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A novel approach to myringotomy simulation 一种模拟鼓膜切开术的新方法
Pub Date : 2022-03-02 DOI: 10.1017/S0022215121004692
Z. Kelly, A. Cao, N. Ahmedli, M. Nassar
Abstract Objective In the wake of the 2019 coronavirus disease pandemic, elective cases and opportunities for clinical application have decreased, and the need for useful simulation models has become more apparent for developing surgical skills. A novel myringotomy with ventilatory tube insertion simulation model was created. Methods Residents across all levels at our institution participated in the simulation. Participants were evaluated in terms of: time of procedure, microscope positioning, cerumen removal, identification of middle ear effusion type, canal wall trauma, tympanic membrane damage and tube placement. Results Eleven residents participated. Scores ranged from 14 to 34, out of a maximum of 40. The average score among junior and senior residents was 24 and 31, respectively. The simulation was felt to be representative of the operating theatre experience. Conclusion This study demonstrates a low-cost simulation model that captures several important, nuanced aspects of myringotomy with tube insertion, often overlooked in previously reported simulations.
摘要目的2019冠状病毒病大流行后,选择性病例和临床应用机会减少,对有用的模拟模型的需求在外科技能的发展中变得更加明显。建立了一种新的鼓膜切开术伴通气管插入的仿真模型。方法我院各级住院医师参与模拟。从手术时间、显微镜定位、耵聍清除、中耳积液类型的识别、管壁损伤、鼓膜损伤和置管等方面对参与者进行评估。结果11名居民参与。满分为40分,分数从14分到34分不等。青少年和老年人的平均得分分别为24分和31分。这种模拟被认为是手术室体验的代表。结论:本研究展示了一种低成本的模拟模型,该模型捕捉到了鼓膜切开术插入管的几个重要而微妙的方面,这些方面在以前的模拟报道中经常被忽视。
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引用次数: 2
Intracellular cytokine expression in invasive fungal sinusitis and its impact on patient outcome 侵袭性真菌性鼻窦炎细胞内细胞因子表达及其对患者预后的影响
Pub Date : 2022-03-02 DOI: 10.1017/S0022215122000561
P. Verma, K. Sikka, H. Verma, A. Thakar, D. Mitra, A. Saurabh, G. Singh
Abstract Background Cell-mediated immunity plays an important role in host defence against fungal pathogens, regulated by differentiation of lymphocytes towards T-helper 1 or 2 cells. This study reports intracellular cytokine variation in terms of invasive fungal sinusitis type and outcome. Methods The mononuclear leukocytes of 15 patients with invasive fungal sinusitis (mucormycosis in 8, aspergillus in 7) were stained with antibodies against intracellular cytokines, after fungal antigen stimulation and culture, and immunophenotyped. Patients were followed up for six months, with clinical course categorised as improvement, worsening or death. Results The mean percentages of mononuclear cells producing interleukins 4, 5, 10 and 12, and interferon-γ, in the mucormycosis group were 0.575, 0.284, 8.661, 4.460 and 1.134, respectively, while percentages in the aspergillosis group were 0.233, 0.492, 4.196, 4.466 and 1.533. Cells producing interleukin 4 and 10 were higher in the mucormycosis group, while those producing interleukin-12 and interferon-γ were lower. Cells producing interleukins 4 and 12 were higher in patients with a poor outcome (p-values of 0.0662 and 0.0373, respectively), while those producing interferon-γ were lower (p = 0.0864). Conclusion Adaptive cell-mediated immunity is expressed differently in two categories of invasive fungal sinusitis, and the cytokine expression pattern is related to prognosis.
细胞介导的免疫在宿主防御真菌病原体中起重要作用,通过淋巴细胞向t -辅助性1或2细胞的分化来调节。本研究报告了侵袭性真菌鼻窦炎类型和结果的细胞内细胞因子变化。方法对15例侵袭性真菌性鼻窦炎患者(毛霉病8例,曲霉菌7例)进行细胞内细胞因子抗体染色,经真菌抗原刺激培养后进行免疫分型。患者随访6个月,临床病程分为改善、恶化或死亡。结果毛霉病组单核细胞产生白细胞介素4、5、10、12和干扰素γ的平均百分比分别为0.575、0.284、8.661、4.460和1.134,曲霉病组单核细胞产生白细胞介素4、5、10、12和干扰素γ的平均百分比分别为0.233、0.492、4.196、4.466和1.533。毛霉病组产生白细胞介素4和10的细胞增多,而产生白细胞介素12和干扰素γ的细胞减少。在预后较差的患者中,产生白细胞介素4和12的细胞较高(p值分别为0.0662和0.0373),而产生干扰素-γ的细胞较低(p = 0.0864)。结论两类侵袭性真菌性鼻窦炎患者适应性细胞介导免疫表达不同,细胞因子表达模式与预后有关。
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引用次数: 0
JLO volume 136 issue 3 Cover and Front matter JLO第136卷第3期封面和封面问题
Pub Date : 2022-03-01 DOI: 10.1017/s002221512200072x
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引用次数: 0
JLO volume 136 issue 3 Cover and Back matter JLO第136卷第3期封面和封底
Pub Date : 2022-03-01 DOI: 10.1017/s0022215122000731
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引用次数: 0
Cancer diagnosis and anosmia recovery in the pandemic update, cholesteatoma diagnosis, otosclerosis in pregnancy, and no renaissance of maxillary sinus irrigation 癌症的诊断和嗅觉障碍的恢复在大流行的更新,胆脂瘤的诊断,耳硬化在妊娠期,并没有上颌窦冲洗复兴
Pub Date : 2022-03-01 DOI: 10.1017/S0022215122000688
E. Fisher, J. Fishman
The latest coronavirus disease 2019 (Covid-19) related articles in The Journal of Laryngology & Otology include an update on head and neck cancer referrals and diagnosis during the pandemic from Wolverhampton. We have covered the topic previously in The Journal, and have articles from before the pandemic for comparison. The 62 per cent reduction in fast-track referrals in early 2020 (compared to 2019) during the study period is of the same order of magnitude that has been experienced elsewhere. The authors highlight that this major change in patient illness related behaviour forms part of the hidden cost of the pandemic. A similar detection rate in the two time periods suggests that there is a cohort of undiagnosed patients in the community, which is worrying, despite the acknowledged limitations of the ‘two-week wait’ system of cancer diagnosis. The anosmia story during the pandemic is updated this month by a study from Italy, which found that over one-third of anosmic Covid-19 patients still had symptoms after over five months, and those who had a complete recovery tended to have a shorter duration of symptoms. A long duration of symptomatic anosmia predicted incomplete recovery. An earlier (small) study from Milan found that 91 per cent of patients had some degree of recovery, with 53 per cent showing total recovery at eight months. Cholesteatoma diagnosis by special sequences of magnetic resonance imaging (MRI) has allowed many patients to avoid costly and inconvenient secondor third-look tympanoplasty operations, as the technique has a high predictive value. Equivocal cases might lead to a negative exploration. This issue’s study of MRI diagnosis of cholesteatoma, from Newcastle upon Tyne, found that, in equivocal cases, when the lesion in the middle-ear cleft has higher signal intensity compared with the ipsilateral temporal lobe, there is high statistical probability of cholesteatoma diagnosis. Human papilloma virus (HPV) and its relevance to head and neck tumours continue to stimulate interest; previous work has investigated the prevalence in paediatric tonsils, which has been low. The paper in this issue, from London, Ontario (Canada), examined paediatric tonsillectomy specimens in 102 children aged 0–18 years, and found that none contained relevant viral subtypes as determined by a quantitative polymerase chain reaction test. This suggests no vertical transmission of the virus in this population, unless the virus is latent, as would be expected from a primarily sexually-transmitted disease, and strengthens the push for HPV vaccination prior to the age of sexual activity. The growing interest in biofilms in inflammatory disorders, and the efficacy of saline douches in the management of chronic rhinosinusitis, has made many rhinologists wonder if the old-fashioned maxillary sinus washout (‘antral lavage’) had some merit and might reappear. This issue has a study from Haifa, Israel, in which patients with chronic rhinosinusitis were treate
《喉科与耳科杂志》上最新的冠状病毒疾病2019 (Covid-19)相关文章包括伍尔弗汉普顿大流行期间头颈癌转诊和诊断的最新情况。我们以前在《华尔街日报》上报道过这个话题,并有大流行之前的文章供比较。在研究期间,2020年初(与2019年相比)快速通道转诊减少了62%,与其他地方的情况相同。这组作者强调,患者疾病相关行为的这一重大变化构成了大流行隐性成本的一部分。这两个时间段的相似检出率表明,社区中有一群未确诊的患者,这令人担忧,尽管公认的“两周等待”癌症诊断系统存在局限性。本月,意大利的一项研究更新了大流行期间的嗅觉缺失故事,该研究发现,超过三分之一的嗅觉缺失的Covid-19患者在五个多月后仍有症状,而那些完全康复的患者往往症状持续时间较短。长时间的症状性嗅觉缺失预示着不完全恢复。米兰早些时候的一项(小型)研究发现,91%的患者有一定程度的康复,53%的患者在8个月时完全康复。通过特殊序列的磁共振成像(MRI)诊断胆脂瘤使许多患者避免了昂贵和不方便的第二或第三次鼓室成形术,因为该技术具有很高的预测价值。模棱两可的案例可能导致消极的探索。本期来自Newcastle upon Tyne的对胆脂瘤MRI诊断的研究发现,在模棱两可的病例中,当中耳裂病变的信号强度高于同侧颞叶时,胆脂瘤的诊断具有较高的统计概率。人类乳头瘤病毒(HPV)及其与头颈部肿瘤的相关性继续激发人们的兴趣;以前的工作调查了儿童扁桃体的患病率,这一直很低。这篇发表在本期杂志上的论文来自加拿大安大略省伦敦市,对102名0-18岁儿童的扁桃体切除标本进行了检查,发现通过定量聚合酶链反应检测,没有发现含有相关的病毒亚型。这表明该病毒在这一人群中没有垂直传播,除非病毒是潜伏的,就像主要由性传播疾病所预期的那样,并加强了在性活动年龄之前接种HPV疫苗的力度。随着人们对生物膜在炎症性疾病中的应用越来越感兴趣,以及生理盐水冲洗治疗慢性鼻窦炎的疗效,许多鼻医生都在想,老式的上颌窦冲洗(“窦腔灌洗”)是否有一些优点,可能会再次出现。这一期有一项来自以色列海法的研究,其中慢性鼻窦炎患者接受药物治疗,有或没有上颌窦冲洗。根据一项仔细的结果评估,灌溉并没有增加任何东西,因此,Tilley Lichtwitz套管针和套管针似乎还不会经历制造业的复兴。耳硬化症在表现上有女性倾向,而且人们早就知道它与怀孕有关,但这种联系到底有多真实呢?本期来自意大利维罗纳的研究回顾了这个话题,但发现很难得到明确的答案。作者得出的结论是,相当一部分确诊为耳硬化的女性(可能超过40%)在怀孕期间或怀孕后听力会下降。
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引用次数: 0
The impact of coronavirus disease 2019 on the head and neck cancer pathway in the West of Scotland 2019冠状病毒病对苏格兰西部头颈癌途径的影响
Pub Date : 2022-02-28 DOI: 10.1017/S0022215122000603
I. Drake, A. Rogers, M. Stewart, J. Montgomery
Abstract Objective The coronavirus disease 2019 pandemic has greatly disrupted head and neck cancer services in the West of Scotland. This study aimed to assess the impact of the first wave of the pandemic on cancer waiting times. Methods A retrospective review of multidisciplinary team records was undertaken between March and May in 2019 and the same months in 2020. Time-to-diagnosis and time-to-treatment for new cancers treated with curative intent were compared between the study periods, and subclassified by referral pathway. Results A total of 236 new cancer patients were included. During the pandemic, pathways benefitted from reduced diagnostic and treatment times resulting from the restructuring of service provisions. A 75 per cent reduction in secondary care referrals and a 33 per cent increase in urgent suspicion of cancer referrals were observed in 2020. Conclusion Head and neck cancer pathway times did not suffer because of the coronavirus pandemic. Innovations introduced to mitigate issues brought about by coronavirus benefitted patients, led to a more streamlined service, and improved diagnostic and treatment target compliance.
摘要目的2019冠状病毒病大流行严重影响了苏格兰西部头颈癌服务。这项研究旨在评估第一波大流行对癌症等待时间的影响。方法回顾性分析2019年3 - 5月及2020年同期的多学科团队记录。在研究期间比较以治愈意图治疗的新发癌症的诊断时间和治疗时间,并根据转诊途径进行细分。结果共纳入236例新发肿瘤患者。在大流行期间,由于服务提供结构调整,缩短了诊断和治疗时间,这些途径从中受益。到2020年,二级保健转诊减少了75%,紧急怀疑癌症转诊增加了33%。结论新冠肺炎疫情未对头颈部肿瘤通路时间造成影响。为缓解冠状病毒带来的问题而引入的创新使患者受益,使服务更加精简,并提高了诊断和治疗目标的依从性。
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引用次数: 1
Head and Neck Oncology: A Concise Guide. Akheel Mohammad, Ashmi Wadhwania ISBN 9780367421311 Published by CRC Press 2021 180 Pages £69.99 头颈肿瘤学:简明指南。阿什米尔·穆罕默德,阿什米·瓦德瓦尼亚ISBN 9780367421311 CRC出版社2021出版180页69.99英镑
Pub Date : 2022-02-17 DOI: 10.1017/s0022215122000524
L. Flood
I did find it hard to review this book, based solely on my reading off a desktop monitor, but, at a time when new texts are few and far between, this beggar will not be too choosy. Although only an e-book is available to reviewers, it seems there is at least a soft back version out there and, from this publisher, I am sure it is well presented. This ‘Concise Guide’ does not follow the usual practice of an international multi-authorship, supervised by a couple of eminent editors. Instead, it is all the work of just two authors (even though the title page still calls them ‘editors’). That has obvious advantages for consistency of style throughout and adherence to deadlines, but, equally, it does place demands on the authors to cover such a wide field comprehensively. The Preface suggests this book is aimed at the vast Indian market and is best seen as an introduction to the subject for trainees. It explains that all management recommendations are based on the guidelines of the National Comprehensive Cancer Network, which certainly does prove to be the case. Most chapters draw heavily on the guidance, quoted word for word, but also on the internationally recognised Union for International Cancer Control tumour–node–metastasis (TNM) classification of tumour staging, and for many chapters these two resources are the sole content. Notably, the work of John Watkinson in Stell and Maran’s Textbook of Head and Neck Surgery (CRC Press, 2011) is very widely referenced in many chapters. This must raise doubts about the novelty of the book’s content. Having these two online resources printed out, ready to hand (and frankly far more readable here than on the National Comprehensive Cancer Network site, which is murder to navigate and read), may well be of advantage to trainees, although again such content is freely available, if you can read off a monitor of course. Randomly scanning through the content, I was struck by some errors and omissions. In the chapter on laryngeal cancer, I was surprised to see Fig. 13.1 telling me that a T3 tumour meant a ‘paralysed’ vocal fold, very different to a fixed vocal fold of course. I confess an obvious personal interest in the ‘Occult Primary’ chapter, but read with persisting incomprehension ‘The exact incidence of epidemiology is unknown, but the occult primary of the head and neck has an incidence of 3–7% presenting with squamous cell carcinoma of the neck’. Fine needle aspiration cytology is recommended, but most would now consider conducting an ultrasound guided needle biopsy, especially as it checks human papilloma virus (HPV) status, with obvious clues as to the site of the primary tumour. Curiously, HPV receives but a single mention throughout the book, in a chapter on oncogenes, and then purely in a list of the culprits. In the ‘Oropharyngeal Cancer’ chapter, the brief coverage is limited to the National Comprehensive Cancer Network guidelines for p16 negative tumours, without reproducing their guidance on p16 pos
我确实发现,仅仅根据我在桌面显示器上的阅读来评价这本书很困难,但是,在新文本很少的时候,这个乞丐不会太挑剔。虽然只有电子书可供评论家使用,但似乎至少有一个软背版,而且我相信这个出版商的书呈现得很好。这个“简明指南”并没有遵循由几个著名编辑监督的国际多作者合作的通常做法。相反,它只是两位作者的作品(尽管标题页仍然称他们为“编辑”)。这对于风格的一致性和对截止日期的遵守有明显的好处,但同样,它也要求作者全面地覆盖如此广泛的领域。序言表明,这本书是针对广大的印度市场,最好被视为一个介绍主题的学员。它解释说,所有的管理建议都是基于国家综合癌症网络的指导方针,这当然证明是这样的。大多数章节大量引用指南,逐字逐句引用,但也引用国际公认的国际癌症控制联盟肿瘤分期的肿瘤-淋巴结-转移(TNM)分类,并且对于许多章节来说,这两个资源是唯一的内容。值得注意的是,John Watkinson在Stell and Maran的头颈外科教科书(CRC Press, 2011)中的工作在许多章节中被广泛引用。这必然会引起人们对这本书内容的新颖性的怀疑。把这两种在线资源打印出来,随手可得(坦率地说,在这里比在国家综合癌症网络网站上更容易阅读,后者的浏览和阅读简直是一场屠杀),可能对学员很有好处,尽管这些内容也是免费的,当然前提是你可以在显示器上阅读。随机浏览了一下内容,我发现了一些错误和遗漏。在关于喉癌的章节中,我惊讶地看到图13.1告诉我T3肿瘤意味着“瘫痪”的声带,当然与固定的声带非常不同。我承认我对“隐匿原发”一章有明显的个人兴趣,但读到“流行病学的确切发病率尚不清楚,但头颈部的隐匿原发发病率为3-7%,表现为颈部鳞状细胞癌”时,我一直无法理解。细针吸细胞学是推荐的,但现在大多数人会考虑进行超声引导下的针活检,特别是因为它可以检查人类乳头状瘤病毒(HPV)状态,并有明显的线索来确定原发肿瘤的位置。奇怪的是,HPV在整本书中只被提及一次,在一个关于致癌基因的章节中,然后纯粹是在一个罪魁祸首的列表中。在“口咽癌”一章中,简短的覆盖范围仅限于p16阴性肿瘤的国家综合癌症网络指南,而没有复制p16阳性肿瘤的指南!我翻到关于成像的一章,发现超声波只用了一行半就被忽略了。插图的大部分是基于透明胶片的摄影(那些日子)在照明的观看屏幕上,现在在我们英国医院的墙上积满了灰尘。这里的问题是房间灯光的反射,在一张引人注目的照片中,我们清楚地看到摄影师拿着平板电脑。校对时遗漏了文本中的一些错误;例如,“而且相当依赖于……”。在关于放射治疗的一章中,我读到一个要点“霉菌和霉菌室”,觉得很有趣。患者模具是在模具室中准备的,作为唯一的内容。也有值得称赞的内容;例如,关于颈动脉爆裂,前哨淋巴结活检和眼眶的章节。这些都是富有想象力的话题,涵盖得很好。解剖的彩色图非常出色,但艺术家首次在网上发表:2022年2月17日https://doi.org/10.1017/S0022215122000524,(2022), 136, 570-571。
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引用次数: 0
Operative Surgery for Head and Neck Tumors Edited By Jagdeep Thakur, Ripu Daman Arora ISBN 9781032155814 Published 2022 by CRC Press 274 Pages £74.99 《头颈部肿瘤的外科手术》,作者:Jagdeep Thakur, Ripu Daman Arora ISBN 9781032155814 2022年CRC出版社出版,274页,74.99英镑
Pub Date : 2022-02-17 DOI: 10.1017/s0022215122000500
L. Flood
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引用次数: 0
The Art and Science of Extended Deep Plane Facelifting and Complementary Facial Rejuvenation Procedures A A Jacono Quality Medical Publishing, 2021 ISBN 978 1 57626 460 7 pp 500 Price US$395.00 延伸深度平面整容和补充面部再生程序的艺术和科学A A Jacono质量医学出版,2021 ISBN 978 1 57626 460 7页500价格US$395.00
Pub Date : 2022-02-14 DOI: 10.1017/s0022215122000378
D. Whitehead
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引用次数: 0
JLO volume 136 issue 2 Cover and Front matter JLO第136卷第2期封面和封面问题
Pub Date : 2022-02-01 DOI: 10.1017/s0022215122000573
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引用次数: 0
期刊
The Journal of Laryngology & Otology
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