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Predictibilidad y tilting de dispositivo en la reparación mitral de borde a borde 边缘到边缘中心修复中的设备可预测性和倾斜性
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-21 DOI: 10.1016/j.recesp.2025.01.023
Chi-Hion Pedro Li , Lluís Asmarats , Albert Massó van Roessel , Helena Capellades , Xavier Millán , Dabit Arzamendi
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引用次数: 0
Beneficio pronóstico de la revascularización percutánea de las oclusiones coronarias crónicas. Paradojas y contradicciones de un debate sin final 慢性冠状动脉闭塞经皮再血管化的预后益处。无休止辩论的悖论和矛盾
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-21 DOI: 10.1016/j.recesp.2025.03.004
Alfonso Jurado-Román , José M. Montero-Cabezas
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引用次数: 0
Diferencias según el sexo en la anatomía de la insuficiencia mitral y resultados de la reparación percutánea de borde a borde 二尖瓣缺损的性别解剖差异和边缘到边缘经皮修复的结果
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-21 DOI: 10.1016/j.recesp.2025.01.024
Chi-Hion Pedro Li , Lluís Asmarats , Albert Massó van Roessel , Helena Capellades , Estefanía Fernández-Peregrina , Dabit Arzamendi
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引用次数: 0
Deterioro de la fracción de eyección del ventrículo izquierdo y eventos cardiovasculares en la miocardiopatía con excesiva trabeculación: hacia la medicina de precisión 左心室弹射分数受损和心肌梗塞过度的心血管事件:走向精准医疗
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-17 DOI: 10.1016/j.recesp.2025.01.005
Guillem Casas , Eduard Ródenas-Alesina , Javier Limeres , Clara Badia-Molins , José M. Larrañaga-Moreira , Jesús G. Mirelis , Javier Navarrete-Navarro , Jesús Martín-Jiménez , Juan E. Alcalá-López , Josefa González-Carrillo , Albert Teis , Rafaela Soler-Fernández , Gisela Teixidó-Turà , Laura Gutiérrez-García , Paula Fernández-Álvarez , Patricia Muñoz-Cabello , José A. Barrabés , Coloma Tirón , Julián Palomino-Doza , José Manuel García-Pinilla , José F. Rodríguez-Palomares

Introduction and objectives

Defining the probability of cardiomyopathy in individuals with excessive trabeculation of the left ventricle (ETLV) is an unmet clinical need. Our aims were: a) to describe the incidence and predictors of left ventricular ejection fraction (LVEF) decline and its correlation with major adverse cardiovascular events (MACE); and b) to identify prognostic factors in low-risk individuals.

Methods

Retrospective multicenter study in patients with ETLV and suspected cardiomyopathy. Two endpoints were analyzed: a) LVEF decline (> 10% absolute decrease in LVEF with LVEF < 50% at follow-up); and b) MACE, a composite of heart failure, ventricular arrhythmias, systemic embolisms, or cardiovascular mortality. Cardiovascular magnetic resonance core-lab analysis was performed in low-risk individuals (LVEF ≥ 50% and negative late gadolinium enhancement).

Results

A total of 530 patients were included, with a mean age of 44 ± 19 years and 44% were women. The mean LVEF was 49 ± 16%. Over a median echocardiographic follow-up of 4.2 years, 29 patients (6%) showed a decline in LVEF. Late gadolinium enhancement (P = .004) and baseline atrial fibrillation (P = .006) were independently associated with LVEF decline. During a subsequent clinical follow-up of 3.8 years, 106 patients (20%) experienced MACE. Factors that remained associated with MACE after adjustment were baseline LVEF (P < .001), LVEF decline (P = .022), baseline atrial fibrillation (P = .001), and QRS ≥ 120 ms (P = .009). Among low-risk individuals, left atrial strain correlated with outcomes and distinguished subclinical cardiomyopathy from physiological excessive trabeculation.

Conclusions

In ETLV, a decline in LVEF predicts cardiovascular events beyond baseline LVEF. In low-risk individuals, left atrial strain defines the probability of cardiomyopathy. A comprehensive assessment might provide valuable insights for differential diagnosis and risk stratification in this population.
前言和目的定义左心室过度小梁(ETLV)个体发生心肌病的可能性是一个尚未满足的临床需求。我们的目的是:a)描述左心室射血分数(LVEF)下降的发生率和预测因素及其与主要不良心血管事件(MACE)的相关性;b)确定低风险个体的预后因素。方法对ETLV合并疑似心肌病患者进行回顾性多中心研究。分析了两个终点:a) LVEF下降(LVEF绝对下降10%,随访时LVEF下降50%);b) MACE,包括心力衰竭、室性心律失常、全身栓塞或心血管死亡。低危个体(LVEF≥50%,晚期钆增强阴性)进行心血管磁共振核心实验室分析。结果共纳入患者530例,平均年龄44±19岁,女性占44%。平均LVEF为49±16%。在4.2年的超声心动图随访中,29例患者(6%)显示LVEF下降。晚期钆增强(P = 0.004)和基线心房颤动(P = 0.006)与LVEF下降独立相关。在随后的3.8年临床随访中,106例患者(20%)经历了MACE。调整后仍与MACE相关的因素是基线LVEF (P < 0.001)、LVEF下降(P = 0.022)、基线心房颤动(P = 0.001)和QRS≥120 ms (P = 0.009)。在低风险个体中,左心房应变与预后相关,并将亚临床心肌病与生理性过度小梁区分开来。结论在ETLV中,LVEF的下降预示着超过基线LVEF的心血管事件。在低风险个体中,左心房劳损决定了心肌病的可能性。一个全面的评估可能为鉴别诊断和危险分层提供有价值的见解。
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引用次数: 0
Implante de Impella por tronco braquiocefálico: una alternativa para soporte izquierdo en accesos axilares pequeños 脑干Impella植入:小腋窝左支撑的替代方案
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-17 DOI: 10.1016/j.recesp.2025.02.021
Enrique Pérez-de la Sota, Andrea Eixerés-Esteve, Jorge Enrique Centeno-Rodríguez, María Jesús López-Gude, Christian Muñoz-Guijosa
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引用次数: 0
Migración de un ateroma gravemente calcificado durante el TAVI TAVI期间严重钙化的肌瘤迁移
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-17 DOI: 10.1016/j.recesp.2025.01.019
Marta Herrero-Brocal , Almudena Ureña , Juan M. Ruiz-Nodar
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引用次数: 0
La cardiotoxicidad de las antraciclinas se asocia a alteraciones en la energética de la miosina cardiaca 蒽环素的心脏毒性与心脏肌凝素能量的改变有关
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-17 DOI: 10.1016/j.recesp.2025.02.001
Danielle Medina-Hernández , Carlos Galán-Arriola , Javier Sánchez-González , Julien Ochala , Borja Ibáñez
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引用次数: 0
Impacto de la amiloidosis en los resultados tras el implante percutáneo de prótesis valvular aórtica 经皮植入主动脉瓣假体后淀粉样变对预后的影响
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-17 DOI: 10.1016/j.recesp.2025.01.018
Luigi Gerra , Tommaso Bucci , Ho Man Lam , Marta Mantovani , Antonios A. Argyris , Muath Alobaida , Kully Sandhu , Joseph Mills , Giuseppe Boriani , Gregory Y.H. Lip

Introduction and objectives

Data on the impact of amyloidosis on outcomes after transcatheter aortic valve implantation (TAVI) are limited. The objective of this study was to evaluate the 1-year risk of adverse events post-TAVI in patients with amyloidosis.

Methods

Patients undergoing TAVI (between 2005 and 2023) were categorized into 2 groups based on the presence of amyloidosis. The primary outcome was the 1-year risk of a composite endpoint: heart failure (HF), ischemic stroke, pacemaker implantation, acute kidney injury, and all-cause death. Secondary outcomes assessed the individual components of the composite. Propensity score matching was used to balance the groups, and Cox regression was used to assess the risk of adverse outcomes associated with amyloidosis. Composite outcomes were analyzed for early (30-days) and long-term (30-days to 1 year) follow-up.

Results

Data from 589 TAVI patients with amyloidosis (mean age 78.9 ± 8.2 years, 31.9% female) were compared with 52 296 individuals without amyloidosis (mean age 78.1 ± 8.8 years, 40.3% female). After propensity score matching, patients with amyloidosis had a significantly higher 1-year risk of adverse events (HR, 1.27; 95%CI, 1.08-1.49). Specifically, patients with amyloidosis showed an increased risk of HF (HR, 1.37; 95%CI, 1.10-1.70). Stroke risk (HR, 1.67; 95%CI, 1.16–2.40) and pacemaker implantation (HR, 2.25; 95%CI, 1.15-4.41) were higher during long-term follow-up, while no differences were found for acute kidney injury or all-cause mortality between the 2 groups.

Conclusions

Among patients undergoing TAVI, those with amyloidosis are at a higher risk of adverse events, particularly HF, and have an increased risk of pacemaker implantation and stroke in the long-term.
简介和目的淀粉样变性对经导管主动脉瓣植入术(TAVI)后预后影响的数据有限。本研究的目的是评估淀粉样变性患者tavi后1年不良事件的风险。方法2005 ~ 2023年TAVI患者根据有无淀粉样变分为两组。主要终点是复合终点的1年风险:心力衰竭(HF)、缺血性卒中、起搏器植入、急性肾损伤和全因死亡。次要结果评估了组合的各个组成部分。倾向评分匹配用于平衡各组,Cox回归用于评估淀粉样变性相关不良结局的风险。对早期(30天)和长期(30天至1年)随访的综合结果进行分析。结果589例TAVI淀粉样变患者(平均年龄78.9±8.2岁,女性31.9%)与5296例无淀粉样变患者(平均年龄78.1±8.8岁,女性40.3%)的数据进行比较。倾向评分匹配后,淀粉样变性患者1年不良事件发生风险显著增高(HR, 1.27; 95%CI, 1.08-1.49)。具体来说,淀粉样变患者发生HF的风险增加(HR, 1.37; 95%CI, 1.10-1.70)。在长期随访中,卒中风险(HR, 1.67; 95%CI, 1.16-2.40)和起搏器植入(HR, 2.25; 95%CI, 1.15-4.41)较高,而急性肾损伤和全因死亡率两组间无差异。结论:在接受TAVI的患者中,淀粉样变患者发生不良事件的风险更高,特别是HF,并且长期内起搏器植入和卒中的风险增加。
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引用次数: 0
Intervención en la dieta mediterránea y evolución de la placa coronaria tras síndrome coronario agudo. El ensayo clínico MEDIMACS 干预地中海饮食与急性冠状动脉综合征后冠状动脉斑块的进化。MEDIMACS临床试验
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-15 DOI: 10.1016/j.recesp.2025.01.008
Ana I. Fernández-Ávila , Enrique Gutiérrez-Ibañes , Álvaro Gabaldón , Josep Gómez-Lara , Miguel Ángel Martínez-González , Javier Bermejo , en representación de los investigadores del estudio MEDIMACS , Irene Martín de Miguel , Ricardo Sanz-Ruiz , Elena Jurado , Francisco Fernández-Avilés , Cristina Razquin Burillo , Rafael de la Torre , Pablo Martínez-Legazpi , Raquel Yotti , Alex Mira , Uri Gophna , Roger Karlsson , Reem Al-Daccak , Dominique Charron
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引用次数: 0
Identificación de fenotipos en la insuficiencia cardiaca con fracción de eyección conservada a partir de 8.161 pacientes de 3 cohortes españolas 从3个西班牙队列的8161名患者中保留射精分数的心力衰竭表型鉴定
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-03-15 DOI: 10.1016/j.recesp.2025.02.019
Òscar Miró , Olivier Peyrony , Joan Carles Trullàs , Aitor Alquézar-Arbé , Julio Núñez , Pedro López-Ayala , Javier Jacob , Héctor Bueno , Manuel Montero-Pérez-Barquero , José Carlos Arévalo-Lorido , Rafael de la Espriella , Gema Miñana , Juan Sanchis , Pere Llorens

Introduction and objectives

To identify phenotypes in heart failure with preserved ejection fraction (HFpEF), compare mortality, and investigate whether treatments have different effects according to phenotype.

Methods

We performed a secondary analysis of 8161 patients with HFpEF included in Spanish cardiology (INCLIVA), internal medicine (RICA), and emergency (EAHFE) registries. Phenotypic clusters based on 16 baseline characteristics were identified using latent class analysis. We analyzed crude and treatment-adjusted 1-year survival, the associations between each treatment and mortality, and their interactions with phenotype.

Results

We identified 4 distinct clusters. One-year mortality was 18.7%. Cluster 4 (younger women with a valvular heart disease phenotype) had the lowest mortality (13.7%; reference category), which increased progressively in cluster 2 (cardiometabolic phenotype; mortality: 15.7%; adjusted HR, 1.28; 95%CI, 1.06-1.54), cluster 3 (very elderly female phenotype; mortality: 20.4%; adjusted HR, 1.63; 95%CI, 1.40-1.90), and cluster 1 (male cardiorespiratory phenotype; mortality: 24.0%; adjusted HR, 1.81; 95%CI, 1.53-2.13). The results were very similar when each registry was analyzed individually. Treatment with renin-angiotensin system inhibitors was associated with better survival in all clusters, beta-blockers were beneficial in cluster 1, and anticoagulants in cluster 4. However, none of the treatments showed a differential association with prognosis according to phenotype.

Conclusions

This study defines 4 HFpEF phenotypes with significantly different prognoses. Among the treatments analyzed, only renin-angiotensin system inhibitors seemed to have a generalized survival benefit, and none demonstrated a differential effect based on phenotype.
前言和目的确定具有保留射血分数(HFpEF)的心力衰竭的表型,比较死亡率,并研究治疗是否根据表型有不同的效果。方法:我们对8161例HFpEF患者进行了二次分析,这些患者分别来自西班牙心脏病学(INCLIVA)、内科(RICA)和急诊(EAHFE)登记处。基于16个基线特征的表型聚类通过潜在类分析确定。我们分析了粗生存率和治疗调整后的1年生存率,每种治疗与死亡率之间的关系,以及它们与表型的相互作用。结果鉴定出4个不同的聚类。一年死亡率为18.7%。第4类(有瓣膜病表型的年轻女性)的死亡率最低(13.7%,参考类别),在第2类(心脏代谢表型,死亡率:15.7%,校正HR, 1.28, 95%CI, 1.06-1.54)、第3类(非常老年女性表型,死亡率:20.4%,校正HR, 1.63, 95%CI, 1.40-1.90)和第1类(男性心肺表型,死亡率:24.0%,校正HR, 1.81, 95%CI, 1.53-2.13)中死亡率逐渐增加。当单独分析每个注册表时,结果非常相似。肾素-血管紧张素系统抑制剂治疗与所有组的更好生存率相关,β受体阻滞剂在组1中有益,抗凝剂在组4中有益。然而,根据表型,没有一种治疗显示出与预后的差异关联。结论本研究定义了4种具有显著预后差异的HFpEF表型。在分析的治疗方法中,只有肾素-血管紧张素系统抑制剂似乎具有普遍的生存益处,没有一种显示出基于表型的差异效应。
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引用次数: 0
期刊
Revista espanola de cardiologia
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