Sabouraudia最新文献

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Scanning electron microscopic studies of Paracoccidioides brasiliensis in the yeast phase. 巴西副球虫酵母期的扫描电镜研究。

Sabouraudia

Pub Date : 1985-11-01 DOI: 10.1080/00362178585380641

G. Minguetti, F. Queiroz Telles, R. M. Hofmeister, O. T. Freitas, R. Lameira

Scanning electron microscopy of four different Paracoccidioides brasiliensis isolates in the yeast phase revealed that mother cells generating multiple, spherically shaped buds may be firmly or tenuously associated with their progeny whereas elongated buds remain attached to the mother cell through stem-like structures and may represent early stages of hypha formation. The yeast cell surfaces were covered with a delicate network of microfibrillar components.

4个不同的巴西副球虫分离株在酵母期的扫描电镜显示，产生多个球形芽的母细胞可能与它们的后代紧密或纤细地联系在一起，而细长的芽通过茎状结构仍然附着在母细胞上，可能代表了菌丝形成的早期阶段。酵母细胞表面覆盖着微纤维组成的精细网络。

引用次数: 2

Canine mycotic keratoconjuntivitis caused by Acremonium kiliense. 克氏顶孢杆菌引起的犬真菌性角膜结膜炎。

Sabouraudia

Pub Date : 1985-11-01 DOI: 10.1080/00362178585380651

L. Mendoza, Á. Donato, A. Padhye

Mycotic keratoconjuntivitis caused by Acremonium kiliense in a German Shepherd bitch was diagnosed with the aid of laboratory tests. The dog presented with photophobia, tearing, corneal edema and reduction of the visual capacity. A thick white layer partially covered the right eye. The left eye showed irritation and small brown stains which were diagnosed as pigmentary keratitis. The initial treatment consisted of 2% yellow mercury oxide. Natamycin was used as final treatment. Seven days later, the natural brightness of the eye as well as the visual capacity were restored.

在实验室检查的帮助下，德国牧羊犬母狗被诊断为由克氏克雷蒙菌引起的真菌性角膜结膜炎。狗表现为畏光、流泪、角膜水肿和视力下降。一层厚厚的白色膜部分覆盖了右眼。左眼出现刺激及小褐色色斑，诊断为色素性角膜炎。最初的处理是2%的黄汞氧化物。纳他霉素作为最后的治疗方法。7天后，眼睛的自然亮度和视力都恢复了。

引用次数: 12

Mycotic pneumonia caused by Fusarium moniliforme in an alligator. 短吻鳄中由镰刀菌引起的真菌性肺炎。

Sabouraudia

Pub Date : 1985-11-01 DOI: 10.1080/00362178585380581

P. Frelier, L. Sigler, P. Nelson

Fatal pulmonary infection in a captive alligator (Alligator mississippiensis) is reported. At necropsy, the animal appeared to be in excellent nutritional condition, but a severe necrotizing bronchitis with bronchiectasis was present. Histological examination revealed numerous branched, septate, hyaline hyphae within the necrotic debris lining the bronchi and rarely infiltrating into the adjacent stroma. The fungus cultured from the lung was identified as F. moniliforme.

报道了一只圈养短吻鳄(密西西比短吻鳄)致命的肺部感染。尸检显示动物营养状况良好，但存在严重的坏死性支气管炎伴支气管扩张。组织学检查显示在支气管周围的坏死碎片内可见大量分枝的、分隔的、透明的菌丝，很少浸润到邻近的间质中。从肺中培养的真菌鉴定为念珠菌。

引用次数: 24

Suppression of ATP in Candida albicans by imidazole and derivative antifungal agents. 咪唑及其衍生物抗真菌药物对白色念珠菌ATP的抑制作用。

Sabouraudia

Pub Date : 1985-11-01 DOI: 10.1080/00362178585380611

F. Odds, S. Cheesman, A. Abbott

Several antifungal agents, at concentrations of 10 micrograms/ml, were shown to suppress ATP concentrations very rapidly in intact cells and spheroplasts of Candida albicans. The highest ATP-suppressing activity was shown by the highly lipophilic imidazole derivatives difonazole, clotrimazole, econazole, isoconazole, miconazole, oxiconazole and tioconazole, which all caused a reduction of cellular ATP content of more than 50% in 10 min. Relatively hydrophilic imidazole derivatives such as ketoconazole were essentially inactive in the test, as were the triazole derivatives fluconazole, ICI 153066, itraconazole and terconazole, and 5-fluorocytosine. Amphotericin B and terbinafine possessed intermediate ATP-suppressing activity, and the dose-response and pH-response curves for these compounds suggested their mechanism of ATP suppression differed from that of the active imidazole derivatives. ATP suppression by azole antifungals did not involve leakage of ATP from the cells and the effect was entirely abrogated by the presence of serum. Intact cells and spheroplasts of yeast-form and hyphal-form C. albicans were generally equally sensitive to ATP suppression, but stationary-phase cells of both morphological forms were less sensitive than exponential-phase cells. The extent of ATP suppression was significantly reduced in stationary-phase yeast cells of a C. albicans strain with known resistance to azole antifungals, but exponential-phase cells of resistant and susceptible strains were equally sensitive. The effect is tentatively ascribed to membrane damage caused directly by the antifungals.

几种浓度为10微克/毫升的抗真菌药物可以非常迅速地抑制白色念珠菌完整细胞和球质体中的ATP浓度。高亲脂性的咪唑类衍生物二芳唑、克霉唑、康康唑、异康唑、咪康唑、奥昔康唑和噻康唑抑制ATP活性最高，均能在10 min内使细胞ATP含量降低50%以上。相对亲水的咪唑类衍生物如酮康唑在实验中基本无活性，三唑类衍生物氟康唑、ICI 153066、伊曲康唑和特康唑以及5-氟胞嘧啶也基本无活性。两性霉素B和特比萘芬具有中等的ATP抑制活性，其剂量-响应曲线和ph -响应曲线表明其抑制ATP的机制与活性咪唑衍生物不同。唑类抗真菌药物对ATP的抑制不涉及ATP从细胞中泄漏，其作用完全被血清的存在所抵消。酵母型和菌丝型白色念珠菌的完整细胞和球质体对ATP抑制的敏感性大致相同，但两种形态的静止期细胞对ATP抑制的敏感性均低于指数期细胞。一株已知对唑类抗真菌药有抗性的白色念珠菌静止期酵母细胞对ATP的抑制程度显著降低，但耐药和敏感菌株的指数期细胞对ATP的抑制程度相同。这种效果初步归因于抗真菌剂直接引起的膜损伤。

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引用次数: 12

Resistogram typing of Candida albicans isolates from oral and cutaneous sites in irradiated patients. 放射病人口腔和皮肤部位白色念珠菌的电阻图分型。

Sabouraudia

Pub Date : 1985-11-01 DOI: 10.1080/00362178585380591

M. C. McCreight, D. Warnock, M. V. Martín

Thirteen resistogram strains of Candida albicans were found among isolates obtained from the mouth and cutaneous sites of irradiation of 27 patients receiving treatment for oral and laryngeal cancer. In all cases the yeast was recovered from the mouth before treatment, but not from the skin site until after treatment had begun. Of the 27 patients, 25 harboured one or more strains with identical resistograms in both sites.

在27例接受口腔癌和喉癌治疗的患者口腔和皮肤照射部位分离的白色念珠菌中检出13株电阻谱菌株。在所有病例中，酵母在治疗前从口腔中恢复，但直到治疗开始后才从皮肤部位恢复。在27例患者中，25例在两个部位携带一种或多种具有相同电阻图的菌株。

引用次数: 26

Variation of a 470 000 daltons antigen complex and catalase antigen in clinical isolates of Aspergillus fumigatus. 47万道尔顿抗原复合物和过氧化氢酶抗原在烟曲霉临床分离株中的变异。

Sabouraudia

Pub Date : 1985-10-01 DOI: 10.1080/00362178585380501

H Schønheyder, L Storgaard, P Andersen

Antigens in ruptured mycelium of 18 Aspergillus strains including 14 clinical isolates of A. fumigatus were studied by immunoelectrophoresis. One antigenic component of molecular weight 470 000 previously characterized by hydrophobic interaction chromatography and gel filtration and a second component with catalase activity were detected in all A. fumigatus isolates but in varying quantities. The 470 000 antigen complex cross-reacted with antigens in A. flavus and A. nidulans but not in A. niger or A. terreus. A. fumigatus catalase antigen cross-reacted with catalase in A. flavus, A. nidulans and A. terreus, but not in A. niger. One A. fumigatus isolate produced two catalase antigens showing a reaction of partial identity. A. flavus also produced two catalase antigens, one of which was species-specific.

采用免疫电泳法对18株曲霉断裂菌丝体抗原进行了研究，其中包括14株烟曲霉临床分离株。在所有烟曲霉分离株中均检测到分子量为470000的抗原成分和具有过氧化氢酶活性的抗原成分，但含量不同。470000抗原复合物与黄曲霉和灰曲霉抗原发生交叉反应，而与黑曲霉和地曲霉抗原不发生交叉反应。烟曲霉过氧化氢酶抗原在黄曲霉、灰曲霉和地曲霉中与过氧化氢酶发生交叉反应，而在黑曲霉中不发生交叉反应。一株烟曲霉分离物产生两种过氧化氢酶抗原，表现出部分同一性反应。黄曲霉也产生两种过氧化氢酶抗原，其中一种是种特异性的。

引用次数: 12

Lack of antibody induction by Histolyn-CYL, a new skin-testing reagent for histoplasmosis. 一种新的组织浆菌病皮肤检测试剂——组织蛋白- cyl缺乏抗体诱导。

Sabouraudia

Pub Date : 1985-10-01 DOI: 10.1080/00362178585380491

G M Scalarone, A Restrepo, L R Schacht, G H Rupp, M D LeRoy

Histolyn-CYL, a yeast phase skin-test reagent, was administered to 85 histoplasmin-sensitive subjects living in the United States and South America. In a multicenter study, sera were obtained at the time the skin tests were read and again 3 weeks later. In no instance did the skin test induce significant complement-fixing antibody changes or antibodies detected by immuno-diffusion.

组织溶蛋白- cyl是一种酵母期皮肤试验试剂，对生活在美国和南美的85名组织浆蛋白敏感的受试者进行了研究。在一项多中心研究中，在读取皮肤测试时获得血清，并在3周后再次获得血清。在任何情况下，皮肤试验都没有引起明显的补体固定抗体变化或免疫扩散检测到的抗体。

引用次数: 4

Changes in surface topography of Candida albicans during morphogenesis. 白色念珠菌形态发生过程中表面形貌的变化。

Sabouraudia

Pub Date : 1985-10-01

D L Brawner, J E Cutler

Temporal studies of germ-tube forming yeast cells of Candida albicans by scanning and transmission electron microscopy indicate that extensive vacuolation and possibly also cell wall changes may cause walls of the parent yeast cell to collapse during specimen preparation. This collapse does not occur in cells which have been grown in conditions that suppress germ tube formation and have undergone the same preparative treatment.

通过扫描和透射电镜对白色念珠菌的试管形成酵母细胞的时间研究表明，在标本制备过程中，广泛的空泡化和细胞壁的变化可能导致母酵母细胞壁塌陷。在抑制胚管形成的条件下生长并经过相同的准备处理的细胞不会发生这种塌陷。

引用次数: 0

Prevalence, pathology and isolation studies on phycomycotic gastric ulcer in neonatal piglets. 新生仔猪植菌性胃溃疡的流行、病理及分离研究。

Sabouraudia

Pub Date : 1985-10-01 DOI: 10.1080/00362178585380561

S Mahanta, B Chaudhury

Rhizopus species was isolated from 8 cases of gastric ulcer in piglets who died 2-5 days after birth. The prevalence of the condition was 0.775% of 1032 live births, and it was the cause of neonatal death in 3.65% of 219 instances. The gross and microscopic pathologies of the lesions are described.

从8例出生后2 ~ 5天死亡的仔猪胃溃疡中分离到根霉。在1032例活产婴儿中，该病的患病率为0.775%，在219例新生儿死亡病例中，该病占3.65%。描述了病变的大体和显微镜病理。

引用次数: 8

Four great coccidioidomycologists: William Ophuls (1871-1933), Myrnie Gifford (1892-1966), and Charles Edward Smith (1904-1967) and William A. Winn (1903-1967). 四大球虫真菌学家:威廉·奥菲尔斯(1871-1933)、默尼·吉福德(1892-1966)、查尔斯·爱德华·史密斯(1904-1967)和威廉·a·温(1903-1967)。

Sabouraudia

Pub Date : 1985-10-01

R W Huntington

The careers of William Ophuls (1871-1933), Myrnie Gifford (1892-1966), Charles Edward Smith (1904-1967) and William A. Winn (1903-1967) are briefly reviewed, with emphasis on their contributions to knowledge of Coccidioides and coccidioidomycosis. All were students with broad interests, and all were quite willing to suggest new concepts and classifications to replace those of their predecessors.

简要回顾了William Ophuls (1871-1933)， Myrnie Gifford (1892-1966)， Charles Edward Smith(1904-1967)和William A. Winn(1903-1967)的职业生涯，重点介绍了他们对球虫和球虫真菌病知识的贡献。他们都是兴趣广泛的学生，而且都非常愿意提出新的概念和分类来取代前人的概念和分类。

引用次数: 0

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