M. A. ElKordy, Fady Rashad Selim, Amani A. Abou, Eman D. ElDesouky, Foad AbdElShaheed Foad
{"title":"C-KIT Negative Gastrointestinal Stromal Tumors: Challenges of Management and Prognosis","authors":"M. A. ElKordy, Fady Rashad Selim, Amani A. Abou, Eman D. ElDesouky, Foad AbdElShaheed Foad","doi":"10.21614/sgo-517","DOIUrl":"https://doi.org/10.21614/sgo-517","url":null,"abstract":"","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85930674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Rama, Marlene Lages, Candida G. Silva, Patrícia C Motta Lima, Ines Campos Gil, M. Guarino, P. Oliveira, M. Dixe, A. Rocha, F. Castro-Poças, J. Pimentel
Aim: Anastomotic leakage (AL) is a severe postoperative complication in colorectal surgery, but its preclinical diagnosis may improve outcomes and increase anastomotic salvage. This study aimed to assess the added value of serum biomarkers for early detection of colorectal AL. Method: We performed a comprehensive literature review, and a qualitative and quantitative analysis of papers retrieved from MEDLINE, Embase, PubMed, Web of Science, Scopus and the Cochrane Library. We included all studies published before September 2021 assessing the serum biomarkers white blood cells (WBC), C-reactive protein (CRP), procalcitonin (PCT) and calprotectin (CLP) for the early diagnosis of AL. Results: Fifteen studies that evaluated three different systemic biomarkers in the context of AL were identified, including 5150 patients. Diagnostic test accuracy was estimated for CRP and PCT. On postoperative day (POD) 5, the highest AUC (87.1%) and specificity (80.2%) values were estimated for CRP. Random-effects meta-analysis and total effect sizes estimation for the biomarkers CRP, PCT and WBC were performed according to POD. The concentration of serum biomarkers is significantly higher in patients presenting AL. Regarding the qualitative analysis, there was significant heterogeneity in the inclusion of different subcategories of the consensus definition of colorectal AL in each paper’s definition. Conclusion: The serum biomarkers CRP and PCT are moderate predictors for AL, showing a high heterogeneity among the studies. Combinations of these biomarkers might improve predictive accuracy, but more studies will be necessary to conduct a quality metaregression.
目的:吻合口漏(AL)是结直肠手术术后严重的并发症，临床前诊断可改善预后，增加吻合口抢救。本研究旨在评估血清生物标志物在结肠直肠AL早期检测中的附加价值。方法:我们进行了全面的文献综述，并对MEDLINE、Embase、PubMed、Web of Science、Scopus和Cochrane图书馆的论文进行了定性和定量分析。我们纳入了2021年9月之前发表的所有评估血清生物标志物白细胞(WBC)、c反应蛋白(CRP)、降钙素原(PCT)和钙保护蛋白(CLP)对AL早期诊断的研究。结果:15项研究评估了AL背景下三种不同的系统生物标志物，包括5150例患者。在术后第5天(POD)， CRP的AUC(87.1%)和特异性(80.2%)估计最高。根据POD对生物标志物CRP、PCT和WBC进行随机效应荟萃分析和总效应大小估计。出现AL的患者血清生物标志物的浓度明显较高。在定性分析方面，每篇论文的定义中包含的结直肠AL共识定义的不同亚类存在显著的异质性。结论:血清生物标志物CRP和PCT是AL的中度预测因子，在研究中显示出较高的异质性。这些生物标记物的组合可能会提高预测的准确性，但需要更多的研究来进行质量回归。
{"title":"The Usefulness of Inflammatory Biomarkers to Predict Anastomotic Leakage after Colorectal Surgery: Systematic Review and Meta-Analysis","authors":"N. Rama, Marlene Lages, Candida G. Silva, Patrícia C Motta Lima, Ines Campos Gil, M. Guarino, P. Oliveira, M. Dixe, A. Rocha, F. Castro-Poças, J. Pimentel","doi":"10.21614/sgo-488","DOIUrl":"https://doi.org/10.21614/sgo-488","url":null,"abstract":"Aim: Anastomotic leakage (AL) is a severe postoperative complication in colorectal surgery, but its preclinical diagnosis may improve outcomes and increase anastomotic salvage. This study aimed to assess the added value of serum biomarkers for early detection of colorectal AL. Method: We performed a comprehensive literature review, and a qualitative and quantitative analysis of papers retrieved from MEDLINE, Embase, PubMed, Web of Science, Scopus and the Cochrane Library. We included all studies published before September 2021 assessing the serum biomarkers white blood cells (WBC), C-reactive protein (CRP), procalcitonin (PCT) and calprotectin (CLP) for the early diagnosis of AL. Results: Fifteen studies that evaluated three different systemic biomarkers in the context of AL were identified, including 5150 patients. Diagnostic test accuracy was estimated for CRP and PCT. On postoperative day (POD) 5, the highest AUC (87.1%) and specificity (80.2%) values were estimated for CRP. Random-effects meta-analysis and total effect sizes estimation for the biomarkers CRP, PCT and WBC were performed according to POD. The concentration of serum biomarkers is significantly higher in patients presenting AL. Regarding the qualitative analysis, there was significant heterogeneity in the inclusion of different subcategories of the consensus definition of colorectal AL in each paper’s definition. Conclusion: The serum biomarkers CRP and PCT are moderate predictors for AL, showing a high heterogeneity among the studies. Combinations of these biomarkers might improve predictive accuracy, but more studies will be necessary to conduct a quality metaregression.","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89220957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diamond Versus V-Y Advancement Flaps for Management of Anal Stenosis: Efficacy and Outcomes","authors":"A. Darwish, Kareem A. Kame, Moheb S. Eskandaros","doi":"10.21614/sgo-382","DOIUrl":"https://doi.org/10.21614/sgo-382","url":null,"abstract":"","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85256599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Usuba, Ryusuke Ito, Masashi Tsunematsu, Ryota Iwase, Yu Kumagai, T. Iida, Masaichi Ogawa, Toru Ikegami
{"title":"Postoperative Movement of an Internal Stent Placed at the Anastomotic Site of Pancreaticojejunostomy During Pancreaticoduodenectomy","authors":"T. Usuba, Ryusuke Ito, Masashi Tsunematsu, Ryota Iwase, Yu Kumagai, T. Iida, Masaichi Ogawa, Toru Ikegami","doi":"10.21614/sgo-431","DOIUrl":"https://doi.org/10.21614/sgo-431","url":null,"abstract":"","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85382363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Sofia Rocha Cavadas, Patricia Cristina Fernandes, Fernanda Maria da, Joaquim Manuel Costa, Sandra Fernandes Martins
{"title":"Perianal Extramammary Paget's Disease: A Case Report","authors":"Ana Sofia Rocha Cavadas, Patricia Cristina Fernandes, Fernanda Maria da, Joaquim Manuel Costa, Sandra Fernandes Martins","doi":"10.21614/sgo-426","DOIUrl":"https://doi.org/10.21614/sgo-426","url":null,"abstract":"","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74129585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Okubo, J. Shindoh, Masaru Matsumura, M. Hashimoto
{"title":"Safety and Efficacy of Gelatin-Thrombin Matrix Sealants (Floseal) for Hemostasis During Liver Resection (with video)","authors":"S. Okubo, J. Shindoh, Masaru Matsumura, M. Hashimoto","doi":"10.21614/sgo-518","DOIUrl":"https://doi.org/10.21614/sgo-518","url":null,"abstract":"","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75692699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fahmy Kmd, Mostafa Nagy, Maged El-Setouy, Jon Mark Hirshon, M. El-Shinawi
{"title":"Assessment of Adherence to the Use of the World Health Organization Surgical Safety Checklist Among Medical Staff in Ain Shams University Hospital, Egypt","authors":"Fahmy Kmd, Mostafa Nagy, Maged El-Setouy, Jon Mark Hirshon, M. El-Shinawi","doi":"10.21614/sgo-404","DOIUrl":"https://doi.org/10.21614/sgo-404","url":null,"abstract":"","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87564073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdelghafar Abo Elrish, Asharf Abbas, Mokhtar Farid, M. Shetiwy, Mohamed Elsaeed Abdu Mohamed, Magdy Basheer, and Abdelrahman Albahy
{"title":"Risk Factors for Mortality in Cases of Obstructed Left Colonic Carcinoma","authors":"Abdelghafar Abo Elrish, Asharf Abbas, Mokhtar Farid, M. Shetiwy, Mohamed Elsaeed Abdu Mohamed, Magdy Basheer, and Abdelrahman Albahy","doi":"10.21614/sgo-463","DOIUrl":"https://doi.org/10.21614/sgo-463","url":null,"abstract":"","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86455062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Goda, Hossam S Abdelrahim, Haitham M. Elmaleh, Ahmed F. Amer, Ehab Mohammed Ali
{"title":"Transversus Abdominis Release Versus Anterior Component Separation in Ventral Abdominal Hernia - A Prospective Comparative Study","authors":"M. Goda, Hossam S Abdelrahim, Haitham M. Elmaleh, Ahmed F. Amer, Ehab Mohammed Ali","doi":"10.21614/sgo-460","DOIUrl":"https://doi.org/10.21614/sgo-460","url":null,"abstract":"","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82403469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Oropharyngeal cancer is the most common type of head and neck cancers, with a 5-years survival of 64.7%. In the last 40 years risk factors and etiology changed, from the incidence associated mostly with tobacco and alcohol to HPV infection in 70% of the cases. Treatments that are standard of care for OPSCC include chemotherapy, radiotherapy or combination of surgery and radiotherapy have a high chronic treatment-related toxicity and functional loss. These therapies have significant impact on the quality of life (QOL) of survivors of oropharyngeal squamous cell carcinoma (OPSCC). Objectives: The objective of this study is to review literature on 1-year evolution of quality of life of patients treated for OPSCC with standard of care. Methods: A comprehensive search of the literature of treated OPSCC patients assessed with EORTC QLQ-30 EORTC H&N-35 at pre-treatment 12-month post treatment. Results: The first study showed that standard of care treatment produces chronic side effects, such as xerostomia, poor oral and dental health, dysphagia, feeding tube dependency in, and other fibrotic changes likely caused by radiotherapy or combination of surgery and radiotherapy. Conclusions: Standard of care treatment produces chronic side effects, such as xerostomia, poor oral and dental health, dysphagia, feeding tube dependency in, and other fibrotic changes.
{"title":"Literature Review of Oropahyngeal Cancer Patients Assessed with EORTC QLQ-30 EORTC HN-35#","authors":"A. Diaconescu, Jvalant N Parekh, Valeriu Buza","doi":"10.21614/sgo-477","DOIUrl":"https://doi.org/10.21614/sgo-477","url":null,"abstract":"Background: Oropharyngeal cancer is the most common type of head and neck cancers, with a 5-years survival of 64.7%. In the last 40 years risk factors and etiology changed, from the incidence associated mostly with tobacco and alcohol to HPV infection in 70% of the cases. Treatments that are standard of care for OPSCC include chemotherapy, radiotherapy or combination of surgery and radiotherapy have a high chronic treatment-related toxicity and functional loss. These therapies have significant impact on the quality of life (QOL) of survivors of oropharyngeal squamous cell carcinoma (OPSCC). Objectives: The objective of this study is to review literature on 1-year evolution of quality of life of patients treated for OPSCC with standard of care. Methods: A comprehensive search of the literature of treated OPSCC patients assessed with EORTC QLQ-30 EORTC H&N-35 at pre-treatment 12-month post treatment. Results: The first study showed that standard of care treatment produces chronic side effects, such as xerostomia, poor oral and dental health, dysphagia, feeding tube dependency in, and other fibrotic changes likely caused by radiotherapy or combination of surgery and radiotherapy. Conclusions: Standard of care treatment produces chronic side effects, such as xerostomia, poor oral and dental health, dysphagia, feeding tube dependency in, and other fibrotic changes.","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89439385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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