{"title":"RETRACTION: The Gut-Facial Aging Axis: A Two-Sample Mendelian Randomization and Mediation Analysis of Gut Microbiota, Gut Microbiota Metabolic Pathways, and Blood Metabolites.","authors":"","doi":"10.1111/srt.70264","DOIUrl":"10.1111/srt.70264","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 10","pages":"e70264"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Artificial Intelligence Analysis of over a Million Chinese Men and Women Reveals Level of Dark Circle in the Facial Skin Aging Process.","authors":"","doi":"10.1111/srt.70240","DOIUrl":"10.1111/srt.70240","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 10","pages":"e70240"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Serum Lipids May Causally Affect the Occurrence of Alopecia Areata: A Mendelian Randomization Study.","authors":"","doi":"10.1111/srt.70242","DOIUrl":"10.1111/srt.70242","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 10","pages":"e70242"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Exploration of the Causality of Frailty Index on Psoriasis: A Mendelian Randomization Study.","authors":"","doi":"10.1111/srt.70244","DOIUrl":"10.1111/srt.70244","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 10","pages":"e70244"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Novel Insights Into Rosacea's Role in Cancer Risk: A Mendelian Randomization Approach.","authors":"","doi":"10.1111/srt.70243","DOIUrl":"10.1111/srt.70243","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 10","pages":"e70243"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Facial Adult Female Acne in China: An Analysis Based on Artificial Intelligence over One Million.","authors":"","doi":"10.1111/srt.70238","DOIUrl":"10.1111/srt.70238","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 10","pages":"e70238"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Clinical Analysis of 10 cases With Subcutaneous Panniculitis-like T-cell Lymphoma and Tissue AURKA Expression.","authors":"","doi":"10.1111/srt.70230","DOIUrl":"10.1111/srt.70230","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70230"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RETRACTION: Causal Relationships Between Dietary Antioxidant Vitamin Intake and Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.","authors":"","doi":"10.1111/srt.70229","DOIUrl":"10.1111/srt.70229","url":null,"abstract":"","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70229"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyungjoon Jeon, Nojin Park, Jong Gu Won, Yong Won Shin, Jiwon Choi, Kyoungin Min, Eunjung Choi, Chang Kyu Kim, Sang-Wook Park, Nam Seo Son
Purpose: This study investigated the enhanced skin permeation and pigmentation reduction effects of an ion-pair complex formed between tranexamic acid (TXA) and mandelic acid (MA). The TXA-MA complex demonstrated superior skin permeability and greater inhibition of cytokine expression compared to TXA alone, ultimately proving more effective in reducing skin pigmentation.
Methods: After spectroscopic analysis of the TXA-MA ion-pairing complex (TXA-MA complex) structure, an in vitro skin permeation study was conducted using a Franz cell system with porcine skin. Additionally, the effect of the TXA-MA complex on UVB (ultraviolet B)-induced expression changes of inflammation-related genes (IL-1α, IL-6, IL-8, COX2) was evaluated using a human epidermal keratinocyte cell lines (HaCaT) cell model. Finally, an in vivo human study was performed to analyze the efficacy of TXA-MA in reducing actual skin pigmentation.
Results: The formation of the TXA-MA complex was confirmed through zeta-potential measurements, 1H NMR study, and Fourier-transform infrared spectroscopy (FT-IR) spectroscopy. Skin permeation studies using porcine skin showed enhanced permeability of the TXA-MA complex compared to TXA at equivalent concentrations. In the HaCaT cell model, the TXA-MA complex exhibited greater inhibition of inflammatory markers IL-1α, IL-6, IL-8, and COX-2 expression than TXA alone. Finally, a 4-week human clinical study using ANTERA 3D imaging demonstrated that the TXA-MA complex was significantly more effective than TXA alone in reducing skin pigmentation.
Conclusion: This study successfully formed a TXA-MA complex. Compared to TXA, the TXA-MA complex showed superior effects in skin permeability, inhibition of inflammatory marker expression, and actual skin pigmentation reduction. These results suggest that the TXA-MA complex holds greater potential as an effective cosmetic ingredient for pigmentation improvement than TXA alone.
{"title":"Enhanced Skin Permeation and Pigmentation Reduction Effects of a Novel Tranexamic Acid-Mandelic Acid Ion-Pairing Complex.","authors":"Hyungjoon Jeon, Nojin Park, Jong Gu Won, Yong Won Shin, Jiwon Choi, Kyoungin Min, Eunjung Choi, Chang Kyu Kim, Sang-Wook Park, Nam Seo Son","doi":"10.1111/srt.70222","DOIUrl":"10.1111/srt.70222","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the enhanced skin permeation and pigmentation reduction effects of an ion-pair complex formed between tranexamic acid (TXA) and mandelic acid (MA). The TXA-MA complex demonstrated superior skin permeability and greater inhibition of cytokine expression compared to TXA alone, ultimately proving more effective in reducing skin pigmentation.</p><p><strong>Methods: </strong>After spectroscopic analysis of the TXA-MA ion-pairing complex (TXA-MA complex) structure, an in vitro skin permeation study was conducted using a Franz cell system with porcine skin. Additionally, the effect of the TXA-MA complex on UVB (ultraviolet B)-induced expression changes of inflammation-related genes (IL-1α, IL-6, IL-8, COX2) was evaluated using a human epidermal keratinocyte cell lines (HaCaT) cell model. Finally, an in vivo human study was performed to analyze the efficacy of TXA-MA in reducing actual skin pigmentation.</p><p><strong>Results: </strong>The formation of the TXA-MA complex was confirmed through zeta-potential measurements, <sup>1</sup>H NMR study, and Fourier-transform infrared spectroscopy (FT-IR) spectroscopy. Skin permeation studies using porcine skin showed enhanced permeability of the TXA-MA complex compared to TXA at equivalent concentrations. In the HaCaT cell model, the TXA-MA complex exhibited greater inhibition of inflammatory markers IL-1α, IL-6, IL-8, and COX-2 expression than TXA alone. Finally, a 4-week human clinical study using ANTERA 3D imaging demonstrated that the TXA-MA complex was significantly more effective than TXA alone in reducing skin pigmentation.</p><p><strong>Conclusion: </strong>This study successfully formed a TXA-MA complex. Compared to TXA, the TXA-MA complex showed superior effects in skin permeability, inhibition of inflammatory marker expression, and actual skin pigmentation reduction. These results suggest that the TXA-MA complex holds greater potential as an effective cosmetic ingredient for pigmentation improvement than TXA alone.</p>","PeriodicalId":21746,"journal":{"name":"Skin Research and Technology","volume":"31 9","pages":"e70222"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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