBBB and 81 controls) were included. The mean age was 65.7 ± 10.2 years, and 106 participants (65.4%) were women. The mean pp-peakVO2 and peakVO2 were 93.6 ± 16.9% and 19.9 ± 6.4 mL/kg/min, respectively. There were no significant differences in cardiovascular risk factors, NT-proBNP, or hemoglobin values between groups. Multivariate analysis showed that the presence of LBBB was associated with lower peakVO2 (−3.3 mL/kg/min, 95%CI,  4.6 to  2.1; P < .001) and pp-peakVO2 (−17.2%; 95%CI, −22.1 to −11.9; P < .001). Regarding secondary endpoints, individuals with LBBB showed higher iLVEDV (+4.4 mL/m2, 95%CI, 1.3 to 7.6; P = .006) and lower LVEF (−2.8%, 95%CI, −4.3 to −1.2; P < .001) compared with controls.

Conclusions

In this study, adults with isolated LBBB showed reduced maximal functional capacity compared with controls.
Registered at ClinicalTrials.gov (NCT05643404).
在无症状个体中,左束支阻滞(LBBB)与心血管事件风险增加有关,但其对最大功能容量的影响尚不清楚。本研究旨在评估无结构性心脏病的无症状LBBB成人的最大有氧能力(峰值vo2),并将其与年龄、体力活动和性别匹配的对照人群进行比较。方法本前瞻性病例对照研究纳入无症状孤立性下脑屏障成人和匹配对照。所有参与者都进行了最大心肺运动测试和超声心动图检查。主要结果是比较LBBB和匹配对照之间的峰值vo2和预测峰值vo2百分比(pp-峰值vo2)。次要结局包括左室指数舒张末期容积(iLVEDV)和左室射血分数(LVEF)的差异。多变量线性混合模型用于分析主要和次要结局。结果共纳入162例受试者,其中LBBB组81例,对照组81例。平均年龄65.7±10.2岁,女性106例(65.4%)。平均pp-peakVO2和peakVO2分别为93.6±16.9%和19.9±6.4 mL/kg/min。两组间心血管危险因素、NT-proBNP或血红蛋白值无显著差异。多因素分析显示,LBBB的存在与较低的峰值vo2 (- 3.3 mL/kg/min, 95%CI, - 4.6 ~ - 2.1; P < .001)和pp-峰值vo2 (- 17.2%, 95%CI, - 22.1 ~ - 11.9; P < .001)相关。至于次要终点,与对照组相比,LBBB患者的iLVEDV较高(+4.4 mL/m2, 95%CI, 1.3至7.6;P = 0.006), LVEF较低(- 2.8%,95%CI, - 4.3至- 1.2;P < 0.001)。结论在本研究中,与对照组相比,孤立性下脑屏障成人的最大功能能力降低。在ClinicalTrials.gov注册(NCT05643404)。
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引用次数: 0
Pequeñas dimensiones telediastólicas del ventrículo izquierdo identifican a pacientes con insuficiencia cardiaca y fracción de eyección supranormal 左心室的小远心室尺寸可识别心脏衰竭和超常射精部分患者
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-16 DOI: 10.1016/j.recesp.2025.03.002
Enrique Santas , Rafael de la Espriella , Gema Miñana , Anna Mollar , Patricia Palau , Julio Núñez
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引用次数: 0
Atresia pulmonar con septo interventricular intacto 肺动脉粥样硬化,心室间隔完整
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-10 DOI: 10.1016/j.recesp.2025.02.023
Alejandro Fernández-Cisneros , Bosco A. Moscoso , Stefano Congiu
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引用次数: 0
Afectación cardiaca poco común en osteosarcoma metastásico 转移性骨肉瘤中罕见的心脏病
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-09 DOI: 10.1016/j.recesp.2025.04.008
Juan Manuel Serrano-Marcos , Víctor Manuel López-Espinosa , Míriam Cantero-Campos
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引用次数: 0
Validación de la secuencia de resonancia magnética 3D de única apnea ESSOS para el estudio de la dilatación aórtica 用于研究主动脉扩张的ESSOS单呼吸机3D磁共振序列的验证
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-08 DOI: 10.1016/j.recesp.2025.04.009
Sandra Gómez-Talavera , Álvaro Navarro-Guzmán , Rodrigo Fernández-Jiménez , Valentín Fuster , Javier Sánchez-González , Borja Ibáñez
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引用次数: 0
Registro español de trasplante cardiaco. XXXVI informe oficial de la Asociación de Insuficiencia Cardiaca de la Sociedad Española de Cardiología 西班牙心脏移植登记。西班牙心脏病学会心脏衰竭协会第三十六届正式报告
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-05-05 DOI: 10.1016/j.recesp.2025.04.010
Francisco González-Vílchez , Luis Almenar-Bonet , Manuel Gómez-Bueno , María G. Crespo-Leiro , Manuel Cobo-Belaustegui , Manuel Crespín-Crespín , Carlos Ortiz-Bautista , Juan F. Delgado-Jiménez , Marta de Antonio-Ferrer , José Manuel Sobrino-Márquez , en representación de los Equipos Españoles de Trasplante Cardiaco , Miguel Llano-Cardenal , José Antonio Vázquez de Prada , Francisco Nistal-Herrera , Cristina Castrillo , Beatriz Díaz-Molina , Vanesa Alonso-Fernández , Cristina Fidalgo-Muñiz , Diego Rangel-Sousa , Antonio Grande-Trillo , Ferrán Gran-Ipiña

Introduction and objectives

This report presents updated data on heart transplants in Spain, including procedures carried out in 2024. It reviews trends over the past decade (2015-2024) in donor and recipient characteristics, surgical techniques, immunosuppression strategies, and survival rates.

Methods

Data were drawn from the Spanish heart transplant registry, which is updated annually. The analysis includes 347 transplants performed in 2024, as well as procedures from 2015 to 2023 (n = 2721).

Results

In 2024, the number of heart transplants increased by 6.8% compared with 2023. There were no significant changes in recipient age or sex, but the proportion of urgent transplants rose to 47.0%. Use of circulatory support devices increased, particularly extracorporeal membrane oxygenation. The average donor age showed a slight increase in 2024, although the long-term trend remained downward. Donation after circulatory death accounted for 29.1% of transplants in 2024. One-year survival rates improved, reaching 85.2% for transplants performed between 2021 and 2023.

Conclusions

The number of heart transplants continued to grow, nearing historic highs, largely due to the expansion of donation after circulatory death. Improved 1-year survival reflects the maturity of transplant programs, advances in surgical and medical management, and better pretransplant conditions in recipients.
本报告介绍了西班牙心脏移植的最新数据,包括2024年进行的手术。它回顾了过去十年(2015-2024)在供体和受体特征、手术技术、免疫抑制策略和生存率方面的趋势。方法数据来自每年更新的西班牙心脏移植登记处。该分析包括2024年进行的347例移植手术,以及2015年至2023年的手术(n = 2721)。结果2024年心脏移植数量较2023年增长6.8%。受者的年龄和性别没有明显变化,但紧急移植的比例上升到47.0%。循环支持装置的使用增加,特别是体外膜氧合。尽管长期趋势仍然是下降的,但2024年平均供体年龄略有增加。2024年循环死亡后捐赠占移植的29.1%。2021年至2023年间进行的移植手术的一年存活率达到85.2%。结论心脏移植数量持续增长,接近历史最高水平,主要是由于循环死亡后捐赠的扩大。1年生存率的提高反映了移植方案的成熟、手术和医疗管理的进步以及移植前受者状况的改善。
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引用次数: 0
期刊
Revista espanola de cardiologia
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