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18F-FDG PET/CT Imaging Features of IgG4-Related Pulmonary Inflammatory Pseudotumor at Initial Diagnosis and During Early Treatment Monitoring igg4相关性肺部炎性假瘤的18F-FDG PET/CT初诊及早期治疗监测特征
Pub Date : 2016-02-04 DOI: 10.2967/jnmt.115.168450
S. Basu, K. Utpat, J. Joshi
We present a proven case of pulmonary inflammatory pseudotumor that illustrates the 18F-FDG PET/CT imaging features of this “great mimicker of malignancy” both at initial diagnosis and during early monitoring of corticosteroid therapy, which is advocated as the first-line treatment. Although the patient showed some symptomatic response to corticosteroid therapy, as well as a modest reduction in SUVmax, complete surgical resection was eventually needed in view of the relative nonresponse. 18F-FDG avidity in untreated cases of pulmonary inflammatory pseudotumor has been quite characteristic and may potentially be used to evaluate early response of this IgG4-related disease to nonsurgical treatment and to detect residual disease or recurrence after therapeutic intervention.
我们报告了一例经证实的肺部炎性假肿瘤,说明了这种“恶性肿瘤的巨大模仿者”在初始诊断和早期监测皮质类固醇治疗时的18F-FDG PET/CT成像特征,皮质类固醇治疗被提倡作为一线治疗。尽管患者对皮质类固醇治疗有一定的症状反应,并且SUVmax有一定程度的降低,但鉴于相对无反应,最终需要完全手术切除。在未经治疗的肺部炎性假肿瘤病例中,18F-FDG贪婪度具有相当的特征性,可能潜在地用于评估这种igg4相关疾病对非手术治疗的早期反应,并在治疗干预后检测残留疾病或复发。
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引用次数: 6
Ectopic Parathyroid Adenoma in the Carotid Sheath 颈动脉鞘异位甲状旁腺瘤
Pub Date : 2016-02-04 DOI: 10.2967/jnmt.115.170993
C. D. Sanders, J. Kirkland, Ely A. Wolin
Primary hyperparathyroidism is predominantly caused by a single parathyroid adenoma. Knowledge of normal and ectopic locations of parathyroid glands is crucial to help guide surgeons who plan targeted unilateral parathyroidectomy to reduce surgical time and risk. We describe a female patient with clinical primary hyperparathyroidism who underwent a failed initial parathyroidectomy, with subsequent imaging localizing an ectopic parathyroid adenoma in the carotid sheath.
原发性甲状旁腺功能亢进主要由单个甲状旁腺瘤引起。了解甲状旁腺的正常和异位位置对指导外科医生计划有针对性的单侧甲状旁腺切除术以减少手术时间和风险至关重要。我们描述了一位临床原发性甲状旁腺功能亢进的女性患者,她接受了最初失败的甲状旁腺切除术,随后的影像学检查发现颈动脉鞘中有异位甲状旁腺瘤。
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引用次数: 4
Radiation Hormesis: Historical and Current Perspectives 辐射激效:历史和当前的观点
Pub Date : 2015-12-01 DOI: 10.2967/jnmt.115.166074
Jonathan D Baldwin, Vesper V Grantham
The purpose of this article is to provide the reader with a better understanding of radiation hormesis, the investigational research that supports or does not support the theory, and the relationship between the theory and current radiation safety guidelines and practices. The concept of radiation hormesis is known to nuclear medicine technologists, but understanding its complexities and the historical development of the theory may bring about a better understanding of radiation safety and regulations.
本文的目的是让读者更好地了解辐射激效,支持或不支持该理论的调查研究,以及该理论与当前辐射安全指南和实践之间的关系。核医学技术人员都知道辐射激效的概念,但了解其复杂性和理论的历史发展可能会更好地了解辐射安全和法规。
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引用次数: 56
Evaluating the Role of Routine Prone Acquisition on Visual Evaluation of SPECT Images 评估常规倾向采集在SPECT图像视觉评价中的作用
Pub Date : 2015-12-01 DOI: 10.2967/jnmt.115.165936
Levent A Guner, B. Çalişkan, Ilknur Isik, T. Aksoy, E. Vardareli, A. Parspur
Attenuation artifacts reduce our ability to evaluate perfusion of affected myocardial segments. The aim of this study was to evaluate the impact of routine prone-position image evaluation within a stepwise visual interpretation of myocardial perfusion studies. Methods: We have included 279 consecutive patients who were referred for evaluation of myocardial ischemia. All patients underwent routine electrocardiogram-gated supine SPECT imaging and non–electrocardiogram-gated prone-position SPECT imaging. Three nuclear medicine physicians interpreted the images in the following order: polar maps, supine images, raw images, motion-frozen gated images, and prone images, using a scale of 0–4. Segments with perfusion abnormalities were noted. Results: All physicians reported lower proportions of equivocal evaluations after evaluating prone images (18.3% vs. 4.7%, 19% vs. 11.1%, and 12.2% vs. 6.1%, P < 0.0001, P = 0.0077, and P = 0.0125, respectively). At the prone stage, normalcy rates were 89%, 87%, and 91%. Two physicians had significantly increased normalcy rates at the prone stage (72%–89%, P = 0.039, and 66%–87%, P = 0.006). At the prone stage, a decision reversal to normal or probably normal was observed in 40% (29/72), 33% (17/51), and 43% (21/48). In men, apical, mid, and basal inferior walls and in women apical and mid parts of anterior walls were more likely to be attributed to attenuation. The 2 steps that increased normalcy rates for interpreters were the review of raw images and of prone images. Conclusion: Routine prone imaging increases interpretive certainty and interobserver agreement and changes the final evaluation in a substantial number of patients and significantly decreases the number of equivocal evaluations.
衰减伪影降低了我们评估受影响心肌节段灌注的能力。本研究的目的是评估常规俯卧位图像评估在心肌灌注研究的逐步视觉解释中的影响。方法:我们纳入279例连续转诊的心肌缺血评估患者。所有患者均接受常规心电图门控仰卧位SPECT成像和非心电图门控俯卧位SPECT成像。三名核医学医生按照以下顺序解释了这些图像:极坐标图、仰卧位图像、原始图像、运动冻结门控图像和俯卧位图像,使用0-4的等级。记录灌注异常的节段。结果:所有医生均报告在评估俯卧图像后模棱两可评价的比例较低(18.3% vs. 4.7%, 19% vs. 11.1%, 12.2% vs. 6.1%, P < 0.0001, P = 0.0077, P = 0.0125)。在俯卧期,正常率分别为89%、87%和91%。两名医生在俯卧期的正常率显著增高(72% ~ 89%,P = 0.039, 66% ~ 87%, P = 0.006)。在倾向阶段,40%(29/72)、33%(17/51)和43%(21/48)的人的决定逆转为正常或可能正常。在男性中,根尖、中壁和基底下壁以及女性前壁的根尖和中壁更有可能被归因于衰减。增加口译员正常率的两个步骤是对原始图像和倾向图像的审查。结论:常规俯卧位成像增加了解释的确定性和观察者间的一致性,改变了大量患者的最终评估,显著减少了模棱两可的评估。
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引用次数: 7
Parathyroid Imaging with Simultaneous Acquisition of 99mTc-Sestamibi and 123I: The Relative Merits of Pinhole Collimation and SPECT/CT 同时采集99mTc-Sestamibi和123I的甲状旁腺成像:针孔准直与SPECT/CT的相对优点
Pub Date : 2015-12-01 DOI: 10.2967/jnmt.115.164939
Paraag R. Bhatt, W. Klingensmith, Brian M. Bagrosky, J. Walter, K. Mcfann, R. McIntyre, C. Raeburn, P. Koo
The objective of this study was to determine the relative utility of 3 state-of-the-art parathyroid imaging protocols: single-time-point simultaneous acquisition of 99mTc-sestamibi and 123I images with pinhole collimation in the anterior and bilateral anterior oblique projections, single-time-point simultaneous acquisition of 99mTc-sestamibi and 123I images with SPECT/CT, and the combination of the first and second protocols. Methods: Fifty-nine patients with surgical proof of parathyroid adenomas were evaluated retrospectively. All 3 protocols included perfectly coregistered subtraction images created by subtracting the 123I images from the 99mTc-sestamibi images, plus an anterior parallel-hole collimator image of the neck and upper chest. The pinhole protocol was performed first, followed by the SPECT/CT protocol. Three image sets were derived from each study in each patient according to the above protocols. Two experienced observers recorded the size, location, and degree of certainty of any identified lesion. Results: The 59 patients had 61 adenomas. For the 2 observers combined, the localization success rate was 88% for the pinhole protocol, 69% for the SPECT/CT protocol, and 81% for the combined protocol. The pinhole protocol detected more adenomas than the SPECT/CT protocol and missed fewer adenomas than either the SPECT/CT protocol or the combined pinhole and SPECT/CT protocol (P < 0.01). The 2 protocols that included SPECT/CT provided superior anatomic information relative to the location and size of the parathyroid adenomas. Conclusion: The pinhole protocol localized significantly more adenomas than the SPECT/CT protocol. However, the protocols that included SPECT/CT provided more anatomic information than pinhole imaging alone.
本研究的目的是确定3种最先进的甲状旁腺成像方案的相对实用性:单时间点同时采集99mTc-sestamibi和123I图像,在前侧和双侧前斜投影中采用针孔准直,单时间点同时采集99mTc-sestamibi和123I图像,SPECT/CT,以及第一和第二种方案的结合。方法:对59例甲状旁腺瘤的手术证据进行回顾性分析。所有3种方案都包括通过从99mTc-sestamibi图像中减去123I图像创建的完美共配减法图像,加上颈部和上胸部的前平行孔准直图像。首先进行针孔检查,然后进行SPECT/CT检查。根据上述方案,从每个患者的每个研究中获得三个图像集。两名经验丰富的观察员记录了任何确定病变的大小、位置和确定程度。结果:59例患者中腺瘤61例。对于2个观察者联合,定位成功率为针孔方案88%,SPECT/CT方案69%,联合方案81%。针孔方案的腺瘤检出率高于SPECT/CT方案,漏诊率低于SPECT/CT方案或针孔与SPECT/CT联合方案(P < 0.01)。包括SPECT/CT在内的两种方案提供了相对于甲状旁腺瘤的位置和大小的优越解剖信息。结论:针孔方案比SPECT/CT方案更能定位腺瘤。然而,包括SPECT/CT的方案比单独的针孔成像提供了更多的解剖信息。
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引用次数: 16
Evaluation of a Case of Inflammatory Breast Cancer with 18F-FDG PET/CT 18F-FDG PET/CT对1例炎性乳腺癌的评价
Pub Date : 2015-12-01 DOI: 10.2967/jnmt.114.148494
Z. Al-faham, S. Al-katib, I. Jaiyesimi, S. Bhavnagri
Inflammatory breast cancer is a rare and aggressive form of cancer characterized by dermal lymphatic invasion and tumor embolization resulting in erythema and edema. In many cases, by the time of diagnosis there is already distant metastasis. Mammography, sonography, CT, and MRI are usually performed for initial staging; however, PET/CT can also be used for initial staging as it offers additional diagnostic information.
炎症性乳腺癌是一种罕见的侵袭性癌症,其特征是真皮淋巴浸润和肿瘤栓塞导致红斑和水肿。在许多病例中,在诊断时已经有远处转移。乳房x光检查、超声检查、CT和MRI通常用于初始阶段;然而,PET/CT也可以用于初始分期,因为它提供了额外的诊断信息。
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引用次数: 3
Quick-Reference Protocol Manual for Nuclear Medicine Technologists 核医学技术人员快速参考规程手册
Pub Date : 2014-09-01 DOI: 10.2967/JNMT.114.143610
J. Prekeges
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引用次数: 6
PET and PET/CT Study Guide: A Review for Passing the PET Specialty Exam PET和PET/CT学习指南:通过PET专业考试的复习
Pub Date : 2013-12-01 DOI: 10.2967/jnmt.113.132183
K. Thomas
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引用次数: 0
Nuclear Medicine Instrumentation 核医学仪器
Pub Date : 2013-06-01 DOI: 10.2967/jnmt.113.120790
William L. Hubble
This soft-cover textbook on nuclear instrumentation was written for an audience of nuclear medicine technology students, medical imaging technologists, nuclear medicine physicians, radiologists, medical imaging residents, biomedical engineers, and any individual interested in gaining an understanding of the topic. According to the author, the purpose of this book is to address a significant deficit of available resources for those seeking a dedicated textbook on the subject matter. This textbook is in its second edition and is presented as 19 chapters and 6 supporting appendices. The chapters are divided into 4 distinct parts that help the reader understand small instruments, g-cameras, SPECT, and PET. The chapter on PET includes a discussion on CT and an introduction to MR imaging. The content of the book begins with introductions to gas-filled detectors, scintillation detectors, semiconductors, and factors relating to radiation measurement. The second part addresses the specifics of g-cameras, including image digitization and display, collimators, image characteristics, performance measures in planar imaging, and quality assurance and quality control of g-cameras. The third part covers the details of SPECT, including image characteristics, the effect of acquisition parameters on SPECT imaging, how to improve SPECT images, and quality control and artifacts in SPECT. The fourth part focuses on PET, including instrumentation, image characteristics, performance measures and quantification, and quality control and artifacts, and concludes with CT and MR imaging. The appendices include atomic structure and interactions of high-energy radiation, basic electronics and devices, film and film processing, computer fundamentals, collimator mathematics, and laboratory accreditation. The author writes in a clear and concise fashion and assumes the reader has little or no background on nuclear medicine instrumentation. The textbook has sample calculations, tables, charts, images, and diagrams throughout, which complement the text and enable the reader to have a more comprehensive understanding of the written material. I applaud the author for including information on semiconductors, CT, and MR imaging. Unfortunately, there are limitations on the CT and MR imaging content due to the book’s focus on nuclear medicine instrumentation. The CT and MR imaging sections are more or less an introduction to these imaging modalities. I would encourage readers seeking comprehensive information on CT and MR imaging to search for other dedicated instrumentation textbooks on these subjects. I would highly recommend this textbook for anyone who is interested in teaching or learning more about nuclear medicine instrumentation. It is a welcomed addition for any medical imaging library. Readers will find it interesting and worthwhile. I have used this book since the release of the first edition in 2011 for my course in nuclear medicine instrumentation. It has replaced 3 textbook
这本关于核仪器的软封面教科书是为核医学技术学生、医学成像技术专家、核医学医师、放射科医生、医学成像住院医师、生物医学工程师和任何有兴趣了解该主题的个人编写的。根据作者的说法,这本书的目的是为那些寻求专门教科书的人解决可用资源的重大赤字。这本教科书是第二版,分为19章和6个辅助附录。章节分为4个不同的部分,帮助读者了解小型仪器,g相机,SPECT和PET。关于PET的章节包括对CT的讨论和对MR成像的介绍。这本书的内容开始介绍气体充满的探测器,闪烁探测器,半导体,以及有关辐射测量的因素。第二部分阐述了g型相机的具体特点,包括图像数字化和显示、准直器、图像特性、平面成像性能指标以及g型相机的质量保证和质量控制。第三部分介绍了SPECT的细节,包括图像特性、采集参数对SPECT成像的影响、如何改进SPECT图像、SPECT中的质量控制和伪影。第四部分重点介绍PET,包括仪器、图像特征、性能测量和量化、质量控制和伪影,最后介绍CT和MR成像。附录包括原子结构和高能辐射的相互作用、基础电子学和器件、胶片和胶片处理、计算机基础、准直器数学和实验室鉴定。作者以清晰简洁的方式写作,并假设读者对核医学仪器有很少或没有背景。教材中有计算示例、表格、图表、图像和图表,这些都是对文本的补充,使读者对书面材料有一个更全面的理解。我赞赏作者在半导体、CT和MR成像方面的信息。不幸的是,由于本书的重点是核医学仪器,因此在CT和MR成像内容上存在局限性。CT和MR成像部分或多或少是这些成像方式的介绍。我鼓励寻求CT和MR成像综合信息的读者去寻找其他关于这些主题的专用仪器教科书。我强烈推荐这本教科书给任何对教学或学习更多核医学仪器感兴趣的人。它是任何医学影像库的一个受欢迎的补充。读者会觉得它很有趣,也很值得。自2011年第一版发行以来,我一直在核医学仪器课程中使用这本书。它取代了我曾经用来教这门课的课本和许多讲义。学生们总是对教科书提出严厉的批评,但这本书却得到了学生们的积极评价。我也为放射科住院医师提供指导,他们也觉得这本书很有用。作者成功地编写并更新了一本教科书,将成为核医学相关教育计划的主要内容。这本教科书清楚地说明了为什么有经验的核医学技术项目主任应该考虑花时间通过编写对每个人都有益的教科书来提高专业水平。
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引用次数: 0
A Clinician’s Guide to Nuclear Medicine 核医学临床医生指南
Pub Date : 2013-03-01 DOI: 10.2967/JNMT.112.108621
Anthony Harris
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引用次数: 3
期刊
The Journal of Nuclear Medicine Technology
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