Satoko Fujieda, Mitsuaki Keira, M. Soma, Yoichi Sasaki, A. Konda, Yuji Mukai, T. Toda, N. Inotsume, H. Yoshida
- 94 Abstract This study aimed to clarify the individual elimination kinetics of serum ritodrine in women pregnant with twins and their twin neonates. Serum ritodrine concentrations in 10 twin pregnant women and their twin neonates were measured by liquid chro-matography-tandem mass spectrometry ( LC - MS ／ MS ) using 100 m L of serum. The ritodrine elimination half-life in mothers was 5 . 0 ± 2 . 2 ( 3 . 7 - 11 . 1 ) h ［ mean ± SD ( range )] , while the half-lives of ritodrine in the first and second newborns were 9 . 0 ± 8 . 4 ( 4 . 2 - 29 . 6 ) and 7 . 2 ± 4 . 3 ( 4 . 3 - 13 . 2 ) h, respectively. Large individual differences in the half-life of ritodrine were observed in both mothers and their newborns. Since ritodrine remained in newborn serum for 24 - 48 h after birth, newborns need to be carefully monitored for ritodrine-related complications during
摘要本研究旨在阐明双胞胎孕妇及其双胞胎新生儿血清利托卡因的个体消除动力学。采用液相色谱-串联质谱法(LC - MS / MS)测定了10例双胞胎孕妇及其双胞胎新生儿的血清利托碱浓度。利托卡因在母亲体内的消除半衰期为5年。0±2。2);7 - 11。1) h [mean±SD (range)]，而利托君在第一、二胎的半衰期分别为9。0±8。4 . b。2 - 29。6)和7。2±4。3 (4);3 - 13。2) h，分别。在母亲和新生儿中观察到利托卡因半衰期的巨大个体差异。由于利托卡因在出生后24 - 48小时仍存在于新生儿血清中，因此需要在分娩过程中仔细监测新生儿是否有利托卡因相关并发症
{"title":"Elimination of Ritodrine in Mothers Pregnant with Twins and Their Neonatal Twins","authors":"Satoko Fujieda, Mitsuaki Keira, M. Soma, Yoichi Sasaki, A. Konda, Yuji Mukai, T. Toda, N. Inotsume, H. Yoshida","doi":"10.3999/JSCPT.48.91","DOIUrl":"https://doi.org/10.3999/JSCPT.48.91","url":null,"abstract":"- 94 Abstract This study aimed to clarify the individual elimination kinetics of serum ritodrine in women pregnant with twins and their twin neonates. Serum ritodrine concentrations in 10 twin pregnant women and their twin neonates were measured by liquid chro-matography-tandem mass spectrometry ( LC - MS ／ MS ) using 100 m L of serum. The ritodrine elimination half-life in mothers was 5 . 0 ± 2 . 2 ( 3 . 7 - 11 . 1 ) h ［ mean ± SD ( range )] , while the half-lives of ritodrine in the first and second newborns were 9 . 0 ± 8 . 4 ( 4 . 2 - 29 . 6 ) and 7 . 2 ± 4 . 3 ( 4 . 3 - 13 . 2 ) h, respectively. Large individual differences in the half-life of ritodrine were observed in both mothers and their newborns. Since ritodrine remained in newborn serum for 24 - 48 h after birth, newborns need to be carefully monitored for ritodrine-related complications during","PeriodicalId":21491,"journal":{"name":"Rinsho Yakuri\\/japanese Journal of Clinical Pharmacology and Therapeutics","volume":"19 1","pages":"91-94"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86654717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In Japan, the National Center Biobank Network (NCBN), comprising six National Centers (NCs), is one of several operating biobank projects that were launched in 2012 as a clinical basic facility project for next-generation medicine. The NCBN is a network-type and federal-type morphological biobank that uses wide-ranging joint research projects to provide bioresources in cooperation with industry, academia, and the government. 5) Information related to biological specimens (blood, deoxyribonucleic acid[DNA], ribonucleic acid[RNA], blood serum, etc.)is collected and stored at each NC, and patient medical data are collected and controlled at a central biobank in a searchable database. 6) However, at present, limited information can be shared among the six NCs, which is mainly due to the lack of standardization of this information in a universal data format. This variation in data formats has caused many problems for collections at the central biobank owing to independent interpretations at each NC and non-compliant entry methods. Consequently, the NCBN catalog data are not currently utilized by outside researchers. The Clinical Data Interchange Standards Consortium (CDISC) standards are a collection of standard specifications regulated by the CDISC, such as definitions of clinical trial content, communications protocols, and standard formats for electronic application data. In 2004, the U.S. Food and Drug 臨床薬理 Jpn J Clin Pharmacol Ther 2017; 48(3): 95-98 95
在日本，国家中心生物银行网络(NCBN)由六个国家中心(nc)组成，是2012年启动的几个正在运行的生物银行项目之一，作为下一代医学的临床基础设施项目。NCBN是一个网络型和联邦型形态生物库，利用广泛的联合研究项目与工业界、学术界和政府合作提供生物资源。5)生物标本相关信息(血液、脱氧核糖核酸(DNA)、核糖核酸(RNA)、血清等)在各NC采集并存储，患者医疗数据在中央生物库采集并控制在可检索的数据库中。6)然而，目前6个nc之间能够共享的信息有限，这主要是由于这些信息缺乏统一的数据格式的标准化。由于每个NC的独立解释和不兼容的输入方法，这种数据格式的变化给中央生物库的收集造成了许多问题。因此，NCBN目录数据目前没有被外部研究人员利用。临床数据交换标准联盟(CDISC)标准是由CDISC规范的标准规范的集合，如临床试验内容的定义、通信协议和电子应用数据的标准格式。2004年，美国食品药品监督管理局(Food and Drug)《临床药学杂志》2017;48(3): 95-98
{"title":"Feasibility of Converting Data of National Center Biobank Network Catalog to Analysis Data Model","authors":"Iori Sakakibara, K. Ide, Y. Kawasaki","doi":"10.3999/JSCPT.48.95","DOIUrl":"https://doi.org/10.3999/JSCPT.48.95","url":null,"abstract":"In Japan, the National Center Biobank Network (NCBN), comprising six National Centers (NCs), is one of several operating biobank projects that were launched in 2012 as a clinical basic facility project for next-generation medicine. The NCBN is a network-type and federal-type morphological biobank that uses wide-ranging joint research projects to provide bioresources in cooperation with industry, academia, and the government. 5) Information related to biological specimens (blood, deoxyribonucleic acid[DNA], ribonucleic acid[RNA], blood serum, etc.)is collected and stored at each NC, and patient medical data are collected and controlled at a central biobank in a searchable database. 6) However, at present, limited information can be shared among the six NCs, which is mainly due to the lack of standardization of this information in a universal data format. This variation in data formats has caused many problems for collections at the central biobank owing to independent interpretations at each NC and non-compliant entry methods. Consequently, the NCBN catalog data are not currently utilized by outside researchers. The Clinical Data Interchange Standards Consortium (CDISC) standards are a collection of standard specifications regulated by the CDISC, such as definitions of clinical trial content, communications protocols, and standard formats for electronic application data. In 2004, the U.S. Food and Drug 臨床薬理 Jpn J Clin Pharmacol Ther 2017; 48(3): 95-98 95","PeriodicalId":21491,"journal":{"name":"Rinsho Yakuri\\/japanese Journal of Clinical Pharmacology and Therapeutics","volume":"231 1","pages":"95-98"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77484634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Hakamata, M. Hashiguchi, T. Tsuru, Takanori Tanaka, S. Irie, Mikiko Shimizu, M. Mochizuki
{"title":"Ethnic and Gender Differences in Genetic Polymorphisms of Tumor Necrosis Factor (TNF) -α in a Japanese Population","authors":"Jun Hakamata, M. Hashiguchi, T. Tsuru, Takanori Tanaka, S. Irie, Mikiko Shimizu, M. Mochizuki","doi":"10.3999/JSCPT.48.21","DOIUrl":"https://doi.org/10.3999/JSCPT.48.21","url":null,"abstract":"","PeriodicalId":21491,"journal":{"name":"Rinsho Yakuri\\/japanese Journal of Clinical Pharmacology and Therapeutics","volume":"29 3 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82731849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Ando, Chieko Yamasaki, H. Iwaki, T. Tsujii, H. Yabe, N. Nishikawa, M. Nagai, M. Nomoto
{"title":"Relationship between Serious Traffic Accidents and Medications in Patients with Parkinson's Disease","authors":"R. Ando, Chieko Yamasaki, H. Iwaki, T. Tsujii, H. Yabe, N. Nishikawa, M. Nagai, M. Nomoto","doi":"10.3999/JSCPT.48.167","DOIUrl":"https://doi.org/10.3999/JSCPT.48.167","url":null,"abstract":"","PeriodicalId":21491,"journal":{"name":"Rinsho Yakuri\\/japanese Journal of Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"167-171"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83667864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：