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Current Concepts in Intra-articular Calcaneus Fractures. 跟骨关节内骨折的最新概念。
Q3 Medicine Pub Date : 2025-07-29 eCollection Date: 2025-06-01 DOI: 10.1055/s-0045-1809886
Rafael Barban Sposeto, Germán Matías-Joannas, Alexandre Leme Godoy-Santos

Intra-articular calcaneal fractures are significant injuries to the locomotor system, often leading to lifelong impairments in foot mechanics with substantial occupational, social, and financial repercussions. The initial imaging diagnosis relies on radiography; however, computed tomography is crucial for understanding the three-dimensional anatomy of the fracture and facilitating surgical planning. The treatment of intra-articular calcaneal fractures remains a subject of debate, with literature supporting diverse approaches for similar fracture types. Currently, the gold standard for managing subtalar joint fractures is surgical intervention. Among the two most common techniques, the extended lateral and the sinus tarsi approaches yield comparable functional outcomes, though the latter is associated with fewer complications. The present article discusses the diagnosis, classification, and treatment of intra-articular calcaneal fractures, focusing on the sinus tarsi and extended lateral "L" approaches, as well as the fixation techniques applicable to each fracture type.

跟骨关节内骨折是运动系统的重大损伤,通常会导致足部力学终身损伤,并带来重大的职业、社会和经济影响。最初的影像学诊断依赖于x线摄影;然而,计算机断层扫描对于了解骨折的三维解剖结构和促进手术计划至关重要。跟骨关节内骨折的治疗仍然是一个有争议的话题,文献支持不同的方法治疗类似的骨折类型。目前,治疗距下关节骨折的金标准是手术干预。在两种最常见的入路中,扩展外侧入路和跗骨窦入路的功能效果相当,尽管后者的并发症较少。本文讨论跟骨关节内骨折的诊断、分类和治疗,重点讨论跗骨窦和扩展外侧“L”入路,以及适用于每种骨折类型的固定技术。
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引用次数: 0
Recommendations and Protocols for the Safe Use of Tourniquets in Upper- and Lower-Extremity Surgeries. 在上肢和下肢手术中安全使用止血带的建议和方案。
Q3 Medicine Pub Date : 2025-07-29 eCollection Date: 2025-06-01 DOI: 10.1055/s-0045-1809689
Antonio Tufi Neder Filho, Túlio Vinícius de Oliveira Campos

The tourniquet (TNQ) interrupts blood flow to a given anatomical segment and has critical applications in orthopedic surgeries by providing a blood-free operating field. The risks and complications attributed to its use are increased pain, reperfusion injury, edema, deep venous thrombosis, and peripheral nerve injury. The main recommendations for TNQ use and to reduce the occurrence of complications include adequate limb padding; TNQ inflation to pressures of 50 mmHg and 100 mmHg above the perfusion pressure for the upper and lower limbs respectively; avoid TNQ use in children and patients with cachexia, lupus, and coagulopathy; avoid keeping the device inflated for more than 2 hours; and have a trained team alert to deflation, which is characterized by the possibility of bleeding, pulmonary embolism, and myonephropathic metabolic syndrome. The present update article summarizes the best evidence on TNQ use in orthopedic surgeries and proposes a protocol for its safe use.

止血带(TNQ)阻断血液流向给定的解剖节段,通过提供无血的手术区域在骨科手术中具有重要的应用。其使用的风险和并发症包括疼痛增加、再灌注损伤、水肿、深静脉血栓形成和周围神经损伤。使用TNQ和减少并发症发生的主要建议包括:适当的肢体填充物;上肢和下肢TNQ充气分别高于灌注压力50 mmHg和100 mmHg;避免儿童和患有恶病质、狼疮和凝血功能障碍的患者使用TNQ;避免使设备充气超过2小时;还要有一支训练有素的队伍,对通货紧缩保持警惕,通货紧缩的特点是可能出现出血、肺栓塞和肌肾代谢综合征。本文总结了TNQ在骨科手术中使用的最佳证据,并提出了其安全使用的方案。
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引用次数: 0
[Lymphocyte Count, Serum Albumin and Transferrin Levels in Patients Undergoing Total Knee Arthroplasty]. [全膝关节置换术患者淋巴细胞计数、血清白蛋白和转铁蛋白水平]。
Q3 Medicine Pub Date : 2025-07-25 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809530
Bernardo Crespo Alves, Amanda S Cavalcanti, Kelly Biancardini Gomes Barbato, João Maurício Barretto, Juliana Arruda de Matos

Objective: To describe the prevalence of preoperative malnutrition in individuals undergoing primary TKA and to assess its association with age, sex, body mass index (BMI), and comorbidities, as well as the risk of prolonged postsurgical hospitalization, early prosthetic joint infection (PJI), or readmission.

Methods: We conducted a cohort study of TKAs performed between 2014 and 2016. Preoperative malnutrition was defined as a total lymphocyte count < 1,500 cells/mm 3 , a serum albumin concentration < 3.5 g/dL, or a transferrin concentration < 200 mg/dL within the six months before surgery.

Results: Out of the 2080 TKAs performed, 1099 had valid lymphometry, albumin, and transferrin data and were included in the analysis. The prevalence of malnutrition was 17.7%. Independent factors associated with a higher prevalence of malnutrition were age (OR = 1.03; 95% CI = (1.01-1.05)), anemia (1.55 (1.05-2.28)), low weight (3.13 (1.50-6.50)), and normal weight (1.85 (1.21-2.82)). Diabetes mellitus was inversely associated with malnutrition (0.60 (0.38-0.96)). Early PJI was diagnosed in 18 (1.6%) participants. There was no statistically significant and independent association between malnutrition and postsurgical complications.

Conclusion: Altered lymphocyte count, serum albumin, and transferrin levels is common among individuals undergoing TKA, particularly in older patients, those with anemia, and individuals with normal or low weight. Future studies with larger sample sizes are needed to better assess the relationship between malnutrition and adverse outcomes following TKA.

目的:描述原发性TKA患者术前营养不良的患病率,并评估其与年龄、性别、体重指数(BMI)、合并症以及术后住院时间延长、早期假体关节感染(PJI)或再入院的风险之间的关系。方法:我们对2014年至2016年间进行的tka进行了队列研究。术前营养不良被定义为总淋巴细胞计数3、血清白蛋白浓度。结果:在进行的2080例tka中,1099例具有有效的淋巴测定、白蛋白和转铁蛋白数据,并被纳入分析。营养不良发生率为17.7%。与营养不良发生率较高相关的独立因素是年龄(OR = 1.03;95% CI =(1.01 - -1.05)),贫血(1.55(1.05 - -2.28)),低体重(3.13(1.50 - -6.50)),和正常体重(1.85(1.21 - -2.82))。糖尿病与营养不良呈负相关(0.60(0.38-0.96))。18名(1.6%)参与者被诊断为早期PJI。营养不良与术后并发症之间没有统计学意义上的独立关联。结论:淋巴细胞计数、血清白蛋白和转铁蛋白水平改变在TKA患者中很常见,特别是在老年患者、贫血患者和体重正常或低的患者中。未来需要更大样本量的研究来更好地评估TKA后营养不良与不良后果之间的关系。
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引用次数: 0
Lymphocyte Count, Serum Albumin and Transferrin Levels in Patients Undergoing Total Knee Arthroplasty. 全膝关节置换术患者的淋巴细胞计数、血清白蛋白和转铁蛋白水平。
Q3 Medicine Pub Date : 2025-07-25 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809529
Bernardo Crespo Alves, Amanda S Cavalcanti, Kelly Biancardini Gomes Barbato, João Maurício Barretto, Juliana Arruda de Matos

Objective: Describe the prevalence of preoperative malnutrition in individuals undergoing primary TKA and to assess its association with age, sex, body mass index (BMI), and comorbidities, as well as the risk of prolonged postsurgical hospitalization, early prosthetic joint infection (PJI), or readmission.

Methods: We conducted a cohort study of TKAs performed between 2014 and 2016. Preoperative malnutrition was defined as a total lymphocyte count < 1,500 cells/mm 3 , a serum albumin concentration < 3.5 g/dL, or a transferrin concentration < 200 mg/dL within the six months before surgery.

Results: Out of the 2080 TKAs performed, 1099 had valid lymphometry, albumin, and transferrin data and were included in the analysis. The prevalence of malnutrition was 17.7%. Independent factors associated with a higher prevalence of malnutrition were age (OR = 1.03; 95% CI = (1.01-1.05)), anemia (1.55 (1.05-2.28)), low weight (3.13 (1.50-6.50)), and normal weight (1.85 (1.21-2.82)). Diabetes mellitus was inversely associated with malnutrition (0.60 (0.38-0.96)). Early PJI was diagnosed in 18 (1.6%) participants. There was no statistically significant and independent association between malnutrition and postsurgical complications.

Conclusion: Altered lymphocyte count, serum albumin, and transferrin levels is common among individuals undergoing TKA, particularly in older patients, those with anemia, and individuals with normal or low weight. Future studies with larger sample sizes are needed to better assess the relationship between malnutrition and adverse outcomes following TKA.

目的:描述原发性TKA患者术前营养不良的患病率,并评估其与年龄、性别、体重指数(BMI)和合并症的关系,以及术后住院时间延长、早期假体关节感染(PJI)或再入院的风险。方法:我们对2014年至2016年间进行的tka进行了队列研究。术前营养不良被定义为总淋巴细胞计数3、血清白蛋白浓度。结果:在进行的2080例tka中,1099例具有有效的淋巴测定、白蛋白和转铁蛋白数据,并被纳入分析。营养不良发生率为17.7%。与营养不良发生率较高相关的独立因素是年龄(OR = 1.03;95% CI =(1.01 - -1.05)),贫血(1.55(1.05 - -2.28)),低体重(3.13(1.50 - -6.50)),和正常体重(1.85(1.21 - -2.82))。糖尿病与营养不良呈负相关(0.60(0.38-0.96))。18名(1.6%)参与者被诊断为早期PJI。营养不良与术后并发症之间没有统计学意义上的独立关联。结论:淋巴细胞计数、血清白蛋白和转铁蛋白水平改变在TKA患者中很常见,特别是在老年患者、贫血患者和体重正常或低的患者中。未来需要更大样本量的研究来更好地评估TKA后营养不良与不良后果之间的关系。
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引用次数: 0
Medial Thigh Cutaneous Flap Irrigated by Perforating Vessels of the Secondary Pedicle of the Gracilis Muscle: Anatomical Study and Clinical Case Report. 股薄肌第二蒂穿支血管灌注大腿内侧皮瓣的解剖学研究及临床病例报告。
Q3 Medicine Pub Date : 2025-07-15 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809398
Gabriel Vique Valeriano, Antonio Carlos da Costa, Diego Figueira Falcochio, Yussef Ali Abdouni

Objective: To analyze the anatomy of the perforating vessels irrigating the skin of the medial aspect of the thigh and originating from the secondary vascular pedicle of the gracilis muscle.

Methods: We dissected 33 thighs from cadavers of both sexes to record and analyze the characteristics of the blood vessels irrigating the gracilis muscle in the middle third of the thigh.

Results: All thighs (100%) had a secondary vascular pedicle in the intermuscular septum between the gracilis and vastus medialis/sartorius muscles, with branches irrigating the overlying skin on the medial aspect. The pedicle presented an arterial diameter ranging from 1.3 to 4.6 mm (mean: 2.3 mm) and a length ranging from 28 to 84 mm (mean: 50.6 mm). In 87.8% of the cases, the pedicle irrigated the gracilis muscle and presented vessels to the overlying skin.

Conclusion: Based on the data found, we conclude that it is feasible to obtain a reliable flap from the medial aspect of the middle third of the thigh.

目的:分析股薄肌次级血管蒂发源于股薄肌内侧皮肤的穿支血管的解剖特点。方法:我们解剖了33例男女尸体的大腿,记录并分析了大腿中三分之一股薄肌的血管特征。结果:所有的大腿(100%)在股薄肌和股内侧肌/缝匠肌之间的肌间隔处有一个二级血管蒂,分支在内侧冲洗覆盖的皮肤。蒂动脉直径为1.3 ~ 4.6 mm(平均2.3 mm),长度为28 ~ 84 mm(平均50.6 mm)。在87.8%的病例中,蒂冲洗股薄肌并向上覆皮肤呈现血管。结论:根据所发现的数据,我们认为从大腿中三分之一内侧获得可靠的皮瓣是可行的。
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引用次数: 0
[Medial Thigh Cutaneous Flap Irrigated by Perforating Vessels of the Secondary Pedicle of the Gracilis Muscle: Anatomical Study and Clinical Case Report]. 股薄肌第二蒂穿支血管灌注大腿内侧皮瓣的解剖学研究及临床病例报告。
Q3 Medicine Pub Date : 2025-07-15 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809523
Gabriel Vique Valeriano, Antonio Carlos da Costa, Diego Figueira Falcochio, Yussef Ali Abdouni

Objective: To analyze the anatomy of the perforating vessels irrigating the skin of the medial aspect of the thigh and originating from the secondary vascular pedicle of the gracilis muscle.

Methods: We dissected 33 thighs from cadavers of both sexes to record and analyze the characteristics of the blood vessels irrigating the gracilis muscle in the middle third of the thigh.

Results: All thighs (100%) had a secondary vascular pedicle in the intermuscular septum between the gracilis and vastus medialis/sartorius muscles, with branches irrigating the overlying skin on the medial aspect. The pedicle presented an arterial diameter ranging from 1.3 to 4.6 mm (mean: 2.3 mm) and a length ranging from 28 to 84 mm (mean: 50.6 mm). In 87.8% of the cases, the pedicle irrigated the gracilis muscle and presented vessels to the overlying skin.

Conclusion: Based on the data found, we conclude that it is feasible to obtain a reliable flap from the medial aspect of the middle third of the thigh.

目的:分析股薄肌次级血管蒂发源于股薄肌内侧皮肤的穿支血管的解剖特点。方法:我们解剖了33例男女尸体的大腿,记录并分析了大腿中三分之一股薄肌的血管特征。结果:所有的大腿(100%)在股薄肌和股内侧肌/缝匠肌之间的肌间隔处有一个二级血管蒂,分支在内侧冲洗覆盖的皮肤。蒂动脉直径为1.3 ~ 4.6 mm(平均2.3 mm),长度为28 ~ 84 mm(平均50.6 mm)。在87.8%的病例中,蒂冲洗股薄肌并向上覆皮肤呈现血管。结论:根据所发现的数据,我们认为从大腿中三分之一内侧获得可靠的皮瓣是可行的。
{"title":"[Medial Thigh Cutaneous Flap Irrigated by Perforating Vessels of the Secondary Pedicle of the Gracilis Muscle: Anatomical Study and Clinical Case Report].","authors":"Gabriel Vique Valeriano, Antonio Carlos da Costa, Diego Figueira Falcochio, Yussef Ali Abdouni","doi":"10.1055/s-0045-1809523","DOIUrl":"10.1055/s-0045-1809523","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the anatomy of the perforating vessels irrigating the skin of the medial aspect of the thigh and originating from the secondary vascular pedicle of the gracilis muscle.</p><p><strong>Methods: </strong>We dissected 33 thighs from cadavers of both sexes to record and analyze the characteristics of the blood vessels irrigating the gracilis muscle in the middle third of the thigh.</p><p><strong>Results: </strong>All thighs (100%) had a secondary vascular pedicle in the intermuscular septum between the gracilis and vastus medialis/sartorius muscles, with branches irrigating the overlying skin on the medial aspect. The pedicle presented an arterial diameter ranging from 1.3 to 4.6 mm (mean: 2.3 mm) and a length ranging from 28 to 84 mm (mean: 50.6 mm). In 87.8% of the cases, the pedicle irrigated the gracilis muscle and presented vessels to the overlying skin.</p><p><strong>Conclusion: </strong>Based on the data found, we conclude that it is feasible to obtain a reliable flap from the medial aspect of the middle third of the thigh.</p>","PeriodicalId":21536,"journal":{"name":"Revista Brasileira de Ortopedia","volume":"60 2","pages":"s00451809523"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hill-Sachs Lesion: Diagnosis, Classification, and Treatment]. [Hill-Sachs病变:诊断、分类和治疗]。
Q3 Medicine Pub Date : 2025-07-10 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809525
Marcel Jun Sugawara Tamaoki, Artur Yudi Utino, Renato Aroca Zan, Fabio Teruo Matsunaga, Nicola Archetti Netto

A lesão de Hill-Sachs é uma condição frequentemente associada à instabilidade anterior do ombro, que desempenha um papel crucial nos resultados de seu tratamento The Hill-Sachs lesion is a condition frequently associated with anterior shoulder instability, which plays a crucial role in the outcomes of its treatment. It is characterized by a posterior compressive fracture in the humeral head caused by an impingement against the anterior rim of the glenoid cavity during dislocation. A thorough understanding of this lesion is essential to support clinical decisions and choose the most appropriate treatment. Advances in imaging modalities, such as magnetic resonance imaging and computed tomography, enabled lesion identification with greater precision and its classification per depth, location, and volume, resulting in a detailed assessment of its role in shoulder instability. The present article reviews the main classifications, diagnostic methods, and treatment options to provide orthopedists with a comprehensive and updated view of the strategies to promote better functional outcomes and minimize the risk of instability recurrence.

Hill-Sachs病变是一种常与肩关节前路不稳定相关的疾病,在其治疗结果中起着至关重要的作用。其特征是脱位时肩关节腔前缘受到撞击,导致肱骨头后侧压缩性骨折。彻底了解这种病变对于支持临床决策和选择最合适的治疗方法至关重要。成像技术的进步,如磁共振成像和计算机断层扫描,使病变识别更加精确,并根据深度、位置和体积进行分类,从而详细评估其在肩部不稳定中的作用。本文回顾了主要的分类、诊断方法和治疗方案,为骨科医生提供了一个全面和最新的策略,以促进更好的功能预后和最小化不稳定性复发的风险。
{"title":"[Hill-Sachs Lesion: Diagnosis, Classification, and Treatment].","authors":"Marcel Jun Sugawara Tamaoki, Artur Yudi Utino, Renato Aroca Zan, Fabio Teruo Matsunaga, Nicola Archetti Netto","doi":"10.1055/s-0045-1809525","DOIUrl":"10.1055/s-0045-1809525","url":null,"abstract":"<p><p>A lesão de Hill-Sachs é uma condição frequentemente associada à instabilidade anterior do ombro, que desempenha um papel crucial nos resultados de seu tratamento The Hill-Sachs lesion is a condition frequently associated with anterior shoulder instability, which plays a crucial role in the outcomes of its treatment. It is characterized by a posterior compressive fracture in the humeral head caused by an impingement against the anterior rim of the glenoid cavity during dislocation. A thorough understanding of this lesion is essential to support clinical decisions and choose the most appropriate treatment. Advances in imaging modalities, such as magnetic resonance imaging and computed tomography, enabled lesion identification with greater precision and its classification per depth, location, and volume, resulting in a detailed assessment of its role in shoulder instability. The present article reviews the main classifications, diagnostic methods, and treatment options to provide orthopedists with a comprehensive and updated view of the strategies to promote better functional outcomes and minimize the risk of instability recurrence.</p>","PeriodicalId":21536,"journal":{"name":"Revista Brasileira de Ortopedia","volume":"60 2","pages":"s00451809525"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Low Back Pain Management with a Combination of Uridine Triphosphate, Cytidine Monophosphate, and Hydroxocobalamin: A Systematic Review and Meta-Analysis]. [联合使用三磷酸尿苷、单磷酸胞苷和羟钴胺素治疗腰痛:系统回顾和荟萃分析]。
Q3 Medicine Pub Date : 2025-07-10 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809521
Marco Antonio N Mibielli, Mendel Suchmacher, Mauro Geller, Spyros G E Mezitis, Carlos P Nunes, Aline Sintoveter

Low back pain is a common complaint. This syndrome comprehends different underlying mechanisms, which are difficult to differentiate in a timely manner only through semiotic, laboratory, and imaging resources available in an emergency setting. Such circumstances make practitioners prone to an initial symptomatic approach in the form of medications (non-steroid anti-inflammatory drugs, analgesics, muscle relaxants) or local procedures (local heat, massage). Peripheral neurotrophic substances, such as pyrimidine nucleotides (uridine triphosphate and cytidine monophosphate) combined with vitamin B12 (hydroxocobalamin), have been used as anabolic precursors able to provide spinal nerve roots with triggering elements useful for nerve and glial cells regeneration, once a likely spinal compression mechanism is contained. The authors performed a systematic review and meta-analysis with the above combination with the aim of better determining its role in low back pain management.

腰痛是常见的主诉。该综合征包含不同的潜在机制,仅通过符号学、实验室和紧急情况下可用的成像资源难以及时区分。这种情况使从业者倾向于以药物(非类固醇抗炎药、镇痛药、肌肉松弛剂)或局部手术(局部加热、按摩)的形式进行初步症状治疗。周围神经营养物质,如嘧啶核苷酸(三磷酸尿苷和单磷酸胞苷)与维生素B12(羟钴胺素)结合,已被用作合成代谢前体,一旦可能的脊髓压迫机制被包含,就能够为脊髓神经根提供对神经和胶质细胞再生有用的触发元素。作者对上述组合进行了系统回顾和荟萃分析,目的是更好地确定其在腰痛治疗中的作用。
{"title":"[Low Back Pain Management with a Combination of Uridine Triphosphate, Cytidine Monophosphate, and Hydroxocobalamin: A Systematic Review and Meta-Analysis].","authors":"Marco Antonio N Mibielli, Mendel Suchmacher, Mauro Geller, Spyros G E Mezitis, Carlos P Nunes, Aline Sintoveter","doi":"10.1055/s-0045-1809521","DOIUrl":"10.1055/s-0045-1809521","url":null,"abstract":"<p><p>Low back pain is a common complaint. This syndrome comprehends different underlying mechanisms, which are difficult to differentiate in a timely manner only through semiotic, laboratory, and imaging resources available in an emergency setting. Such circumstances make practitioners prone to an initial symptomatic approach in the form of medications (non-steroid anti-inflammatory drugs, analgesics, muscle relaxants) or local procedures (local heat, massage). Peripheral neurotrophic substances, such as pyrimidine nucleotides (uridine triphosphate and cytidine monophosphate) combined with vitamin B12 (hydroxocobalamin), have been used as anabolic precursors able to provide spinal nerve roots with triggering elements useful for nerve and glial cells regeneration, once a likely spinal compression mechanism is contained. The authors performed a systematic review and meta-analysis with the above combination with the aim of better determining its role in low back pain management.</p>","PeriodicalId":21536,"journal":{"name":"Revista Brasileira de Ortopedia","volume":"60 2","pages":"s00451809521"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lowback Pain Management with a Combination of Uridine Triphosphate, Cytidine Monophosphate, and Hydroxocobalamin: A Systematic Review and Meta-Analysis. 三磷酸尿苷、单磷酸胞苷和羟钴胺联合治疗腰痛:系统回顾和荟萃分析。
Q3 Medicine Pub Date : 2025-07-10 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1804495
Marco Antonio N Mibielli, Mendel Suchmacher, Mauro Geller, Spyros G E Mezitis, Carlos P Nunes, Aline Sintoveter

Low back pain is a common complaint. This syndrome comprehends different underlying mechanisms, which are difficult to differentiate in a timely manner only through semiotic, laboratory, and imaging resources available in an emergency setting. Such circumstances make practitioners prone to an initial symptomatic approach in the form of medications (non-steroid anti-inflammatory drugs, analgesics, muscle relaxants) or local procedures (local heat, massage). Peripheral neurotrophic substances, such as pyrimidine nucleotides (uridine triphosphate and cytidine monophosphate) combined with vitamin B12 (hydroxocobalamin), have been used as anabolic precursors able to provide spinal nerve roots with triggering elements useful for nerve and glial cells regeneration, once a likely spinal compression mechanism is contained. The authors performed a systematic review and meta-analysis with the above combination with the aim of better determining its role in low back pain management.

腰痛是常见的主诉。该综合征包含不同的潜在机制,仅通过符号学、实验室和紧急情况下可用的成像资源难以及时区分。这种情况使从业者倾向于以药物(非类固醇抗炎药、镇痛药、肌肉松弛剂)或局部手术(局部加热、按摩)的形式进行初步症状治疗。周围神经营养物质,如嘧啶核苷酸(三磷酸尿苷和单磷酸胞苷)与维生素B12(羟钴胺素)结合,已被用作合成代谢前体,一旦可能的脊髓压迫机制被包含,就能够为脊髓神经根提供对神经和胶质细胞再生有用的触发元素。作者对上述组合进行了系统回顾和荟萃分析,目的是更好地确定其在腰痛治疗中的作用。
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引用次数: 0
Postoperative Outcomes with and without Neoadjuvant Denosumab in Grade-III Giant Cell Tumor of the Proximal Femur: A Comparative Retrospective Study. 使用和不使用新辅助Denosumab治疗股骨近端iii级巨细胞瘤的术后结果:一项比较回顾性研究
Q3 Medicine Pub Date : 2025-07-10 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809397
Sheikh Muhammad Ebad Ali, Badaruddin Sahito, Hina Khan, Awais Abro, Sunel Kumar, Muhammad Usman Ali

Objective: To retrospectively compare the impact of using neoadjuvant denosumab for Campanacci grade-III giant cell tumor (GCT) of the proximal femur involving the hip joint.

Methods: We retrospectively reviewed 18 cases of Campanacci grade-III GCT of the proximal femur receiving surgery between January 2014 and December 2019 from our hospital. One group of 10 patients received weekly neoadjuvant denosumab 120 mg for 4 weeks, while the other group of 8 patients did not receive denosumab before surgery. Two patients were subjected to intralesional curettage while the others received resection and hip arthroplasty. Comparisons were made using unpaired t -test and Fisher's exact test. Functional outcomes were assessed by revised Musculoskeletal Tumor Society (MSTS) score and Harris Hip Score (HHS) at 6 weeks, 6 months, and 12 months of follow-up, as well as incidence of recurrence.

Results: The comparison of the mean MSTS scores of the denosumab and non-denosumab groups was as follows: 24.0 ± 6.5 versus 20.0 ± 6.0 ( p  = 0.04) at 6 weeks respectively; 26.0 ± 5.0 versus 23.0 ± 0.67 ( p  = 0.04) at 6 months respectively; and 28.8 ± 1.7 versus 29.5 ± 0.33 ( p  = 0.35) at 12 months respectively. The comparison of HHSs between the denosumab and non-denosumab groups was as follows: 61.02 ± 7.36 versus 48.52 ± 3.97 ( p  = 0.03) at 6 weeks respectively; 81.1 ± 2.97 versus 79.15 ± 3.24 ( p  = 0.82) at 6 months respectively; and 89.84 ± 3.75 versus 90.05 ± 3.00 ( p  = 0.38) at 12 months respectively. There was no recurrence.

Conclusion: Denosumab was clinically effective in improving the short-term functional outcomes, but long-term functional outcomes remained similar between the groups. We did not find an increased recurrence rate in the denosumab group.

目的:回顾性比较新辅助denosumab治疗累及髋关节的股骨近端Campanacci iii级巨细胞瘤(GCT)的疗效。方法:回顾性分析我院2014年1月至2019年12月接受手术的18例股骨近端Campanacci iii级GCT。其中一组10例患者每周接受新辅助降噪单抗120mg,持续4周,另一组8例患者术前未接受降噪单抗治疗。2例患者行病灶内刮除术,其余患者行切除和髋关节置换术。采用非配对t检验和Fisher精确检验进行比较。在随访6周、6个月和12个月时,通过修订后的肌肉骨骼肿瘤协会(MSTS)评分和Harris髋关节评分(HHS)以及复发率来评估功能结局。结果:denosumab组与非denosumab组MSTS平均评分比较:6周时分别为24.0±6.5分与20.0±6.0分(p = 0.04);6个月时分别为26.0±5.0 vs 23.0±0.67 (p = 0.04);12个月时分别为28.8±1.7 vs 29.5±0.33 (p = 0.35)。denosumab组与非denosumab组hhs比较:6周时分别为61.02±7.36 vs 48.52±3.97 (p = 0.03);6个月时分别为81.1±2.97 vs 79.15±3.24 (p = 0.82);12个月时89.84±3.75 vs 90.05±3.00 (p = 0.38)。无复发。结论:Denosumab在改善短期功能结局方面临床有效,但两组间的长期功能结局相似。我们没有发现denosumab组复发率增加。
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引用次数: 0
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Revista Brasileira de Ortopedia
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