首页 > 最新文献

Romanian Journal of Internal Medicine最新文献

英文 中文
Early mortality in acute promyelocytic leukemia - a single center experience. 急性早幼粒细胞白血病的早期死亡率--单个中心的经验。
IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-24 Print Date: 2024-12-01 DOI: 10.2478/rjim-2024-0025
Andreea Spînu, Iuliana Iordan, Minodora Onisâi, Cristina Mambet, Raluca Nistor, Ana-Maria Vlădăreanu
{"title":"Early mortality in acute promyelocytic leukemia - a single center experience.","authors":"Andreea Spînu, Iuliana Iordan, Minodora Onisâi, Cristina Mambet, Raluca Nistor, Ana-Maria Vlădăreanu","doi":"10.2478/rjim-2024-0025","DOIUrl":"10.2478/rjim-2024-0025","url":null,"abstract":"","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"371-373"},"PeriodicalIF":1.6,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship of visceral adiposity with endothelial functions and subclinical atherosclerosis in obese individuals. 内脏脂肪与肥胖者内皮功能和亚临床动脉粥样硬化的关系。
IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-09 Print Date: 2024-12-01 DOI: 10.2478/rjim-2024-0024
Merve Polat Kose, Mehmet Emin Piskinpasa, Yalcin Hacioglu, Turgut Karabag

Introduction: On the cardiovascular system, obesity accelerates atherosclerosis progression, inducing pathophysiological changes that are detectable already from young adults. Endothelial dysfunction is one of the earliest vascular alterations observed in obesity. In this study, we aimed to determine endothelial functions and carotid intima-media thickness in patients with obesity without overt cardiovascular disease.

Methods: The study was conducted with 112 individuals with obesity without overt cardiovascular disease and any chronical diseases (BMI>30 kg/m2) (84 female, 28 male, mean age: 46.3±11.2 years) and 49 healthy individuals with no diseases (33 female, 16 male, mean age: 44.6±10.2 years). All patients were examined for endothelial functions by the flow-mediated dilatation (FMD) method and carotid intima-media thicknesses (CIMT). All measurements were performed by the same imaging specialist, averaging 3 different measurements. In addition to the body mass index and waist circumference visceral adiposity index (VAI) and triponderal mass index (TPI) also calculated.

Results: The percentage of FMD obtained by brachial artery ultrasound was significantly lower, visceral adipose tissue, perirenal adipose tissue thicknesses measured by abdominal ultrasound and CIMT were significantly thicker in Group 1 compared to Group 2. FMD had a negative significant correlation with body mass index, visceral adipose tissue thickness, perirenal adipose tissue thickness, and waist and hip circumferences, and carotid intima-media thickness and CIMT had a significant correlation with visceral adipose tissue thickness, perirenal adipose tissue thickness, VAI, TPI and waist, hip circumferences.

Conclusion: Individuals with obesity have impaired endothelial functions and greater carotid intima-media thicknesses compared to healthy individuals. This impairment in endothelial functions is proportional to the amount of visceral and perirenal fat accumulation. Parameterss reflecting visceral fat distribution such as VAI and TPI are also related with these impairment.

引言在心血管系统中,肥胖会加速动脉粥样硬化的发展,诱发从青壮年时期就能发现的病理生理变化。内皮功能障碍是肥胖症最早出现的血管变化之一。在这项研究中,我们旨在确定无明显心血管疾病的肥胖症患者的内皮功能和颈动脉内膜中层厚度:研究对象为 112 名无明显心血管疾病和任何慢性疾病的肥胖症患者(BMI>30 kg/m2)(84 名女性,28 名男性,平均年龄(46.3±11.2)岁)和 49 名无疾病的健康人(33 名女性,16 名男性,平均年龄(44.6±10.2)岁)。所有患者都通过血流介导扩张(FMD)法和颈动脉内膜中层厚度(CIMT)检查了内皮功能。所有测量均由同一影像专家进行,取 3 次不同测量的平均值。除了体重指数和腰围外,还计算了内脏脂肪指数(VAI)和三叉神经质量指数(TPI):结果:与第 2 组相比,第 1 组通过肱动脉超声获得的 FMD 百分比明显较低,通过腹部超声和 CIMT 测量的内脏脂肪组织和肾周脂肪组织厚度明显较厚。FMD 与体重指数、内脏脂肪组织厚度、肾周脂肪组织厚度、腰围和臀围呈显著负相关,而颈动脉内膜厚度和 CIMT 与内脏脂肪组织厚度、肾周脂肪组织厚度、VAI、TPI 以及腰围和臀围呈显著相关:结论:与健康人相比,肥胖症患者的内皮功能受损,颈动脉内膜中层厚度增大。内皮功能受损与内脏和肾周脂肪堆积量成正比。反映内脏脂肪分布的参数(如 VAI 和 TPI)也与这些损伤有关。
{"title":"The relationship of visceral adiposity with endothelial functions and subclinical atherosclerosis in obese individuals.","authors":"Merve Polat Kose, Mehmet Emin Piskinpasa, Yalcin Hacioglu, Turgut Karabag","doi":"10.2478/rjim-2024-0024","DOIUrl":"10.2478/rjim-2024-0024","url":null,"abstract":"<p><strong>Introduction: </strong>On the cardiovascular system, obesity accelerates atherosclerosis progression, inducing pathophysiological changes that are detectable already from young adults. Endothelial dysfunction is one of the earliest vascular alterations observed in obesity. In this study, we aimed to determine endothelial functions and carotid intima-media thickness in patients with obesity without overt cardiovascular disease.</p><p><strong>Methods: </strong>The study was conducted with 112 individuals with obesity without overt cardiovascular disease and any chronical diseases (BMI>30 kg/m<sup>2</sup>) (84 female, 28 male, mean age: 46.3±11.2 years) and 49 healthy individuals with no diseases (33 female, 16 male, mean age: 44.6±10.2 years). All patients were examined for endothelial functions by the flow-mediated dilatation (FMD) method and carotid intima-media thicknesses (CIMT). All measurements were performed by the same imaging specialist, averaging 3 different measurements. In addition to the body mass index and waist circumference visceral adiposity index (VAI) and triponderal mass index (TPI) also calculated.</p><p><strong>Results: </strong>The percentage of FMD obtained by brachial artery ultrasound was significantly lower, visceral adipose tissue, perirenal adipose tissue thicknesses measured by abdominal ultrasound and CIMT were significantly thicker in Group 1 compared to Group 2. FMD had a negative significant correlation with body mass index, visceral adipose tissue thickness, perirenal adipose tissue thickness, and waist and hip circumferences, and carotid intima-media thickness and CIMT had a significant correlation with visceral adipose tissue thickness, perirenal adipose tissue thickness, VAI, TPI and waist, hip circumferences.</p><p><strong>Conclusion: </strong>Individuals with obesity have impaired endothelial functions and greater carotid intima-media thicknesses compared to healthy individuals. This impairment in endothelial functions is proportional to the amount of visceral and perirenal fat accumulation. Parameterss reflecting visceral fat distribution such as VAI and TPI are also related with these impairment.</p>","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"404-413"},"PeriodicalIF":1.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Efficacy of Microwave versus Radiofrequency Ablation in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis of Randomized-Controlled Trials. 微波消融术与射频消融术在肝细胞癌中的疗效比较:随机对照试验的系统回顾和元分析。
IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-21 Print Date: 2024-12-01 DOI: 10.2478/rjim-2024-0022
Imelda Rey, Darmadi Darmadi

Introduction: Hepatocellular carcinoma (HCC) is a leading global cause of cancer-related deaths. Thermal ablation techniques, especially radiofrequency ablation (RFA) and microwave ablation (MWA), have become pivotal treatments for HCC. This systematic review and meta-analysis aim to compare these modalities, highlighting their efficacy, strengths, and limitations in treating HCC. Methods: A comprehensive literature search was conducted across major databases (PubMed, MEDLINE, Springer, ProQuest, EBSCOhost, Cochrane, and EMBASE) targeting studies on hepatocellular carcinoma with RFA and MWA. Heterogeneity analyses and pooled outcomes using random-effect models with were evaluated to compare both thermal ablation methods. Results: Nine studies, which consists of 368 patients underwent RFA and 387 patients underwent MWA, were included in review. The findings showed no significant differences in pooled analysis of volume of ablation, complete ablation rate, local tumor progression, survival rates, major complications, and adverse events. Subgroup analysis showed significantly higher risk of local tumor progression in RFA in African populations. Conclusion: No statistically significant difference was seen between outcomes across studies. MWA may offer a potential for longer therapeutic response with comparable risk of complications and adverse outcomes.

简介肝细胞癌(HCC)是全球癌症相关死亡的主要原因。热消融技术,尤其是射频消融(RFA)和微波消融(MWA),已成为治疗 HCC 的关键方法。本系统综述和荟萃分析旨在对这些方法进行比较,突出它们在治疗 HCC 方面的疗效、优势和局限性。方法:我们在主要数据库(PubMed、MEDLINE、Springer、ProQuest、EBSCOhost、Cochrane 和 EMBASE)中进行了全面的文献检索,以使用 RFA 和 MWA 治疗肝细胞癌的研究为目标。使用随机效应模型对异质性分析和汇总结果进行了评估,以比较两种热消融方法。结果:共纳入 9 项研究,包括 368 名接受 RFA 的患者和 387 名接受 MWA 的患者。研究结果显示,在消融量、完全消融率、局部肿瘤进展、生存率、主要并发症和不良事件的汇总分析中,两者无明显差异。亚组分析显示,非洲裔人群接受 RFA 的局部肿瘤进展风险明显更高。结论:各项研究的结果在统计学上没有明显差异。MWA 有可能在并发症和不良反应风险相当的情况下延长治疗反应时间。
{"title":"Comparative Efficacy of Microwave versus Radiofrequency Ablation in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis of Randomized-Controlled Trials.","authors":"Imelda Rey, Darmadi Darmadi","doi":"10.2478/rjim-2024-0022","DOIUrl":"10.2478/rjim-2024-0022","url":null,"abstract":"<p><p><b>Introduction</b>: Hepatocellular carcinoma (HCC) is a leading global cause of cancer-related deaths. Thermal ablation techniques, especially radiofrequency ablation (RFA) and microwave ablation (MWA), have become pivotal treatments for HCC. This systematic review and meta-analysis aim to compare these modalities, highlighting their efficacy, strengths, and limitations in treating HCC. <b>Methods</b>: A comprehensive literature search was conducted across major databases (PubMed, MEDLINE, Springer, ProQuest, EBSCOhost, Cochrane, and EMBASE) targeting studies on hepatocellular carcinoma with RFA and MWA. Heterogeneity analyses and pooled outcomes using random-effect models with were evaluated to compare both thermal ablation methods. <b>Results</b>: Nine studies, which consists of 368 patients underwent RFA and 387 patients underwent MWA, were included in review. The findings showed no significant differences in pooled analysis of volume of ablation, complete ablation rate, local tumor progression, survival rates, major complications, and adverse events. Subgroup analysis showed significantly higher risk of local tumor progression in RFA in African populations. <b>Conclusion</b>: No statistically significant difference was seen between outcomes across studies. MWA may offer a potential for longer therapeutic response with comparable risk of complications and adverse outcomes.</p>","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"374-386"},"PeriodicalIF":1.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilization of Probiotics in Relieving Post-Colonoscopy Gastrointestinal Symptoms: A Systematic Review and Meta-Analysis. 利用益生菌缓解结肠镜检查后的胃肠道症状:系统回顾与元分析》。
IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-18 Print Date: 2024-12-01 DOI: 10.2478/rjim-2024-0023
Virly Nanda Muzellina, Steven Alvianto, Nicolas Daniel Widjanarko

Introduction: Colonoscopy is regarded as a safe diagnostic and therapeutic procedure, nevertheless, some patients may still encounter post-colonoscopy gastrointestinal symptoms. This study aimed to evaluate the utilization of probiotics before and after colonoscopy to relieve those symptoms.

Methodology: This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Included studies were all interventional studies examining the effects of probiotics use before and after colonoscopy. Articles were retrieved from MEDLINE, EBSCO-Host, Cochrane, ProQuest, and Google Scholar electronic databases, utilized specific keywords ( " Probiotic " OR " Probiotics ") AND (" Colonoscopy " OR " Colonoscopies "). The Cochrane Risk of Bias (RoB) 2 and Joanna Briggs Institute (JBI) Critical Appraisal tools were used for study quality assessment, as well as Review Manager (RevMan) 5.4 to perform the meta-analysis.

Results: A total of ten studies were included in this systematic review. Six studies assessed the effect of probiotics consumption after colonoscopy, three examined the impact before colonoscopy, and one study assessed both. The most common type of probiotics used were Lactobacillus and Bifidobacterium. Quantitative synthesis of probiotics before colonoscopy showed no significant differences among bloating, abdominal pain, nausea, and vomiting symptoms (p=0.49, p=0.14, p=0.30, and p=0.42, respectively). Similarly, quantitative synthesis of probiotics after colonoscopy showed no significant differences in bloating and abdominal pain (p=0.16 and p=0.63, respectively).

Conclusions: Probiotic administration pre- and post-colonoscopy exhibited preliminary evidence for reducing gastrointestinal symptoms, but a quantitative synthesis revealed non-significant findings, necessitating further investigations.

简介:结肠镜检查被认为是一种安全的诊断和治疗方法:结肠镜检查被认为是一种安全的诊断和治疗方法,但一些患者在结肠镜检查后仍可能出现胃肠道症状。本研究旨在评估结肠镜检查前后使用益生菌缓解这些症状的情况:本研究采用《系统综述和荟萃分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analysis, PRISMA)2020 指南进行。纳入的研究均为检查结肠镜检查前后使用益生菌效果的干预性研究。文章从 MEDLINE、EBSCO-Host、Cochrane、ProQuest 和 Google Scholar 电子数据库中检索,使用特定关键词("益生菌 "或 "益生菌")和("结肠镜检查 "或 "结肠镜检查")。使用 Cochrane Risk of Bias (RoB) 2 和 Joanna Briggs Institute (JBI) Critical Appraisal 工具进行研究质量评估,并使用 Review Manager (RevMan) 5.4 进行荟萃分析:本系统综述共纳入十项研究。其中六项研究评估了结肠镜检查后服用益生菌的效果,三项研究探讨了结肠镜检查前服用益生菌的影响,一项研究对两者都进行了评估。最常用的益生菌是乳酸杆菌和双歧杆菌。结肠镜检查前定量合成益生菌的结果显示,腹胀、腹痛、恶心和呕吐症状之间没有显著差异(分别为 p=0.49、p=0.14、p=0.30 和 p=0.42)。同样,结肠镜检查后益生菌的定量合成显示,腹胀和腹痛症状无明显差异(分别为 p=0.16 和 p=0.63):结论:在结肠镜检查前后服用益生菌可减轻胃肠道症状的初步证据,但定量综合结果显示并无显著差异,因此有必要进行进一步研究。
{"title":"Utilization of Probiotics in Relieving Post-Colonoscopy Gastrointestinal Symptoms: A Systematic Review and Meta-Analysis.","authors":"Virly Nanda Muzellina, Steven Alvianto, Nicolas Daniel Widjanarko","doi":"10.2478/rjim-2024-0023","DOIUrl":"10.2478/rjim-2024-0023","url":null,"abstract":"<p><strong>Introduction: </strong>Colonoscopy is regarded as a safe diagnostic and therapeutic procedure, nevertheless, some patients may still encounter post-colonoscopy gastrointestinal symptoms. This study aimed to evaluate the utilization of probiotics before and after colonoscopy to relieve those symptoms.</p><p><strong>Methodology: </strong>This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Included studies were all interventional studies examining the effects of probiotics use before and after colonoscopy. Articles were retrieved from MEDLINE, EBSCO-Host, Cochrane, ProQuest, and Google Scholar electronic databases, utilized specific keywords <i>(</i> <i>\"</i> <i>Probiotic</i> <i>\" OR \"</i> <i>Probiotics</i> <i>\"</i>) <i>AND</i> (<i>\"</i> <i>Colonoscopy</i> <i>\" OR \"</i> <i>Colonoscopies</i> <i>\"</i>). The Cochrane Risk of Bias (RoB) 2 and Joanna Briggs Institute (JBI) Critical Appraisal tools were used for study quality assessment, as well as Review Manager (RevMan) 5.4 to perform the meta-analysis.</p><p><strong>Results: </strong>A total of ten studies were included in this systematic review. Six studies assessed the effect of probiotics consumption after colonoscopy, three examined the impact before colonoscopy, and one study assessed both. The most common type of probiotics used were <i>Lactobacillus</i> and <i>Bifidobacterium</i>. Quantitative synthesis of probiotics before colonoscopy showed no significant differences among bloating, abdominal pain, nausea, and vomiting symptoms (p=0.49, p=0.14, p=0.30, and p=0.42, respectively). Similarly, quantitative synthesis of probiotics after colonoscopy showed no significant differences in bloating and abdominal pain (p=0.16 and p=0.63, respectively).</p><p><strong>Conclusions: </strong>Probiotic administration pre- and post-colonoscopy exhibited preliminary evidence for reducing gastrointestinal symptoms, but a quantitative synthesis revealed non-significant findings, necessitating further investigations.</p>","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"387-403"},"PeriodicalIF":1.6,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIV and kidney transplantation in Romania: The index case. 罗马尼亚的艾滋病毒与肾移植:索引案例。
IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-07 Print Date: 2024-09-01 DOI: 10.2478/rjim-2024-0020
Bogdan Marian Sorohan, Gener Ismail, Cristiana Oprea, Dorina Tacu, Ileana Constantinescu, Liliana Domnișor, Ionuț Manea, Ioanel Sinescu, Cătălin Baston

Introduction: Human immunodeficiency virus (HIV) is no longer considered a contraindication for kidney transplantation (KT). KT management in HIV patients is a complex process with challenges, such as drug interactions between immunosuppression and antiretroviral (ARV) therapy. In our country, no KT has been performed thus far in this category of patients.

Case presentation: We present the case of a 29-year-old female patient with HIV and end-stage renal disease (ESRD) who performed a KT from a related living donor in March 2022. KT immediate evolution was favorable. No transplant-related complications were reported. HIV viral load remained undetectable and CD4+ T cells were constantly > 500 cell/ μL, during the 18 months of follow-up. The main challenge in our case was the drug interaction between the protease inhibitor-based regimen and tacrolimus. This led to tacrolimus overdose, and, subsequently, change in ARV therapy. ARV switching was performed on a regimen based on integrase inhibitor and nucleoside reverse transcriptase inhibitors. After the ARV change, the therapeutic level of tacrolimus was easily reached and maintained. Kidney graft function remained normal during follow-up, despite tacrolimus overexposure, and no rejection or anti-HLA antibodies were observed. Another challenge was related to the donor's hepatitis C virus status (positive antibodies, negative nucleic acid test). The recipient did not develop seroconversion or detectable viremia at 3-, 6-, 12- and 18-months post-KT.

Conclusion: We reported the first case of a successful KT in an ESRD patient with HIV in Romania, in whom the post-transplant evolution was favorable.

导言:人类免疫缺陷病毒(HIV)不再被视为肾移植(KT)的禁忌症。艾滋病病毒感染者的肾移植管理是一个复杂的过程,充满挑战,例如免疫抑制和抗逆转录病毒(ARV)治疗之间的药物相互作用。在我国,迄今为止还没有为这类患者实施过 KT:我们介绍的病例是一名 29 岁的女性艾滋病病毒感染者和终末期肾病(ESRD)患者,她于 2022 年 3 月接受了相关活体供体的 KT。KT 术后情况良好。未报告移植相关并发症。在 18 个月的随访期间,HIV 病毒载量一直检测不到,CD4+ T 细胞一直大于 500 cells/μL。在我们的病例中,主要的挑战在于以蛋白酶抑制剂为基础的治疗方案与他克莫司之间的药物相互作用。这导致他克莫司用药过量,进而改变了抗逆转录病毒疗法。在更换抗逆转录病毒疗法后,采用了以整合酶抑制剂和核苷类逆转录酶抑制剂为基础的治疗方案。更换抗逆转录病毒疗法后,他克莫司很容易达到并维持治疗水平。在随访期间,尽管他克莫司暴露过量,但肾移植功能仍保持正常,也没有观察到排斥反应或抗 HLA 抗体。另一个挑战与供体的丙型肝炎病毒状态有关(抗体阳性,核酸检测阴性)。受体在接受 KT 后 3、6、12 和 18 个月未出现血清转换或可检测到病毒血症:我们报告了罗马尼亚首例成功进行 KT 的艾滋病 ESRD 患者,其移植后的发展情况良好。
{"title":"HIV and kidney transplantation in Romania: The index case.","authors":"Bogdan Marian Sorohan, Gener Ismail, Cristiana Oprea, Dorina Tacu, Ileana Constantinescu, Liliana Domnișor, Ionuț Manea, Ioanel Sinescu, Cătălin Baston","doi":"10.2478/rjim-2024-0020","DOIUrl":"10.2478/rjim-2024-0020","url":null,"abstract":"<p><strong>Introduction: </strong>Human immunodeficiency virus (HIV) is no longer considered a contraindication for kidney transplantation (KT). KT management in HIV patients is a complex process with challenges, such as drug interactions between immunosuppression and antiretroviral (ARV) therapy. In our country, no KT has been performed thus far in this category of patients.</p><p><strong>Case presentation: </strong>We present the case of a 29-year-old female patient with HIV and end-stage renal disease (ESRD) who performed a KT from a related living donor in March 2022. KT immediate evolution was favorable. No transplant-related complications were reported. HIV viral load remained undetectable and CD4+ T cells were constantly > 500 cell/ μL, during the 18 months of follow-up. The main challenge in our case was the drug interaction between the protease inhibitor-based regimen and tacrolimus. This led to tacrolimus overdose, and, subsequently, change in ARV therapy. ARV switching was performed on a regimen based on integrase inhibitor and nucleoside reverse transcriptase inhibitors. After the ARV change, the therapeutic level of tacrolimus was easily reached and maintained. Kidney graft function remained normal during follow-up, despite tacrolimus overexposure, and no rejection or anti-HLA antibodies were observed. Another challenge was related to the donor's hepatitis C virus status (positive antibodies, negative nucleic acid test). The recipient did not develop seroconversion or detectable viremia at 3-, 6-, 12- and 18-months post-KT.</p><p><strong>Conclusion: </strong>We reported the first case of a successful KT in an ESRD patient with HIV in Romania, in whom the post-transplant evolution was favorable.</p>","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"362-368"},"PeriodicalIF":1.6,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In memoriam: Professor Radu Voiosu. 纪念:拉杜-沃奥苏教授。
IF 1.9 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-04-03 DOI: 10.2478/rjim-2024-0014
{"title":"In memoriam: Professor Radu Voiosu.","authors":"","doi":"10.2478/rjim-2024-0014","DOIUrl":"https://doi.org/10.2478/rjim-2024-0014","url":null,"abstract":"","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is there an association between lymph node size and hyperprogression in immunotherapy-treated patients? 免疫治疗患者的淋巴结大小和过度进展之间是否存在关联?
IF 1.9 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-23 Print Date: 2024-03-01 DOI: 10.2478/rjim-2023-0025
Mohammad S Alkader, Rashed Z Altaha, Eslam H Jabali, Ola A Attieh, Ala' W Matalqa

Background: Hyperprogressive disease (HPD) can be described as an accelerated increase in the growth rate of tumors combined with rapid clinical deterioration observed in a subset of cancer patients undergoing immunotherapy, specifically with immune checkpoint inhibitors (ICIs). The reported incidence of HPD ranges from 5.9% to 43.1% in patients receiving ICIs. In this context, identifying reliable predictive risk factors for HPD is crucial as it may allow for earlier intervention and ultimately improve patient outcomes.

Methods: This study retrospectively analyzed ten metastatic renal cell carcinoma (mRCC) patients. The identification of HPD was based on the diagnostic criteria proposed by Ferrara R et al. This study aimed to investigate whether there is an association between LN size and HPD using a cutoff value of 3 cm for LN size. Given the limited sample size, Fisher's exact test was used to test this association. We conducted a Kaplan-Meier (KM) analysis to estimate the median overall survival (OS) of patients with HPD and compared it to those without HPD.

Results: Three patients (30%) developed HPD, while seven (70%) did not. Fisher's exact test revealed a statistically significant association between the HPD and LN size ≥ 3 cm (p=0.008). In the HPD group, the median OS was significantly shorter, with a median OS of 3 months, whereas in the non-HPD group, the median OS was not reached (P =0.001).

Conclusion: The present study found a significant association between LN size ≥ 3 cm in the pretreatment period and HPD development.

背景:超进行性疾病(HPD)可被描述为在接受免疫疗法(特别是免疫检查点抑制剂(ICIs))的癌症患者中观察到的肿瘤生长率加速增加,并伴有临床快速恶化。据报道,在接受ICIs的患者中,HPD的发病率在5.9%-43.1%之间。在这种情况下,确定HPD的可靠预测风险因素至关重要,因为它可以更早地进行干预,并最终改善患者的预后。方法:本研究回顾性分析了10例转移性肾细胞癌(mRCC)患者。HPD的鉴定基于Ferrara R等人提出的诊断标准。本研究旨在研究LN大小与HPD之间是否存在关联,LN大小的临界值为3cm。在样本量有限的情况下,使用Fisher精确检验来检验这种关联。我们进行了Kaplan-Meier(KM)分析来估计HPD患者的中位总生存期(OS),并将其与无HPD患者进行了比较。结果:3名患者(30%)出现HPD,7名患者(70%)没有。Fisher精确检验显示,HPD和LN大小≥3cm之间存在统计学显著相关性(p=0.008)。在HPD组中,中位OS明显更短,中位OS3个月,而在非HPD组,中位OS未达到(P=0.001)。结论:本研究发现,治疗前LN大小≥3cm与HPD的发生有显著相关性。
{"title":"Is there an association between lymph node size and hyperprogression in immunotherapy-treated patients?","authors":"Mohammad S Alkader, Rashed Z Altaha, Eslam H Jabali, Ola A Attieh, Ala' W Matalqa","doi":"10.2478/rjim-2023-0025","DOIUrl":"10.2478/rjim-2023-0025","url":null,"abstract":"<p><strong>Background: </strong>Hyperprogressive disease (HPD) can be described as an accelerated increase in the growth rate of tumors combined with rapid clinical deterioration observed in a subset of cancer patients undergoing immunotherapy, specifically with immune checkpoint inhibitors (ICIs). The reported incidence of HPD ranges from 5.9% to 43.1% in patients receiving ICIs. In this context, identifying reliable predictive risk factors for HPD is crucial as it may allow for earlier intervention and ultimately improve patient outcomes.</p><p><strong>Methods: </strong>This study retrospectively analyzed ten metastatic renal cell carcinoma (mRCC) patients. The identification of HPD was based on the diagnostic criteria proposed by Ferrara R <i>et al.</i> This study aimed to investigate whether there is an association between LN size and HPD using a cutoff value of 3 cm for LN size. Given the limited sample size, Fisher's exact test was used to test this association. We conducted a Kaplan-Meier (KM) analysis to estimate the median overall survival (OS) of patients with HPD and compared it to those without HPD.</p><p><strong>Results: </strong>Three patients (30%) developed HPD, while seven (70%) did not. Fisher's exact test revealed a statistically significant association between the HPD and LN size ≥ 3 cm (p=0.008). In the HPD group, the median OS was significantly shorter, with a median OS of 3 months, whereas in the non-HPD group, the median OS was not reached (P =0.001).</p><p><strong>Conclusion: </strong>The present study found a significant association between LN size ≥ 3 cm in the pretreatment period and HPD development.</p>","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"33-43"},"PeriodicalIF":1.9,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The crucial role of gadolinium-enhanced MRI in a case of amaurosis fugax - a case report and literature review. 钆增强MRI在一例黑蒙中的重要作用——一例报告和文献综述。
IF 1.9 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-23 Print Date: 2024-03-01 DOI: 10.2478/rjim-2023-0026
Maria Mirabela Manea, Dorin Dragoş, Ana-Maria Dobri, Maria Iuliana Ghenu, Iulia-Cosmina Stoican, Iulia-Ioana Enache, Sorin Tuta

Optic perineuritis is the inflammation of the optic nerve sheath. This affliction can lead to visual field impairment and other signs and symptoms related to the orbital space, such as pain, disc edema, ophthalmoplegia, proptosis. However, not all patients present with such suggestive symptoms, requiring a thorough assessment. We report the case of a young male admitted to our hospital for recurrent episodes of monocular blindness. Amaurosis fugax is a well-known presentation of transient ischemic attacks (TIA) and it was ruled out. Gadolinium-enhanced MRI revealed a typical aspect of optic perineuritis. It was mandatory to consider all possible causes of secondary optic perineuritis as they all represent serious clinical conditions, even if the idiopathic form is more frequent. The clinical and paraclinical evaluation of the patient excluded an underlying disease and primary optic perineuritis was diagnosed. Corticosteroid therapy is usually curative and a course of methylprednisolone was initiated for our patient with good outcome. However, response to treatment is not diagnostic as both primary and secondary optic perineuritis are normally responsive, hence thorough differential diagnosis is necessary.

视神经会阴炎是视神经鞘的炎症。这种痛苦会导致视野损伤和其他与眼眶相关的体征和症状,如疼痛、椎间盘水肿、眼肌麻痹、眼球突出。然而,并非所有患者都出现这种提示性症状,需要进行彻底评估。我们报告了一例年轻男性因单眼失明复发而入院的病例。黑蒙是短暂性脑缺血发作(TIA)的常见表现,已被排除在外。钆增强MRI显示了视神经会阴炎的一个典型方面。必须考虑继发性视神经会尿炎的所有可能原因,因为它们都代表着严重的临床状况,即使特发性会尿炎更常见。患者的临床和临床旁评估排除了潜在疾病,并诊断为原发性视神经会尿炎。皮质类固醇治疗通常是有疗效的,我们的患者开始了一个疗程的甲基强的松龙治疗,效果良好。然而,对治疗的反应并不是诊断性的,因为原发性和继发性视神经会尿炎都有正常反应,因此有必要进行彻底的鉴别诊断。
{"title":"The crucial role of gadolinium-enhanced MRI in a case of amaurosis fugax - a case report and literature review.","authors":"Maria Mirabela Manea, Dorin Dragoş, Ana-Maria Dobri, Maria Iuliana Ghenu, Iulia-Cosmina Stoican, Iulia-Ioana Enache, Sorin Tuta","doi":"10.2478/rjim-2023-0026","DOIUrl":"10.2478/rjim-2023-0026","url":null,"abstract":"<p><p>Optic perineuritis is the inflammation of the optic nerve sheath. This affliction can lead to visual field impairment and other signs and symptoms related to the orbital space, such as pain, disc edema, ophthalmoplegia, proptosis. However, not all patients present with such suggestive symptoms, requiring a thorough assessment. We report the case of a young male admitted to our hospital for recurrent episodes of monocular blindness. Amaurosis fugax is a well-known presentation of transient ischemic attacks (TIA) and it was ruled out. Gadolinium-enhanced MRI revealed a typical aspect of optic perineuritis. It was mandatory to consider all possible causes of secondary optic perineuritis as they all represent serious clinical conditions, even if the idiopathic form is more frequent. The clinical and paraclinical evaluation of the patient excluded an underlying disease and primary optic perineuritis was diagnosed. Corticosteroid therapy is usually curative and a course of methylprednisolone was initiated for our patient with good outcome. However, response to treatment is not diagnostic as both primary and secondary optic perineuritis are normally responsive, hence thorough differential diagnosis is necessary.</p>","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"75-81"},"PeriodicalIF":1.9,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The hidden and complex relationship between dietary phosphorus and malnutrition in hemodialysis patients with chronic kidney disease. 慢性肾脏疾病血液透析患者膳食磷与营养不良之间隐藏而复杂的关系
IF 1.9 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-23 Print Date: 2024-03-01 DOI: 10.2478/rjim-2023-0029
Clonia Milla, Widodo, Teddy Heri Wardhana

Introduction: Chronic kidney disease (CKD) has always been a complicated global challenge, ranking as the 12th leading cause of death worldwide. Hemodialysis, being one of the most opted renal replacement therapies (RRTs) for patients with end-stage renal disease (ESRD), still possesses some limitations in preventing complications, such as malnutrition and mineral bone disease (CKD-MBD). While efforts have focused on controlling CKD-MBD parameters like calcium and phosphate, less attention has been given to dietary interventions. Moreover, the adoption of low-phosphorus diets for hemodialysis patients is very complex due to potential conflicts with the guideline-recommended high-protein dietary approach. This study sought to investigate the relationship between dietary phosphorus intake and nutritional status in CKD patients undergoing regular hemodialysis.

Method: This non-randomized cross-sectional study comprising 88 patients was conducted at the Hemodialysis Unit, RSUD Dr. Soetomo, Surabaya, East Java, using a three-day dietary record in March 2022. Relationships between variables were analyzed using Spearman and ANOVA tests.

Result: No significant positive association was found between dietary calcium with corrected calcium levels (p = 0.988; rs = -0.002) and between dietary phosphorus with plasma phosphate levels (p = 0.082; rs = 0.187). However, Spearman's analysis revealed a weak but positive correlation between dietary phosphorus and nutritional status (p = 0.022; rs = 0.215*).

Conclusion: Our study highlights a positive relationship between dietary phosphorus and nutritional status among hemodialysis patients, offering insights into potential strategies for optimizing patient care and outcomes.

慢性肾病(CKD)一直是一个复杂的全球性挑战,在全球死亡原因中排名第12位。血液透析作为终末期肾病(ESRD)患者最常用的肾脏替代疗法(RRTs)之一,在预防营养不良和矿物质骨病(CKD-MBD)等并发症方面仍存在一定局限性。虽然研究的重点是控制CKD-MBD参数,如钙和磷酸盐,但对饮食干预的关注较少。此外,血液透析患者采用低磷饮食是非常复杂的,因为它可能与指南推荐的高蛋白饮食方法相冲突。本研究旨在探讨定期进行血液透析的CKD患者膳食磷摄入量与营养状况之间的关系。方法:这项非随机横断面研究包括88名患者,于2022年3月在东爪哇泗水RSUD Dr. Soetomo血液透析部门进行,使用为期三天的饮食记录。采用Spearman检验和ANOVA检验分析变量之间的关系。结果:膳食钙与校正钙水平无显著正相关(p = 0.988;Rs = -0.002),且饲粮磷与血浆磷水平之间存在显著性差异(p = 0.082;Rs = 0.187)。然而,Spearman的分析显示,膳食磷与营养状况之间存在微弱的正相关关系(p = 0.022;Rs = 0.215*)。结论:我们的研究强调了血液透析患者膳食磷与营养状况之间的正相关关系,为优化患者护理和预后的潜在策略提供了见解。
{"title":"The hidden and complex relationship between dietary phosphorus and malnutrition in hemodialysis patients with chronic kidney disease.","authors":"Clonia Milla, Widodo, Teddy Heri Wardhana","doi":"10.2478/rjim-2023-0029","DOIUrl":"10.2478/rjim-2023-0029","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) has always been a complicated global challenge, ranking as the 12th leading cause of death worldwide. Hemodialysis, being one of the most opted renal replacement therapies (RRTs) for patients with end-stage renal disease (ESRD), still possesses some limitations in preventing complications, such as malnutrition and mineral bone disease (CKD-MBD). While efforts have focused on controlling CKD-MBD parameters like calcium and phosphate, less attention has been given to dietary interventions. Moreover, the adoption of low-phosphorus diets for hemodialysis patients is very complex due to potential conflicts with the guideline-recommended high-protein dietary approach. This study sought to investigate the relationship between dietary phosphorus intake and nutritional status in CKD patients undergoing regular hemodialysis.</p><p><strong>Method: </strong>This non-randomized cross-sectional study comprising 88 patients was conducted at the Hemodialysis Unit, RSUD Dr. Soetomo, Surabaya, East Java, using a three-day dietary record in March 2022. Relationships between variables were analyzed using Spearman and ANOVA tests.</p><p><strong>Result: </strong>No significant positive association was found between dietary calcium with corrected calcium levels (p = 0.988; r<sub>s</sub> = -0.002) and between dietary phosphorus with plasma phosphate levels (p = 0.082; r<sub>s</sub> = 0.187). However, Spearman's analysis revealed a weak but positive correlation between dietary phosphorus and nutritional status (p = 0.022; r<sub>s</sub> = 0.215*).</p><p><strong>Conclusion: </strong>Our study highlights a positive relationship between dietary phosphorus and nutritional status among hemodialysis patients, offering insights into potential strategies for optimizing patient care and outcomes.</p>","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"52-60"},"PeriodicalIF":1.9,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune dysfunction in patients with end stage kidney disease; Immunosenescence - Review. 终末期肾病患者的免疫功能障碍免疫衰老-综述。
IF 1.9 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-23 Print Date: 2024-03-01 DOI: 10.2478/rjim-2023-0030
Viorica Ileana Bumbea, Horia Bumbea, Ana Maria Vladareanu

The body's defense against environmental factors is realized by physical barriers and cells of both the innate and adaptive immune systems. Patients with end stage kidney disease (ESKD), especially those treated by hemodialysis, have changes in both the function and the number or percent of different leukocyte subsets. Changes were described at the level of monocytes and lymphocyte subsets, which are associated with immunodeficiencies and pro-inflammatory status correlated with degenerative changes and increased cardiovascular risk. These abnormalities have been compared over the past years with alterations appearing as a result ageing. Also, similitudes regarding immunosenescence observed in ESKD patients, in combination with chronic inflammation, are described as the so-called "inflammaging syndrome".

机体对环境因素的防御是通过先天免疫系统和适应性免疫系统的物理屏障和细胞来实现的。终末期肾病(ESKD)患者,特别是那些接受血液透析治疗的患者,在功能和不同白细胞亚群的数量或百分比上都有变化。在单核细胞和淋巴细胞亚群水平上描述了变化,这些变化与免疫缺陷和与退行性变化和心血管风险增加相关的促炎状态有关。在过去的几年里,这些异常与衰老导致的变化进行了比较。此外,在ESKD患者中观察到的与慢性炎症有关的免疫衰老的相似之处被描述为所谓的“炎症综合征”。
{"title":"Immune dysfunction in patients with end stage kidney disease; Immunosenescence - Review.","authors":"Viorica Ileana Bumbea, Horia Bumbea, Ana Maria Vladareanu","doi":"10.2478/rjim-2023-0030","DOIUrl":"10.2478/rjim-2023-0030","url":null,"abstract":"<p><p>The body's defense against environmental factors is realized by physical barriers and cells of both the innate and adaptive immune systems. Patients with end stage kidney disease (ESKD), especially those treated by hemodialysis, have changes in both the function and the number or percent of different leukocyte subsets. Changes were described at the level of monocytes and lymphocyte subsets, which are associated with immunodeficiencies and pro-inflammatory status correlated with degenerative changes and increased cardiovascular risk. These abnormalities have been compared over the past years with alterations appearing as a result ageing. Also, similitudes regarding immunosenescence observed in ESKD patients, in combination with chronic inflammation, are described as the so-called \"inflammaging syndrome\".</p>","PeriodicalId":21463,"journal":{"name":"Romanian Journal of Internal Medicine","volume":" ","pages":"12-19"},"PeriodicalIF":1.9,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Romanian Journal of Internal Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1