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Combined Endoscopic-Radiologic Minimally Invasive Rescue Technique for the Removal of a Migrated and Embedded Biliary Metal Stent 内镜-放射联合微创胆道金属支架移置术的应用
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/sgo-26-4-388
P. Antypas, M. Corona, Cristian Eugeniu Boru, Chiara Eberspacher, D. Mascagni, F. Fiocca
Bile duct injuries represent a rare but potentially serious complication after laparoscopic cholecystectomy, that often need multidisciplinary therapeutic approaches. Additionally, post cholecystectomy clip migration into the biliary tree has been described, mainly because of local inflammatory processes. We present a case of a 65-year-old male with a bile duct injury and stricture after laparoscopic cholecystectomy treated endoscopically with sphincterotomy and stent positioning; initially with a plastic 10Fr stent and later with a totally covered metal stent. At the removal, the metal stent appeared proximally migrated and embedded with a surgical clip, the latter also migrated into the bile duct. The endoscopic retrieval of the stent was unsuccessful and thus a simultaneous right percutaneous transhepatic approach was adopted to liberate the stent and to facilitate the endoscopic procedure. The combined endoscopic-radiologic minimally-invasive approach seemed to be an effective and safe rescue technique, avoiding in this way complex surgical procedures.
胆管损伤是腹腔镜胆囊切除术后罕见但潜在的严重并发症,通常需要多学科的治疗方法。此外,胆囊切除术后夹子迁移到胆道树也有报道,主要是由于局部炎症过程。我们报告一例65岁男性,腹腔镜胆囊切除术后胆管损伤和狭窄,内窥镜下采用括约肌切开术和支架定位治疗;最初是一个塑料支架,后来是一个完全覆盖的金属支架。在取出时,金属支架出现近端迁移并嵌入手术夹,后者也迁移到胆管中。内镜下支架取出不成功,因此同时采用右经皮经肝入路释放支架,方便内镜手术。内镜-放射微创联合入路似乎是一种有效和安全的抢救技术,避免了复杂的外科手术。
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引用次数: 0
Modified Blumgart Anastomosis in Patients Undergoing Robotic Pancreaticoduodenectomy: The Results of a Preliminary Experience 改良Blumgart吻合在机器人胰十二指肠切除术中的应用:初步经验的结果
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/sgo-26-4-393
M. Marino, Adrian Chiow Kah Heng, G. Vaccarella, O. Potapov, Andrzej Lech Komorowski
Backgrounds: Several anastomoses have been described for the reconstruction of the pancreatic stump after pancreaticoduodenectomy. No technique showed a superiority over the others in terms of post-operative pancreatic fistula formation (POPF) in open neither during a minimally invasive approach. Methods: We compared the surgical outcomes of fourteen patients classified as high-risk for POPF who underwent a Blumgart anastomosis (BA) with that of patients who underwent a Cattell-Warren (CW). A 1:1 case-matched analysis was performed according to the variables of the risk score for post-operative pancreatic fistula (POPF) formation. Results: The overall operative time was similar (373±115 vs 398±127 min, p=0.567) while fashioning of the CW anastomosis required a longer time (38±21 vs 29±10, p<0.05). The overall morbidity rate was comparable among the two groups (p=0.273), while the incidence of clinically relevant-POPF was lower in the BA group (0 vs 3, p<0.05). No differences were observed in reoperation rate (p=0.445) and in postoperative length of stay (11.5 vs 12.6, p=0.367). Conclusion: The BA anastomosis is a potential alternative to the CW technique in a high-risk population for POPF formation. It shows benefits in terms of shorter anastomotic time and lower rate of clinically relevant-POPF.
背景:几种吻合方式用于胰十二指肠切除术后胰残端重建。在开放性和微创入路手术后胰瘘形成(POPF)方面,没有一种技术比其他技术优越。方法:我们比较了14例高危POPF患者行Blumgart吻合(BA)和行cattel - warren吻合(CW)的手术结果。根据术后胰瘘(POPF)形成风险评分变量进行1:1病例匹配分析。结果:两组总手术时间相近(373±115 min vs 398±127 min, p=0.567),但CW吻合口形成时间较长(38±21 min vs 29±10 min, p<0.05)。两组总发病率相当(p=0.273),而BA组临床相关- popf发生率较低(0 vs 3, p<0.05)。再手术率(p=0.445)和术后住院时间(11.5 vs 12.6, p=0.367)差异无统计学意义。结论:在POPF形成的高危人群中,BA吻合术是一种潜在的替代CW技术。它在缩短吻合时间和降低临床相关- popf率方面显示出益处。
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引用次数: 0
A Rare Liver Tumor: Case Report and Literature Review 罕见肝脏肿瘤1例报告及文献复习
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/sgo-ec-350
Choi Chin Wa, Leong Chin Wan, Iao Kin Sang, Chu Man Leng, J. Costa-Maia, Pang Heong Keong
The incidence of distant metastasis from meningioma is reported to be rare. Only about 0.1% of meningiomas metastasize outside the central nervous system (1), with 11 cases of liver metastasis reported in PubMed. A consensus about screening programs and treatment plan for metastatic meningioma is still lacking. Surgical resection remains the first option for the treatment and should be performed in Centers with adequate experience. We report a case of metastatic liver tumor from an atypical meningioma and reviewed similar previously publishedcases, summarizing potential risk factors for liver metastasis and screening recommendations. 48-year-old female was diagnosed with meningioma in 2000 and underwent complete surgical resection with pathology indicating a fibrous meningioma.
据报道,脑膜瘤远处转移的发生率是罕见的。只有约0.1%的脑膜瘤转移到中枢神经系统以外(1),PubMed报道了11例肝转移。目前对于转移性脑膜瘤的筛查方案和治疗方案仍缺乏共识。手术切除仍然是治疗的第一选择,应该在有足够经验的中心进行。我们报告一例非典型脑膜瘤转移性肝肿瘤,并回顾了先前发表的类似病例,总结了肝转移的潜在危险因素和筛查建议。女性,48岁,2000年被诊断为脑膜瘤,病理显示为纤维性脑膜瘤,接受了完整的手术切除。
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引用次数: 0
Inflammatory Responses in Liver Transplantation 肝移植中的炎症反应
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/SGO-26-326
Kantoku Nagakawa, A. Soyama, S. Eguchi
Successful liver transplantation requires proper mitigation of stress responses. Systemic effects caused by liver cirrhosis, invasive surgery, ischemia-reperfusion injury, rejection, and infection, all of which are relevant to liver transplantation, are mediated by inflammatory factors. Recently, the detailed mechanisms of inflammation have been elucidated. Damage-associated molecular patterns (DAMPs) released from cells damaged by ischemia or injury, or pathogen-associated molecular patterns (PAMPs) released by pathogens, are recognized by internal cell receptors or cell surface receptors, leading to the synthesis of inflammatory proteins including proinflammatory/anti-inflammatory cytokines, which are then secreted by the cells. These cytokines stimulate the production of additional cytokines, causing a vicious circle of inflammatory responses, such as innate immune responses by macrophages. In addition, lymphocytes activated by these cytokines stimulate adaptive immunity. During liver transplantation, the general preoperative condition of the patient and surgical invasiveness are associated with organ failure and ischemia-reperfusion injury, which can lead to transplant rejection. It has been suggested that progressive immunodeficiency and organ failure as a result of pre-transplant cirrhosis are associated with postoperative multiple organ failure and death, and that elevated intraoperative DAMPs correlate with organ failure. Furthermore, DAMP receptors and inflammatory cytokines are increased by ischemia-reperfusion injury, indicating its role in promoting innate and adaptive immunity. In addition, inflammatory signals induced by postoperative infections are similar to those induced by ischemia-reperfusion injury and rejection, indicating that pathogen-derived inflammation can also lead to rejection. In summary, most complications in liver transplantation can be explained in a unified manner by abnormal inflammatory responses; therefore, controlling inflammation might be of benefit for the struggle of safe and effective liver transplantation.
成功的肝移植需要适当减轻应激反应。肝硬化、侵袭性手术、缺血再灌注损伤、排斥反应、感染等与肝移植相关的全身性影响均由炎症因子介导。近年来,炎症的详细机制已被阐明。损伤相关分子模式(DAMPs)由缺血或损伤损伤的细胞释放,或病原体释放的病原体相关分子模式(PAMPs)被细胞内部受体或细胞表面受体识别,导致炎症蛋白的合成,包括促炎/抗炎细胞因子,然后由细胞分泌。这些细胞因子刺激其他细胞因子的产生,引起炎症反应的恶性循环,如巨噬细胞的先天免疫反应。此外,被这些细胞因子激活的淋巴细胞刺激适应性免疫。在肝移植过程中,患者的一般术前状况和手术的侵入性与器官衰竭和缺血再灌注损伤有关,这可能导致移植排斥反应。有研究表明,移植前肝硬化导致的进行性免疫缺陷和器官衰竭与术后多器官衰竭和死亡有关,术中DAMPs升高与器官衰竭有关。此外,缺血再灌注损伤后,DAMP受体和炎症细胞因子增加,表明其在促进先天免疫和适应性免疫中的作用。此外,术后感染引起的炎症信号与缺血再灌注损伤和排斥反应引起的炎症信号相似,表明病原性炎症也可导致排斥反应。综上所述,大多数肝移植并发症可以统一解释为异常的炎症反应;因此,控制炎症可能有利于争取安全有效的肝移植。
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引用次数: 0
Study the Relation between Blood Ammonia Level and Esophageal Varices in Egyptian Patients with Liver Cirrhosis 埃及肝硬化患者血氨水平与食管静脉曲张的关系研究
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/sgo-ec-348
E. A. Abd ELatti, Ahmed Ibrahim Mohammed, Walid Mouhamed Fathy, Abdel-Naser Abdel-Aty Gad Allah
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引用次数: 0
Liver Transplantation and Surgery in the Management of Hepatocellular Carcinoma 肝移植和手术治疗肝细胞癌
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/SGO-26-320
M. Malágo, D. Raptis, C. Imber, Giovanni Dalla Serra, O. Kornasiewicz
Hepatocellular carcinoma (HCC) is the second cause of cancer–related deaths worldwide constitutes a major global health problem. Although our understanding of the molecular pathogenesis of hepatocellular HCC has improved, detected driver mutations are not yet sufficiently reliable therapeutic targets. The modern management of HCC is conceived only within multidisciplinary schemes. Current systemic therapies are not curative and surgical treatments remain the only potential curative treatments for selected patients with early stage HCC. The role of parenchyma sparing liver resection for appropriately selected patients may vary in different environments according to organ availability,and liver resection remains a reliable curative method for HCC. Meta-analyses have shown that clinical outcomes of surgical resection are superior to ablative treatments in early stage HCC. Liver transplantation is still the standard treatment for patients with early stage HCC. Lately the Milan Criteria are considered too restrictive, still recognizing that the extension of transplantation criteria beyond Milano criteria increases the risk of HCC recurrence. Resection, ablation, transarterial embolization and trans-arterial radiation are commonly applied to bridge patients to transplant. Despite enormous advances in the therapy of HCC treatments at present, there are currently no genuine breakthroughs for patients with HCC. The Clinical Trials Planning Meeting (CTPM) in HCC convened by the American Society of Clinical Oncology identified the key knowledge gaps in HCC and define clinical research priorities. Major improvements in survival provided by multimodal treatments witnessed in other cancers are not yet available for HCC because effective systemic treatment modalities for HCC are still lacking. Integration of bio-genetic tumor information into current tested treatment schemes and truly multimodal surgery-based treatment schemes will enable the recruitment of less selected patients in larger numbers to curative treatments.
肝细胞癌(HCC)是全球癌症相关死亡的第二大原因,构成了一个重大的全球健康问题。虽然我们对肝细胞性HCC的分子发病机制的了解有所提高,但检测到的驱动突变还不够可靠的治疗靶点。HCC的现代管理只能在多学科方案中构想。目前的全身治疗无法治愈,手术治疗仍然是早期HCC患者的唯一潜在治疗方法。根据器官可用性的不同,在不同的环境下,适当选择保留实质的肝切除术对患者的作用可能会有所不同,肝切除术仍然是HCC的可靠治疗方法。荟萃分析显示,在早期HCC中,手术切除的临床效果优于消融治疗。肝移植仍是早期HCC患者的标准治疗方法。最近米兰标准被认为过于严格,仍然认识到移植标准超出米兰标准会增加HCC复发的风险。切除、消融术、经动脉栓塞和经动脉放射治疗通常用于架桥患者进行移植。尽管目前HCC的治疗方法取得了巨大的进步,但对于HCC患者来说,目前还没有真正的突破。由美国临床肿瘤学会召集的HCC临床试验计划会议(CTPM)确定了HCC的关键知识缺口并确定了临床研究重点。由于目前还缺乏有效的肝细胞癌的全身治疗方式,因此在其他癌症中发现的多模式治疗对肝细胞癌生存率的重大改善尚不可用于肝细胞癌。将肿瘤生物遗传信息整合到目前已测试的治疗方案和真正的基于多模式手术的治疗方案中,将使较少选择的患者能够更多地接受治愈性治疗。
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引用次数: 0
Unusual Presentation of a Gastrointestinal Tumor in Excluded Stomach - the Need to Think About the Hidden Enemy 胃肠肿瘤的不寻常表现-需要考虑隐藏的敌人
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/sgo-26-4-323
T. Guedes, D. Ferreira, José Ricardo Brandão, Jose Ramon Vizcaino, I. Pedroto
Obesity and its surgical treatment have been increasing in the last decade. Roux-en-Y gastric bypass (RYGB) is one of the most common procedures performed, resulting in an excluded stomach that can be the home of pre- and postoperative pathology. We present a case report of a 52 years-old man with melena and refractory anemia 2 years after RYGB. Although a possible etiology was found through esophagogastroduodenoscopy, the persistence of anemia determined the search for other causes. Additional abdominal CT revealed a tumoral mass in the excluded stomach with subsequent biopsy findings compatible with a gastrointestinal stromal tumor (GIST). Neoadjuvant imatinib therapy and surgery werewas performed confirming the diagnosis and showing GIST ulcerating the mucosa of the excluded stomach. After surgery, imatinib treatment was restarted and maintained so far with no recurrence of anemia. Malignancy of excluded stomach are frequently of epithelial origin and, to our knowledge, GIST occurrence is a very rare finding on an excluded stomach. This highlights the importance of considering the occurrence of hidden pathology in the excluded stomach, as well as the need for a high-qualityhigh quality EGD in pre-bariatric surgery evaluation.
在过去的十年里,肥胖及其手术治疗一直在增加。Roux-en-Y胃旁路术(RYGB)是最常见的手术之一,其结果是胃被排除在外,这可能是术前和术后病理的所在地。我们提出一个病例报告,52岁的男子黑黑和难治性贫血后2年RYGB。虽然通过食管胃十二指肠镜检查发现了可能的病因,但贫血的持续存在决定了寻找其他原因。另外的腹部CT显示在排除的胃有一个肿瘤肿块,随后的活检结果与胃肠道间质瘤(GIST)相符。新辅助伊马替尼治疗和手术证实诊断,并显示胃肠道间质瘤溃疡的胃粘膜排除。术后重新开始伊马替尼治疗并维持至今,无贫血复发。排除胃的恶性肿瘤经常是上皮起源,据我们所知,GIST的发生是一个非常罕见的发现排除胃。这突出了考虑排除胃中隐藏病理发生的重要性,以及在减肥前手术评估中需要高质量的EGD。
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引用次数: 0
Emergency Laparoscopic Cholecystectomy with Low-Pressure Pneumo-Peritoneum in Cardiopulmonary Risk Patients: Fundus-Calot Cholecystectomy versus Calot First Cholecystectomy. Randomized Controlled Trial 急诊腹腔镜胆囊切除术加低压腹膜肺治疗心肺危险患者:胃底胆囊切除术vs胃底胆囊切除术。随机对照试验
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/sgo-ec-370
T. Habeeb, Mahmoud Abdouyassin, Fady Mehaney Habib, Muhammad A. Baghdadi
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引用次数: 0
Correlation of HIV Status to Non-HPV Associated Benign Surgical Perianal Pathologies HIV状态与非hpv相关良性手术肛周病变的相关性
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/sgo-ec-221
M. Motsumi, John Thato Tlhakanelo
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引用次数: 0
Preoperative Clinical and Radiological Variables for Prediction of Difficult Laparoscopic Cholecystectomy 预测腹腔镜胆囊切除术困难的术前临床和影像学指标
Q4 Medicine Pub Date : 2021-01-01 DOI: 10.21614/sgo-26-4-386
S. Elgarf, Tamer M. Elmahdy, M. Ghazaly, A. Swelam
Introduction: Laparoscopic cholecystectomy (LC) has replaced open technique as the main surgical intervention in the treatment of gall bladder stones. There are different clinical and radiological predictors that are indicators for technically difficult LC. Aim of the work: The aim of this study was to identify the clinical and radiological variables associated with difficult LC. Methods: During the period from March 2018 to March 2021, 452 adult patients who presented with symptomatic gall bladder stones underwent LC. Different clinical and radiological data were collected as: abdominal scar, palpable gall bladder, previous hospitalization, history of ERCP, total leucocyte count, thickness of the gall bladder wall, peri-cholecystic collection, solitary or multiple gall bladder stones, impacted stone and diameter of the CBD. Results: Age of 50 years or over (P value 0.001), male gender (P value 0.001), previous hospital admission (P value 0.001), impacted stones (P value 0.003), and leukocytosis (P value 0.031) were found statistically significant with area under ROC curve is 0.814 with 95 % confidence interval. Conclusion: These preoperative risk factors; old age, male gender, previous hospitalization for biliary problem, impacted stone, and leukocytosis could potentially predict difficult LC, and give surgeons and their assistants the chance to predict the risk of complications intraoperatively and the possibility to convert the maneuver to a bail-out one.
腹腔镜胆囊切除术(LC)已取代开放技术成为治疗胆囊结石的主要手术干预手段。有不同的临床和放射学预测指标是技术上困难的LC的指标。工作目的:本研究的目的是确定与难治性LC相关的临床和放射学变量。方法:2018年3月至2021年3月,452例出现症状性胆囊结石的成年患者行LC。收集不同的临床和影像学资料,如:腹部疤痕、可触及的胆囊、既往住院、ERCP史、白细胞总数、胆囊壁厚度、胆囊周围收集、单发或多发胆囊结石、嵌塞结石和CBD直径。结果:50岁及以上(P值0.001)、男性(P值0.001)、既往住院史(P值0.001)、嵌塞结石(P值0.003)、白细胞增多(P值0.031)的差异有统计学意义,ROC曲线下面积为0.814,可信区间为95%。结论:术前危险因素;老年、男性、既往因胆道问题住院、嵌塞结石和白细胞增多可能预测难治性LC,使外科医生及其助手有机会预测术中并发症的风险,并有可能将手术转为救助手术。
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引用次数: 0
期刊
Surgery, Gastroenterology and Oncology
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