Pub Date : 2023-09-12DOI: 10.15829/1560-4071-2023-5596
K. G. Pereverzeva
.
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{"title":"To the anniversary – Sergey S. Yakushin","authors":"K. G. Pereverzeva","doi":"10.15829/1560-4071-2023-5596","DOIUrl":"https://doi.org/10.15829/1560-4071-2023-5596","url":null,"abstract":".","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135885110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-12DOI: 10.15829/1560-4071-20235392
Yu. V. Stavtseva, M. A. Teterina, D. A. Ubaydullaeva, A. S. Vorobyov, I. Meray, Zh. D. Kobalava
We present a clinical description of a patient with recurrent resistant episodes of ventricular tachycardia that first appeared at the myocarditis onset and remained the only disease manifestations for several years. During follow-up, the patient was diagnosed with dilated cardiomyopathy, which required heart transplantation.
{"title":"Chronic myocarditis as a cause of recurrent episodes of ventricular tachycardia and dilated cardiomyopathy requiring heart transplantation: a case report","authors":"Yu. V. Stavtseva, M. A. Teterina, D. A. Ubaydullaeva, A. S. Vorobyov, I. Meray, Zh. D. Kobalava","doi":"10.15829/1560-4071-20235392","DOIUrl":"https://doi.org/10.15829/1560-4071-20235392","url":null,"abstract":"We present a clinical description of a patient with recurrent resistant episodes of ventricular tachycardia that first appeared at the myocarditis onset and remained the only disease manifestations for several years. During follow-up, the patient was diagnosed with dilated cardiomyopathy, which required heart transplantation.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.15829/1560-4071-20235453
S. T. Enginoev, A. A. Zenkov, G. M. Magomedov, U. K. Abdulmejidova, M. A. Guliyev, I. I. Chernov, E. Yu. Gubareva
The issue of optimal surgical scope in patients with aortic root abscess due to infective endocarditis remains open, since there are different strategies and interventional methods. In addition, the guidelines do not give preference to any particular type of surgical intervention and recommend an individual approach to each situation. The study included 25 patients with aortic root abscess due to aortic valve infective endocarditis. The most frequently performed surgical intervention in patients was the Ross procedure (n=12, 48%). Eight (32%) patients of the center underwent aortic homograft root replacement. Combined surgery was performed in 7 (28%) patients as follows: 3 (12%) patients — interventions on the mitral valve (all patients underwent mitral valve repair due to mitral valve involvement in abscess), 3 (12%) — coronary artery bypass grafting, 1 (4%) — ascending aortic replacement due to dilatation. Five- and ten-year survival after surgical treatment of patients with aortic root abscess was 86,9% and 78,6%, respectively. There was no reintervention and recurrence of infective endocarditis in the long-term period.
{"title":"Surgical treatment of aortic root abscess: 10-year single center experience","authors":"S. T. Enginoev, A. A. Zenkov, G. M. Magomedov, U. K. Abdulmejidova, M. A. Guliyev, I. I. Chernov, E. Yu. Gubareva","doi":"10.15829/1560-4071-20235453","DOIUrl":"https://doi.org/10.15829/1560-4071-20235453","url":null,"abstract":"The issue of optimal surgical scope in patients with aortic root abscess due to infective endocarditis remains open, since there are different strategies and interventional methods. In addition, the guidelines do not give preference to any particular type of surgical intervention and recommend an individual approach to each situation. The study included 25 patients with aortic root abscess due to aortic valve infective endocarditis. The most frequently performed surgical intervention in patients was the Ross procedure (n=12, 48%). Eight (32%) patients of the center underwent aortic homograft root replacement. Combined surgery was performed in 7 (28%) patients as follows: 3 (12%) patients — interventions on the mitral valve (all patients underwent mitral valve repair due to mitral valve involvement in abscess), 3 (12%) — coronary artery bypass grafting, 1 (4%) — ascending aortic replacement due to dilatation. Five- and ten-year survival after surgical treatment of patients with aortic root abscess was 86,9% and 78,6%, respectively. There was no reintervention and recurrence of infective endocarditis in the long-term period.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.15829/15604071-2023-5545
V. K. Zafiraki, A. M. Namitokov, I. V. Gilevich, M. V. Gradovskaya, O. V. Malyarevskaya, K. V. Karabakhtsieva
To date, there is no doubt about the participation of triglyceride-rich lipoproteins in atherogenesis. However, the variety of clinical manifestations of hypertriglyceridemia does not always allow timely recognition of patients with high cardiovascular risk for the timely initiation of therapy. The article presents 3 following cases: patient with isolated hypertriglyceridemia without clinical manifestations and with a good response to treatment, a patient with skin manifestations of hypertriglyceridemia and a patient with severe multifocal atherosclerosis, diabetes and recurrent pancreatitis. References are also provided for each case.
{"title":"Variety of clinical manifestations of hypertriglyceridemia: a case series","authors":"V. K. Zafiraki, A. M. Namitokov, I. V. Gilevich, M. V. Gradovskaya, O. V. Malyarevskaya, K. V. Karabakhtsieva","doi":"10.15829/15604071-2023-5545","DOIUrl":"https://doi.org/10.15829/15604071-2023-5545","url":null,"abstract":"To date, there is no doubt about the participation of triglyceride-rich lipoproteins in atherogenesis. However, the variety of clinical manifestations of hypertriglyceridemia does not always allow timely recognition of patients with high cardiovascular risk for the timely initiation of therapy. The article presents 3 following cases: patient with isolated hypertriglyceridemia without clinical manifestations and with a good response to treatment, a patient with skin manifestations of hypertriglyceridemia and a patient with severe multifocal atherosclerosis, diabetes and recurrent pancreatitis. References are also provided for each case.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.15829/1560-4071-20235384
S. T. Enginoev, V. V. Demetskaya, D. Yu. Kozmin, V. V. Pasyuga, D. A. Demin, E. V. Demina, D. R. Stompel, I. I. Chernov
Aim. To assess postoperative complications and predictors of mortality in surgery for left-sided infective endocarditis (IE). Material and methods . The retrospective analysis included 222 cases of IE in 216 patients who were operated on from January 2015 to November 2022. Inclusion criteria: age of patients ≥18 years, definite or probable (Duke criteria) left-sided IE of aortic and/or mitral valves. There were following exclusion criteria: isolated right-sided IE (tricuspid valve, pacemaker endocarditis), nonbacterial thrombotic endocarditis and chronic IE. Endpoints: inhospital mortality, postoperative complications (delirium; perioperative stroke; resternotomy for bleeding; perioperative myocardial infarction; acute heart failure requiring extracorporeal membrane oxygenation or intra-aortic balloon pumping; respiratory failure requiring tracheostomy; acute kidney injury requiring renal replacement therapy; conduction disorder requiring pacemaker implantation). Results . Median age was 53 [38,0; 61,0] years, while the majority of patients were men (73,9%). Inhospital mortality was 8,6%. The most common postoperative complications were delirium (19,8%) and bleeding requiring resternotomy (10,4%). The incidence of perioperative stroke was 2,3%, perioperative myocardial infarction - 0,9%, respiratory failure with tracheostomy – 4,5%, pacemaker implantation – 2,7%, renal replacement therapy – 6,8%. According to multivari ate analysis, Predictors of inhospital mortality were creatinine clearance level (odds ratio (OR), 0,976; 95% confidence interval (CI): 0,956-0,996; p=0,020), time of cardiopulmonary bypass (OR, 1,014; 95% CI: 1,006-1,021 , p<0,001), deli rium (OR, 7,058; 95% CI: 1,824-27,330, p=0,005) and acute kidney injury requiring renal replacement therapy (OR, 28,620; 95% CI: 6,508-125,964; p<0,001). Conclusion. Surgical treatment of left-sided IE has satisfactory inho spital outcomes. The study identified simple clinical factors (creatinine clearance, cardiopulmonary bypass time, delirium, acute kidney injury) associated with inhospital mortality.
{"title":"Postoperative complications and predictors of mortality in surgery for left-sided infective endocarditis: a single-center retrospective study","authors":"S. T. Enginoev, V. V. Demetskaya, D. Yu. Kozmin, V. V. Pasyuga, D. A. Demin, E. V. Demina, D. R. Stompel, I. I. Chernov","doi":"10.15829/1560-4071-20235384","DOIUrl":"https://doi.org/10.15829/1560-4071-20235384","url":null,"abstract":"Aim. To assess postoperative complications and predictors of mortality in surgery for left-sided infective endocarditis (IE). Material and methods . The retrospective analysis included 222 cases of IE in 216 patients who were operated on from January 2015 to November 2022. Inclusion criteria: age of patients ≥18 years, definite or probable (Duke criteria) left-sided IE of aortic and/or mitral valves. There were following exclusion criteria: isolated right-sided IE (tricuspid valve, pacemaker endocarditis), nonbacterial thrombotic endocarditis and chronic IE. Endpoints: inhospital mortality, postoperative complications (delirium; perioperative stroke; resternotomy for bleeding; perioperative myocardial infarction; acute heart failure requiring extracorporeal membrane oxygenation or intra-aortic balloon pumping; respiratory failure requiring tracheostomy; acute kidney injury requiring renal replacement therapy; conduction disorder requiring pacemaker implantation). Results . Median age was 53 [38,0; 61,0] years, while the majority of patients were men (73,9%). Inhospital mortality was 8,6%. The most common postoperative complications were delirium (19,8%) and bleeding requiring resternotomy (10,4%). The incidence of perioperative stroke was 2,3%, perioperative myocardial infarction - 0,9%, respiratory failure with tracheostomy – 4,5%, pacemaker implantation – 2,7%, renal replacement therapy – 6,8%. According to multivari ate analysis, Predictors of inhospital mortality were creatinine clearance level (odds ratio (OR), 0,976; 95% confidence interval (CI): 0,956-0,996; p=0,020), time of cardiopulmonary bypass (OR, 1,014; 95% CI: 1,006-1,021 , p<0,001), deli rium (OR, 7,058; 95% CI: 1,824-27,330, p=0,005) and acute kidney injury requiring renal replacement therapy (OR, 28,620; 95% CI: 6,508-125,964; p<0,001). Conclusion. Surgical treatment of left-sided IE has satisfactory inho spital outcomes. The study identified simple clinical factors (creatinine clearance, cardiopulmonary bypass time, delirium, acute kidney injury) associated with inhospital mortality.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.15829/1560-40712023-5472
N. I. Novitsky, A. N. Baglikov, A. E. Soloveva, S. V. Kruchinova, E. D. Kosmacheva, S. V. Villevalde
Nonvalvular atrial fibrillation (AF) is the most common cause of arterial thromboembolism, especially of ischemic stroke. Other than stroke AF-associated embolic events are usually underestimated but at least similarly important. We present a rare case of simultaneous multiple embolism in a 70 years old women with permanent AF.
{"title":"Perfect storm: a clinical case of multisite (brain, coronary, renal and spleen) embolism in patient with atrial fibrillation","authors":"N. I. Novitsky, A. N. Baglikov, A. E. Soloveva, S. V. Kruchinova, E. D. Kosmacheva, S. V. Villevalde","doi":"10.15829/1560-40712023-5472","DOIUrl":"https://doi.org/10.15829/1560-40712023-5472","url":null,"abstract":"Nonvalvular atrial fibrillation (AF) is the most common cause of arterial thromboembolism, especially of ischemic stroke. Other than stroke AF-associated embolic events are usually underestimated but at least similarly important. We present a rare case of simultaneous multiple embolism in a 70 years old women with permanent AF.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.15829/1560-4071-2023-5553
N. R. Khasanov, N. Sh. Zagidullin, I. I. Shaposhnik, T. N. Zvereva, N. Yu. Grigoryeva, E. I. Tarlovskaya
on behalf of the Committees of the Russian Society of Cardiology for work with medical schools of the Russian Federation and for educational activities and youth policy Cardiovascular diseases take a leading place in the morbidity pattern worldwide, and therefore improving the cardiology education in medical schools is very relevant. In addition, the rapid development of diagnostic and treatment methods poses very different challenges for students and teachers. In particular, at present, high-tech methods, such as radiofrequency ablation, molecular diagnostics, are practically not included in the standard curriculum. Also, differences in educational tracks in different universities often do not allow creating a single educational cardiology space. The article discusses the continuity of cardiology education at the university at different departments (study years), as well as theoretical, practical competencies of 3-6 study years at internal medicine departments, as well as electives and academic competitions in cardiology and the related problems.
{"title":"Position of the Russian Society of Cardiology experts on improving the cardiology education in medical schools in compliance with the educational continuity","authors":"N. R. Khasanov, N. Sh. Zagidullin, I. I. Shaposhnik, T. N. Zvereva, N. Yu. Grigoryeva, E. I. Tarlovskaya","doi":"10.15829/1560-4071-2023-5553","DOIUrl":"https://doi.org/10.15829/1560-4071-2023-5553","url":null,"abstract":"on behalf of the Committees of the Russian Society of Cardiology for work with medical schools of the Russian Federation and for educational activities and youth policy Cardiovascular diseases take a leading place in the morbidity pattern worldwide, and therefore improving the cardiology education in medical schools is very relevant. In addition, the rapid development of diagnostic and treatment methods poses very different challenges for students and teachers. In particular, at present, high-tech methods, such as radiofrequency ablation, molecular diagnostics, are practically not included in the standard curriculum. Also, differences in educational tracks in different universities often do not allow creating a single educational cardiology space. The article discusses the continuity of cardiology education at the university at different departments (study years), as well as theoretical, practical competencies of 3-6 study years at internal medicine departments, as well as electives and academic competitions in cardiology and the related problems.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.15829/1560-4071-2023-5477
O. A. Rubanenko, A. O. Rubanenko, S. V. Villevalde, D. V. Duplyakov
Aim. To study the efficacy and safety of acetazolamide administered orally to patients with decompensated heart failure (HF) at the hospital stage within 72 hours from admission, compared with standard therapy. Material and methods. This open-label, prospective, randomized, multicenter study is planned to include 400 patients urgently admitted to hospital with NYHA class II-IV decompensated HF: 200 patients each in the standard therapy group and additional acetazolamide (tablets) group. The primary endpoint includes the number of patients who achieved compensation in accordance with the criteria for diuretic therapy discontinuation. There are secondary endpoints: increase in urine output in the first 72 hours of hospitalization (since randomization), weight loss, 24-hour natriuresis, length of stay in hospital, length of stay in the intensive care unit, 90-day any-cause death, 90-day cardiovascular death, 90-day death due to chronic HF decompensation or acute decompensated HF, the number of pleuro- and pericardiocentesis episodes during the hospitalization, scale for clinical condition assessment of HF patient (SHOKS) at discharge from the hospital, 6-minute walk test at discharge from the hospital. The planned follow-up duration is a hospital period with an assessment of the clinical picture and laboratory parameters. Telemedicine contact with patients is carried out after 14, 30 and 90 days using a structured questionnaire. Conclusion. Analysis of clinical, laboratory and echocardiographic parameters of patients using acetazolamide tablets will make it possible to determine the criteria for the effectiveness of diuretic therapy in patients with decompensated HF in the short and long term.
{"title":"Efficacy and safety of acetazolamide in patients with NYHA class II-IV decompensated heart failure: protocol of an open-label prospective randomized multicenter study (ORION-A)","authors":"O. A. Rubanenko, A. O. Rubanenko, S. V. Villevalde, D. V. Duplyakov","doi":"10.15829/1560-4071-2023-5477","DOIUrl":"https://doi.org/10.15829/1560-4071-2023-5477","url":null,"abstract":"Aim. To study the efficacy and safety of acetazolamide administered orally to patients with decompensated heart failure (HF) at the hospital stage within 72 hours from admission, compared with standard therapy. Material and methods. This open-label, prospective, randomized, multicenter study is planned to include 400 patients urgently admitted to hospital with NYHA class II-IV decompensated HF: 200 patients each in the standard therapy group and additional acetazolamide (tablets) group. The primary endpoint includes the number of patients who achieved compensation in accordance with the criteria for diuretic therapy discontinuation. There are secondary endpoints: increase in urine output in the first 72 hours of hospitalization (since randomization), weight loss, 24-hour natriuresis, length of stay in hospital, length of stay in the intensive care unit, 90-day any-cause death, 90-day cardiovascular death, 90-day death due to chronic HF decompensation or acute decompensated HF, the number of pleuro- and pericardiocentesis episodes during the hospitalization, scale for clinical condition assessment of HF patient (SHOKS) at discharge from the hospital, 6-minute walk test at discharge from the hospital. The planned follow-up duration is a hospital period with an assessment of the clinical picture and laboratory parameters. Telemedicine contact with patients is carried out after 14, 30 and 90 days using a structured questionnaire. Conclusion. Analysis of clinical, laboratory and echocardiographic parameters of patients using acetazolamide tablets will make it possible to determine the criteria for the effectiveness of diuretic therapy in patients with decompensated HF in the short and long term.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-06DOI: 10.15829/1560-4071-2023-5597
Yu. A. Karpov, N. A. Logunova, B. B. Kvasnikov, Yu. V. Khomitskaya
Aim. To describe the antihypertensive efficacy of triple fixeddose combination of amlodipine/indapamide/perindopril and assess the predictors of efficacy in young patients (<50 years). Material and methods. The TRICOLOR study (NCT03722524) is an observational prospective study (n=1247) that demonstrated high antihypertensive effectiveness and good tolerability of the triple singlepill combination (SPC) of amlodipine/ indapamide/perindopril. This subgroup analysis was performed on 199 patients aged <50 years (16% of the total population), and the comparison group consisted of 925 patients (82,3% of the total population) aged 50 years or older. Results. In young patients, during triple therapy with SPC amlodipine/indapa mide/perindopril, a positive trend in blood pressure (BP) reduction was observed compared to the baseline: an average decrease in BP after 12 weeks was 32,6 (11,0)/14,8 (8,5) mm Hg (p<0,0001), comparable to patients over 50 years of age in terms of reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) after 2, 4 and 12 weeks of followup. A greater number of young patients achieved a reduction in blood pressure <140/90 mm Hg after 2 weeks of therapy compared to patients 50 years of age and older (49,7% vs 38,8%, p=0,004), and blood pressure <130/80 mm Hg – after 4 and 12 weeks (51,3% vs 43,5% (p=0,041) and 74,9% vs 67,5% (p=0,038), respectively). Left ventricular hypertrophy was a significant negative predictor of SBP reduction by 12 weeks of therapy, and the presence of grade 2 hypertension (HTN) and statin use, on the contrary, were positive predictors of changes in SBP by the end of observation. More adherent younger patients were significantly more likely to have a decrease in DBP by 12 weeks of follow-up. In addition, in young patients, male sex and the presence of dyslipidemia significantly increased the chances of blood pressure control at the end of observation. Waist circumference, body mass index, and grade 2 HTN were negative predictors of achieving the target blood pressure level. Conclusion. Thus, in young patients, good antihypertensive effectiveness of amlodipine/indapamide/perindopril was observed, comparable in the degree of blood pressure reduction with the older age group of 50 years and older.
的目标。目的:观察氨氯地平/吲达帕胺/培哚普利三组固定剂量联合治疗年轻患者(50岁)的降压疗效，并评估其预测因素。材料和方法。TRICOLOR研究(NCT03722524)是一项观察性前瞻性研究(n=1247)，证明氨氯地平/吲达帕胺/培哚普利三联单丸组合(SPC)具有较高的降压效果和良好的耐受性。该亚组分析纳入199例50岁患者(占总人数的16%)，对照组包括925例50岁及以上患者(占总人数的82.3%)。结果。在年轻患者中，在SPC氨氯地平/吲达帕胺/培哚普利三联治疗期间，与基线相比，观察到血压(BP)降低的积极趋势:12周后血压平均下降为32,6 (11,0)/14,8 (8,5)mm Hg (p< 0.0001)，与50岁以上患者在2、4和12周后收缩压(SBP)和舒张压(DBP)的降低相当。与50岁及以上的患者相比，更多的年轻患者在治疗2周后血压降低了140/90 mm Hg (49.7% vs 38.8%， p= 0.004)，在4周和12周后血压降低了130/80 mm Hg (51.3% vs 43.5% (p= 0.041)和74.9% vs 67.5% (p= 0.038))。左心室肥厚是治疗12周时收缩压降低的显著阴性预测因子，相反，2级高血压(HTN)的存在和他汀类药物的使用是观察结束时收缩压变化的阳性预测因子。在12周的随访中，更坚持治疗的年轻患者更有可能出现舒张压下降。此外，在年轻患者中，男性和血脂异常的存在显著增加了观察结束时血压控制的机会。腰围、体重指数和2级HTN是达到目标血压水平的负预测因子。结论。因此，在年轻患者中，氨氯地平/吲达帕胺/培哚普利的降压效果良好，其降压程度与50岁及以上老年患者相当。
{"title":"New data from a subanalysis of the TRICOLOR study: antihypertensive effectiveness of the triple single-pill combination of amlodipine/indapamide/perindopril and predictors of effectiveness and blood pressure control in young patients","authors":"Yu. A. Karpov, N. A. Logunova, B. B. Kvasnikov, Yu. V. Khomitskaya","doi":"10.15829/1560-4071-2023-5597","DOIUrl":"https://doi.org/10.15829/1560-4071-2023-5597","url":null,"abstract":"Aim. To describe the antihypertensive efficacy of triple fixeddose combination of amlodipine/indapamide/perindopril and assess the predictors of efficacy in young patients (<50 years). Material and methods. The TRICOLOR study (NCT03722524) is an observational prospective study (n=1247) that demonstrated high antihypertensive effectiveness and good tolerability of the triple singlepill combination (SPC) of amlodipine/ indapamide/perindopril. This subgroup analysis was performed on 199 patients aged <50 years (16% of the total population), and the comparison group consisted of 925 patients (82,3% of the total population) aged 50 years or older. Results. In young patients, during triple therapy with SPC amlodipine/indapa mide/perindopril, a positive trend in blood pressure (BP) reduction was observed compared to the baseline: an average decrease in BP after 12 weeks was 32,6 (11,0)/14,8 (8,5) mm Hg (p<0,0001), comparable to patients over 50 years of age in terms of reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) after 2, 4 and 12 weeks of followup. A greater number of young patients achieved a reduction in blood pressure <140/90 mm Hg after 2 weeks of therapy compared to patients 50 years of age and older (49,7% vs 38,8%, p=0,004), and blood pressure <130/80 mm Hg – after 4 and 12 weeks (51,3% vs 43,5% (p=0,041) and 74,9% vs 67,5% (p=0,038), respectively). Left ventricular hypertrophy was a significant negative predictor of SBP reduction by 12 weeks of therapy, and the presence of grade 2 hypertension (HTN) and statin use, on the contrary, were positive predictors of changes in SBP by the end of observation. More adherent younger patients were significantly more likely to have a decrease in DBP by 12 weeks of follow-up. In addition, in young patients, male sex and the presence of dyslipidemia significantly increased the chances of blood pressure control at the end of observation. Waist circumference, body mass index, and grade 2 HTN were negative predictors of achieving the target blood pressure level. Conclusion. Thus, in young patients, good antihypertensive effectiveness of amlodipine/indapamide/perindopril was observed, comparable in the degree of blood pressure reduction with the older age group of 50 years and older.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-05DOI: 10.15829/1560-4071-2023-5593
E. V. Shlyakhto, Yu. N. Belenkov, S. A. Boytsov, S. V. Villevalde, A. S. Galyavich, N. G. Glezer, N. E. Zvartau, Zh. D. Kobalava, Yu. M. Lopatin, V. Yu. Mareev, S. N. Tereshchenko, I. V. Fomin, O. L. Barbarash, N. G. Vinogradova, D. V. Duplyakov, I. V. Zhirov, E. D. Kosmacheva, V. A. Nevzorova, O. M. Reitblat, A. E. Solovieva, E. A. Zorina
Aim. To describe demographic and clinical laboratory characteristics, concomitant diseases and drug therapy of outpatients with heart failure (HF) in the Russian Federation. Material and methods. An interim analysis of a prospective observational multicenter registry study of patients with chronic heart failure in the Russian Federation ("PRIORITET-CHF") was performed. The study included outpatients with HF followed by a general practitioner or cardiologist. Results. Data from 6255 patients were analyzed (31,3% of the study sample; median age, 65 years; men, 65%). HF with reduced ejection fraction (HFrEF) was diagnosed in 42,4%, HF with preserved EF — in 31,9%. In addition, 57,4% of patients were characterized by NYHA class II HF. The most common causes of HF were hypertension, coronary artery disease, and atrial fibrillation or flutter. Of the concomitant diseases, doctors most often reported chronic kidney disease (CKD) (43,2%), obesity (37,8%) and diabetes (26,7%) in HF. Conclusion. In the Russian Federation, among outpatients with HF, there was domination of men, HFrEF phenotype, NYHA class II. The relatively young mean age and frequent associations of HF with cardiovascular risk factors and diseases underscore the importance of timely prevention initiatives. The identified high proportion of patients with CKD requires special attention and separate analysis. Despite the relatively high prescription rate of certain classes of diseasemodifying therapy for HF, the prescription of optimal quadruple therapy and electrophysiological treatments for HFrEF is insufficient.
{"title":"Interim analysis of a prospective observational multicenter registry study of patients with chronic heart failure in the Russian Federation \"PRIORITET-CHF\": initial characteristics and treatment of the first included patients","authors":"E. V. Shlyakhto, Yu. N. Belenkov, S. A. Boytsov, S. V. Villevalde, A. S. Galyavich, N. G. Glezer, N. E. Zvartau, Zh. D. Kobalava, Yu. M. Lopatin, V. Yu. Mareev, S. N. Tereshchenko, I. V. Fomin, O. L. Barbarash, N. G. Vinogradova, D. V. Duplyakov, I. V. Zhirov, E. D. Kosmacheva, V. A. Nevzorova, O. M. Reitblat, A. E. Solovieva, E. A. Zorina","doi":"10.15829/1560-4071-2023-5593","DOIUrl":"https://doi.org/10.15829/1560-4071-2023-5593","url":null,"abstract":"Aim. To describe demographic and clinical laboratory characteristics, concomitant diseases and drug therapy of outpatients with heart failure (HF) in the Russian Federation. Material and methods. An interim analysis of a prospective observational multicenter registry study of patients with chronic heart failure in the Russian Federation (\"PRIORITET-CHF\") was performed. The study included outpatients with HF followed by a general practitioner or cardiologist. Results. Data from 6255 patients were analyzed (31,3% of the study sample; median age, 65 years; men, 65%). HF with reduced ejection fraction (HFrEF) was diagnosed in 42,4%, HF with preserved EF — in 31,9%. In addition, 57,4% of patients were characterized by NYHA class II HF. The most common causes of HF were hypertension, coronary artery disease, and atrial fibrillation or flutter. Of the concomitant diseases, doctors most often reported chronic kidney disease (CKD) (43,2%), obesity (37,8%) and diabetes (26,7%) in HF. Conclusion. In the Russian Federation, among outpatients with HF, there was domination of men, HFrEF phenotype, NYHA class II. The relatively young mean age and frequent associations of HF with cardiovascular risk factors and diseases underscore the importance of timely prevention initiatives. The identified high proportion of patients with CKD requires special attention and separate analysis. Despite the relatively high prescription rate of certain classes of diseasemodifying therapy for HF, the prescription of optimal quadruple therapy and electrophysiological treatments for HFrEF is insufficient.","PeriodicalId":21389,"journal":{"name":"Russian Journal of Cardiology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135368844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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