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Application of facial fat injections 面部脂肪注射的应用
Pub Date : 2022-04-05 DOI: 10.18282/jsd.v7.i2.188
Lingling Sheng, W. Cao
Autologous fat has become an ideal filler material due to its easy acquisition, good compatibility and no foreign body sensation after transplantation. In recent years, autologous fat has been widely used in facial rejuvenation or repair and reconstruction, and achieved satisfactory results, which is also in line with the currently advocated minimally invasive treatment direction. Autologous fat transplantation mainly includes fat extraction, separation, transplantation and postoperative treatment, each of which can affect the activity of fat particles and/or fat retention rate after transplantation. In this paper, the application of autologous fat in facial rejuvenation or reconstruction is described in detail.
自体脂肪以其易于获取、相容性好、移植后无异物感等优点成为一种理想的填充材料。近年来,自体脂肪被广泛应用于面部年轻化或修复重建,并取得了满意的效果,这也符合目前提倡的微创治疗方向。自体脂肪移植主要包括脂肪提取、分离、移植和术后处理,每一个环节都会影响移植后脂肪颗粒的活性和/或脂肪潴留率。本文对自体脂肪在面部年轻化或重建中的应用进行了详细的介绍。
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引用次数: 1
Effect of cryotherapy and ALA-PDT therapy on skin cancer 冷冻治疗与ALA-PDT治疗皮肤癌的疗效观察
Pub Date : 2022-03-24 DOI: 10.18282/jsd.v7.i2.187
Zhi-lian Zhong, Hong-An Deng, Wei Liu
Objective: to study the effect of cryotherapy and ALA-PDT therapy on skin cancer. Methods: this study selected 60 patients with skin cancer admitted to Ankang People’s Hospital of Shaanxi Province from January 2014 to December 2019. According to different treatment methods, 30 patients treated with ALA-PDT were included in the control group, while 30 patients treated with cryotherapy combined with ALA-PDT were included in the observation group. The total effective rate, pain score, surgical trauma area, incidence of adverse reactions and total satisfaction rate of appearance were compared between the two groups. Results: the treatment efficiency of the observation group was 96.7%, which was higher than that of the control group (73.3%), with a statistically significant difference (P < 0.05). The pain score in the observation group was (4.12 ± 1.03), higher than that of the control group (3.45 ± 0.86), and the surgical trauma area was (1.26 ± 0.04) cm2, lower than that of the control group (1.39 ± 0.05) cm2, with a statistically significant difference (P < 0.05). The difference was statistically significant (all P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Besides, the total satisfaction rate of the observation group was 93.3%, which was higher than that of the control group (66.7%), and the difference was statistically significant (P < 0.05). Conclusion: Cryotherapy combined with ALA-PDT therapy are clinically effective in the treatment of skin cancer, with less invasive surgical areas and higher patient satisfaction with appearance. However, the pain score is relatively higher. Therefore, the appropriate treatment can be clinically considered in a comprehensive manner.
目的:探讨冷冻治疗与ALA-PDT治疗皮肤癌的疗效。方法:选取2014年1月至2019年12月陕西省安康人民医院收治的60例皮肤癌患者。根据治疗方法的不同,将30例采用ALA-PDT治疗的患者作为对照组,将30例采用冷冻联合ALA-PDT治疗的患者作为观察组。比较两组患者的总有效率、疼痛评分、手术创伤面积、不良反应发生率及外观总满意度。结果:观察组治疗有效率为96.7%,高于对照组的73.3%,差异有统计学意义(P < 0.05)。观察组患者疼痛评分为(4.12±1.03)分,高于对照组(3.45±0.86)分,手术创伤面积为(1.26±0.04)cm2,低于对照组(1.39±0.05)cm2,差异有统计学意义(P < 0.05)。差异有统计学意义(P < 0.05)。两组患者不良反应发生率比较,差异无统计学意义(P > 0.05)。观察组总满意率为93.3%,高于对照组的66.7%,差异有统计学意义(P < 0.05)。结论:冷冻联合ALA-PDT治疗皮肤癌临床疗效显著,手术面积小,患者外观满意度高。然而,疼痛评分相对较高。因此,在临床上可以综合考虑适当的治疗方法。
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引用次数: 0
Treatment of keloids: What’s news? 治疗瘢痕疙瘩:有什么新闻吗?
Pub Date : 2022-01-09 DOI: 10.18282/jsd.v7.i1.179
S. Aghaei
Keloids are still therapeutic glitches, mostly disfiguring lesions which cause physical, functional and psychological burdens. Most patients with keloids are worried about cosmetic, some have grievances of itchy pain or a burning sense around them, though. The firmness can range from pliable to rigid. Most lesions tend to nurture gradually over a few months to a year. Most of them finally discontinue growing and stay unchanging or even withdraw to some extent[1,3]. No particular therapeutic modality is best for all lesions. The place, extent, penetration of the lesion, age of the patients and the previous reaction to treatments conclude the type of next step of therapy. The main key would be prevention, but intralesional steroid injections are usually the first-line strategy in the treatment of restricted keloid or hypertrophic scars. Other currently used treatments consist of occlusive silicon bandages, compression therapy , cryotherapy, surgical excision, radiation, laser surgery, interferons (IFN), 5-fluorouracil (5-FU), retinoic acid, doxorubicin, bleomycin, verapamil, retinoic acid, imiquimod 5% cream, tamoxifen, tacrolimus, botulinum toxin injection, hydrogel scaffolding, and over-the-counter treatments (such as onion extract, Lemon Juice, Baking Soda, and the combination of hydrocortisone, silicon, and vitamin E)[4]. Some promising treatments comprise anti-angiogenic factors, such as the inhibitors of vascular endothelial growth factor (VEGF) (for example bevacizumab), inhibitors of mannose-6-phosphate (M6P), combination of butyrate and docosahexaenoic acid, topical captopril, and phototherapies such as: (photodynamic therapy [PdT], intense pulsed light [IPL], ultraviolet A [UVA]-1 therapy, narrowband ultraviolet B [UVB] therapy). Inhibitors of transforming growth factor (TGF)–beta, inhibitors of tumor necrosis factor (TNF)–alpha (etanercept), recombinant human epidermal growth factor (rhEGF), and recombinant human interleukin (rhIL)–10 are some other newer modalities, which are focused at reducing collagen production[4,5]. A new study of keloids reveals that combined therapy of intralesional triamcinolone and verapamil injections results in noteworthy scar improvement with a long-term unchanging result[6]. Topical captopril could be considered as a prospective therapy for keloid lesions[5]. According to a recent study, captopril may decrease the expression of angiotensin, platelet-derived growth factor (PdGF), transforming growth factor beta 1 (TGF-β1) and heat shock protein 47 (HSP47), and more inhibit the proliferation and collagen production of fibroblasts in keloids, which were the key in keloid creation[7]. In another new research, favorable effects of the combination of 5-FU and verapamil merit further survey[8]. Mesenchymal stem cells would be a valuable source in regenerative medicine, and the medium acquired from stem cells seemingly hinders inflammation. Keloids are made up of abnormal fibrosis, produced by fibroblasts in reacti
瘢痕疙瘩仍然是治疗上的小问题,主要是毁容的病变,造成身体、功能和心理上的负担。大多数患有瘢痕疙瘩的患者担心美容,但有些人对周围的瘙痒疼痛或灼烧感感到不满。硬度可以从柔韧到坚硬。大多数损伤倾向于在几个月到一年的时间里逐渐形成。其中大多数最终停止生长,保持不变,甚至在一定程度上退缩[1,3]。没有特定的治疗方式对所有病变都是最好的。病变的部位、程度、渗透程度、患者的年龄以及以往对治疗的反应决定了下一步治疗的类型。主要的关键是预防,但局部注射类固醇通常是治疗限制性瘢痕疙瘩或增生性疤痕的一线策略。目前使用的其他治疗方法包括封闭硅绷带、压迫疗法、冷冻疗法、手术切除、放射、激光手术、干扰素(IFN)、5-氟尿嘧啶(5-FU)、视黄酸、阿霉素、博来霉素、维拉帕米、视黄酸、咪喹莫特5%乳膏、他莫昔芬、他克莫司、肉毒杆菌毒素注射、水凝胶支架和非处方治疗(如洋葱提取物、柠檬汁、小苏打和氢化可的松、硅和维生素E的组合)[4]。一些有前景的治疗方法包括抗血管生成因子,如血管内皮生长因子(VEGF)抑制剂(如贝伐单抗),甘露糖-6-磷酸(M6P)抑制剂,丁酸盐和二十二碳六烯酸联合用药,外用卡托普,以及光疗法,如光动力疗法[PdT],强脉冲光[IPL],紫外线A [UVA]-1治疗,窄带紫外线B [UVB]治疗)。转化生长因子(TGF) - β抑制剂、肿瘤坏死因子(TNF) - α(依那西普)抑制剂、重组人表皮生长因子(rhEGF)和重组人白细胞介素(rhIL) -10抑制剂是其他一些较新的模式,它们的重点是减少胶原蛋白的产生[4,5]。一项关于瘢痕疙瘩的新研究表明,局部注射曲安奈德和维拉帕米联合治疗可显著改善瘢痕,且效果长期不变。局部卡托普利可作为治疗瘢痕疙瘩的一种前瞻性治疗方法。根据最近的研究,卡托普利可能降低血管紧张素、血小板衍生生长因子(PdGF)、转化生长因子β1 (TGF-β1)和热休克蛋白47 (HSP47)的表达,并进一步抑制瘢痕疙瘩中成纤维细胞的增殖和胶原蛋白的产生,而成纤维细胞是瘢痕疙瘩形成的关键。在另一项新的研究中,5-FU与维拉帕米联合使用的良好效果值得进一步研究。间充质干细胞将是再生医学的宝贵来源,从干细胞中获得的培养基似乎可以抑制炎症。瘢痕疙瘩由异常纤维化组成,由成纤维细胞在炎症反应中产生。在一项研究中,作者评估了这种来自羊膜干细胞的培养基是否能阻止瘢痕疙瘩成纤维细胞的增殖和活化,是否能作为局部药物治疗瘢痕疙瘩。另一项研究显示,瘢痕疙瘩切除后近距离放疗治疗顽固性瘢痕疙瘩优于病灶内冷冻治疗,但仍需进一步研究病灶内冷冻治疗原发性瘢痕疙瘩的疗效。近距离放射治疗是使用放射源[10]进行放射治疗。世界上有数百万的患者患有瘢痕疙瘩。然而,在治疗中有条约的损失。此外,瘢痕疙瘩的研究在理解其发病机制方面留下了宝贵的经验。
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引用次数: 0
The efficacy and safety of a 70% glycolic acid peel with vitamin C for the treatment of photoaging 70%乙醇酸果皮加维生素C治疗光老化的有效性和安全性
Pub Date : 2021-01-21 DOI: 10.18282/jsd.v6.i1.80
S. Yang, M. M. Liau, Jun Khee Heng, Han Sim Matthias Toh, Chen Wee Derrick Aw, S. Ho
Glycolic acid peels have been shown in many studies to improve the appearance of photoaged skin. Vitamin C is known to be a potent natural antioxidant and plays an important role in the collagen biosynthetic pathway. In this study, we report our clinical experience with 70% glycolic acid peel added with vitamin C. We found that all parameters of photoaging, in particular the composite wrinkling score, discolouration score and the global photoaged score, showed statistically significant improvement. Patient satisfaction also revealed improvement in keeping with the physician assessment. It is also associated with an excellent safety profile. In conclusion, a combination of 70% glycolic acid with vitamin C chemical peel is a well-tolerated effective treatment of photoaging in Asian skin.
许多研究表明,乙醇酸去皮可以改善光老化皮肤的外观。维生素C是一种有效的天然抗氧化剂,在胶原蛋白生物合成途径中起着重要作用。在这项研究中,我们报告了我们在70%乙醇酸果皮中添加维生素c的临床经验。我们发现所有的光老化参数,特别是复合皱纹评分、变色评分和整体光老化评分,都有统计学上显著的改善。患者满意度也与医生的评估保持一致。它还具有良好的安全性。综上所述,70%乙醇酸与维生素C化学去皮的组合是一种耐受性良好的治疗亚洲皮肤光老化的有效方法。
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引用次数: 0
Tuberculosis verrucosa cutis 疣状皮肤结核
Pub Date : 2021-01-16 DOI: 10.18282/jsd.v6.i1.160
K. S
We report a case of 23-year-old male patient with tuberculosis verrucous cutis on the foot for a duration of six months without responding to routine treatment. Tuberculosis is a common disease worldwide. Extrapulmonary tuberculosis contributes to 10% of cases. Cutaneous tuberculosis occupies a small spectrum of extrapulmonary tuberculosis. Tuberculosis verrucosa cutis is an exogenous infection occurring in a previously sensitized patient by direct inoculation of the organism. It occurs in sensitized patients with a moderate to high immune response. The diagnosis in our patient was confirmed by history, clinical examination, histopathological examination and the patient’s response to anti-tuberculous therapy.
我们报告一例23岁的男性患者结核疣状皮肤的脚持续6个月没有响应常规治疗。结核病是世界范围内的一种常见疾病。肺外结核占病例的10%。皮肤结核在肺外结核中占一小部分。皮肤疣状结核是一种外源性感染,发生在一个以前敏感的病人直接接种的有机体。它发生在中度至高度免疫反应的敏感患者中。通过病史、临床检查、组织病理学检查和患者对抗结核治疗的反应证实了本病例的诊断。
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引用次数: 0
Analysis of chemokine receptors from angiosarcoma as the potential tumor marker 血管肉瘤趋化因子受体作为潜在肿瘤标志物的分析
Pub Date : 2020-04-19 DOI: 10.18282/jsd.v7.i1.152
Editorial Office
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引用次数: 0
Rare manifestation of neoplastica alopecia in metastatic cancer 肿瘤性脱发在转移性癌症中的罕见表现
Pub Date : 2020-04-06 DOI: 10.18282/jsd.v6.i1.132
Editorial Office
{"title":"Rare manifestation of neoplastica alopecia in metastatic cancer","authors":"Editorial Office","doi":"10.18282/jsd.v6.i1.132","DOIUrl":"https://doi.org/10.18282/jsd.v6.i1.132","url":null,"abstract":"","PeriodicalId":213687,"journal":{"name":"Journal of Surgical Dermatology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130452332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective treatment of necrobiosis lipoidica using intense pulsed light therapy 强脉冲光疗法有效治疗脂质坏死性坏死
Pub Date : 2019-01-24 DOI: 10.18282/jsd.v6.i2.129
Editorial Office
“The successful outcome of this case report suggested that IPL may represent a worthwhile option in the treatment of NL, offering low risks of collateral effects, especially when administered by experienced professionals,” wrote Dr. Marisa Gonzaga da Cunha and her co-authors from São Paulo‟s Faculty of Medicine of ABC and Federal University of São Paulo, Brazil, in a case study published by Journal of Surgical Dermatology (JSD).
“该病例报告的成功结果表明,IPL可能是治疗NL的一种有价值的选择,附带效应风险低,特别是当由经验丰富的专业人员管理时,”Marisa Gonzaga da Cunha博士和她的合著者来自巴西圣保罗大学医学院和巴西圣保罗联邦大学,在《外科皮肤病学杂志》(JSD)上发表的一项案例研究中写道。
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引用次数: 0
Nevus of Ota associated with intracranial melanoma: Case report and review of the literature 太田痣伴颅内黑色素瘤:病例报告及文献回顾
Pub Date : 2018-07-03 DOI: 10.18282/JSD.V3.I2.180
R. Krishnan, Christy Badgwell, D. Yoshor, I. Orengo
There is a known association between nevus of Ota and melanomas involving the brain parenchyma and/or the meninges. We present the unusual case of a 32-year-old African-American female with a nevus of Ota and a contralateral parenchymal, primary CNS melanoma. We discuss the unique features of this case and provide a brief review of the literature regarding nevi of Ota and associated CNS melanoma. Our patient is a 32 year-old, African-American female with a left-sided nevus of Ota who presented with a three month history of headaches and paresthesias involving her left face and arm. An MRI of the brain revealed a hemorrhagic mass in the right temporal lobe, which, after craniotomy, was determined to be a melanoma. Extensive imaging, ophthamologic examination and full-body skin examination revealed no other foci of melanoma. To our knowlege, this is the only case of a nevus of Ota associated with contralateral parenchymal melanoma in an African-American patient. The association of contralateral parenchymal primary CNS melanoma with nevus of Ota is extremely unusual.  Futhermore, despite the association of nevus of Ota with CNS melanoma, the literature does not support routine screening of patients with nevus of Ota for CNS melanoma with imaging modalities. 
已知太田痣与累及脑实质和/或脑膜的黑色素瘤有关联。我们提出一个不寻常的情况下,32岁的非裔美国女性太田痣和对侧实质,原发性中枢神经系统黑色素瘤。我们讨论了这个病例的独特特征,并提供了一个简短的文献回顾有关太田痣和相关的中枢神经系统黑色素瘤。我们的病人是一名32岁的非裔美国女性,患有左侧太田痣,她有三个月的头痛和感觉异常史,包括左脸和手臂。脑部的核磁共振成像显示,右颞叶有一个出血性肿块,在开颅后,被确定为黑色素瘤。广泛的影像学、眼科检查和全身皮肤检查未发现其他黑色素瘤灶。据我们所知,这是非洲裔美国患者中唯一一例与对侧实质黑色素瘤相关的太田痣。对侧原发性中枢神经系统实质黑色素瘤合并太田痣是非常罕见的。此外,尽管太田痣与中枢神经系统黑色素瘤存在关联,但文献并不支持对太田痣患者进行常规影像学筛查以检测中枢神经系统黑色素瘤。
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引用次数: 0
The diagnostic accuracy of the mobile phone teledermatoscopy 手机遥控皮肤镜的诊断准确性
Pub Date : 2018-07-03 DOI: 10.18282/jsd.v3.i2.178
H. Yıldız, Memet Erşan Bilgili, H. Simsek
The positive predictive value (PPV) of smart mobile phone teledermatoscopy is not known. The main purpose of the present study was to investigate the sensitivity and positive predictive values (PPVs) of smart mobile phone teledermatoscopy. Over a period of 6 months, up to three clinical and dermatoscopic images were obtained of 67 skin lesions from 67 patients using a mobile phone camera and standard pocket dermatoscopy device. Out of the 67 patients, 44 were men (65.67%) and 23 were women (34.32%). The mean age of the patients was 39.56 ± 22.19 years (ranging from 18 to 92). The majority of the lesions (71.64%; n=48) were benign, while 11.94% (n=8) of the biopsies were premalignant and 16.41% (n=11) of the lesions were malignant. The sensitivity for the diagnosis of benign, premalignant, and malignant lesions were 93.8%, 100%, and 100%, respectively. PPVs for the diagnosis of benign, premalignant, and malignant lesions were 93.8%, 100%, and 100%, respectively. The sensitivity and PPVs of all lesions were 95.9% and 95.7%. The accuracy of the teledermatoscopic consultation with a mobile phone is very high. We therefore think that it can be a cost effective and useful method in the consultation at distance.
智能手机远镜的阳性预测值(PPV)尚不清楚。本研究的主要目的是探讨智能手机远镜的敏感性和阳性预测值(PPVs)。在6个月的时间里,使用手机相机和标准口袋皮肤镜设备,对67名患者的67个皮肤病变获得了多达3张临床和皮肤镜图像。其中男性44例(65.67%),女性23例(34.32%)。患者平均年龄39.56±22.19岁(18 ~ 92岁)。绝大多数病变(71.64%;48例为良性,11.94% (N =8)为癌前病变,16.41% (N =11)为恶性病变。对良性、癌前、恶性病变的诊断敏感性分别为93.8%、100%、100%。ppv对良性、癌前和恶性病变的诊断率分别为93.8%、100%和100%。所有病变的敏感性和ppv分别为95.9%和95.7%。用手机进行远镜会诊的准确性非常高。因此,我们认为它在远程协商中是一种成本效益高和有用的方法。
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引用次数: 0
期刊
Journal of Surgical Dermatology
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