The Brown University Child & Adolescent Psychopharmacology Update最新文献

While reducing the dose, or discontinuing completely, antipsychotics after remission from first-episode psychosis (FEP) increases the short-term risk of relapse, the benefits of functioning over the long-term make this concept controversial. Researchers compared the short- and long-term effects between reduction/discontinuation of the dose within 12 months of relapse and maintaining the dose. The research was done as a randomized clinical trial.

Psychopathology is associated with the development of gaming disorder among adolescents, according to a cohort study of young adolescents. In particular, depression, anxiety, social problems, and attention deficit/hyperactivity disorder (ADHD). Addressing these underlying issues may reduce the severity incidence of gaming disorder, the researchers concluded, noting that psychopathology seemed to come first.

Last month, the federal Food and Drug Administration (FDA) released the below warnings about nicotine pouches.

The prevalence of extreme obesity in children in the United States has increased from 0.32% in 2008 to 1.13% in 2023, with concomitant high risks of metabolic complications, researchers have found. The risks of these complications, which included liver disease, prediabetes and diabetes, severe insulin resistance, and metabolic syndrome, were higher than for those with milder or no obesity. Extreme obesity was highest among adolescents and non-Hispanic Black individuals.

Because anorexia nervosa is both prevalent and has poor outcomes, the field needs to make significant scientific breakthroughs, according to a recent clinical review. Current treatments were developed decades ago, and the eating disorders field in general has two big problems: overspecialization and an overly narrow focus on weight restoration. The authors made specific recommendations, which center on a more holistic approach.

Conducting a systemic review and meta-analysis, researchers have found an occurrence of psychotic symptoms, psychotic disorders, or bipolar disorder (BD) in individuals with attention deficit/hyperactivity disorder (ADHD) treated with stimulants. The study did not establish causality, and one significant limitation was the inability to determine whether the psychotic symptoms were related to the ADHD itself, or to the treatment.

Researchers have looked at whether treatment with methadone or buprenorphine is better in terms of cost-effectiveness outcomes on low birth weight and preterm birth on newborns of mothers treated for opioid use disorder (OUD). The study showed that buprenorphine had greater value than methadone during pregnancy based on lifetime models accounting for infant outcomes. However, both methadone and buprenorphine were found to be valuable for pregnant women with OUD.

Fluvoxamine Maleate (generic) Luvox, Luvox CR (brand)

When the federal Food and Drug Administration (FDA) recently discussed the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy, the result was confusion among many. For years, research has shown that risks to the fetus and newborn — and developing child — are minor, and that these risks are outweighed by benefits to the mother. The benefits are to the child as well, because of the risks of maternal depression on children. But the FDA panel specifically discussed the risks of SSRIs in pregnancy.