Saudi Journal of Medicine & Medical Sciences最新文献

英文中文

Sarcopenia of Ageing: Does a Healthier Lifestyle Matter in Reversing the Trajectory? A Brief Narrative Review and a Call for Action in Saudi Arabia. 老年性肌肉疏松症：更健康的生活方式对扭转这一轨迹重要吗？沙特阿拉伯的简要回顾和行动呼吁。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI: 10.4103/sjmms.sjmms_54_23

Abdullah F Alghannam, Dalal S Alharbi, Hazzaa M Al-Hazzaa

The concept of health span is an emerging topic in recent years, with a truly palpable relevance to public health. With ageing comes a loss of skeletal muscle mass, strength, and performance, which is termed as sarcopenia. Sarcopenia is a major public health concern and poses a challenge to health-care systems. Modifiable lifestyle factors may be linked to the course of sarcopenia progression. Many countries developed diagnostic tools to accurately detect sarcopenia for its prevention, delay, or treatment. However, to date, there is no sufficient information regarding the status of sarcopenia in Saudi Arabia. The review aims to discuss sarcopenia and relevant updates in research and literature, the association with modifiable lifestyle factors, the implications of sarcopenia in a rapidly developing country such as Saudi Arabia, and the current state and need for research in Saudi Arabia in this domain along with future directions in combating this disease.

健康寿命的概念是近年来的一个新兴话题，与公共卫生有着切实的关系。随着年龄的增长，骨骼肌的质量、力量和性能都会下降，这就是所谓的 "肌肉疏松症"。肌肉疏松症是一个重大的公共卫生问题，对医疗保健系统构成挑战。可改变的生活方式因素可能与肌肉疏松症的发展过程有关。许多国家开发了诊断工具，以准确检测肌肉疏松症，从而预防、延缓或治疗肌肉疏松症。然而，迄今为止，还没有关于沙特阿拉伯肌肉疏松症现状的充足信息。本综述旨在讨论肌肉疏松症及相关研究和文献的最新进展、与可改变的生活方式因素的关联、肌肉疏松症对沙特阿拉伯这样一个快速发展国家的影响、沙特阿拉伯在这一领域的研究现状和需求，以及防治这一疾病的未来方向。

引用次数: 0

Response: Video-EEG Monitoring and Cerebral Imaging are Mandatory in Patients with Functional Seizures. 回应：功能性癫痫发作患者必须接受视频脑电图监控和脑成像。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI: 10.4103/sjmms.sjmms_509_23

Hussain Alyami

引用次数: 0

Video-electroencephalography Monitoring and Cerebral Imaging are Mandatory in Patients with Functional Seizures. 功能性癫痫发作患者必须接受视频脑电图监测和脑成像。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI: 10.4103/sjmms.sjmms_413_23

Josef Finsterer

引用次数: 0

Lipid Management in Kidney Transplant Recipients Per KDIGO and American Heart Association Guidelines: A Single-Center Experience. 根据 KDIGO 和美国心脏协会指南对肾移植受者进行血脂管理：单中心经验

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI: 10.4103/sjmms.sjmms_95_23

Ziad Arabi, Mohammed Tawhari, Abdullah Ashour Alghamdi, Ahmad Alnasrullah

Background: The 2013 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommends statin treatment for all adult kidney transplant recipients (KTRs), except those aged <30 years of age and without prior cardiovascular risk factors (CVRF), but does not specify on-treatment low-density lipoprotein cholesterol (LDL) target levels. The 2018 American Heart Association (AHA) guidelines addressed the management of hyperlipidemia in the general population based on an individualized approach of the CVRF with a specific on-treatment LDL target.

Objective: To analyze dyslipidemia management according to the recommendations of the KDIGO and AHA guidelines.

Methods: This retrospective study included all KTRs who underwent transplantation between January 2017 and May 2020 at King Abdulaziz Medical Center, Riyadh, Saudi Arabia. The rate of statins prescription in general, rate of statins prescription among KTRs per their CVRF, and rate of achieving the proposed LDL goals, as defined by the AHA, were analyzed.

Results: A total of 287 KTRs were included. Of the 214 (74.6%) patients aged ≥30 years, 80% received a statin. Statins were prescribed in 93% and 96% of KTRs with diabetes or coronary artery disease, respectively. In patients aged ≥30 years, LDL targets, per AHA guidelines, were achieved in 62% with a target of 2.6 mmol/l, and in 19% with a target of 1.8 mmol/l. Statin therapy resulted in non-significant changes in the mean LDL values from baseline to 12 months after transplantation (P = 0.607), even when only patients prescribed statin after transplantation were included (P = 0.34).

Conclusion: By applying the KDIGO guidelines, a high rate of statin prescriptions was achieved among KTRs with multiple CVRF and KTRs in general. However, a significant proportion of these KTRs did not achieve the LDL targets proposed by the AHA guidelines, suggesting that higher-intensity statins would be required to achieve these targets.

背景介绍2013 年肾脏病：改善全球结果（KDIGO）指南建议所有成年肾移植受者（KTR）均应接受他汀类药物治疗，但年龄较大者除外：分析根据 KDIGO 和 AHA 指南建议进行的血脂异常管理：这项回顾性研究纳入了2017年1月至2020年5月期间在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗中心接受移植手术的所有KTR。研究分析了他汀类药物的总体处方率、KTR根据其CVRF开具他汀类药物处方的比率以及达到AHA规定的低密度脂蛋白目标的比率：结果：共纳入 287 名 KTR。在 214 名（74.6%）年龄≥30 岁的患者中，80% 接受了他汀类药物治疗。在患有糖尿病或冠心病的 KTR 中，分别有 93% 和 96% 的患者服用了他汀类药物。在年龄≥30 岁的患者中，根据 AHA 指南，62% 的患者低密度脂蛋白目标值为 2.6 毫摩尔/升，19% 的患者目标值为 1.8 毫摩尔/升。他汀类药物治疗导致平均低密度脂蛋白值从基线到移植后12个月的变化不显著（P = 0.607），即使只包括移植后服用他汀类药物的患者（P = 0.34）也是如此：结论：通过应用 KDIGO 指南，具有多个 CVRF 的 KTR 和一般 KTR 的他汀类药物处方率较高。结论：通过应用 KDIGO 指南，具有多个 CVRF 的 KTR 和一般 KTR 的他汀类药物处方率较高，但这些 KTR 中有相当一部分没有达到 AHA 指南提出的低密度脂蛋白目标，这表明要达到这些目标需要更高强度的他汀类药物。

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引用次数: 0

Thrombolytic Therapy in Strokes: A Retrospective Clinical Data Analysis of 40 Patients in a 7-Year Period: The Experience of a Greek Internal Medicine Department 脑卒中的溶栓治疗:对7年40例患者的回顾性临床数据分析:希腊内科的经验

Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2023-11-06 DOI: 10.36348/sjm.2023.v08i11.001

Athina Myrou, Anthoula Tsolaki, Thomas Tegos, Christos Savopoulos

Stroke is one of the main causes of mortality and disability in developed countries. In acute ischemic stroke, the standard treatment is recombinant tissue plasminogen activator (rt-PA). The benefits of the treatment depend on the time of administration, the earlier it is administered, the greater its benefit. There are limited studies on the retrospective outcome of thrombolytic therapy in patients with acute ischemic stroke outside of clinical trials. The present retrospective study aimed to analyze the clinical data of 40 patients over 7 years who were hospitalized with acute ischemic stroke at the AHEPA University Hospital in Greece. From January 2013 to December 2020, 40 patients with acute ischemic stroke were admitted and treated. Computed tomography (CT) was performed at 24 h after thrombolytic treatment or earlier in case of neurological worsening. The hospital had 3 months follow-up at the stroke clinic and data consisting of the National Institute of Health Stroke Scale (NIHSS), functional outcome assessed by modified Rankin Scale (mRS) and mortality were reviewed in the medical records from the stroke clinic. The clinical outcome of functional independence defined by the modified Rankin Scale (mRS) ≤ 2 at 3 months was evaluated. Safety outcomes were in-hospital mortality, mortality at 3 months, and symptomatic intracerebral hemorrhage (sICH) defined by the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) criteria. The main finding of the present study, that there was an overall reduction in the NIHSS scale after thrombolysis, proves that the patients showed improvement after performing thrombolysis. Consequently, from the total of 40 thrombolysis performed at the clinic, it can be concluded that most patients had a good outcome.

中风是发达国家造成死亡和残疾的主要原因之一。急性缺血性卒中的标准治疗是重组组织型纤溶酶原激活剂(rt-PA)。治疗的好处取决于给药的时间，越早给药，好处越大。在临床试验之外，关于急性缺血性卒中患者溶栓治疗的回顾性结果的研究有限。本回顾性研究旨在分析在希腊AHEPA大学医院住院的40例7年以上急性缺血性脑卒中患者的临床资料。2013年1月至2020年12月共收治急性缺血性脑卒中患者40例。在溶栓治疗后24小时或在神经系统恶化的情况下更早进行计算机断层扫描(CT)。本院卒中门诊随访3个月，资料包括国立卫生研究院卒中量表(NIHSS)、修正Rankin量表(mRS)评估的功能结局和卒中门诊病死率。3个月时以改良Rankin量表(mRS)≤2定义的功能独立性临床结局进行评估。安全性结果是住院死亡率、3个月死亡率和卒中监测研究(sit - most)中安全实施溶栓标准定义的症状性脑出血(sICH)。本研究的主要发现是溶栓后NIHSS量表整体下降，证明溶栓后患者病情有所改善。因此，从临床共进行的40例溶栓手术中，可以得出结论，大多数患者预后良好。

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引用次数: 0

Case Report of Numb Chin Syndrome (NCS) in Sickle Cell Disease (SCD) 镰状细胞病(SCD)伴麻木颏综合征1例报告

Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2023-10-19 DOI: 10.36348/sjm.2023.v08i10.005

Omar Basubrain

Numb chin syndrome is a rare presentation due to injury to mental nerve characterized by numbness, hypoesthesia, and paresthesia. This syndrome is mostly presented with dental interventions, traumatic injuries, or malignant pathologies. We report a unique case of a 20-year-old male diagnosed with sickle cell disease presented with loss of sensation over right chin area secondary to the vaso-occlusive crisis. This case depicts a complex relationship between neurological complications and hemoglobinopathies of SCD.

颏麻木综合征是一种罕见的表现，由于精神神经损伤，其特点是麻木，感觉不足，和感觉异常。这种综合征主要表现为牙科干预、创伤性损伤或恶性病变。我们报告一个独特的情况下，20岁的男性诊断为镰状细胞病提出感觉丧失在右下巴区域继发血管闭塞危机。本病例描述了SCD的神经并发症和血红蛋白病之间的复杂关系。

引用次数: 0

Disease X: Are we Ready to Tackle the Next Global Pandemic Again? X疾病:我们准备好再次应对下一次全球大流行了吗?

Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2023-10-17 DOI: 10.36348/sjm.2023.v08i10.004

Rahul shil, Shreyasee Das

引用次数: 0

Health Care Associated Infective Endocarditis in Hemodialysis: More than Just Valve Infection- A Case Series 血液透析中保健相关的感染性心内膜炎:不仅仅是瓣膜感染-一个病例系列

Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2023-10-15 DOI: 10.36348/sjm.2023.v08i10.003

Devanath, D, Prashant G. Kedlaya, Jairam, A, Renuka Renuka, Shashank S. Dhareshwar

Cardiovascular diseases and infections are the two main causes of mortality in Hemodialysis patients [1, 6]. Health care associated infective endocarditis among them carries higher morbidity and mortality. The following is a case series of 3 Enterococcal endocarditis in HD patients and our experience in the management.

心血管疾病和感染是导致血液透析患者死亡的两大主要原因[1,6]。其中与卫生保健相关的感染性心内膜炎具有较高的发病率和死亡率。以下是3例HD患者肠球菌性心内膜炎的病例系列和我们的治疗经验。

引用次数: 0

Unusual Presentation of Rhabdomyolysis & Acute Kidney Injury in a Young Patient with Associated Pancreatitis of Un-Known Etiology 横纹肌溶解症的特殊表现急性肾损伤的年轻患者合并不明原因的胰腺炎

Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2023-10-15 DOI: 10.36348/sjm.2023.v08i10.002

Arif Noormohammed Thekiya, Ahmed Salah Eid, Aalya Mohamed, Magdoleen Ibrahim A. Sabbah, Ali Aziz, Waleed H. Flayyih, Sameh Mohamed, Rehan Ahmed, Alaa Bbiker M. Ahmed

A case of 41-year-old patient presented with left lower leg cellulitis, laboratory investigations showed elevated CK levels of more than 193000 U/L, high pancreatic enzymes level namely amylase & lipase, significant electrolyte and acid base abnormalities. Diagnosis of Rhabdomyolysis made based on CK level results in acute pancreatitis. This patient developed acute renal failure with all above in mind, he stayed inpatient for 19 days. The purpose of this case report is to highlight the unusually high CK with unusual association of acute pancreatitis leading to rhabdo¬myolysis and the associated morbidity.

1例41岁左下肢蜂窝组织炎患者，实验室检查显示CK升高193000 U/L以上，胰酶即淀粉酶高;脂肪酶，明显的电解质和酸碱异常。基于CK水平诊断急性胰腺炎横纹肌溶解。考虑到上述情况，该患者发生急性肾衰竭，住院19天。本病例报告的目的是强调异常高CK与急性胰腺炎导致横纹肌溶解和相关发病率的异常关联。

引用次数: 0

Hiccups of Neurological Origin: A Case Report 神经性打嗝1例报告

Q2 MEDICINE, GENERAL & INTERNAL

Saudi Journal of Medicine & Medical Sciences

Pub Date : 2023-10-11 DOI: 10.36348/sjm.2023.v08i10.001

Y. Aroudam, N. Benzoubeir, I. Errabih, H. El Bacha

Hiccups are most often benign and short-lived, but they can also be persistent (> 48h) or even refractory (> 1 month). In these cases, it impairs qualitý of life and can have serious health consequences. We report the case of a patient who consulted for chronic hiccups with absences and in whom the neurological origin was confirmed on brain MRI.

打嗝通常是良性和短暂的，但也可能是持续性的(>48h)甚至耐火(>1个月)。在这些情况下，它会损害qualitý的生命，并可能产生严重的健康后果。我们报告的情况下，病人谁咨询慢性打嗝缺席，并在脑MRI证实了神经起源。

引用次数: 0

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