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The American review of respiratory disease最新文献

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The effects of airway anesthesia on magnitude estimation of added inspiratory resistive and elastic loads. 气道麻醉对吸入附加阻力和弹性负荷大小估计的影响。
Pub Date : 2015-05-14 DOI: 10.1164/ARRD.1983.127.1.2
N. Burki, P. Davenport, F. Safdar, F. Zechman
The effects of airway anesthesia on the magnitude estimation of added inspiratory loads were studied in 5 healthy normal subjects. The subjects assessed the magnitude of a given load by means of a handgrip dynamometer; 5 suprathreshold resistive loads. (range, 2.9 to 21.0 cmH2O/L/s) and 7 suprathreshold elastic loads (range, 4.6 to 24.0 cmH2O/L) were used. Anesthesia of the upper and lower airways was obtained by gargling and inhalation of 4% lidocaine solution; the adequacy of airway anesthesia was assessed by the inhalation of 20% citric acid solution. Studies were performed in the control state and during the airway anesthetized state. The relationship between log added load and log handgrip response, represented by the regression coefficient between these two variables, was in accord with the psychophysical power law of Stevens in all the studies. The regression coefficient during the control state of resistive loads (mean = 0.566) and elastic loads (mean = 0.516) did not alter significantly (p greater than 0.05) during the airway anesthetized state. These results indicate that the magnitude estimation of added inspiratory loads is not primarily mediated through receptors in the upper or lower airways.
研究了气道麻醉对5例健康正常受试者吸入负荷增加幅度的影响。受试者通过握力计评估给定负荷的大小;5 .超阈值电阻性负载。(范围,2.9至21.0 cmH2O/L/s)和7个超阈值弹性载荷(范围,4.6至24.0 cmH2O/L)。通过漱口和吸入4%利多卡因溶液获得上、下气道麻醉;通过吸入20%柠檬酸溶液评估气道麻醉的充分性。研究分别在对照状态和气道麻醉状态下进行。对数附加负荷与对数握拍反应之间的关系,用两变量之间的回归系数表示,在所有研究中都符合Stevens的心理物理幂律。气道麻醉状态下,阻力负荷(均值= 0.566)和弹性负荷(均值= 0.516)控制状态下的回归系数无显著变化(p > 0.05)。这些结果表明,增加吸气负荷的大小估计主要不是通过上呼吸道或下呼吸道的受体介导的。
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引用次数: 36
Pharmacogenetics. Heredity and the Response to Drugs 遗传药理学。遗传和药物反应
Pub Date : 2015-05-14 DOI: 10.7326/0003-4819-58-4-757
A. Bearn
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引用次数: 8
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Pub Date : 2015-05-14 DOI: 10.7326/0003-4819-52-6-1366_1
G. Hobby
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引用次数: 0
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Pub Date : 2015-05-14 DOI: 10.1016/s0140-6736(70)92714-5
T. Biscoe
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引用次数: 0
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Pub Date : 2015-05-14 DOI: 10.7326/0003-4819-66-3-625
J. L. Wilson
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引用次数: 0
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Pub Date : 2015-05-14 DOI: 10.1001/jama.1963.03700040117081
H. Weiner
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引用次数: 0
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Pub Date : 2015-05-14 DOI: 10.1164/ARRD.1980.121.3.607A
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Pub Date : 2015-05-14 DOI: 10.7326/0003-4819-89-4-588_2
Carl A. Berntsen
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Pub Date : 2015-05-14 DOI: 10.1164/arrd.1963.87.4.602
D. Louria
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Pub Date : 2015-05-14 DOI: 10.7326/0003-4819-59-2-260
D. Böhme
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引用次数: 0
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The American review of respiratory disease
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