Pub Date : 2023-01-01DOI: 10.2306/scienceasia1513-1874.2023.032
Tarique Hussain, G. Murtaza, Dildar Hussain Kalhoro, Muhammad Saleem Kalhoro, Muhammad Ismail Chughtai, Anjaleena Yaseen
: Pregnancy is a complex physiological phenomenon involving maternal-fetal communication. Uterine natural killer (uNK) cells established a profound lymphocyte population in the early pregnant uterus. These cells are closely linked with extravillous trophoblast (EVT) and spiral arteries and play a vital role in remodeling spiral arteries, trophoblast invasion and placental development. The uNK cells are the potent releasers of cytokines and growth factors; with close association to EVTs in the maternal-fetal interface, it drives an essential function in the trophoblast. At present, limited studies are available explaining the significance of uNK cells in normal pregnancy and pregnancy-associated problems. This review article elucidates the descriptive role of uNK cells in pregnancy problems and their crosstalk with other immune cell components. Moreover, we will also discuss whether uNK cells become a threat to pregnancy with clinical evidence
{"title":"Exploiting the significance of uterine natural killer cells in pregnancy","authors":"Tarique Hussain, G. Murtaza, Dildar Hussain Kalhoro, Muhammad Saleem Kalhoro, Muhammad Ismail Chughtai, Anjaleena Yaseen","doi":"10.2306/scienceasia1513-1874.2023.032","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.032","url":null,"abstract":": Pregnancy is a complex physiological phenomenon involving maternal-fetal communication. Uterine natural killer (uNK) cells established a profound lymphocyte population in the early pregnant uterus. These cells are closely linked with extravillous trophoblast (EVT) and spiral arteries and play a vital role in remodeling spiral arteries, trophoblast invasion and placental development. The uNK cells are the potent releasers of cytokines and growth factors; with close association to EVTs in the maternal-fetal interface, it drives an essential function in the trophoblast. At present, limited studies are available explaining the significance of uNK cells in normal pregnancy and pregnancy-associated problems. This review article elucidates the descriptive role of uNK cells in pregnancy problems and their crosstalk with other immune cell components. Moreover, we will also discuss whether uNK cells become a threat to pregnancy with clinical evidence","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68624008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.2306/scienceasia1513-1874.2023.035
Chakkrit Poonpakdee, Khabele Z. Ntlopo, J. Onthong, K. Khawmee, Yao-Tung Lin
{"title":"Response and efficiency of magnesium fertilizer application in soybean (Glycine max) and sunflower (Helianthus annuus)","authors":"Chakkrit Poonpakdee, Khabele Z. Ntlopo, J. Onthong, K. Khawmee, Yao-Tung Lin","doi":"10.2306/scienceasia1513-1874.2023.035","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.035","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"302 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68624279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimization of phenolic extraction from Syzygium samarangense fruit and its protective properties against glucotoxicity-induced pancreatic β-cell death","authors":"Kanchana Suksri, Bancha Yingngam, Nipaporn Muangchan","doi":"10.2306/scienceasia1513-1874.2023.043","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.043","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68624745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.2306/scienceasia1513-1874.2023.068
J. R. Ketudat Cairns, A. Karunambigai, J. Jeon, Jisnuson Svasti
{"title":"Functions of rice beta-glucosidases and transglucosidases","authors":"J. R. Ketudat Cairns, A. Karunambigai, J. Jeon, Jisnuson Svasti","doi":"10.2306/scienceasia1513-1874.2023.068","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.068","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68626733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.2306/scienceasia1513-1874.2023.138
Pongpat Chaisawasd, Sirawit Ittisoponpisan
As of 14 January 2022, 2.3 million people in Thailand had been reportedly infected with SARS-CoV-2, and 21,883 people had died. Spike glycoprotein, on the SARS-CoV-2 membrane, is a key factor for viral infection. Some scientists have demonstrated that some amino acid mutations in the protein increase infectivity and transmissibility of the virus. However, many studies concerning mutations in the spike glycoprotein, particularly in Thailand, were not comprehensive enough to illustrate the impacts of the mutations on the spike glycoprotein. To narrow this gap, we examined approximately 8.3 million spike glycoprotein sequences retrieved from GISAID Initiative and NCBI Virus databases to identify novel mutations. Limiting our scope to the Thai samples, we demonstrated how local SARS-CoV-2 strains changed over 2021. In addition, we found that T95I had emerged and become one of the main characteristics of delta strains in Thailand. We further detected 28 Thailand-specific novel mutations, which were then analyzed with amino acid-based analysis tools to gain insights into their impacts on the spike glycoprotein. Upon closer examination, we found that 2 novel mutations, L249E and R457W, were likely to diminish the interactions between the spike glycoprotein and neutralizing antibodies in silico. This finding suggests that both mutations may hinder the neutralization, allowing the virus to escape the antibodies. Additionally, our study highlights the significant effects of some novel mutations on the stability and functionality of the spike glycoprotein, which may be useful for COVID-19 diagnosis and vaccine development. [ FROM AUTHOR]
{"title":"Computational analysis of the novel Thailand-specific mutations in SARS-CoV-2 spike glycoprotein sequences","authors":"Pongpat Chaisawasd, Sirawit Ittisoponpisan","doi":"10.2306/scienceasia1513-1874.2023.138","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.138","url":null,"abstract":"As of 14 January 2022, 2.3 million people in Thailand had been reportedly infected with SARS-CoV-2, and 21,883 people had died. Spike glycoprotein, on the SARS-CoV-2 membrane, is a key factor for viral infection. Some scientists have demonstrated that some amino acid mutations in the protein increase infectivity and transmissibility of the virus. However, many studies concerning mutations in the spike glycoprotein, particularly in Thailand, were not comprehensive enough to illustrate the impacts of the mutations on the spike glycoprotein. To narrow this gap, we examined approximately 8.3 million spike glycoprotein sequences retrieved from GISAID Initiative and NCBI Virus databases to identify novel mutations. Limiting our scope to the Thai samples, we demonstrated how local SARS-CoV-2 strains changed over 2021. In addition, we found that T95I had emerged and become one of the main characteristics of delta strains in Thailand. We further detected 28 Thailand-specific novel mutations, which were then analyzed with amino acid-based analysis tools to gain insights into their impacts on the spike glycoprotein. Upon closer examination, we found that 2 novel mutations, L249E and R457W, were likely to diminish the interactions between the spike glycoprotein and neutralizing antibodies in silico. This finding suggests that both mutations may hinder the neutralization, allowing the virus to escape the antibodies. Additionally, our study highlights the significant effects of some novel mutations on the stability and functionality of the spike glycoprotein, which may be useful for COVID-19 diagnosis and vaccine development. [ FROM AUTHOR]","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68627011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.2306/scienceasia1513-1874.2023.008
E. Tan, K. Chua, S. Jones, Lay Koon Tan, A. Loch, B. Kee
{"title":"Genetic investigation of point mutations in sarcomeric genes in Malaysian patients with cardiomyopathy","authors":"E. Tan, K. Chua, S. Jones, Lay Koon Tan, A. Loch, B. Kee","doi":"10.2306/scienceasia1513-1874.2023.008","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.008","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68622722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.2306/scienceasia1513-1874.2023.073
Lei Xin, Xu Yang, Yijie Xu, Xinlei Ye, Yiling Zhang, Guodong Zhao
{"title":"Pyrethroid pesticide-induced differential gene expression in midguts of two silkworm (Bombyx mori) strains of different susceptibilities","authors":"Lei Xin, Xu Yang, Yijie Xu, Xinlei Ye, Yiling Zhang, Guodong Zhao","doi":"10.2306/scienceasia1513-1874.2023.073","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.073","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"389 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.2306/scienceasia1513-1874.2022.143
Manuel Carrillo-Morales, A. Wong-Villarreal, L. Aguilar-Marcelino, G. Castañeda-Ramírez, J. A. Pineda-Alegría, E. Hernández-Núñez
{"title":"Chemical composition and antifungal and nematicidal activities of the hexanic and methanolic extracts of Syzygium aromaticum","authors":"Manuel Carrillo-Morales, A. Wong-Villarreal, L. Aguilar-Marcelino, G. Castañeda-Ramírez, J. A. Pineda-Alegría, E. Hernández-Núñez","doi":"10.2306/scienceasia1513-1874.2022.143","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2022.143","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68621857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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