首页 > 最新文献

Scandinavian Journal of Immunology最新文献

英文 中文
Mite-negative allergic rhinitis: A model of the regulation mechanism of atopy onset. 螨阴性过敏性鼻炎:过敏性鼻炎发病调节机制模型。
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-03-31 DOI: 10.1111/sji.13367
Yasuhiro Horiuchi
{"title":"Mite-negative allergic rhinitis: A model of the regulation mechanism of atopy onset.","authors":"Yasuhiro Horiuchi","doi":"10.1111/sji.13367","DOIUrl":"10.1111/sji.13367","url":null,"abstract":"","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13367"},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Major low-energy trauma results in non-specific immunoglobulin generation without evidence for specific autoantibody production: A prospective cohort study. 重大低能量创伤会导致非特异性免疫球蛋白生成,但无证据表明会产生特异性自身抗体:一项前瞻性队列研究。
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI: 10.1111/sji.13368
Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova

Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertrochanteric femur fracture undergoing intramedullary nail osteosynthesis in a prospective cohort study and followed them at 3-4 days, 6 weeks, 12 weeks and 12 months postoperatively. By standard techniques, we assessed levels of total immunoglobulins, anti-nuclear antibodies (ANA), anti-cardiolipin antibodies, anti-dsDNA antibodies and anti-C1q antibodies, as well as antibodies against cytomegalovirus (CMV) as a control. Blood leukocyte differential and lymphocyte subpopulations were determined at baseline and in the first two postoperative samples. The mean age of the patients reached 80.1 years, and 23 (46%) completed all visits. Serum concentrations of total IgG, IgM and IgA increased at all follow-up time points. The ANA fluorescence light intensity units increased at 12 weeks and 12 months postoperatively (p < 0.0001), but the proportion of ANA-positive patients did not change (35%). The values of anti-C1q mildly increased at all follow-up visits, but not the ratio to total IgG. Anti-dsDNA remained negative in all patients, and anti-cardiolipin IgG/IgM antibodies did not change. Anti-CMV IgG antibodies increased significantly at all follow-up visits, without change in the ratio to total IgG. Flow cytometry showed an increased proportion of B-cells 3-4 days postoperatively. In conclusion, major musculoskeletal trauma in elderly patients induces a generalized non-specific increase in immunoglobulin production without laboratory signs for enhanced systemic autoimmunity.

巨大创伤产生的细胞碎片可能会压垮清道夫机制并导致自身免疫反应。我们分析了人类在遭受定义明确的重大创伤后数月内是否会诱发一过性自身免疫的实验室迹象。我们在一项前瞻性队列研究中纳入了 50 名接受髓内钉骨整合术的股骨转子前骨折患者,并在术后 3-4 天、6 周、12 周和 12 个月对他们进行了随访。通过标准技术,我们评估了总免疫球蛋白、抗核抗体(ANA)、抗心磷脂抗体、抗dsDNA抗体和抗C1q抗体的水平,并以巨细胞病毒(CMV)抗体作为对照。在基线和术后前两次样本中测定了血液白细胞差值和淋巴细胞亚群。患者的平均年龄为 80.1 岁,其中 23 人(46%)完成了所有检查。总 IgG、IgM 和 IgA 的血清浓度在所有随访时间点均有所上升。术后 12 周和 12 个月时,ANA 荧光强度单位均有所增加(p
{"title":"Major low-energy trauma results in non-specific immunoglobulin generation without evidence for specific autoantibody production: A prospective cohort study.","authors":"Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova","doi":"10.1111/sji.13368","DOIUrl":"10.1111/sji.13368","url":null,"abstract":"<p><p>Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertrochanteric femur fracture undergoing intramedullary nail osteosynthesis in a prospective cohort study and followed them at 3-4 days, 6 weeks, 12 weeks and 12 months postoperatively. By standard techniques, we assessed levels of total immunoglobulins, anti-nuclear antibodies (ANA), anti-cardiolipin antibodies, anti-dsDNA antibodies and anti-C1q antibodies, as well as antibodies against cytomegalovirus (CMV) as a control. Blood leukocyte differential and lymphocyte subpopulations were determined at baseline and in the first two postoperative samples. The mean age of the patients reached 80.1 years, and 23 (46%) completed all visits. Serum concentrations of total IgG, IgM and IgA increased at all follow-up time points. The ANA fluorescence light intensity units increased at 12 weeks and 12 months postoperatively (p < 0.0001), but the proportion of ANA-positive patients did not change (35%). The values of anti-C1q mildly increased at all follow-up visits, but not the ratio to total IgG. Anti-dsDNA remained negative in all patients, and anti-cardiolipin IgG/IgM antibodies did not change. Anti-CMV IgG antibodies increased significantly at all follow-up visits, without change in the ratio to total IgG. Flow cytometry showed an increased proportion of B-cells 3-4 days postoperatively. In conclusion, major musculoskeletal trauma in elderly patients induces a generalized non-specific increase in immunoglobulin production without laboratory signs for enhanced systemic autoimmunity.</p>","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13368"},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non‐alcoholic fatty liver disease Isoliquiritigenin 通过与 Syk 对接限制巨噬细胞炎性体的激活,从而缓解小鼠非酒精性脂肪肝的病情
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-04-27 DOI: 10.1111/sji.13371
Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong
Isoliquiritigenin (ISL) is a chalcone‐type flavonoid derived from the root of licorice with antioxidant, anti‐inflammatory, anti‐tumour and neuroprotective properties. ISL has been proven to downregulate the productions of IL‐1β, TNF‐α and IL‐6 by macrophages. However, detailed molecular mechanisms of this modulation remain elusive. Here, ISL suppressed Syk phosphorylation and CD80, CD86, IL‐1β, TNF‐α and IL‐6 expressions in lipopolysaccharide‐stimulated macrophages ex vivo. ApoC3‐transgenic (ApoC3TG) mice had more activated macrophages. ISL was also able to downregulate the inflammatory activities of macrophages from ApoC3TG mice. Administration of ISL inhibited Syk activation and inflammatory activities of macrophages in ApoC3TG mice in vivo. The treatment of ISL further alleviated MCD‐induced non‐alcoholic fatty liver disease (NAFLD) in wild‐type and ApoC3TG mice, accompanied by less recruitment and activation of liver macrophages. Due to the inhibition of Syk phosphorylation, ISL‐treated macrophages displayed less production of cytoplasmic ROS, NLRP3, cleaved‐GSDMD and cleaved‐IL‐1β, suggesting less inflammasome activation. Finally, the molecular docking study demonstrated that ISL bound to Syk directly with the Kd of 1.273 × 10−8 M. When the Syk expression was knocked down by its shRNA, the inhibitory effects of ISL on activated macrophages disappeared, indicating that Syk was at least one of key docking‐molecules of ISL. Collectively, ISL could alleviate MCD‐induced NAFLD in mice involved with the inhibition of macrophage inflammatory activity by the blockade of Syk‐induced inflammasome activation.
Isoliquiritigenin (ISL) 是一种从甘草根中提取的查耳酮类黄酮,具有抗氧化、抗炎、抗肿瘤和保护神经的特性。事实证明,ISL 能降低巨噬细胞产生的 IL-1β、TNF-α 和 IL-6。然而,这种调节作用的详细分子机制仍然难以捉摸。在这里,ISL抑制了体内外脂多糖刺激的巨噬细胞中Syk磷酸化和CD80、CD86、IL-1β、TNF-α和IL-6的表达。ApoC3转基因(ApoC3TG)小鼠的巨噬细胞活化程度更高。ISL 还能降低 ApoC3TG 小鼠巨噬细胞的炎症活性。服用 ISL 可抑制体内 ApoC3TG 小鼠的 Syk 活化和巨噬细胞的炎症活动。ISL治疗进一步缓解了MCD诱导的野生型和载脂蛋白C3TG小鼠非酒精性脂肪肝(NAFLD),同时减少了肝巨噬细胞的募集和活化。由于抑制了 Syk 的磷酸化,ISL 处理的巨噬细胞显示出较少的细胞质 ROS、NLRP3、裂解-GSDMD 和裂解-IL-1β 的产生,这表明炎性体的激活较少。最后,分子对接研究表明,ISL与Syk直接结合,Kd为1.273×10-8 M;当用shRNA敲除Syk表达时,ISL对活化巨噬细胞的抑制作用消失,表明Syk至少是ISL的关键对接分子之一。综上所述,ISL可通过阻断Syk诱导的炎性体活化来抑制巨噬细胞的炎性活性,从而缓解MCD诱导的小鼠非酒精性脂肪肝。
{"title":"Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non‐alcoholic fatty liver disease","authors":"Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong","doi":"10.1111/sji.13371","DOIUrl":"https://doi.org/10.1111/sji.13371","url":null,"abstract":"Isoliquiritigenin (ISL) is a chalcone‐type flavonoid derived from the root of licorice with antioxidant, anti‐inflammatory, anti‐tumour and neuroprotective properties. ISL has been proven to downregulate the productions of IL‐1β, TNF‐α and IL‐6 by macrophages. However, detailed molecular mechanisms of this modulation remain elusive. Here, ISL suppressed Syk phosphorylation and CD80, CD86, IL‐1β, TNF‐α and IL‐6 expressions in lipopolysaccharide‐stimulated macrophages ex vivo. ApoC3‐transgenic (ApoC3<jats:sup>TG</jats:sup>) mice had more activated macrophages. ISL was also able to downregulate the inflammatory activities of macrophages from ApoC3<jats:sup>TG</jats:sup> mice. Administration of ISL inhibited Syk activation and inflammatory activities of macrophages in ApoC3<jats:sup>TG</jats:sup> mice in vivo. The treatment of ISL further alleviated MCD‐induced non‐alcoholic fatty liver disease (NAFLD) in wild‐type and ApoC3<jats:sup>TG</jats:sup> mice, accompanied by less recruitment and activation of liver macrophages. Due to the inhibition of Syk phosphorylation, ISL‐treated macrophages displayed less production of cytoplasmic ROS, NLRP3, cleaved‐GSDMD and cleaved‐IL‐1β, suggesting less inflammasome activation. Finally, the molecular docking study demonstrated that ISL bound to Syk directly with the K<jats:sub>d</jats:sub> of 1.273 × 10<jats:sup>−8</jats:sup> M. When the Syk expression was knocked down by its shRNA, the inhibitory effects of ISL on activated macrophages disappeared, indicating that Syk was at least one of key docking‐molecules of ISL. Collectively, ISL could alleviate MCD‐induced NAFLD in mice involved with the inhibition of macrophage inflammatory activity by the blockade of Syk‐induced inflammasome activation.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"75 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptomatic SARS‐CoV‐2 infection: A possible role of platelet HLA class I expression level 无症状 SARS-CoV-2 感染:血小板 HLA I 类表达水平的可能作用
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-04-08 DOI: 10.1111/sji.13370
Rocco Cantisani, Adriano Spreafico, Giuseppe Marotta
{"title":"Asymptomatic SARS‐CoV‐2 infection: A possible role of platelet HLA class I expression level","authors":"Rocco Cantisani, Adriano Spreafico, Giuseppe Marotta","doi":"10.1111/sji.13370","DOIUrl":"https://doi.org/10.1111/sji.13370","url":null,"abstract":"","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"27 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140574517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated levels of anti‐Golgi antibodies: An early sign of seronegative rheumatoid arthritis 抗高尔基体抗体水平升高:血清阴性类风湿性关节炎的早期征兆
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-04-03 DOI: 10.1111/sji.13369
Emrah Salman, Bedia Dinç
Anti‐Golgi antibodies are uncommon antibodies that exhibit specific, polarized cytoplasmic staining on the Hep‐2 substrate. The objective of our study was to identify the clinical and laboratory features associated with anti‐Golgi antibodies. We examined 4.5 years of data from a Turkish tertiary hospital in this retrospective cohort analysis. The indirect immunofluorescence staining patterns, antinuclear antibody (ANA) titres and clinical data of all patients were obtained from the hospital record system. A total of 146,055 ANAs were detected, of which 224 patients (0.15%) exhibited anti‐Golgi antibody staining. In total, 39.4% of diagnosed patients had autoimmune diseases (AIDs). Of the AIDs, 26 (46.4%) were rheumatoid arthritis (RA). This is a very high rate and another remarkable point is that 17 (65.3%) of these patients had seronegative RA. High‐titre results (1 ≥ 1/320) were more common in patients with AID. Anti‐Ro52 was prevalent in 50% of extractable nuclear antigen (ENA)‐positive patients, making it a remarkable finding. The majority of individuals with high‐titre anti‐Golgi antibodies had AID, particularly RA. The majority of these patients also tested negative for anti‐cyclic citrullinated peptide (anti‐CCP) and rheumatoid factor (RF). Finally, high‐titre anti‐Golgi antibodies may be an important serologic marker for seronegative RA in the Turkish population.
抗高尔基体抗体是一种不常见的抗体,它在 Hep-2 基质上表现出特异性、极化的细胞质染色。我们的研究旨在确定与抗高尔基体抗体相关的临床和实验室特征。在这项回顾性队列分析中,我们研究了一家土耳其三级医院 4.5 年的数据。所有患者的间接免疫荧光染色模式、抗核抗体(ANA)滴度和临床数据均来自医院记录系统。共检测出 146,055 个 ANA,其中 224 名患者(0.15%)表现出抗高尔基体抗体染色。共有 39.4% 的确诊患者患有自身免疫性疾病(AID)。其中,26 例(46.4%)为类风湿性关节炎(RA)。这是一个非常高的比例,另一个值得注意的问题是,这些患者中有 17 人(65.3%)血清阴性 RA。高滴度结果(1 ≥ 1/320)在 AID 患者中更为常见。50%的可提取核抗原(ENA)阳性患者普遍存在抗 Ro52,这是一个显著的发现。大多数高滴度抗高尔基体抗体患者都患有 AID,尤其是 RA。大多数患者的抗环瓜氨酸肽(anti-CCP)和类风湿因子(RF)检测结果也呈阴性。最后,高滴度抗高尔基体抗体可能是土耳其人群中血清阴性 RA 的重要血清学标志。
{"title":"Elevated levels of anti‐Golgi antibodies: An early sign of seronegative rheumatoid arthritis","authors":"Emrah Salman, Bedia Dinç","doi":"10.1111/sji.13369","DOIUrl":"https://doi.org/10.1111/sji.13369","url":null,"abstract":"Anti‐Golgi antibodies are uncommon antibodies that exhibit specific, polarized cytoplasmic staining on the Hep‐2 substrate. The objective of our study was to identify the clinical and laboratory features associated with anti‐Golgi antibodies. We examined 4.5 years of data from a Turkish tertiary hospital in this retrospective cohort analysis. The indirect immunofluorescence staining patterns, antinuclear antibody (ANA) titres and clinical data of all patients were obtained from the hospital record system. A total of 146,055 ANAs were detected, of which 224 patients (0.15%) exhibited anti‐Golgi antibody staining. In total, 39.4% of diagnosed patients had autoimmune diseases (AIDs). Of the AIDs, 26 (46.4%) were rheumatoid arthritis (RA). This is a very high rate and another remarkable point is that 17 (65.3%) of these patients had seronegative RA. High‐titre results (1 ≥ 1/320) were more common in patients with AID. Anti‐Ro52 was prevalent in 50% of extractable nuclear antigen (ENA)‐positive patients, making it a remarkable finding. The majority of individuals with high‐titre anti‐Golgi antibodies had AID, particularly RA. The majority of these patients also tested negative for anti‐cyclic citrullinated peptide (anti‐CCP) and rheumatoid factor (RF). Finally, high‐titre anti‐Golgi antibodies may be an important serologic marker for seronegative RA in the Turkish population.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"37 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140574511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of bile acid receptor TGR5 in regulating inflammatory signalling. 胆汁酸受体 TGR5 在调节炎症信号中的作用
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-04-01 Epub Date: 2024-02-02 DOI: 10.1111/sji.13361
Daijiao Ye, Jiayao He, Xiaofei He

Takeda G protein-coupled receptor 5 (TGR5) is a bile acid receptor, and its role in regulating metabolism after binding with bile acids has been established. Since the immune response depends on metabolism to provide biomolecules and energy to cope with challenging conditions, emerging evidence reveals the regulatory effects of TGR5 on the immune response. An in-depth understanding of the effect of TGR5 on immune regulation can help us disentangle the interaction of metabolism and immune response, accelerating the development of TGR5 as a therapeutic target. Herein, we reviewed more than 200 articles published in the last 20 years in PubMed, to discuss the roles of TGR5 in regulating inflammatory response, the molecular mechanism, as well as existing problems. Particularly, its anti-inflammation effect is emphasized.

武田 G 蛋白偶联受体 5(TGR5)是一种胆汁酸受体,它与胆汁酸结合后在调节新陈代谢方面的作用已被证实。由于免疫反应依赖于新陈代谢来提供生物分子和能量以应对具有挑战性的条件,新的证据揭示了 TGR5 对免疫反应的调节作用。深入了解 TGR5 对免疫调节的影响有助于我们厘清新陈代谢与免疫反应之间的相互作用,从而加速 TGR5 作为治疗靶点的开发。在此,我们回顾了近20年发表在PubMed上的200多篇文章,探讨了TGR5在调节炎症反应中的作用、分子机制以及存在的问题。特别强调了其抗炎作用。
{"title":"The role of bile acid receptor TGR5 in regulating inflammatory signalling.","authors":"Daijiao Ye, Jiayao He, Xiaofei He","doi":"10.1111/sji.13361","DOIUrl":"10.1111/sji.13361","url":null,"abstract":"<p><p>Takeda G protein-coupled receptor 5 (TGR5) is a bile acid receptor, and its role in regulating metabolism after binding with bile acids has been established. Since the immune response depends on metabolism to provide biomolecules and energy to cope with challenging conditions, emerging evidence reveals the regulatory effects of TGR5 on the immune response. An in-depth understanding of the effect of TGR5 on immune regulation can help us disentangle the interaction of metabolism and immune response, accelerating the development of TGR5 as a therapeutic target. Herein, we reviewed more than 200 articles published in the last 20 years in PubMed, to discuss the roles of TGR5 in regulating inflammatory response, the molecular mechanism, as well as existing problems. Particularly, its anti-inflammation effect is emphasized.</p>","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13361"},"PeriodicalIF":3.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic analysis of mucosal‐associated invariant T cells in haematological malignancies 对血液恶性肿瘤中粘膜相关不变 T 细胞的系统分析
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-03-06 DOI: 10.1111/sji.13364
Barbora Bacova, Jakub Cierny, Lucia Nemcekova, Jitka Smetanova/Brozova, Jan Novak
Mucosal‐associated invariant T‐cells (MAIT) are unconventional T‐cells with cytotoxic and pro‐inflammatory properties. Previous research has reported contradictory findings on their role in cancerogenesis with data being even scarcer in haematological malignancies. Here, we report the results of a systematic analysis of MAIT cells in treatment‐naïve patients with a broad range of haematological malignancies. We analysed peripheral blood of 204 patients and 50 healthy subjects. The pool of haematological patients had a statistically significant lower both the absolute value (median values, 0.01 × 109/L vs. 0.05 × 109/L) of MAIT cells and their percentage (median values 0.94% vs. 2.56%) among T‐cells compared to the control group. Separate analysis showed that the decrease in the absolute number of MAIT cells is significant in patients with acute myeloid leukaemia, myeloproliferative neoplasms, plasma cell myeloma, B‐cell non‐Hodgkin lymphomas, otherwise not specified, diffuse large B‐cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma compared to the control population. Furthermore, in haematological malignancies, MAIT cells overexpress PD‐1 (average values, 51.7% vs. 6.7%), HLA‐DR (average values, 40.2% vs. 7%), CD38 (average values, 25.9% vs. 4.9%) and CD69 (average values, 40.2% vs. 9.2%). Similar results were obtained when comparing patients with individual malignancies to the control population. Our data show that the depletion of circulating MAIT cells is a common observation in a broad spectrum of haematological malignancies. In addition to their reduced numbers, MAIT cells acquire an activated/exhausted phenotype.
粘膜相关不变 T 细胞(MAIT)是一种非常规 T 细胞,具有细胞毒性和促炎特性。以往的研究对它们在癌症发生过程中的作用报道不一,而血液恶性肿瘤方面的数据更是少之又少。在此,我们报告了对各种血液恶性肿瘤的治疗无效患者体内 MAIT 细胞进行系统分析的结果。我们分析了 204 名患者和 50 名健康人的外周血。与对照组相比,血液病患者库中 MAIT 细胞的绝对值(中位值为 0.01 × 109/L 对 0.05 × 109/L)及其在 T 细胞中所占的百分比(中位值为 0.94% 对 2.56%)均明显降低。单独分析表明,与对照组相比,急性髓性白血病、骨髓增生性肿瘤、浆细胞骨髓瘤、B 细胞非霍奇金淋巴瘤(未列明)、弥漫大 B 细胞淋巴瘤、滤泡淋巴瘤、套细胞淋巴瘤、边缘区淋巴瘤患者 MAIT 细胞绝对数量明显减少。此外,在血液恶性肿瘤中,MAIT 细胞过度表达 PD-1(平均值 51.7% 对 6.7%)、HLA-DR(平均值 40.2% 对 7%)、CD38(平均值 25.9% 对 4.9%)和 CD69(平均值 40.2% 对 9.2%)。将个别恶性肿瘤患者与对照组人群进行比较也得到了类似的结果。我们的数据显示,循环中的 MAIT 细胞减少是多种血液恶性肿瘤中的常见现象。MAIT 细胞除了数量减少外,还出现了活化/耗竭表型。
{"title":"Systematic analysis of mucosal‐associated invariant T cells in haematological malignancies","authors":"Barbora Bacova, Jakub Cierny, Lucia Nemcekova, Jitka Smetanova/Brozova, Jan Novak","doi":"10.1111/sji.13364","DOIUrl":"https://doi.org/10.1111/sji.13364","url":null,"abstract":"Mucosal‐associated invariant T‐cells (MAIT) are unconventional T‐cells with cytotoxic and pro‐inflammatory properties. Previous research has reported contradictory findings on their role in cancerogenesis with data being even scarcer in haematological malignancies. Here, we report the results of a systematic analysis of MAIT cells in treatment‐naïve patients with a broad range of haematological malignancies. We analysed peripheral blood of 204 patients and 50 healthy subjects. The pool of haematological patients had a statistically significant lower both the absolute value (median values, 0.01 × 10<jats:sup>9</jats:sup>/L vs. 0.05 × 10<jats:sup>9</jats:sup>/L) of MAIT cells and their percentage (median values 0.94% vs. 2.56%) among T‐cells compared to the control group. Separate analysis showed that the decrease in the absolute number of MAIT cells is significant in patients with acute myeloid leukaemia, myeloproliferative neoplasms, plasma cell myeloma, B‐cell non‐Hodgkin lymphomas, otherwise not specified, diffuse large B‐cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma compared to the control population. Furthermore, in haematological malignancies, MAIT cells overexpress PD‐1 (average values, 51.7% vs. 6.7%), HLA‐DR (average values, 40.2% vs. 7%), CD38 (average values, 25.9% vs. 4.9%) and CD69 (average values, 40.2% vs. 9.2%). Similar results were obtained when comparing patients with individual malignancies to the control population. Our data show that the depletion of circulating MAIT cells is a common observation in a broad spectrum of haematological malignancies. In addition to their reduced numbers, MAIT cells acquire an activated/exhausted phenotype.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"18 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140053698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in serum immunoglobulin G glycosylation patterns for antiphospholipid syndrome patients with lectin microarray 利用凝集素芯片分析抗磷脂综合征患者血清免疫球蛋白 G 糖基化模式的变化
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-03-05 DOI: 10.1111/sji.13366
Yifei Wang, Siting Li, Jingjing Meng, Rui Yu, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng, Jiulang Zhao, Chaojun Hu
Antiphospholipid syndrome is a rare autoimmune disease characterized by persistent antiphospholipid antibodies. Immunoglobulin G plays a vital role in disease progression, with its structure and function affected by glycosylation. We aimed to investigate the changes in the serum immunoglobulin G glycosylation pattern in antiphospholipid syndrome patients. We applied lectin microarray on samples from 178 antiphospholipid syndrome patients, 135 disease controls (including Takayasu arteritis, rheumatoid arthritis and cardiovascular disease) and 100 healthy controls. Lectin blots were performed for validation of significant differences. Here, we show an increased immunoglobulin G‐binding level of soybean agglutinin (p = 0.047, preferring N‐acetylgalactosamine) in antiphospholipid syndrome patients compared with healthy and disease controls. Additionally, the immunoglobulin G from antiphospholipid syndrome patients diagnosed with pregnancy events had lower levels of fucosylation (p = 0.001, recognized by Lotus tetragonolobus) and sialylation (p = 0.030, recognized by Sambucus nigra I) than those with simple thrombotic events. These results suggest the unique serum immunoglobulin G glycosylation profile of antiphospholipid syndrome patients, which may inform future studies to design biomarkers for more accurate diagnosis of antiphospholipid syndrome and even for the prediction of clinical symptoms in patients.
抗磷脂综合征是一种罕见的自身免疫性疾病,其特征是持续存在抗磷脂抗体。免疫球蛋白G在疾病进展中起着至关重要的作用,其结构和功能受糖基化的影响。我们旨在研究抗磷脂综合征患者血清免疫球蛋白G糖基化模式的变化。我们对 178 名抗磷脂综合征患者、135 名疾病对照组(包括高安动脉炎、类风湿性关节炎和心血管疾病)和 100 名健康对照组的样本进行了凝集素芯片分析。为验证显著差异,还进行了凝集素印迹分析。在此,我们发现与健康对照组和疾病对照组相比,抗磷脂综合征患者体内大豆凝集素的免疫球蛋白 G 结合水平升高(p = 0.047,更倾向于 N-乙酰半乳糖胺)。此外,与单纯血栓事件患者相比,被诊断为妊娠事件的抗磷脂综合征患者的免疫球蛋白 G 的岩藻糖基化(p = 0.001,被四角莲识别)和硅烷基化(p = 0.030,被黑三叶草 I 识别)水平较低。这些结果表明,抗磷脂综合征患者的血清免疫球蛋白G糖基化谱具有独特性,可为今后的研究提供参考,从而设计出生物标记物,更准确地诊断抗磷脂综合征,甚至预测患者的临床症状。
{"title":"Changes in serum immunoglobulin G glycosylation patterns for antiphospholipid syndrome patients with lectin microarray","authors":"Yifei Wang, Siting Li, Jingjing Meng, Rui Yu, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng, Jiulang Zhao, Chaojun Hu","doi":"10.1111/sji.13366","DOIUrl":"https://doi.org/10.1111/sji.13366","url":null,"abstract":"Antiphospholipid syndrome is a rare autoimmune disease characterized by persistent antiphospholipid antibodies. Immunoglobulin G plays a vital role in disease progression, with its structure and function affected by glycosylation. We aimed to investigate the changes in the serum immunoglobulin G glycosylation pattern in antiphospholipid syndrome patients. We applied lectin microarray on samples from 178 antiphospholipid syndrome patients, 135 disease controls (including Takayasu arteritis, rheumatoid arthritis and cardiovascular disease) and 100 healthy controls. Lectin blots were performed for validation of significant differences. Here, we show an increased immunoglobulin G‐binding level of soybean agglutinin (<jats:italic>p</jats:italic> = 0.047, preferring N‐acetylgalactosamine) in antiphospholipid syndrome patients compared with healthy and disease controls. Additionally, the immunoglobulin G from antiphospholipid syndrome patients diagnosed with pregnancy events had lower levels of fucosylation (<jats:italic>p</jats:italic> = 0.001, recognized by <jats:italic>Lotus tetragonolobus</jats:italic>) and sialylation (<jats:italic>p</jats:italic> = 0.030, recognized by <jats:italic>Sambucus nigra</jats:italic> I) than those with simple thrombotic events. These results suggest the unique serum immunoglobulin G glycosylation profile of antiphospholipid syndrome patients, which may inform future studies to design biomarkers for more accurate diagnosis of antiphospholipid syndrome and even for the prediction of clinical symptoms in patients.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"4 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140046310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood defense system – Proposal for a new concept of an immune system against blood borne pathogens comprising the liver, spleen and bone marrow 血液防御系统--关于由肝、脾和骨髓组成的血液传播病原体免疫系统新概念的建议
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-03-05 DOI: 10.1111/sji.13363
Makoto Kashimura
Blood‐borne pathogen (BBP) infections can rapidly progress to life‐threatening sepsis and must therefore be promptly eliminated by the host's immune system. Intravascular macrophages of the liver sinusoid, splenic marginal zone and red pulp and perisinusoidal macrophage protrusions in the bone marrow (BM) directly phagocytose BBPs in the blood as an innate immune response. The liver, spleen and BM thereby work together as the blood defence system (BDS) in response to BBPs by exerting their different immunological roles. The liver removes the vast majority of these invading organisms via innate immunity, but their complete elimination is not possible without the actions of antibodies. Splenic marginal zone B cells promptly produce IgM and IgG antibodies against BBPs. The splenic marginal zone transports antigenic information from the innate to the adaptive immune systems. The white pulp of the spleen functions as adaptive immune tissue and produces specific and high‐affinity antibodies with an immune memory against BBPs. The BM works to maintain immune memory by supporting the survival of memory B cells, memory T cells and long‐lived plasma cells (LLPCs), all of which have dedicated niches. Furthermore, BM perisinusoidal naïve follicular B cells promptly produce IgM antibodies against BBPs in the BM sinusoid and the IgG memory B cells residing in the BM rapidly transform to plasma cells which produce high‐affinity IgG antibodies upon reinfection. This review describes the complete immune defence characteristics of the BDS against BBPs through the collaboration of the liver, spleen and BM with combined different immunological roles.
血源性病原体(BBP)感染可迅速发展为危及生命的败血症,因此必须由宿主的免疫系统及时清除。肝窦、脾边缘区和红髓的血管内巨噬细胞以及骨髓(BM)窦周的巨噬细胞突起直接吞噬血液中的 BBP,这是一种先天性免疫反应。因此,肝脏、脾脏和骨髓作为血液防御系统(BDS),通过发挥各自不同的免疫作用,共同应对 BBPs。肝脏通过先天性免疫清除这些入侵生物的绝大部分,但如果没有抗体的作用,就不可能完全清除它们。脾边缘区 B 细胞会迅速产生针对 BBPs 的 IgM 和 IgG 抗体。脾边缘区将抗原信息从先天性免疫系统传递到适应性免疫系统。脾脏白髓作为适应性免疫组织,产生特异性和高亲和性抗体,对 BBPs 具有免疫记忆。基础细胞膜通过支持记忆 B 细胞、记忆 T 细胞和长寿命浆细胞(LLPCs)的存活来维持免疫记忆,所有这些细胞都有专门的龛位。此外,BM 窦状体周围的幼稚滤泡 B 细胞会迅速产生针对 BBPs 的 IgM 抗体,驻留在 BM 中的 IgG 记忆 B 细胞会迅速转化为浆细胞,在再次感染时产生高亲和性 IgG 抗体。本综述描述了 BDS 通过肝脏、脾脏和 BM 的协作,结合不同的免疫学作用,对 BBPs 的完整免疫防御特征。
{"title":"Blood defense system – Proposal for a new concept of an immune system against blood borne pathogens comprising the liver, spleen and bone marrow","authors":"Makoto Kashimura","doi":"10.1111/sji.13363","DOIUrl":"https://doi.org/10.1111/sji.13363","url":null,"abstract":"Blood‐borne pathogen (BBP) infections can rapidly progress to life‐threatening sepsis and must therefore be promptly eliminated by the host's immune system. Intravascular macrophages of the liver sinusoid, splenic marginal zone and red pulp and perisinusoidal macrophage protrusions in the bone marrow (BM) directly phagocytose BBPs in the blood as an innate immune response. The liver, spleen and BM thereby work together as the blood defence system (BDS) in response to BBPs by exerting their different immunological roles. The liver removes the vast majority of these invading organisms via innate immunity, but their complete elimination is not possible without the actions of antibodies. Splenic marginal zone B cells promptly produce IgM and IgG antibodies against BBPs. The splenic marginal zone transports antigenic information from the innate to the adaptive immune systems. The white pulp of the spleen functions as adaptive immune tissue and produces specific and high‐affinity antibodies with an immune memory against BBPs. The BM works to maintain immune memory by supporting the survival of memory B cells, memory T cells and long‐lived plasma cells (LLPCs), all of which have dedicated niches. Furthermore, BM perisinusoidal naïve follicular B cells promptly produce IgM antibodies against BBPs in the BM sinusoid and the IgG memory B cells residing in the BM rapidly transform to plasma cells which produce high‐affinity IgG antibodies upon reinfection. This review describes the complete immune defence characteristics of the BDS against BBPs through the collaboration of the liver, spleen and BM with combined different immunological roles.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"22 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140046051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The presence of autoantibodies as a potential prognostic biomarker for breast cancer 作为乳腺癌潜在预后生物标志物的自身抗体的存在
IF 3.7 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-02-29 DOI: 10.1111/sji.13365
Libo Ouyang, Keying Jing, Chunkai Zhu, Rong Wang, Peiming Zheng
The presence of autoantibodies is closely associated with the occurrence and development of cancer. Autoantibodies can be used as biomarkers for early breast cancer diagnosis. However, the relationship between autoantibodies and the prognosis of breast cancer patients remains elusive. This retrospective study aimed to investigate the correlation between the presence of autoantibodies and outcomes in breast cancer patients. This study included a total of 155 patients from People's Hospital of Henan University (Zhengzhou, China) who were diagnosed with breast cancer from January 2017 to December 2021. The enrolled patients' clinicopathological features were collected, and 88 patients were ultimately involved in the analysis. Univariate and multivariate Cox regression analyses were performed to search for the risk factors related to the poor prognosis of breast cancer patients. The association between the presence of autoantibodies and patients' survival was analysed using Kaplan–Meier curves. After screening, there were 38 autoantibody‐positive cases and 50 autoantibody‐negative cases. Breast cancer patients with autoantibody‐positive had a 57% lower risk of death compared with autoantibody‐negative patients. Multivariate Cox regression analysis indicated that the presence of autoantibody could be a potential prognostic predictor for breast cancer, independent of age, histological grade, pathological classification, clinical stage, and the expression levels of hormonal receptors. In addition, autoantibody‐positive breast cancer patients had longer progression‐free survival and overall survival compared with autoantibody‐negative cases. Positive autoantibody was found as an independent biomarker of better prognosis in breast cancer patients, providing a new strategy for the prognostic assessment of breast cancer patients.
自身抗体的存在与癌症的发生和发展密切相关。自身抗体可作为早期乳腺癌诊断的生物标志物。然而,自身抗体与乳腺癌患者预后之间的关系仍然难以捉摸。这项回顾性研究旨在探讨自身抗体的存在与乳腺癌患者预后之间的相关性。本研究纳入了河南大学人民医院(中国郑州)2017年1月至2021年12月期间确诊的155例乳腺癌患者。收集了入组患者的临床病理特征,最终有88名患者参与分析。通过单变量和多变量Cox回归分析,寻找与乳腺癌患者不良预后相关的危险因素。采用 Kaplan-Meier 曲线分析了自身抗体的存在与患者生存期之间的关系。经过筛查,共有 38 例自身抗体阳性病例和 50 例自身抗体阴性病例。与自身抗体阴性患者相比,自身抗体阳性乳腺癌患者的死亡风险降低了57%。多变量考克斯回归分析表明,自身抗体的存在可能是预测乳腺癌预后的潜在指标,不受年龄、组织学分级、病理分类、临床分期和激素受体表达水平的影响。此外,与自身抗体阴性病例相比,自身抗体阳性乳腺癌患者的无进展生存期和总生存期更长。研究发现,自身抗体阳性是乳腺癌患者预后较好的独立生物标志物,这为乳腺癌患者的预后评估提供了一种新策略。
{"title":"The presence of autoantibodies as a potential prognostic biomarker for breast cancer","authors":"Libo Ouyang, Keying Jing, Chunkai Zhu, Rong Wang, Peiming Zheng","doi":"10.1111/sji.13365","DOIUrl":"https://doi.org/10.1111/sji.13365","url":null,"abstract":"The presence of autoantibodies is closely associated with the occurrence and development of cancer. Autoantibodies can be used as biomarkers for early breast cancer diagnosis. However, the relationship between autoantibodies and the prognosis of breast cancer patients remains elusive. This retrospective study aimed to investigate the correlation between the presence of autoantibodies and outcomes in breast cancer patients. This study included a total of 155 patients from People's Hospital of Henan University (Zhengzhou, China) who were diagnosed with breast cancer from January 2017 to December 2021. The enrolled patients' clinicopathological features were collected, and 88 patients were ultimately involved in the analysis. Univariate and multivariate Cox regression analyses were performed to search for the risk factors related to the poor prognosis of breast cancer patients. The association between the presence of autoantibodies and patients' survival was analysed using Kaplan–Meier curves. After screening, there were 38 autoantibody‐positive cases and 50 autoantibody‐negative cases. Breast cancer patients with autoantibody‐positive had a 57% lower risk of death compared with autoantibody‐negative patients. Multivariate Cox regression analysis indicated that the presence of autoantibody could be a potential prognostic predictor for breast cancer, independent of age, histological grade, pathological classification, clinical stage, and the expression levels of hormonal receptors. In addition, autoantibody‐positive breast cancer patients had longer progression‐free survival and overall survival compared with autoantibody‐negative cases. Positive autoantibody was found as an independent biomarker of better prognosis in breast cancer patients, providing a new strategy for the prognostic assessment of breast cancer patients.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"21 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140002270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Scandinavian Journal of Immunology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1