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The correlation between the immunohistochemical expression of DF3 antigen and serum CA15-3 in breast cancer patients. 乳腺癌患者DF3抗原免疫组化表达与血清CA15-3的相关性
Pub Date : 1991-03-01 DOI: 10.1007/BF02470899
N Ohuchi, S Sato, M Akimoto, Y Taira, N Matoba, K Takahashi, S Mori

The immunohistochemical expression of DF3 antigen and serum concentrations of CA15-3, a breast carcinoma-associated antigen recognized by the monoclonal antibodies (MAbs) 115D8 and DF3, was investigated in breast cancer patients. The levels of serum CA15-3 in 23 primary breast cancer patients did not correlate to the percentage cytoplasmic reactivity of MAb DF3 with the carcinoma cells in tissue specimens from each respective patient. In 17 patients who subsequently developed metastatic breast cancer, however, the serum CA15-3 concentrations generally correlated well to the cytoplasmic reactivity of MAb DF3 with the carcinoma cells in specimens obtained at initial biopsy or mastectomy. Elevated levels of serum CA15-3 were seen in metastatic breast cancer patients when the carcinoma cells in their primary specimens expressed enhanced levels of cytoplasmic DF3 antigen. The results of this study suggest that the immunohistochemical demonstration of DF3 antigen in tissue specimens, together with the periodical measurement of circulating CA15-3 antigen, may be important for monitoring the clinical course of breast cancer patients.

研究了乳腺癌患者中DF3抗原的免疫组化表达和CA15-3(一种被单克隆抗体(mab) 115D8和DF3识别的乳腺癌相关抗原)的血清浓度。23例原发性乳腺癌患者的血清CA15-3水平与每位患者组织标本中MAb DF3与癌细胞的细胞质反应性百分比无关。然而,在17例随后发展为转移性乳腺癌的患者中,血清CA15-3浓度通常与最初活检或乳房切除术获得的标本中MAb DF3与癌细胞的细胞质反应性良好相关。在转移性乳腺癌患者中,当原发标本中的癌细胞表达高水平的细胞质DF3抗原时,血清CA15-3水平升高。本研究结果提示,组织标本中DF3抗原的免疫组化显示,结合循环CA15-3抗原的定期检测,可能对监测乳腺癌患者的临床病程具有重要意义。
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引用次数: 7
Peutz-Jeghers syndrome associated with adenocarcinoma of the cecum and focal carcinomas in hamartomatous polyps of the colon: a case report. Peutz-Jeghers综合征与盲肠腺癌和结肠错构瘤性息肉局灶性癌相关:1例报告。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470912
K Niimi, H Tomoda, M Furusawa, I Hayashi, Y Okumura

We report herein a case of Peutz-Jeghers syndrome associated with an adenocarcinoma of the cecum and four focal cancers arising in hamartomatous polyps of the colon. There were a total 27 polyps in the intestine; 4 in the small intestine and the rest in the large intestine. The hamartomatous polyps in which the 4 focal cancers were found showed no component of adenoma, and the other polyps removed from the colon and small intestine at the same time were all hamartomas with no evidence of dysplasia or malignancy. This case was rare in that multiple focal cancers may have arisen directly from the hamartomous polyps of the colon.

我们在此报告一例Peutz-Jeghers综合征与盲肠腺癌和四局灶性癌引起的结肠错构瘤息肉。肠内息肉共27个;4个在小肠,其余的在大肠。4例局灶性癌的错构瘤息肉无腺瘤成分,同时从结肠和小肠切除的其他息肉均为错构瘤,未见异常增生或恶性肿瘤的迹象。这种情况是罕见的,因为多重局灶性癌症可能直接由结肠错构瘤息肉引起。
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引用次数: 9
Primary venous aneurysm of the forearm in a child. 儿童前臂原发性静脉动脉瘤。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470916
K Nishida, Y Miyazawa, K Matsumoto, K Okinaga, T Imamura

A 5 year old girl who presented with two bluish, cystic masses in her right forearm was shown on ultrasonography to have two localized saccular dilatations of the right radial vein. This led to the suspicion of venous aneurysms which was later confirmed by venography. They were finally excised because of the gradual increase in size and pain she had experienced over the previous two months.

一个5岁的女孩,在她的右前臂表现为两个蓝色的囊性肿块,超声显示有两个局部的囊性扩张的右桡静脉。这导致怀疑静脉动脉瘤,后来通过静脉造影证实。由于在过去的两个月里她经历了逐渐增加的大小和疼痛,他们最终被切除了。
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引用次数: 8
Extracorporeal circulation for the removal of serum myoglobin in experimentally induced myonephropathic metabolic syndrome in dogs. 体外循环去除实验性诱导犬肌肾病代谢综合征的血清肌红蛋白。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470909
H Takasaki, T Hadama, R Matsushima, S Watanabe, J Shirabe

The removal of serum myoglobin with extracorporeal circulation using a column filled with methylmethacrylate-divinylbenzene (MMA-DVB) was studied in experimentally induced myonephropathic metabolic syndrome in the dog. All animals showed marked edema in the hind limbs and degeneration or necrosis of the adductor muscle 5 hours after the reestablishment of arterial flow. The serum levels of myoglobin, creatinine phosphokinase, glutamic oxaloacetic transaminase and aldolase increased linearly after the reperfusion of blood in the group of animals which received no extracorporeal circulation (group 1). Sediments of numerous myoglobin casts in the renal tubules and immunoreactive myoglobin in the renal epithelium of almost all the tubules were seen in 4 out of 5 cases. In the group of animals reperfused with extracorporeal circulation using the MMA-DVB column, serum myoglobin was adsorbed selectively by the column and showed a significantly lower value at 0.5, 1, 2 and 3 hours than that of the group 1 animals. Concomitantly, the immunoreactive myoglobin was absent or scant in the renal epithelium of the proximal convoluted tubule. The present study therefore indicates that extracorporeal circulation using the MMA-DVB column is useful for the removal of serum myoglobin from experimentally induced myonephropathic metabolic syndrome.

用甲基丙烯酸甲酯-二乙烯基苯(MMA-DVB)填充柱体外循环去除狗实验性肌肾病代谢综合征的血清肌红蛋白。所有动物在动脉血流恢复后5小时后肢均出现明显水肿,内收肌变性或坏死。无体外循环组(1组)血液再灌注后血清肌红蛋白、肌酸酐磷酸激酶、谷草转氨酶和醛缩酶水平呈线性升高。5例中有4例肾小管中有大量肌红蛋白铸型沉积物,几乎所有小管的肾上皮中都有免疫反应性肌红蛋白。采用MMA-DVB柱体外循环再灌注组,血清肌红蛋白被柱选择性吸附,在0.5、1、2和3 h时明显低于1组。同时,近曲小管肾上皮中缺乏或缺乏免疫反应性肌红蛋白。因此,本研究表明,体外循环使用MMA-DVB柱可用于从实验诱导的肌肾病代谢综合征中去除血清肌红蛋白。
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引用次数: 1
Nonspecific giant ulcer of the sigmoid colon--a case report. 乙状结肠非特异性巨大溃疡1例。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470911
M Haraguchi, S Matsushima, Y Fujie, K Sugimachi

An unusual case of a 44 year old woman who developed a nonspecific ulcer of the sigmoid colon is reported herein. She presented with lower abdominal pain and fever and colonoscopy revealed a large, sigmoid colon ulcer with normal surrounding mucosa and a well-defined margin. A temporary sigmoidostomy was done to decompress the bowel content and, after the abdominal pain and fever had subsided, the involved segment with an ulcer of 6.1 X 2.5 cm was resected. Her postoperative course was uneventful and she has remained well since.

一个不寻常的情况下,44岁的妇女谁发展了非特异性溃疡乙状结肠报告在这里。她表现为下腹疼痛和发热,结肠镜检查发现一个大的乙状结肠溃疡,周围粘膜正常,边界清晰。暂时性乙状结肠造口减压肠内容物,腹痛和发热消退后,切除6.1 X 2.5 cm溃疡的受病节段。她的术后过程很顺利,此后一直保持良好状态。
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引用次数: 0
Hormonal regulation of plasminogen activator and peroxidase activities in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors and the rat uterus. 7,12-二甲基苯(a)蒽诱导大鼠乳腺肿瘤和子宫中纤溶酶原激活物和过氧化物酶活性的激素调节。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470918
K Inada, J Yamashita, T Yoshimura, S Matsuo, Y Nakashima, S Yamashita, A Misumi, M Ogawa

Oophorectomy was found to decrease the plasminogen activator activity of rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) to less than 7 per cent, while in vivo estradiol treatment restored its activity in a dose dependent fashion. The peroxidase activity was not changed either by oophorectomy or by the administration of estrogen. In the rat uterus, plasminogen activator activity was not changed by oophorectomy or by the administration of estrogen, however, its peroxidase activity decreased to less than 2 per cent following oophorectomy, while estrogen administration restored its activity. Estrogen regulated plasminogen activator activity in the DMBA-induced rat mammary tumors but not in the uterus and thus, the specific hormonal regulation of this enzyme may be an important factor for the hormonal dependent growth of such tumors.

研究发现,卵巢切除术使7,12-二甲基苯(a)蒽(DMBA)诱导的大鼠乳腺肿瘤的纤溶酶原激活物活性降低至7%以下,而体内雌二醇治疗则以剂量依赖性的方式恢复其活性。过氧化物酶活性没有改变,无论是卵巢切除或雌激素的管理。在大鼠子宫中,纤溶酶原激活物的活性未因卵巢切除或雌激素的施用而改变,但其过氧化物酶活性在卵巢切除后降至2%以下,而雌激素的施用使其活性恢复。雌激素在dba诱导的大鼠乳腺肿瘤中调节纤溶酶原激活物活性,而在子宫中不调节,因此,该酶的特异性激素调节可能是此类肿瘤激素依赖性生长的重要因素。
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引用次数: 1
The usefulness of cyclophosphamide pretreatment for subrenal capsule assay against human esophageal cancer. 环磷酰胺预处理在人食管癌肾下胶囊试验中的应用。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470907
M Terashima, K Ikeda, S Kawamura, C Maesawa, K Ishida, M Sato, K Saito

In order to suppress the host immune reaction in subrenal capsule assay (SRCA) using normal immunocompetent mice, the effects of cyclophosphamide (CPM) pretreatment were compared to those obtained after cyclosporine A (CSA) treatment. CPM and CSA suppressed the host reaction until day 6 and day 12, respectively, however, the histological evaluation of the tumors on day 6 revealed no differences between the two groups. The cytotoxicity of CPM in mouse serum against P388 cells was measured to evaluate the residual activity of CPM against the implanted tumor. No cytotoxicity was observed in the serum 36 hours after the CPM injection. In the histological analysis of clinical samples, inflammatory infiltration was observed in only 4 of 25 samples and tumor cell preservation recognized in 27 of 28 samples. A persistence of tumor cells was recognized in the samples rich in tumor cells. Adequate growth of the tumor in the control groups was obtained from 30 of 33 tumors (91 per cent), and the response rates of this assay were comparable to those of prior clinical experiences on each of these drugs. These results indicated the feasibility of SRCA with CPM pretreatment as a predictive test of chemotherapeutic agents for esophageal cancer.

为了在肾下胶囊实验(SRCA)中抑制正常免疫活性小鼠的免疫反应,比较了环磷酰胺(CPM)预处理与环孢素A (CSA)处理的效果。CPM和CSA对宿主反应的抑制作用分别持续到第6天和第12天,但第6天的肿瘤组织学评价显示两组之间没有差异。测定小鼠血清中CPM对P388细胞的细胞毒性,评价CPM对移植肿瘤的残留活性。注射CPM后36小时血清中未见细胞毒性。在临床样本的组织学分析中,25例样本中只有4例观察到炎症浸润,28例样本中有27例发现肿瘤细胞保存。在富含肿瘤细胞的样品中发现了肿瘤细胞的持久性。在对照组中,33个肿瘤中有30个(91%)获得了足够的肿瘤生长,该试验的反应率与之前使用这些药物的临床经验相当。这些结果表明SRCA与CPM预处理作为食管癌化疗药物预测试验的可行性。
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引用次数: 0
Evaluation of a new calcium containing cardioplegic solution in the isolated rabbit heart in comparison to a calcium-free, low sodium solution. 一种新的含钙心脏截瘫液在兔离体心脏中与无钙低钠溶液的比较。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470908
F Mori, K Suzuki, H Noda, T Kato, H Tsuboi, M Miyamoto, K Esato, A Imamura, S Kawahara, J Uchiyama

Isolated perfused rabbit hearts were studied to compare the effects of 3 hour ischemic arrest following either calcium-free or calcium-containing cardioplegia, on the recovery of isovolumic function of the left ventricle, coronary flow, release of creatine phosphokinase and myocardial water content. The hearts perfused with the calcium-containing solution (Ca 0.5 mmol/L) showed better recovery of the developed pressure in the left ventricle, and its first derivative and compliance. Coronary flow at a constant perfusion pressure was better restored during reperfusion in the hearts with calcium-containing solution. The release of less CPK and a lower water content were also observed in the hearts reperfused with calcium-containing solution. We concluded that calcium-containing cardioplegic solution with a high concentration of magnesium (10 mmol/L) was superior to calcium-free solution for myocardial protection.

研究了兔离体灌注心脏,比较无钙和含钙心脏骤停后3小时缺血停搏对左心室等容功能恢复、冠状动脉血流、肌酸磷酸激酶释放和心肌含水量的影响。含钙溶液(Ca 0.5 mmol/L)灌注后的心脏左心室压力恢复较好,其一阶导数和顺应性较好。在心脏再灌注时,含钙溶液能更好地恢复恒灌注压下的冠状动脉血流。再灌注含钙溶液的心脏CPK释放量减少,含水量降低。我们认为含镁(10 mmol/L)的含钙停搏液对心肌的保护作用优于无钙停搏液。
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引用次数: 3
Long-term results of living related kidney transplantation: a retrospective study on 114 recipients followed over 10 years. 活体亲属肾移植的长期结果:对114名受者随访10年的回顾性研究。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470900
T Yasumura, T Oka, Y Omori, Y Nakane

The long-term patient and graft survivals, causes of death, complications and rehabilitation status in the second decade were analyzed in 114 patients who received living related kidney transplants and were followed up for 10 years or longer. Azathioprine and prednisolone were used for basal immunosuppressive therapy in all patients. The actual patient and graft survival rates at 10 years were 76.3 per cent and 50.9 per cent respectively, the main causes of death being serious infection (10 cases), malignant disease (5 cases), cerebral bleeding (4 cases), hepatic failure (3 cases), gastrointestinal bleeding (2 cases) and cardiovascular disorder (2 cases). Four patients died from complications after re-admission for hemodialysis. The cumulative patient and graft survival rates at 15 years in 58 patients whose graft survived for over 10 years were 87 per cent and 75 per cent, respectively. Of the 51 patients still surviving at the end of the study, the complete rehabilitation rate was 90.2 per cent, however, de novo malignant disease and hepatic disorder were significant complications which not only disturbed the patients' quality of life but also reduced their survival rate. Therefore, regular follow-up of patients and appropriate management procedures are necessary to enhance the long-term success of kidney transplantation.

对114例接受活体亲属肾移植并随访10年及以上的患者进行随访,分析其长期存活、移植存活、死亡原因、并发症及第二个10年的康复情况。所有患者均使用硫唑嘌呤和强的松龙进行基础免疫抑制治疗。患者10年实际生存率为76.3%,移植体10年实际生存率为50.9%,主要死亡原因为严重感染(10例)、恶性疾病(5例)、脑出血(4例)、肝功能衰竭(3例)、消化道出血(2例)和心血管疾病(2例)。4例患者再次入院进行血液透析后死于并发症。在58例移植物存活超过10年的患者中,15年的累积患者和移植物存活率分别为87%和75%。在研究结束时仍存活的51例患者中,完全康复率为90.2%,但新生恶性疾病和肝脏疾病是严重的并发症,不仅扰乱了患者的生活质量,而且降低了患者的生存率。因此,定期随访患者和适当的管理程序是提高肾移植长期成功的必要条件。
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引用次数: 1
Dumbbell neurogenic tumor of the mediastinum: a report of three cases undergoing single-staged complete removal without thoracotomy. 纵隔哑铃神经源性肿瘤:3例单期完全切除,不开胸。
Pub Date : 1991-03-01 DOI: 10.1007/BF02470913
H Osada, H Aoki, K Yokote, Y Taira, N Yamate

Of a total thirteen patients who underwent surgery for a neurogenic tumor in the posterior mediastinum 4 (30.8 per cent) presented with dumbbell type development of the tumor. Along with a comparatively greater incidence in the number of cases of dumbbell neurogenic tumors in the posterior mediastinum, resection has also recently become more popular, necessitating the establishment of a standard operative approach for this type of tumor. We successfully removed dumbbell neurogenic tumor from the posterior mediastinum in our 3 most recent cases via a dorsal approach by virtue of a laminectomy and resection of a small portion of the neighbouring rib root without opening the parietal pleura at all. These three patients were a 14 year old female, a 54 year old male and a 68 year old female, respectively, and the largest diameter in cm and level of origin of the tumors were 5.5 at Th 1 in case 1, 3.0 at Th 2 in case 2 and 3.7 at Th 11 in case 3. The operative approach described herein was easy to perform, felt secure and was less invasive and better tolerated by the patients than the thoracotomy approach. Avoiding a thoracotomy in such cases has many advantages to enumerate, but does not seem to have been clearly aimed at by others to date. We therefore propose our technique as a standard approach for dumbbell neurogenic tumors in the posterior mediastinum.

在13例接受后纵隔神经源性肿瘤手术的患者中,4例(30.8%)表现为哑铃型肿瘤。随着后纵隔哑铃神经源性肿瘤的发病率相对较高,近年来切除术也越来越流行,需要为这类肿瘤建立标准的手术入路。在我们最近的3例病例中,我们通过背侧入路成功地切除了后纵隔的哑铃神经源性肿瘤,通过椎板切除术切除了一小部分邻近的肋骨根,而完全没有打开胸膜壁层。3例患者女14岁,男54岁,女68岁,病例1最大直径5.5 cm,病例2最大直径3.0 cm,病例3最大直径3.7 cm。与开胸入路相比,本文所述的手术入路操作简单、安全、创伤小、患者耐受性好。在这种情况下避免开胸手术有许多优点可以列举,但迄今为止似乎还没有被其他人明确地瞄准。因此,我们建议我们的技术作为后纵隔哑铃神经源性肿瘤的标准入路。
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引用次数: 13
期刊
The Japanese journal of surgery
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