M. Heravi, Vahideh Zadsirjan, Masumeh Heydari, B. Masoumi
The Friedel ‐ Crafts alkylation (F ‐ CA) reaction is a special kind of carbon−carbon bond formations, which is frequently being used for the formation of such bond in some aromatic rings in organic synthesis. Its asymmetric variant gives enantiorich products. Commonly, an in situ organocatalyzed asymmetric Friedel ‐ Crafts alkylation (AF ‐ CA) proceeds via generation of an enamine as an intermediate. The organocatalyzed ‐ AF ‐ CA was discovered and established in the mid ‐ 1980s and reviewed comprehensively in 2010. In this report, we are trying to update the applications of novel organocatalysts in the AF ‐ CA as a versatile synthetic strategy, which is frequently used in the effective asymmetric synthesis of complex molecules, pharmaceutically important compounds and most importantly in the total synthesis of biologically active natural products .
{"title":"Organocatalyzed Asymmetric Friedel‐Crafts Reactions: An Update","authors":"M. Heravi, Vahideh Zadsirjan, Masumeh Heydari, B. Masoumi","doi":"10.1002/TCR.201800190","DOIUrl":"https://doi.org/10.1002/TCR.201800190","url":null,"abstract":"The Friedel ‐ Crafts alkylation (F ‐ CA) reaction is a special kind of carbon−carbon bond formations, which is frequently being used for the formation of such bond in some aromatic rings in organic synthesis. Its asymmetric variant gives enantiorich products. Commonly, an in situ organocatalyzed asymmetric Friedel ‐ Crafts alkylation (AF ‐ CA) proceeds via generation of an enamine as an intermediate. The organocatalyzed ‐ AF ‐ CA was discovered and established in the mid ‐ 1980s and reviewed comprehensively in 2010. In this report, we are trying to update the applications of novel organocatalysts in the AF ‐ CA as a versatile synthetic strategy, which is frequently used in the effective asymmetric synthesis of complex molecules, pharmaceutically important compounds and most importantly in the total synthesis of biologically active natural products .","PeriodicalId":22443,"journal":{"name":"The Chemical Record","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87239497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kwit, J. Grajewski, P. Skowronek, Mikołaj Zgorzelak, J. Gawroński
{"title":"Cover Picture: One‐Step Construction of the Shape Persistent, Chiral But Symmetrical Polyimine Macrocycles (Chem. Rec. 2‐3/2019)","authors":"M. Kwit, J. Grajewski, P. Skowronek, Mikołaj Zgorzelak, J. Gawroński","doi":"10.1002/TCR.201980201","DOIUrl":"https://doi.org/10.1002/TCR.201980201","url":null,"abstract":"","PeriodicalId":22443,"journal":{"name":"The Chemical Record","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91487412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Monguchi, T. Ichikawa, Tsuyoshi Yamada, Y. Sawama, H. Sajiki
{"title":"Cover Picture: Continuous‐Flow Suzuki‐Miyaura and Mizoroki‐Heck Reactions under Microwave Heating Conditions (Chem. Rec. 1/2019)","authors":"Y. Monguchi, T. Ichikawa, Tsuyoshi Yamada, Y. Sawama, H. Sajiki","doi":"10.1002/TCR.201980101","DOIUrl":"https://doi.org/10.1002/TCR.201980101","url":null,"abstract":"","PeriodicalId":22443,"journal":{"name":"The Chemical Record","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79747078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Nakayama, Kenta Kanamori, Koki Nakano, R. Jalem, I. Takeuchi, H. Yamasaki
{"title":"Data‐Driven Materials Exploration for Li‐Ion Conductive Ceramics by Exhaustive and Informatics‐Aided Computations","authors":"M. Nakayama, Kenta Kanamori, Koki Nakano, R. Jalem, I. Takeuchi, H. Yamasaki","doi":"10.1002/TCR.201800129","DOIUrl":"https://doi.org/10.1002/TCR.201800129","url":null,"abstract":"","PeriodicalId":22443,"journal":{"name":"The Chemical Record","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79802640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cover Picture: The Catalytic Reduction of Carboxylic Acid Derivatives and CO\u0000 2\u0000 by Metal Nanoparticles on Lewis‐Acidic Supports (Chem. Rec. 10/2018)","authors":"Takashi Toyao, S. H. Siddiki, K. Kon, K. Shimizu","doi":"10.1002/TCR.201881001","DOIUrl":"https://doi.org/10.1002/TCR.201881001","url":null,"abstract":"","PeriodicalId":22443,"journal":{"name":"The Chemical Record","volume":"83 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89600989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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