{"title":"Sterbehilfe – vom Tod her gedacht","authors":"P. Rothen","doi":"10.4414/SYN.2021.01411","DOIUrl":"https://doi.org/10.4414/SYN.2021.01411","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46517827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Entscheidung am Lebensende – Entscheidung für ein Lebensende?","authors":"Christiane Leupold-Gross","doi":"10.4414/SYN.2021.01412","DOIUrl":"https://doi.org/10.4414/SYN.2021.01412","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42684973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Universitäres Zentrum für Hausarztmedizin beider Basel
{"title":"Wichtige Termine 2021","authors":"Universitäres Zentrum für Hausarztmedizin beider Basel","doi":"10.4414/SYN.2021.01414","DOIUrl":"https://doi.org/10.4414/SYN.2021.01414","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43235535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"«Ziel der Palliativmedizin ist nicht immer die Behandlung der Beschwerden, sondern diesen Beschwerden einen sicheren Raum zu geben»","authors":"B. Stricker","doi":"10.4414/SYN.2021.01407","DOIUrl":"https://doi.org/10.4414/SYN.2021.01407","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49145974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vereinigung der Hausärzte und Hausärztinnen beider Basel
{"title":"Reorganisation der VHBB","authors":"Vereinigung der Hausärzte und Hausärztinnen beider Basel","doi":"10.4414/SYN.2021.01415","DOIUrl":"https://doi.org/10.4414/SYN.2021.01415","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47260503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ambivalente Erfahrungen geriatrischer Kliniken mit der Covid-Pandemie","authors":"Tobias Meyer, Bernhard Flückiger","doi":"10.4414/SYN.2021.01408","DOIUrl":"https://doi.org/10.4414/SYN.2021.01408","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42944653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"«Es geht nicht darum, dem Leben mehr Tage zu geben, sondern den Tagen mehr Leben»","authors":"B. Stricker","doi":"10.4414/SYN.2021.01406","DOIUrl":"https://doi.org/10.4414/SYN.2021.01406","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47219595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Im Labyrinth der Patientenverfügungen – ein Blick nach vorn","authors":"Christiane Leupold-Gross","doi":"10.4414/SYN.2021.01409","DOIUrl":"https://doi.org/10.4414/SYN.2021.01409","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48783725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Schlagwörter: Wie aus Pyramiden Urnen werden","authors":"Karin Hirschi","doi":"10.4414/SYN.2021.01413","DOIUrl":"https://doi.org/10.4414/SYN.2021.01413","url":null,"abstract":"","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43943546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyle A Windisch, Sanoara Mazid, Megan A Johnson, Elina Ashirova, Yan Zhou, Lennox Gergoire, Sydney Warwick, Bruce S McEwen, Mary Jeanne Kreek, Teresa A Milner
Our prior studies demonstrated that the rat hippocampal opioid system can undergo sex-specific adaptations to external stimuli that can influence opioid-associated learning processes. This opioid system extensively overlaps with the cannabinoid system. Moreover, acute administration of Δ9 Tetrahydrocannabinoid (THC), the primary psychoactive constituent of cannabis, can alter cognitive behaviors that involve the hippocampus. Here, we use light and electron microscopic immunocytochemical methods to examine the effects of acute THC (5 mg/kg, i.p., 1 h) on mossy fiber Leu-Enkephalin (LEnk) levels and the distribution and phosphorylation levels of delta and mu opioid receptors (DORs and MORs, respectively) in CA3 pyramidal cells and parvalbumin dentate hilar interneurons of adult female and male Sprague-Dawley rats. In females with elevated estrogen states (proestrus/estrus stage), acute THC altered the opioid system so that it resembled that seen in vehicle-injected females with low estrogen states (diestrus) and males: (1) mossy fiber LEnk levels in CA2/3a decreased; (2) phosphorylated-DOR levels in CA2/3a pyramidal cells increased; and (3) phosphorylated-MOR levels increased in most CA3b laminae. In males, acute THC resulted in the internalization of MORs in parvalbumin-containing interneuron dendrites which would decrease disinhibition of granule cells. In both sexes, acute THC redistributed DORs to the near plasma membrane of CA3 pyramidal cell dendrites, however, the dendritic region varied with sex. Additionally, acute THC also resulted in a sex-specific redistribution of DORs within CA3 pyramidal cell dendrites which could differentially promote synaptic plasticity and/or opioid-associated learning processes in both females and males.
{"title":"Acute Delta 9-tetrahydrocannabinol administration differentially alters the hippocampal opioid system in adult female and male rats.","authors":"Kyle A Windisch, Sanoara Mazid, Megan A Johnson, Elina Ashirova, Yan Zhou, Lennox Gergoire, Sydney Warwick, Bruce S McEwen, Mary Jeanne Kreek, Teresa A Milner","doi":"10.1002/syn.22218","DOIUrl":"https://doi.org/10.1002/syn.22218","url":null,"abstract":"<p><p>Our prior studies demonstrated that the rat hippocampal opioid system can undergo sex-specific adaptations to external stimuli that can influence opioid-associated learning processes. This opioid system extensively overlaps with the cannabinoid system. Moreover, acute administration of Δ<sup>9</sup> Tetrahydrocannabinoid (THC), the primary psychoactive constituent of cannabis, can alter cognitive behaviors that involve the hippocampus. Here, we use light and electron microscopic immunocytochemical methods to examine the effects of acute THC (5 mg/kg, i.p., 1 h) on mossy fiber Leu-Enkephalin (LEnk) levels and the distribution and phosphorylation levels of delta and mu opioid receptors (DORs and MORs, respectively) in CA3 pyramidal cells and parvalbumin dentate hilar interneurons of adult female and male Sprague-Dawley rats. In females with elevated estrogen states (proestrus/estrus stage), acute THC altered the opioid system so that it resembled that seen in vehicle-injected females with low estrogen states (diestrus) and males: (1) mossy fiber LEnk levels in CA2/3a decreased; (2) phosphorylated-DOR levels in CA2/3a pyramidal cells increased; and (3) phosphorylated-MOR levels increased in most CA3b laminae. In males, acute THC resulted in the internalization of MORs in parvalbumin-containing interneuron dendrites which would decrease disinhibition of granule cells. In both sexes, acute THC redistributed DORs to the near plasma membrane of CA3 pyramidal cell dendrites, however, the dendritic region varied with sex. Additionally, acute THC also resulted in a sex-specific redistribution of DORs within CA3 pyramidal cell dendrites which could differentially promote synaptic plasticity and/or opioid-associated learning processes in both females and males.</p>","PeriodicalId":22131,"journal":{"name":"Synapse","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/syn.22218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39181146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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