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Single-cell profiling of MC1R-inhibited melanocytes mc1r抑制黑色素细胞的单细胞分析。
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-11-16 DOI: 10.1111/pcmr.13141
H. Matthew Berns, Dawn E. Watkins-Chow, Sizhu Lu, Pakavarin Louphrasitthiphol, Tongwu Zhang, Kevin M. Brown, Pedro Moura-Alves, Colin R. Goding, William J. Pavan

The human red hair color (RHC) trait is caused by increased pheomelanin (red-yellow) and reduced eumelanin (black-brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function. In addition, individuals harboring the RHC trait are predisposed to melanoma development. While MC1R variants have been established as causative of RHC and are a well-defined risk factor for melanoma, it remains unclear mechanistically why decreased MC1R signaling alters pigmentation and increases melanoma susceptibility. Here, we use single-cell RNA sequencing (scRNA-seq) of melanocytes isolated from RHC mouse models to define a MC1R-inhibited Gene Signature (MiGS) comprising a large set of previously unidentified genes which may be implicated in melanogenesis and oncogenic transformation. We show that one of the candidate MiGS genes, TBX3, a well-known anti-senescence transcription factor implicated in melanoma progression, binds both E-box and T-box elements to regulate genes associated with melanogenesis and senescence bypass. Our results provide key insights into further mechanisms by which melanocytes with reduced MC1R signaling may regulate pigmentation and offer new candidates of study toward understanding how individuals with the RHC phenotype are predisposed to melanoma.

人类的红发色(RHC)特征是由于黑色素皮质素1受体(MC1R)功能减弱,皮肤和头发中的泛黑素(红黄色)增加,真黑素(黑棕色)减少造成的。此外,具有RHC特征的个体易患黑色素瘤。虽然MC1R变异已被确定为RHC的病因,并且是黑色素瘤的明确危险因素,但仍不清楚MC1R信号减少改变色素沉着并增加黑色素瘤易感性的机制。在这里,我们使用从RHC小鼠模型中分离的黑素细胞的单细胞RNA测序(scRNA-seq)来定义mc1r抑制基因签名(MiGS),其中包含大量先前未识别的基因,这些基因可能与黑素形成和致癌转化有关。我们发现候选MiGS基因之一TBX3是一种众所周知的与黑色素瘤进展有关的抗衰老转录因子,它结合E-box和T-box元件来调节与黑色素形成和衰老绕道相关的基因。我们的研究结果为进一步了解MC1R信号减少的黑素细胞可能调节色素沉着的机制提供了关键见解,并为理解具有RHC表型的个体如何易患黑色素瘤提供了新的研究候选人。
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引用次数: 0
TFE3 promotes ferroptosis in melanoma TFE3促进黑色素瘤中的铁下垂。
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-11-12 DOI: 10.1111/pcmr.13149
Diogo Dias, Pakavarin Louphrasitthiphol, Colin R. Goding

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引用次数: 0
IPCC2023: Looking for translational opportunities by persevering in basic pigment cell research IPCC2023:通过坚持基础色素细胞研究寻找转化机会。
IF 3.9 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-11-02 DOI: 10.1111/pcmr.13148
María D. Boyano, Aintzane Asumendi, José Carlos Garcia-Borrón, Lluís Montoliu, Santos Alonso
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引用次数: 0
Cytoglobin functions as a redox regulator of melanogenesis in normal epidermal melanocytes 在正常表皮黑素细胞中,细胞球蛋白作为黑素生成的氧化还原调节剂发挥作用。
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-11-02 DOI: 10.1111/pcmr.13146
Yo Tanaka, Misako Sato-Matsubara, Daisuke Tsuruta, Hiroshi Tanaka, Chiho Kadono, Koji Sugawara, Norifumi Kawada, Kazumasa Wakamatsu, Shosuke Ito, Katsutoshi Yoshizato

Epidermal melanocytes are continuously exposed to sunlight-induced reactive oxygen species (ROS) and oxidative stress generated during the synthesis of melanin. Therefore, they have developed mechanisms that maintain normal redox homeostasis. Cytoglobin (CYGB), a ubiquitously expressed intracellular iron hexacoordinated globin, exhibits antioxidant activity and regulates the redox state of mammalian cells through its activities as peroxidase and nitric oxide (NO) dioxygenase. We postulated that CYGB functions in the melanogenic process as a regulator that maintains oxidative stress within a physiological level. This was examined by characterizing normal human melanocytes with the knockdown (KD) of CYGB using morphological and molecular biological criteria. CYGB-KD cells were larger, had more dendrites, and generated more melanin granules in the advanced stages of melanogenesis than control cells. The expression levels of major melanogenesis-associated genes and proteins were higher in CYGB-KD melanocytes than in wild type (WT) cells. As expected, CYGB-KD melanocytes generated more ROS and NO than WT cells. In conclusion, CYGB physiologically contributes to maintaining redox homeostasis in the melanogenic activity of normal melanocytes by controlling the intracellular levels of ROS and NO.

表皮黑色素细胞持续暴露于阳光诱导的活性氧(ROS)和黑色素合成过程中产生的氧化应激。因此,他们开发了维持正常氧化还原稳态的机制。细胞球蛋白(CYGB)是一种广泛表达的细胞内铁六配位球蛋白,具有抗氧化活性,并通过其作为过氧化物酶和一氧化氮(NO)双加氧酶的活性调节哺乳动物细胞的氧化还原状态。我们假设CYGB在黑色素生成过程中作为一种调节因子发挥作用,将氧化应激维持在生理水平内。这是通过使用形态学和分子生物学标准用CYGB的敲除(KD)表征正常人黑素细胞来进行检测的。在黑色素生成的晚期,CYGB-KD细胞比对照细胞更大,有更多的树突,并产生更多的黑色素颗粒。CYGB-KD黑色素细胞中主要黑色素生成相关基因和蛋白质的表达水平高于野生型(WT)细胞。正如预期的那样,CYGB-KD黑素细胞比WT细胞产生更多的ROS和NO。总之,CYGB通过控制细胞内ROS和NO的水平,在生理上有助于维持正常黑素细胞黑素生成活性的氧化还原稳态。
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引用次数: 0
20th Anniversary of the Society for Melanoma Research: Celebrating two decades of progress in melanoma research 黑色素瘤研究学会成立20周年:庆祝黑色素瘤20年的研究进展。
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-10-30 DOI: 10.1111/pcmr.13134
Ravi Amaravadi, Andrew Aplin, Meenhard Herlyn, Sheri Holmen, Richard White, Jessie Villanueva
<p>Dear Colleagues,</p><p>It is with great enthusiasm that we look forward to welcoming you to Philadelphia to celebrate a milestone for the melanoma research community: the <i>20th Anniversary of the Society for Melanoma Research (SMR)</i>. The SMR was established in 2003 during the First International Melanoma Research Congress in Philadelphia. Meenhard Herlyn and Kate O'Neill were the driving force behind the inaugural SMR congress. Kate O'Neill wanted to honor the memory of her sister Noreen, who sadly lost her battle with melanoma. Four years earlier, Kate, Noreen, and Meenhard came together to establish the Noreen O'Neill Foundation for Melanoma Research, which served as the sponsor for the first SMR congress. They jointly envisioned a global community of basic scientists and clinicians sharing their expertise to combat one of the most challenging and deadly forms of cancer. Over the years this vision has become a reality, and a united community with almost 700 members has emerged. The SMR Congress brings together clinicians and scientists from diverse backgrounds to openly share their insights and latest research, and foster collective efforts aimed at battling melanoma.</p><p>The SMR has fostered numerous productive collaborations and nurtured the growth of rising talents. By promoting mentorship, exchange of knowledge and resources, and open discussions within the society's annual meetings, the SMR has supported the career of both junior and established researchers, as well as inspired the next generation of melanoma scientists.</p><p>In the past 20 years, groundbreaking discoveries and novel therapeutic approaches have shaped the landscape of melanoma treatment. From decoding the complexities of melanoma genetics, unraveling the intricate interactions within the tumor microenvironment, to developing immunotherapies that have revolutionized the treatment of melanoma, the collective efforts of the SMR community have brought us closer to conquering this challenging disease.</p><p>To mark the SMR's 20th Anniversary, some of our colleagues reflect on the past two decades, revisiting pivotal moments, landmark discoveries, and the evolution of our society. In this special issue of <i>PCMR</i>, the contributing authors will take us through a journey, tracing the progress of the field under the SMR umbrella.</p><p>We sincerely thank our colleagues who have contributed to this special issue, and those who have been part of this journey—researchers, clinicians, trainees, patients, and advocates. The progress made is tangible proof of the power of collaboration, which has placed the melanoma field at the forefront of cancer research uncovering a therapeutic armamentarium that has revolutionized the clinical management of melanoma.</p><p>We invite you to join us in Philadelphia to celebrate the accomplishments of the field and the many melanoma researchers who have dedicated their careers to investigating and combating this challenging disease. Here
我们怀着极大的热情欢迎你们来到费城,庆祝黑色素瘤研究界的一个里程碑:黑色素瘤研究协会(SMR)成立20周年。SMR于2003年在费城举行的第一届国际黑色素瘤研究大会期间成立。Meenhard Herlyn和Kate O'Neill是首届SMR大会背后的推动力量。凯特·奥尼尔想要纪念她的妹妹诺琳,诺琳在与黑色素瘤的斗争中不幸丧生。四年前,Kate, Noreen和Meenhard一起成立了Noreen O'Neill黑色素瘤研究基金会,该基金会是第一届SMR大会的赞助商。他们共同设想建立一个由基础科学家和临床医生组成的全球社区,分享他们的专业知识,以对抗最具挑战性和最致命的癌症之一。多年来,这一愿景已经成为现实,一个拥有近700名成员的团结社区已经出现。SMR大会汇集了来自不同背景的临床医生和科学家,公开分享他们的见解和最新研究,并促进共同努力,以对抗黑色素瘤。SMR促进了许多富有成效的合作,培养了崭露头角的人才。通过促进指导,知识和资源的交流,以及在协会年度会议上的公开讨论,SMR支持了初级和成熟研究人员的职业生涯,并激励了下一代黑色素瘤科学家。在过去的20年里,突破性的发现和新的治疗方法塑造了黑色素瘤治疗的格局。从破解黑色素瘤遗传学的复杂性,揭示肿瘤微环境中复杂的相互作用,到开发彻底改变黑色素瘤治疗的免疫疗法,SMR社区的集体努力使我们更接近征服这一具有挑战性的疾病。为了纪念SMR成立20周年,我们的一些同事回顾了过去20年,回顾了关键时刻、里程碑式的发现和我们社会的演变。在这期《PCMR》特刊中,特约作者将带我们走过一段旅程,追踪SMR保护伞下该领域的进展。我们衷心感谢为本期特刊做出贡献的同事,以及参与这一旅程的研究人员、临床医生、学员、患者和倡导者。所取得的进展是合作力量的切实证明,它将黑色素瘤领域置于癌症研究的前沿,揭示了一种治疗手段,彻底改变了黑色素瘤的临床管理。我们邀请您与我们一起在费城庆祝该领域的成就,以及许多黑色素瘤研究人员,他们将自己的职业生涯奉献给了调查和对抗这种具有挑战性的疾病。为未来20年的进步、激动人心的发现和更多的突破干杯,在我们攻克黑色素瘤的道路上。第20届国际黑色素瘤研究协会大会组委会。
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引用次数: 0
Epilogue 后记
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-10-30 DOI: 10.1111/pcmr.13143
Vijayasaradhi Setaluri, Evan P. and Marion Helfaer

It has been an honor and privilege to serve as Editor-in-Chief of Pigment Cell & Melanoma Research. This is a unique journal in many respects. It is the official journal of two scientific societies. Established first as Pigment Cell Research under the auspices of the Federation of Pigment Cell Societies, later became Pigment Cell & Melanoma Research by welcoming Society for Melanoma Research to be equal partner. With this merger, the scope of manuscripts now published span the widest range of topics that include chemistry of melanin, vertebrate pigmentation, and pigmentary diseases to melanoma biology and clinical trials. I enjoyed the front row view of this expansive landscape and made every effort to make each issue reflect the scope of the journal.

I have many individuals to thank for making it a worthwhile journey. Foremost, the Associate Editors, who often shouldered equal burden, colleagues, who stepped up every time they were asked to review manuscripts, and the journal staff at Wiley, who supported the workflow. I will miss the opportunity and the privilege of being the first to glimpse research coming out from laboratories across the world. I will miss the opportunity to read the insightful reviews from researchers I hold in high esteem.

Six years ago, when I accepted to serve as Editor-in-Chief of this journal, there was some unspoken skepticism about the viability of the journal in its current form in the fast-changing landscape of journal publishing. As an optimist, I brushed aside such skepticism. Even after 6 years in the trenches, including the difficult period of COVID-19 pandemic, I remain optimistic about the future of this unique journal. There are and will be many challenges to overcome. A journal is only as good as the quality of manuscripts it receives and the peer reviews of those manuscripts. Therefore, it is my sincere hope that the members of the pigment cell and melanoma community, bound together by our interest in this fascinating entity we call “melanocyte”, choose this journal as their first choice to submit and publish their best work and be ready and willing to serve as reviewers. More than anything else, this will be a true test of the commitment of members of this community to the success of this journal. As a member of both pigment cell and melanoma societies, I commit to continue to do my part.

担任《色素细胞》杂志主编是我的荣幸。黑素瘤的研究。这是一本在很多方面都很独特的杂志。它是两个科学学会的官方期刊。在色素细胞学会联合会的支持下,最初以色素细胞研究成立,后来成为色素细胞&欢迎黑色素瘤研究协会成为平等的合作伙伴。通过这次合并,现在出版的手稿范围涵盖了最广泛的主题,包括黑色素化学、脊椎动物色素沉着、色素疾病到黑色素瘤生物学和临床试验。我喜欢坐在前排欣赏这个广阔的景观,并尽一切努力使每期都能反映杂志的范围。我要感谢很多人,是他们让我的旅程变得有价值。最重要的是经常承担同等责任的副编辑、每次被要求审稿时都挺身而出的同事,以及支持整个工作流程的Wiley的期刊工作人员。我将失去第一个看到世界各地实验室的研究成果的机会和特权。我将错过阅读我所尊敬的研究人员的深刻评论的机会。六年前,当我接受这份杂志的总编辑一职时,在期刊出版业快速变化的大环境下,人们对这份杂志目前的生存能力存在着一些不言而喻的怀疑。作为一个乐观主义者,我不理会这种怀疑。即使在6年的战壕中,包括COVID-19大流行的困难时期,我仍然对这份独特期刊的未来持乐观态度。现在和将来都有许多挑战需要克服。一本期刊的好坏取决于它收到的稿件的质量和对这些稿件的同行评议。因此,我真诚地希望色素细胞和黑色素瘤社区的成员,因为我们对这个迷人的实体的兴趣而联系在一起,我们称之为“黑素细胞”,选择这本杂志作为他们提交和发表他们最好的作品的首选,并准备好并愿意担任审稿人。最重要的是,这将是对这个社区成员对这本杂志成功的承诺的真正考验。作为色素细胞和黑色素瘤协会的成员,我承诺继续尽我的一份力量。
{"title":"Epilogue","authors":"Vijayasaradhi Setaluri,&nbsp;Evan P. and Marion Helfaer","doi":"10.1111/pcmr.13143","DOIUrl":"10.1111/pcmr.13143","url":null,"abstract":"<p>It has been an honor and privilege to serve as Editor-in-Chief of Pigment Cell &amp; Melanoma Research. This is a unique journal in many respects. It is the official journal of two scientific societies. Established first as Pigment Cell Research under the auspices of the Federation of Pigment Cell Societies, later became Pigment Cell &amp; Melanoma Research by welcoming Society for Melanoma Research to be equal partner. With this merger, the scope of manuscripts now published span the widest range of topics that include chemistry of melanin, vertebrate pigmentation, and pigmentary diseases to melanoma biology and clinical trials. I enjoyed the front row view of this expansive landscape and made every effort to make each issue reflect the scope of the journal.</p><p>I have many individuals to thank for making it a worthwhile journey. Foremost, the Associate Editors, who often shouldered equal burden, colleagues, who stepped up every time they were asked to review manuscripts, and the journal staff at Wiley, who supported the workflow. I will miss the opportunity and the privilege of being the first to glimpse research coming out from laboratories across the world. I will miss the opportunity to read the insightful reviews from researchers I hold in high esteem.</p><p>Six years ago, when I accepted to serve as Editor-in-Chief of this journal, there was some unspoken skepticism about the viability of the journal in its current form in the fast-changing landscape of journal publishing. As an optimist, I brushed aside such skepticism. Even after 6 years in the trenches, including the difficult period of COVID-19 pandemic, I remain optimistic about the future of this unique journal. There are and will be many challenges to overcome. A journal is only as good as the quality of manuscripts it receives and the peer reviews of those manuscripts. Therefore, it is my sincere hope that the members of the pigment cell and melanoma community, bound together by our interest in this fascinating entity we call “melanocyte”, choose this journal as their first choice to submit and publish their best work and be ready and willing to serve as reviewers. More than anything else, this will be a true test of the commitment of members of this community to the success of this journal. As a member of both pigment cell and melanoma societies, I commit to continue to do my part.</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"36 6","pages":"454"},"PeriodicalIF":4.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71409996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
List of reviewers for PCMR (01.01.2023–30.09.2023) PCMR评审员名单(01.01.2023-30.09.2023)。
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-10-30 DOI: 10.1111/pcmr.13142

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引用次数: 0
Clinicopathological features, current status, and progress of primary central nervous system melanoma diagnosis and treatment 原发性中枢神经系统黑色素瘤的临床病理特点、现状及诊治进展。
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-10-27 DOI: 10.1111/pcmr.13140
Pengna Guo, Xiaoting Wei, Zhen Guo, Di Wu

Primary central nervous system (CNS) melanoma is an extremely rare condition, with an incidence rate of 0.01 per 100,000 individuals per year. Despite its rarity, the etiology and pathogenesis of this disease are not yet fully understood. Primary CNS melanoma exhibits highly aggressive biological behavior and presents clinically in a distinct manner from other types of melanomas. It can develop at any age, predominantly affecting the meninges as the primary site, with clinical symptoms varying depending on the neoplasm’s location. Due to the lack of specificity in its presentation and the challenging nature of imaging diagnosis, distinguishing primary CNS melanoma from other CNS diseases. The combination of challenges in early detection, heightened tumor aggressiveness, and the obscured location of its origin contribute to an unfavorable prognostic outcome. Furthermore, there has been currently no consensus on a standardized treatment approach for primary CNS melanoma. Despite recent advancements in targeted therapy and immunotherapy for CNS melanoma, patients with primary CNS melanoma have limited treatment options due to their inadequate response to these therapies. Here, we provided a comprehensive summary of the epidemiology, clinical features, molecular pathological manifestations, and available diagnostic and therapeutic approaches of primary CNS melanoma. Additionally, we proposed potential therapeutic strategies for it.

原发性中枢神经系统(CNS)黑色素瘤是一种极为罕见的疾病,其发病率为每年每100000人中有0.01人。尽管这种疾病很罕见,但其病因和发病机制尚不完全清楚。原发性中枢神经系统黑色素瘤表现出高度侵袭性的生物学行为,临床表现与其他类型的黑色素瘤不同。它可以在任何年龄发展,主要影响作为主要部位的脑膜,临床症状因肿瘤的位置而异。由于其表现缺乏特异性,且影像学诊断具有挑战性,因此将原发性中枢神经系统黑色素瘤与其他中枢神经系统疾病区分开来。早期检测的挑战、肿瘤侵袭性的增强以及其起源位置的模糊导致了不利的预后结果。此外,目前还没有就原发性中枢神经系统黑色素瘤的标准化治疗方法达成共识。尽管中枢神经系统黑色素瘤的靶向治疗和免疫疗法最近取得了进展,但原发性中枢神经系统黑素瘤患者由于对这些疗法的反应不足,治疗选择有限。在此,我们对原发性中枢神经系统黑色素瘤的流行病学、临床特征、分子病理表现以及可用的诊断和治疗方法进行了全面总结。此外,我们还提出了潜在的治疗策略。
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引用次数: 0
The MFSD12 p.Tyr182His common variant is sufficient to alter mouse agouti coat color MFSD12 p. tyr182的常见变异足以改变鼠刺鼠的毛色。
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-10-24 DOI: 10.1111/pcmr.13144
Dawn E. Watkins-Chow, Arturo A. Incao, Cecelia Rivas, Gene Elliott, Lisa J. Garrett, William J. Pavan

MFSD12 functions as a transmembrane protein required for import of cysteine into melanosomes and lysosomes. The MFSD12 locus has been associated with phenotypic variation in skin color across African, Latin American, and East Asian populations. The frequency of a particular MFSD12 coding variant, rs2240751 (MAF = 0.08), has been reported to correlate with solar radiation and occur at highest frequency in Peruvian (PEL MAF = 0.48) and Han Chinese (CHB MAF = 0.40) populations, suggesting it could be causative for associated phenotypic variation in skin color. We have generated a mouse knock-in allele, Mfsd12Y182H, to model the human missense p.Tyr182His human variant. We demonstrate that the variant transcript is stably expressed and that agouti mice homozygote for the variant allele are viable with an altered coat color. This in vivo data confirms that the MFSD12 p.Tyr182His variant functions as a hypomorphic allele sufficient to alter mammalian pigmentation.

MFSD12作为半胱氨酸输入黑素体和溶酶体所需的跨膜蛋白发挥作用。MFSD12基因座与非洲、拉丁美洲和东亚人群的肤色表型变异有关。特定MFSD12编码变体rs2240751(MAF = 0.08),据报道与太阳辐射有关,并且在秘鲁发生的频率最高(PEL-MAF = 0.48)和汉族(CHB-MAF = 0.40)群体,这表明它可能是皮肤颜色相关表型变异的原因。我们已经产生了一个小鼠敲除等位基因Mfsd12Y182H,以模拟人类错义p.Tyr182His人类变体。我们证明了变体转录物是稳定表达的,并且变体等位基因纯合的agouti小鼠在毛色改变的情况下是可行的。该体内数据证实MFSD12 p.Tyr182His变体作为足以改变哺乳动物色素沉着的亚形态等位基因发挥作用。
{"title":"The MFSD12 p.Tyr182His common variant is sufficient to alter mouse agouti coat color","authors":"Dawn E. Watkins-Chow,&nbsp;Arturo A. Incao,&nbsp;Cecelia Rivas,&nbsp;Gene Elliott,&nbsp;Lisa J. Garrett,&nbsp;William J. Pavan","doi":"10.1111/pcmr.13144","DOIUrl":"10.1111/pcmr.13144","url":null,"abstract":"<p>MFSD12 functions as a transmembrane protein required for import of cysteine into melanosomes and lysosomes. The <i>MFSD12</i> locus has been associated with phenotypic variation in skin color across African, Latin American, and East Asian populations. The frequency of a particular <i>MFSD12</i> coding variant, rs2240751 (MAF = 0.08), has been reported to correlate with solar radiation and occur at highest frequency in Peruvian (PEL MAF = 0.48) and Han Chinese (CHB MAF = 0.40) populations, suggesting it could be causative for associated phenotypic variation in skin color. We have generated a mouse knock-in allele, <i>Mfsd12</i><sup><i>Y182H</i></sup>, to model the human missense p.Tyr182His human variant. We demonstrate that the variant transcript is stably expressed and that agouti mice homozygote for the variant allele are viable with an altered coat color. This in vivo data confirms that the MFSD12 p.Tyr182His variant functions as a hypomorphic allele sufficient to alter mammalian pigmentation.</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"37 2","pages":"259-264"},"PeriodicalIF":4.3,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.13144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50156658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-generation of melanoma researchers: Trainee perspectives from around the world 下一代黑色素瘤研究人员:来自世界各地的受训者观点。
IF 4.3 3区 医学 Q2 CELL BIOLOGY Pub Date : 2023-10-11 DOI: 10.1111/pcmr.13136
Marie R. Webster, Roderick Brathwaite, Jeremy A. Bravo Narula, Vissy M. Elad, Yanni Ma, Mei Fong Ng, Manoel Oliveira de Moraes Junior, Majahonkhe Shabangu, Christina Tsiavou, Jessie Villanueva, Vito W. Rebecca

The Society for Melanoma Research (SMR) was created 20 years ago and has unequivocally contributed to the vast progress of the field, particularly for the treatment of melanoma patients with metastatic disease by facilitating synergistic collaborations between clinicians, researchers at the bench, and industry. In commemoration of the 20th anniversary of the first SMR International Congress (held in 2003 in Philadelphia), we look to the future by highlighting the perspectives of the next generation of rising stars, medical, and graduate students across six continents.

黑色素瘤研究学会成立20 几年前,通过促进临床医生、研究人员和行业之间的协同合作,明确地为该领域的巨大进步做出了贡献,特别是在治疗患有转移性疾病的黑色素瘤患者方面。为了纪念第一届SMR国际大会(2003年在费城举行)20周年,我们展望未来,强调六大洲下一代后起之秀、医学生和研究生的观点。
{"title":"Next-generation of melanoma researchers: Trainee perspectives from around the world","authors":"Marie R. Webster,&nbsp;Roderick Brathwaite,&nbsp;Jeremy A. Bravo Narula,&nbsp;Vissy M. Elad,&nbsp;Yanni Ma,&nbsp;Mei Fong Ng,&nbsp;Manoel Oliveira de Moraes Junior,&nbsp;Majahonkhe Shabangu,&nbsp;Christina Tsiavou,&nbsp;Jessie Villanueva,&nbsp;Vito W. Rebecca","doi":"10.1111/pcmr.13136","DOIUrl":"10.1111/pcmr.13136","url":null,"abstract":"<p>The Society for Melanoma Research (SMR) was created 20 years ago and has unequivocally contributed to the vast progress of the field, particularly for the treatment of melanoma patients with metastatic disease by facilitating synergistic collaborations between clinicians, researchers at the bench, and industry. In commemoration of the 20th anniversary of the first SMR International Congress (held in 2003 in Philadelphia), we look to the future by highlighting the perspectives of the next generation of rising stars, medical, and graduate students across six continents.</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"36 6","pages":"588-593"},"PeriodicalIF":4.3,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41186666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Pigment Cell & Melanoma Research
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