Sedentary behavior (SB) may affect arterial stiffness, preceding the development of cardiovascular disease. We investigated the association of objectively measured SB with arterial stiffness. We also investigated factors that affected this association. We recruited adult volunteers and measured SB with thigh-worn accelerometery for 24 hrs/day for eight consecutive days. Central (carotid-femoral pulse wave velocity, cfPWV, gold standard) and local carotid arterial stiffness (stiffness index Beta and pressure-strain elasticity EP) were measured with ultrasound. Linear regression was used and adjusted for demographics, cardiometabolic factors, and moderate-to-vigorous physical activity (MVPA) volume. Effect modification was studied with interaction terms. Participants (N = 664, 64 (standard deviation: 11, range: 23-89) years, 397 (59.8%) male) demonstrated 9.1 (1.6) hrs/day of SB, and arterial stiffness was 8.6 (3.0) m/s for cfPWV, 6.4 (2.9) for Beta, and 87 (43) kPa for EP. SB was not associated with cfPWV (β = 0.04 95% CI (-0.11, 0.18), p = 0.60). The association of SB with local arterial stiffness was modified by systolic blood pressure (SBP) and MVPA volume. Stratified analyses revealed positive associations of SB with Beta (β = 0.29 (0.05, 0.53), p = 0.016) and EP (β = 4.83 (1.39, 8.27), p = 0.006) in participants with SBP > 134 mmHg or > 103 min/day of MVPA (β = 0.23 (0.03, 0.42), p = 0.024 and β = 3.55 (0.82, 6.29), p = 0.011, respectively). We found no association of objectively measured SB with central arterial stiffness. However, SB was positively associated with local carotid stiffness in participants with higher SBP or MVPA levels. In certain subgroups, SB may affect carotid arterial stiffening, reinforcing the relation between SB and cardiovascular disease.
Competitive skiing has gained increasing popularity among adolescent, yet it comes with injury risks. The aim was to determine injury incidence, type and time of injury, localization, and diagnosis, among adolescent competitive skiers (alpine, cross-country, ski-cross, mogul), and to compare between skiing discipline, sex, and high school year. All students (n = 190) enrolled in a ski high school from August 2013 to June 2018 were included. All injuries during the study period were prospectively registered by the physiotherapist at the high school. Demographic and injury data were registered. Absolute injury incidence (injuries/100 skiers) was calculated. In total, 166 (87%) skiers reported 502 injuries, which corresponds to an absolute injury incidence of 264.2 injuries/100 skiers during the 5-year follow-up. A higher injury incidence was shown in school year 1 compared with year 2-4 (131.3 vs. 79.5-98.4; p < 0.05). No differences in injury incidence were found between sex or skiing discipline. Females were more prone of having a gradual-onset injury compared with males (179.3 vs. 96.3; p < 0.001). Mogul skiers had higher incidence of acute injuries compared with the other disciplines (220.0 vs. 71.4-160.0; p < 0.001). The knee was the most common localization across all skiing disciplines, except for cross-country (lower leg). Low back pain was the predominant diagnosis, except in ski-cross (concussion). Skiers attending specialized ski high schools exhibited a significantly high injury incidence, with first-year students being the most susceptible to injuries, across all skiing disciplines and both sexes. While the knee was the most common injury location, concussion was remarkably frequent, particularly among ski-cross skiers.