Pub Date : 2022-07-01DOI: 10.1007/s00281-022-00909-9
Christy E Trussoni, Steven P O'Hara, Nicholas F LaRusso
The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are three cholangiopathies with significant immune-mediated pathogenesis where chronic inflammation and fibrosis lead to obliteration of bile ducts and eventual liver cirrhosis. Cellular senescence is a state of cell cycle arrest in which cells become resistant to apoptosis and profusely secrete a bioactive secretome. Recent evidence indicates that cholangiocyte senescence contributes to the pathogenesis of BA, PBC, and PSC. This review explores the role of cholangiocyte senescence in BA, PBC, and PSC, ascertains how cholangiocyte senescence may promote a senescence-associated immunopathology in these cholangiopathies, and provides the rationale for therapeutically targeting senescence as a treatment option for BA, PBC, and PSC.
{"title":"Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target.","authors":"Christy E Trussoni, Steven P O'Hara, Nicholas F LaRusso","doi":"10.1007/s00281-022-00909-9","DOIUrl":"https://doi.org/10.1007/s00281-022-00909-9","url":null,"abstract":"<p><p>The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are three cholangiopathies with significant immune-mediated pathogenesis where chronic inflammation and fibrosis lead to obliteration of bile ducts and eventual liver cirrhosis. Cellular senescence is a state of cell cycle arrest in which cells become resistant to apoptosis and profusely secrete a bioactive secretome. Recent evidence indicates that cholangiocyte senescence contributes to the pathogenesis of BA, PBC, and PSC. This review explores the role of cholangiocyte senescence in BA, PBC, and PSC, ascertains how cholangiocyte senescence may promote a senescence-associated immunopathology in these cholangiopathies, and provides the rationale for therapeutically targeting senescence as a treatment option for BA, PBC, and PSC.</p>","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 4","pages":"527-544"},"PeriodicalIF":9.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256763/pdf/nihms-1783414.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9729550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.1007/s00281-022-00940-w
N. Richardson, G. Wootton, A. Bozward, Y. Oo
{"title":"Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease","authors":"N. Richardson, G. Wootton, A. Bozward, Y. Oo","doi":"10.1007/s00281-022-00940-w","DOIUrl":"https://doi.org/10.1007/s00281-022-00940-w","url":null,"abstract":"","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"461 - 474"},"PeriodicalIF":9.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43271886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.1007/s00281-022-00949-1
Hema Mehta, M. Lett, P. Klenerman, Magdalena Filipowicz Sinnreich
{"title":"MAIT cells in liver inflammation and fibrosis","authors":"Hema Mehta, M. Lett, P. Klenerman, Magdalena Filipowicz Sinnreich","doi":"10.1007/s00281-022-00949-1","DOIUrl":"https://doi.org/10.1007/s00281-022-00949-1","url":null,"abstract":"","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"429 - 444"},"PeriodicalIF":9.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43753666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-30DOI: 10.1007/s00281-022-00941-9
N. Chihara, T. Yamamura
{"title":"Immuno-pathogenesis of neuromyelitis optica and emerging therapies","authors":"N. Chihara, T. Yamamura","doi":"10.1007/s00281-022-00941-9","DOIUrl":"https://doi.org/10.1007/s00281-022-00941-9","url":null,"abstract":"","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"599 - 610"},"PeriodicalIF":9.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49495424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-26DOI: 10.1007/s00281-022-00946-4
D. Latorre, F. Sallusto, C. Bassetti, U. Kallweit
{"title":"Correction to: Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation","authors":"D. Latorre, F. Sallusto, C. Bassetti, U. Kallweit","doi":"10.1007/s00281-022-00946-4","DOIUrl":"https://doi.org/10.1007/s00281-022-00946-4","url":null,"abstract":"","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"739 - 739"},"PeriodicalIF":9.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42615647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-10DOI: 10.1007/s00281-022-00936-6
T. Liwinski, Melina Heinemann, C. Schramm
{"title":"The intestinal and biliary microbiome in autoimmune liver disease—current evidence and concepts","authors":"T. Liwinski, Melina Heinemann, C. Schramm","doi":"10.1007/s00281-022-00936-6","DOIUrl":"https://doi.org/10.1007/s00281-022-00936-6","url":null,"abstract":"","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"485 - 507"},"PeriodicalIF":9.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42113359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-05DOI: 10.1007/s00281-022-00942-8
C. Gottwick, A. Carambia, J. Herkel
{"title":"Harnessing the liver to induce antigen-specific immune tolerance","authors":"C. Gottwick, A. Carambia, J. Herkel","doi":"10.1007/s00281-022-00942-8","DOIUrl":"https://doi.org/10.1007/s00281-022-00942-8","url":null,"abstract":"","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"475 - 484"},"PeriodicalIF":9.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45623683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-05DOI: 10.1007/s00281-022-00939-3
R. Dhodapkar, Diego Martell, B. Hafler
{"title":"Glial-mediated neuroinflammatory mechanisms in age-related macular degeneration","authors":"R. Dhodapkar, Diego Martell, B. Hafler","doi":"10.1007/s00281-022-00939-3","DOIUrl":"https://doi.org/10.1007/s00281-022-00939-3","url":null,"abstract":"","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"673 - 683"},"PeriodicalIF":9.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45053895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-04DOI: 10.1007/s00281-022-00938-4
M. Mercau, Siraj Patwa, K. Bhat, Sourav Ghosh, C. Rothlin
{"title":"Cell death in development, maintenance, and diseases of the nervous system","authors":"M. Mercau, Siraj Patwa, K. Bhat, Sourav Ghosh, C. Rothlin","doi":"10.1007/s00281-022-00938-4","DOIUrl":"https://doi.org/10.1007/s00281-022-00938-4","url":null,"abstract":"","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 1","pages":"725 - 738"},"PeriodicalIF":9.0,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42072410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01Epub Date: 2022-02-04DOI: 10.1007/s00281-022-00913-z
Kaushik Amancherla, John A Wells, Alexander G Bick
Somatic mutations in hematopoietic stem cells are common with aging and can result in expansion of clones harboring mutations, termed clonal hematopoiesis. This results in an increased risk of blood cancers but has also been linked with chronic inflammatory disease states. In recent years, clonal hematopoiesis has been established to have a causative role in atherogenesis and cardiovascular disease. Additionally, as the effector cells have been identified to be immune cells, there is ongoing interest in assessing whether dysregulated immune function plays a role in other chronic inflammatory conditions such as rheumatologic disease. Here, we summarize current understanding of clonal hematopoiesis with a focus on cardiovascular disease and inflammation while outlining the potential, yet unexplored, relationship between clonal hematopoiesis and autoimmune disease. Hematopoietic stem cells (HSCs) continually regenerate blood cells. Acquisition of a somatic mutation that provides a selective advantage, a driver mutation, can result in clonal expansion. Clonal hematopoiesis of indeterminate potential, where somatic mutations in certain cancer-associated genes result in clonal expansion in the absence of overt malignancy, can result in atherosclerotic cardiovascular disease in multiple vascular beds, inflammation, and may also contribute to the pathogenesis of autoimmune disease. Many questions remain unanswered regarding the relationship between clonal hematopoiesis and inflammatory disorders.
{"title":"Clonal hematopoiesis and vascular disease.","authors":"Kaushik Amancherla, John A Wells, Alexander G Bick","doi":"10.1007/s00281-022-00913-z","DOIUrl":"10.1007/s00281-022-00913-z","url":null,"abstract":"<p><p>Somatic mutations in hematopoietic stem cells are common with aging and can result in expansion of clones harboring mutations, termed clonal hematopoiesis. This results in an increased risk of blood cancers but has also been linked with chronic inflammatory disease states. In recent years, clonal hematopoiesis has been established to have a causative role in atherogenesis and cardiovascular disease. Additionally, as the effector cells have been identified to be immune cells, there is ongoing interest in assessing whether dysregulated immune function plays a role in other chronic inflammatory conditions such as rheumatologic disease. Here, we summarize current understanding of clonal hematopoiesis with a focus on cardiovascular disease and inflammation while outlining the potential, yet unexplored, relationship between clonal hematopoiesis and autoimmune disease. Hematopoietic stem cells (HSCs) continually regenerate blood cells. Acquisition of a somatic mutation that provides a selective advantage, a driver mutation, can result in clonal expansion. Clonal hematopoiesis of indeterminate potential, where somatic mutations in certain cancer-associated genes result in clonal expansion in the absence of overt malignancy, can result in atherosclerotic cardiovascular disease in multiple vascular beds, inflammation, and may also contribute to the pathogenesis of autoimmune disease. Many questions remain unanswered regarding the relationship between clonal hematopoiesis and inflammatory disorders.</p>","PeriodicalId":21704,"journal":{"name":"Seminars in Immunopathology","volume":"44 3","pages":"303-308"},"PeriodicalIF":7.9,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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