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Never tested for HIV among men who have sex with men, Hanoi, Vietnam: correlates and missed opportunities.
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-18 DOI: 10.1097/OLQ.0000000000002123
Hoang Thi Hai Van, Dang Thi Huong, Nguyen Thi Thu Hong, Willi McFarland, Vu Bich Diep, Lung Bich Ngoc, Le Minh Giang

Abstract: Introduction: Understanding levels of HIV testing among populations at risk for acquisition is essential to meeting the goal of the United Nations that 95% of individuals living with HIV know their status. This study assessed HIV testing prevalence among men who had sex with men (MSM), characteristics of MSM who have never tested for HIV, and missed testing opportunities in Hanoi, Vietnam.Methods: We measured the prevalence of never testing for HIV and missed opportunities for testing in the baseline data of a cohort study of MSM recruited in 2017-2019 in Hanoi. Logistic regression analysis characterized MSM who had never tested prior to cohort participation.Results: Of 1,893 MSM enrolled in the cohort, 39.4% had never previously tested for HIV. MSM with children (aOR 1.75, 95% CI 1.09-2.82) and those who did not know or remember having a male partner living with HIV (aOR 1.41, 95% CI 1.07-1.84) were more likely to have never tested. Older age, university education, higher income, and having a male partner living with HIV were associated with a lower likelihood of never having been tested. The most common missed testing opportunities to test MSM who had never been tested were when receiving free condoms from health educators (35.3%), testing for other sexually transmitted infections (STIs) (23.3%), reporting their MSM status to healthcare workers (16.4%), and receiving an STI diagnosis (13.0%). The most common barriers identified by MSM who had never tested were fear of seeking health care due to their sexual orientation (82.7%) and having been refused healthcare due to their sexual oreitnation (76.2%).Conclusions: Facilitating provider-initiated HIV testing in STI clinics and other healthcare services, community-based testing, and HIV self-test kits should enhance HIV testing options for young MSM, especially those with lower education and income.

{"title":"Never tested for HIV among men who have sex with men, Hanoi, Vietnam: correlates and missed opportunities.","authors":"Hoang Thi Hai Van, Dang Thi Huong, Nguyen Thi Thu Hong, Willi McFarland, Vu Bich Diep, Lung Bich Ngoc, Le Minh Giang","doi":"10.1097/OLQ.0000000000002123","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002123","url":null,"abstract":"<p><strong>Abstract: </strong>Introduction: Understanding levels of HIV testing among populations at risk for acquisition is essential to meeting the goal of the United Nations that 95% of individuals living with HIV know their status. This study assessed HIV testing prevalence among men who had sex with men (MSM), characteristics of MSM who have never tested for HIV, and missed testing opportunities in Hanoi, Vietnam.Methods: We measured the prevalence of never testing for HIV and missed opportunities for testing in the baseline data of a cohort study of MSM recruited in 2017-2019 in Hanoi. Logistic regression analysis characterized MSM who had never tested prior to cohort participation.Results: Of 1,893 MSM enrolled in the cohort, 39.4% had never previously tested for HIV. MSM with children (aOR 1.75, 95% CI 1.09-2.82) and those who did not know or remember having a male partner living with HIV (aOR 1.41, 95% CI 1.07-1.84) were more likely to have never tested. Older age, university education, higher income, and having a male partner living with HIV were associated with a lower likelihood of never having been tested. The most common missed testing opportunities to test MSM who had never been tested were when receiving free condoms from health educators (35.3%), testing for other sexually transmitted infections (STIs) (23.3%), reporting their MSM status to healthcare workers (16.4%), and receiving an STI diagnosis (13.0%). The most common barriers identified by MSM who had never tested were fear of seeking health care due to their sexual orientation (82.7%) and having been refused healthcare due to their sexual oreitnation (76.2%).Conclusions: Facilitating provider-initiated HIV testing in STI clinics and other healthcare services, community-based testing, and HIV self-test kits should enhance HIV testing options for young MSM, especially those with lower education and income.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resurgence of Syphilis: A Critical Time to Improve Access to Penicillin Allergy Evaluation.
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-16 DOI: 10.1097/OLQ.0000000000002122
Laura Ann Wang, Sean T O'Leary, Alysse Wurcel, Kimberly Blumenthal
{"title":"Resurgence of Syphilis: A Critical Time to Improve Access to Penicillin Allergy Evaluation.","authors":"Laura Ann Wang, Sean T O'Leary, Alysse Wurcel, Kimberly Blumenthal","doi":"10.1097/OLQ.0000000000002122","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002122","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Childhood sexual abuse, alcohol problem scores, and race are associated with syphilis incidence in a prospective cohort of young sexual and gender minority adults assigned male at birth. 在一个前瞻性队列中,性少数群体和性别少数群体的年轻成年人在出生时被指定为男性,他们的童年性虐待、酗酒问题得分和种族与梅毒发病率有关。
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-16 DOI: 10.1097/OLQ.0000000000002120
Casey D Xavier Hall, Daniel T Ryan, Christina Hayford, Ethan Morgan, Richard D'Aquila, Brian Mustanski

Background: Syphilis rates in the United States have dramatically increased in recent years and are high among young men who have sex with men and transgender women. Yet, few studies have examined a wide-range of risk factors for syphilis incidence prospectively in young sexual and gender minority (YSGM) populations in the U.S. One framework which may have utility in understanding syphilis risk factors is syndemics, which focuses on co-morbid factors and their mutual influence. The current analysis examines demographic, comorbid health and socio-structural risk factors for syphilis in YSGM assigned male at birth including applying a syndemic framework.

Methods: Participants were part of a Chicago-based prospective cohort called RADAR (n = 738). All participants were YSGM. Syphilis cases were identified by serologic screening with a reverse-sequence testing algorithm. Risk factors included demographics, indicators of sexual risk, mental health, substance use, and violence victimization. Syndemic component score was calculated by adding the number of syndemic conditions. Analyses included multivariable logistic regressions.

Results: In multivariable predictive modeling, Black identity, childhood sexual abuse and alcohol problems predicted incident syphilis. Though roughly 37% of participants were indicated as having at least 2 syndemic conditions, the syndemic component did not predict syphilis incidence.

Conclusions: Syphilis incidence is high in this sample of YSGM. Additional research is needed to better understand mechanisms driving associations between childhood sexual abuse and syphilis incidence as well as to develop interventions improve testing and treatment among Black YSGM, YSGM who experience childhood sexual abuse, and YSGM who experience alcohol problems.

{"title":"Childhood sexual abuse, alcohol problem scores, and race are associated with syphilis incidence in a prospective cohort of young sexual and gender minority adults assigned male at birth.","authors":"Casey D Xavier Hall, Daniel T Ryan, Christina Hayford, Ethan Morgan, Richard D'Aquila, Brian Mustanski","doi":"10.1097/OLQ.0000000000002120","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002120","url":null,"abstract":"<p><strong>Background: </strong>Syphilis rates in the United States have dramatically increased in recent years and are high among young men who have sex with men and transgender women. Yet, few studies have examined a wide-range of risk factors for syphilis incidence prospectively in young sexual and gender minority (YSGM) populations in the U.S. One framework which may have utility in understanding syphilis risk factors is syndemics, which focuses on co-morbid factors and their mutual influence. The current analysis examines demographic, comorbid health and socio-structural risk factors for syphilis in YSGM assigned male at birth including applying a syndemic framework.</p><p><strong>Methods: </strong>Participants were part of a Chicago-based prospective cohort called RADAR (n = 738). All participants were YSGM. Syphilis cases were identified by serologic screening with a reverse-sequence testing algorithm. Risk factors included demographics, indicators of sexual risk, mental health, substance use, and violence victimization. Syndemic component score was calculated by adding the number of syndemic conditions. Analyses included multivariable logistic regressions.</p><p><strong>Results: </strong>In multivariable predictive modeling, Black identity, childhood sexual abuse and alcohol problems predicted incident syphilis. Though roughly 37% of participants were indicated as having at least 2 syndemic conditions, the syndemic component did not predict syphilis incidence.</p><p><strong>Conclusions: </strong>Syphilis incidence is high in this sample of YSGM. Additional research is needed to better understand mechanisms driving associations between childhood sexual abuse and syphilis incidence as well as to develop interventions improve testing and treatment among Black YSGM, YSGM who experience childhood sexual abuse, and YSGM who experience alcohol problems.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Missing Link: Hepatitis C Linkage to Care through a Public Sexual Health Clinic.
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-16 DOI: 10.1097/OLQ.0000000000002114
Amirtha Dileepan, Lucy Alderton, Oluyomi Obafemi, Sarah E Rowan, Karen A Wendel

Abstract: This study evaluates hepatitis C testing and referral for treatment among patients attending a public sexual health clinic. In patients with hepatitis C infection, progression from linkage to care to sustained virologic response was low. Innovative approaches are needed to optimally integrate hepatitis C care in sexual health clinics.

{"title":"The Missing Link: Hepatitis C Linkage to Care through a Public Sexual Health Clinic.","authors":"Amirtha Dileepan, Lucy Alderton, Oluyomi Obafemi, Sarah E Rowan, Karen A Wendel","doi":"10.1097/OLQ.0000000000002114","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002114","url":null,"abstract":"<p><strong>Abstract: </strong>This study evaluates hepatitis C testing and referral for treatment among patients attending a public sexual health clinic. In patients with hepatitis C infection, progression from linkage to care to sustained virologic response was low. Innovative approaches are needed to optimally integrate hepatitis C care in sexual health clinics.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to "Qualitatively Assessing ChatGPT Responses to Frequently Asked Questions Regarding Sexually Transmitted Diseases: Considerations". 对 "Qualitatively Assessing ChatGPT Responses to Frequently Asked Questions Regarding Sexually Transmitted Diseases:考虑因素"。
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-16 DOI: 10.1097/OLQ.0000000000002121
Elijah Moothedan, Vama Jhumkhawala, Sara Burgoa, Lisa Martinez, Lea Sacca
{"title":"Response to \"Qualitatively Assessing ChatGPT Responses to Frequently Asked Questions Regarding Sexually Transmitted Diseases: Considerations\".","authors":"Elijah Moothedan, Vama Jhumkhawala, Sara Burgoa, Lisa Martinez, Lea Sacca","doi":"10.1097/OLQ.0000000000002121","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002121","url":null,"abstract":"","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mpox vaccine communication among sexually active men who have sex with men. 在性活跃的男男性行为者中传播麻风腮疫苗。
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-14 DOI: 10.1097/OLQ.0000000000002117
Winston E Abara, Tom Carpino, Kaitlyn Atkins, Marissa Hannah, O Winslow Edwards, Kaytlin J Renfro, Stefan Baral, Travis Sanchez, Emily R Learner, Eboni Galloway, Amy Lansky

Abstract: We assessed mpox vaccine communication and sexual behavior among U.S. MSM during the 2022 mpox outbreak. Less than 40% of respondents asked a new male sex partner about their mpox vaccination status. Mpox vaccine communication was positively associated with condomless anal sex and group sex. Mpox vaccine communication is low but may inform and sexual behaviors among MSM.

摘要:我们评估了美国 MSM 在 2022 年麻风腮疫情爆发期间的麻风腮疫苗沟通和性行为。不到 40% 的受访者会向新的男性性伴侣询问他们的麻痘疫苗接种情况。接种麻痘疫苗与无套肛交和群交呈正相关。接种麻痘疫苗的传播率很低,但可以为男男性行为者的性行为提供信息。
{"title":"Mpox vaccine communication among sexually active men who have sex with men.","authors":"Winston E Abara, Tom Carpino, Kaitlyn Atkins, Marissa Hannah, O Winslow Edwards, Kaytlin J Renfro, Stefan Baral, Travis Sanchez, Emily R Learner, Eboni Galloway, Amy Lansky","doi":"10.1097/OLQ.0000000000002117","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002117","url":null,"abstract":"<p><strong>Abstract: </strong>We assessed mpox vaccine communication and sexual behavior among U.S. MSM during the 2022 mpox outbreak. Less than 40% of respondents asked a new male sex partner about their mpox vaccination status. Mpox vaccine communication was positively associated with condomless anal sex and group sex. Mpox vaccine communication is low but may inform and sexual behaviors among MSM.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimum inhibitory concentrations of extended spectrum cephalosporins: A systematic review and meta-analysis of Neisseria gonorrhoeae treatment failures.
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-14 DOI: 10.1097/OLQ.0000000000002116
Victoria Fotini Miari, Jonna Messina Mosoff, R Matthew Chico

Background: Neisseria gonorrhoeae is one of the recognised global antimicrobial resistance priorities. Extended spectrum cephalosporins, the last remaining reliable antimicrobial, increasingly fail to clear N. gonorrhoeae infections, especially pharyngeal gonorrhoea, leading to limited future treatment options.

Methods: We conducted a systematic review and meta-analysis of gonococcal treatment failures and compared the minimum inhibitory concentrations (MIC) of isolates from pharyngeal and extra-pharyngeal anatomical sites (PROSPERO registration: CRD42020189101).

Results: The overall pooled mean MIC for cefixime was 0.17 mg/L (95% [CI]: 0.07, 0.41) and ceftriaxone was 0.10 mg/L (95% [CI]: 0.05, 0.22). For cefixime, the mean MIC estimates for pharyngeal and extra-pharyngeal treatment failures were 0.05 mg/L (95% [CI]: 0.02, 0.14) and 0.29 mg/L (95% [CI]: 0.11, 0.81), and for ceftriaxone 0.09 mg/L (95% [CI]: 0.03, 0.22) and 0.14 mg/L (95% [CI]: 0.03, 0.73), respectively. The pooled mean MICs for pharyngeal isolates are below the phenotypic European Committee on Antimicrobial Susceptibility Testing (EUCAST) resistance breakpoint for both antimicrobials (>0.125 mg/L).

Conclusions: Our findings underscore the need to review the current resistance breakpoints used for pharyngeal infection and the urgency to establish international standards for MIC testing, and advance efforts of the World Health Organization's global action plan to control the spread and impact of antimicrobial resistance in N. gonorrhoeae. Ongoing susceptibility testing of gonococcal isolates and surveillance of treatment failures are central to informing appropriate public health responses.

{"title":"Minimum inhibitory concentrations of extended spectrum cephalosporins: A systematic review and meta-analysis of Neisseria gonorrhoeae treatment failures.","authors":"Victoria Fotini Miari, Jonna Messina Mosoff, R Matthew Chico","doi":"10.1097/OLQ.0000000000002116","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002116","url":null,"abstract":"<p><strong>Background: </strong>Neisseria gonorrhoeae is one of the recognised global antimicrobial resistance priorities. Extended spectrum cephalosporins, the last remaining reliable antimicrobial, increasingly fail to clear N. gonorrhoeae infections, especially pharyngeal gonorrhoea, leading to limited future treatment options.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis of gonococcal treatment failures and compared the minimum inhibitory concentrations (MIC) of isolates from pharyngeal and extra-pharyngeal anatomical sites (PROSPERO registration: CRD42020189101).</p><p><strong>Results: </strong>The overall pooled mean MIC for cefixime was 0.17 mg/L (95% [CI]: 0.07, 0.41) and ceftriaxone was 0.10 mg/L (95% [CI]: 0.05, 0.22). For cefixime, the mean MIC estimates for pharyngeal and extra-pharyngeal treatment failures were 0.05 mg/L (95% [CI]: 0.02, 0.14) and 0.29 mg/L (95% [CI]: 0.11, 0.81), and for ceftriaxone 0.09 mg/L (95% [CI]: 0.03, 0.22) and 0.14 mg/L (95% [CI]: 0.03, 0.73), respectively. The pooled mean MICs for pharyngeal isolates are below the phenotypic European Committee on Antimicrobial Susceptibility Testing (EUCAST) resistance breakpoint for both antimicrobials (>0.125 mg/L).</p><p><strong>Conclusions: </strong>Our findings underscore the need to review the current resistance breakpoints used for pharyngeal infection and the urgency to establish international standards for MIC testing, and advance efforts of the World Health Organization's global action plan to control the spread and impact of antimicrobial resistance in N. gonorrhoeae. Ongoing susceptibility testing of gonococcal isolates and surveillance of treatment failures are central to informing appropriate public health responses.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Using a Standardized Questionnaire on Sexual History Documentation and Testing to Diagnose Gonorrhea and Chlamydia Among Men Who have Sex with Men with HIV. 使用标准化问卷对性史记录和检测诊断淋病和衣原体感染的影响。
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-14 DOI: 10.1097/OLQ.0000000000002119
Danielle deMontigny Avila, Brooke Rabe, Arunmozhi Aravagiri, Martin Joseph, James Ray M Lim, Maryam Naveed, Raina Rappel, Berna Villanueva, Maithili Khandekar, Atehkeng Zinkeng, Sarah Yates, Lori E Fantry

Abstract: Background: Most Neisseria gonorrhoea (GC) and Chlamydia trachomatis (CT) infections in men who have sex with men (MSM) are diagnosed at extragenital sites. However, testing at these sites is often lacking. The purpose of this study was to determine if a standardized questionnaire administered by physicians and clinical assistants improves documentation of sex activity and increases extragenital testing and diagnoses of GC and CT among MSM.Methods: A standardized sexual history questionnaire was implemented on 11/1/2022. Electronic medical records of 664 MSM with HIV, including 1064 encounters, were reviewed to compare pre- and post- implementation sexual history documentation, adequacy of documentation, extragenital GC and CT testing, and GC and CT diagnoses. Analysis included Chi-square and exact tests and logistic regression adjusting for physician cluster effects.Results: The standardized questionnaire was used by 53.7% of physicians and 85.9% of coordinators. Documentation of whether sexual activity occurred increased from 79.3% [95%confidence interval (CI) 0.758- 0.828] in the pre-intervention pre-COVID-19 period to 95.2% (95% CI 0.925-0.970) in the post-intervention period with an adjusted odds ratio of 4.7 (95% CI 2.7-8.8). Specific questions about anal and oral sex increased from 42.0% to 88.1% (p < 0.001) and 23.7% to 88.7% (p < 0.001), respectively. Anal and pharyngeal testing increased from 14.4% to 20.2% (p = 0.040) and 17.2% to 23.3% (p = 0.045), respectively.Conclusions: This study demonstrates that using a standardized questionnaire during clinical encounters can improve documentation of sexual activity and testing for GC and CT at extragenital sites.

{"title":"The Effect of Using a Standardized Questionnaire on Sexual History Documentation and Testing to Diagnose Gonorrhea and Chlamydia Among Men Who have Sex with Men with HIV.","authors":"Danielle deMontigny Avila, Brooke Rabe, Arunmozhi Aravagiri, Martin Joseph, James Ray M Lim, Maryam Naveed, Raina Rappel, Berna Villanueva, Maithili Khandekar, Atehkeng Zinkeng, Sarah Yates, Lori E Fantry","doi":"10.1097/OLQ.0000000000002119","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002119","url":null,"abstract":"<p><strong>Abstract: </strong>Background: Most Neisseria gonorrhoea (GC) and Chlamydia trachomatis (CT) infections in men who have sex with men (MSM) are diagnosed at extragenital sites. However, testing at these sites is often lacking. The purpose of this study was to determine if a standardized questionnaire administered by physicians and clinical assistants improves documentation of sex activity and increases extragenital testing and diagnoses of GC and CT among MSM.Methods: A standardized sexual history questionnaire was implemented on 11/1/2022. Electronic medical records of 664 MSM with HIV, including 1064 encounters, were reviewed to compare pre- and post- implementation sexual history documentation, adequacy of documentation, extragenital GC and CT testing, and GC and CT diagnoses. Analysis included Chi-square and exact tests and logistic regression adjusting for physician cluster effects.Results: The standardized questionnaire was used by 53.7% of physicians and 85.9% of coordinators. Documentation of whether sexual activity occurred increased from 79.3% [95%confidence interval (CI) 0.758- 0.828] in the pre-intervention pre-COVID-19 period to 95.2% (95% CI 0.925-0.970) in the post-intervention period with an adjusted odds ratio of 4.7 (95% CI 2.7-8.8). Specific questions about anal and oral sex increased from 42.0% to 88.1% (p < 0.001) and 23.7% to 88.7% (p < 0.001), respectively. Anal and pharyngeal testing increased from 14.4% to 20.2% (p = 0.040) and 17.2% to 23.3% (p = 0.045), respectively.Conclusions: This study demonstrates that using a standardized questionnaire during clinical encounters can improve documentation of sexual activity and testing for GC and CT at extragenital sites.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicenter Clinical Performance Evaluation of the NeuMoDx™ CT/NG Assay 2.0.
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-04 DOI: 10.1097/OLQ.0000000000002075
B Van Der Pol, A Avery, S N Taylor, J Miller, C L Emery, A English, G B Lazenby, R Lillis, J Ruth, D Young, S Young, S Chavoustie, L Crane, V Reid, G Wall, S Johnson

Background: Given the continued increases in rates of both Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection, additional diagnostic assays may be useful in increasing access to testing for these sexually transmitted infections. We evaluated the performance of the NeuMoDx™ CT/NG Assay 2.0 on the NeuMoDx-96 and NeuMoDx-288 Molecular Systems.

Methods: The clinical sensitivity and specificity of the assay was assessed when used with: 1) endocervical swabs; 2) self-, and clinician-collected vaginal swabs; and 3) first-catch urine specimens (female and male). Results were compared to a patient infection status based on US Food and Drug Administration (FDA)-cleared assays.

Results: The NeuMoDx CT/NG Assay 2.0 demonstrated high sensitivity and specificity in both symptomatic and asymptomatic participants. All specimen types other than endocervical swabs had >95% sensitivity and > 99% specificity for both pathogens. For endocervical samples, sensitivity was 93.2% and 93.3% for CT and NG, respectively. There was no difference in performance based on platform. The frequency of invalid results was low (<1%).

Conclusions: The NeuMoDx CT/NG Assay 2.0 demonstrated performance similar to currently FDA-cleared assays, with the added choice of a moderate- (96-sample) or a high-throughput (288-sample) platform. The system therefore offers solutions to laboratories running lower volumes of testing that may obviate the need for outsourcing to larger reference laboratories.

{"title":"Multicenter Clinical Performance Evaluation of the NeuMoDx™ CT/NG Assay 2.0.","authors":"B Van Der Pol, A Avery, S N Taylor, J Miller, C L Emery, A English, G B Lazenby, R Lillis, J Ruth, D Young, S Young, S Chavoustie, L Crane, V Reid, G Wall, S Johnson","doi":"10.1097/OLQ.0000000000002075","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002075","url":null,"abstract":"<p><strong>Background: </strong>Given the continued increases in rates of both Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection, additional diagnostic assays may be useful in increasing access to testing for these sexually transmitted infections. We evaluated the performance of the NeuMoDx™ CT/NG Assay 2.0 on the NeuMoDx-96 and NeuMoDx-288 Molecular Systems.</p><p><strong>Methods: </strong>The clinical sensitivity and specificity of the assay was assessed when used with: 1) endocervical swabs; 2) self-, and clinician-collected vaginal swabs; and 3) first-catch urine specimens (female and male). Results were compared to a patient infection status based on US Food and Drug Administration (FDA)-cleared assays.</p><p><strong>Results: </strong>The NeuMoDx CT/NG Assay 2.0 demonstrated high sensitivity and specificity in both symptomatic and asymptomatic participants. All specimen types other than endocervical swabs had >95% sensitivity and > 99% specificity for both pathogens. For endocervical samples, sensitivity was 93.2% and 93.3% for CT and NG, respectively. There was no difference in performance based on platform. The frequency of invalid results was low (<1%).</p><p><strong>Conclusions: </strong>The NeuMoDx CT/NG Assay 2.0 demonstrated performance similar to currently FDA-cleared assays, with the added choice of a moderate- (96-sample) or a high-throughput (288-sample) platform. The system therefore offers solutions to laboratories running lower volumes of testing that may obviate the need for outsourcing to larger reference laboratories.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preferences and Acceptability of Testing for Sexually Transmitted Infections in an HIV Pre-Exposure Prophylaxis clinic in Hanoi, Vietnam.
IF 2.4 4区 医学 Q3 INFECTIOUS DISEASES Pub Date : 2024-12-03 DOI: 10.1097/OLQ.0000000000002109
Hao T M Bui, Paul C Adamson, Thanh C Nguyen, Nguyen S Dau, Khanh D Nguyen, Loc Q Pham, Giang M Le, Jeffrey D Klausner

Background: Men who have sex with men (MSM) using HIV Pre-Exposure Prophylaxis (PrEP) are a vulnerable population with a high prevalence of sexually transmitted infections (STIs). Self-collection of specimens could improve STI testing, yet implementation in low-resource settings is limited. The study aimed to assess the feasibility and acceptability of self-collection for STI testing and to understand STI testing preferences among PrEP clients in Hanoi, Vietnam.

Methods: From January to December 2022 MSM aged 16 and older, participating in a clinic-based HIV PrEP program were enrolled. Participants self-collected pharyngeal, anal, and urine samples for Chlamydia trachomatis and Neisseria gonorrhoeae testing. Testing preferences were assessed through conjoint analysis using eight hypothetical testing profiles across five testing attributes; each profile was rated on a Likert scale (0-5) to create an impact score. Differences between attributes were assessed using a two-sided, one-sample t-test of the impact score.

Results: There were 529 participants enrolled; all were male. Specimens from three sites were provided by 97.9% (518/529). Mean satisfaction with self-collection was 4.3 (SD: 1.0), 99.4% reported they would perform again. In conjoint analysis, cost (free vs. $17USD) had the highest impact on testing preference (Impact Score: 25.2; p = <0.001). A one-week time to test result notification was preferred to 90 minutes (Impact Score: -0.8; p = 0.03).

Conclusion: We found high acceptability of self-collection for STI testing among HIV PrEP clients in Vietnam. Cost was the most important factor affecting testing uptake. Expanding self-collection and lowering costs could improve STI testing in HIV PrEP programs.

{"title":"Preferences and Acceptability of Testing for Sexually Transmitted Infections in an HIV Pre-Exposure Prophylaxis clinic in Hanoi, Vietnam.","authors":"Hao T M Bui, Paul C Adamson, Thanh C Nguyen, Nguyen S Dau, Khanh D Nguyen, Loc Q Pham, Giang M Le, Jeffrey D Klausner","doi":"10.1097/OLQ.0000000000002109","DOIUrl":"https://doi.org/10.1097/OLQ.0000000000002109","url":null,"abstract":"<p><strong>Background: </strong>Men who have sex with men (MSM) using HIV Pre-Exposure Prophylaxis (PrEP) are a vulnerable population with a high prevalence of sexually transmitted infections (STIs). Self-collection of specimens could improve STI testing, yet implementation in low-resource settings is limited. The study aimed to assess the feasibility and acceptability of self-collection for STI testing and to understand STI testing preferences among PrEP clients in Hanoi, Vietnam.</p><p><strong>Methods: </strong>From January to December 2022 MSM aged 16 and older, participating in a clinic-based HIV PrEP program were enrolled. Participants self-collected pharyngeal, anal, and urine samples for Chlamydia trachomatis and Neisseria gonorrhoeae testing. Testing preferences were assessed through conjoint analysis using eight hypothetical testing profiles across five testing attributes; each profile was rated on a Likert scale (0-5) to create an impact score. Differences between attributes were assessed using a two-sided, one-sample t-test of the impact score.</p><p><strong>Results: </strong>There were 529 participants enrolled; all were male. Specimens from three sites were provided by 97.9% (518/529). Mean satisfaction with self-collection was 4.3 (SD: 1.0), 99.4% reported they would perform again. In conjoint analysis, cost (free vs. $17USD) had the highest impact on testing preference (Impact Score: 25.2; p = <0.001). A one-week time to test result notification was preferred to 90 minutes (Impact Score: -0.8; p = 0.03).</p><p><strong>Conclusion: </strong>We found high acceptability of self-collection for STI testing among HIV PrEP clients in Vietnam. Cost was the most important factor affecting testing uptake. Expanding self-collection and lowering costs could improve STI testing in HIV PrEP programs.</p>","PeriodicalId":21837,"journal":{"name":"Sexually transmitted diseases","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Sexually transmitted diseases
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