Pub Date : 2020-10-22DOI: 10.2174/2666150002006010012
A. Pote, V. Pande, V. Patel, M. Giri, Aniket Uttam Pund, Nitin Vijay Shelke
The recent advances in the drug delivery system using a variety of technological platforms have resulted in innovation in the attitude towards diagnosis and therapeutics alike in the present times. Mesoporous Silica possesses favourable chemical properties, thermal stability, and biocompatibility. The unique structure of mesoporous silica makes possible the effective loading of drugs and their subsequent release in a controlled manner at the target site. The properties like pore size, high drug loading, and porosity as well as the surface properties of Mesoporous silica make them a suitable platform for many drug delivery applications. This review focuses on the applications and the advances made in the mesoporous silica to broaden the spectrum of its use especially in the field of medicine. The Mesoporous Silica carrier has proved its use in the field of biosensing, controlled and targeted drug release, gene delivery, water treatment, solubility and bioavailability enhancement and wound healing.
{"title":"State of the Art Review on Emerging Applications of Mesoporous Silica","authors":"A. Pote, V. Pande, V. Patel, M. Giri, Aniket Uttam Pund, Nitin Vijay Shelke","doi":"10.2174/2666150002006010012","DOIUrl":"https://doi.org/10.2174/2666150002006010012","url":null,"abstract":"The recent advances in the drug delivery system using a variety of technological platforms have resulted in innovation in the attitude towards diagnosis and therapeutics alike in the present times. Mesoporous Silica possesses favourable chemical properties, thermal stability, and biocompatibility. The unique structure of mesoporous silica makes possible the effective loading of drugs and their subsequent release in a controlled manner at the target site. The properties like pore size, high drug loading, and porosity as well as the surface properties of Mesoporous silica make them a suitable platform for many drug delivery applications. This review focuses on the applications and the advances made in the mesoporous silica to broaden the spectrum of its use especially in the field of medicine. The Mesoporous Silica carrier has proved its use in the field of biosensing, controlled and targeted drug release, gene delivery, water treatment, solubility and bioavailability enhancement and wound healing.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"13 1","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2020-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83438530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-19DOI: 10.2174/1875933501805010016
Said Said Elshama, M. Abdallah, Rehab I Abdel-Karim
Despite the widespread application of zinc oxide nanoparticles in biomedicine, their use is still a controversial issue. Zinc oxide nanoparticles were reported to have therapeutic benefits. However, they were reported to have toxicological hazards as well. Several studies reported the antibacterial, anticancer, antioxidant, and immunomodulatory effects of zinc oxide nanoparticles. Additionally, zinc oxide nanoparticles were used in sunscreens. Furthermore, the ability to use zinc oxide nanoparticles as an adjuvant treatment to alleviate the toxic effects of chemotherapeutic drugs has been reported. However, zinc oxide nanoparticles were shown to induce toxic effects in different body organs and systems. The affected organs included liver, spleen, kidney, stomach, pancreas, heart and lung. In addition, zinc oxide nanoparticles were reported to adversely affect the neurological system, lymphatic system, hematological indices, sex hormones levels, and fetal development. The toxic effects of zinc oxide nanoparticles were based on their concentration, their dose, the route of their administration, and the time of exposure to those particles. Thus, it is crucial to assess their efficacy and safety to determine their toxicological risks and therapeutic benefits.
{"title":"Zinc Oxide Nanoparticles: Therapeutic Benefits and Toxicological Hazards","authors":"Said Said Elshama, M. Abdallah, Rehab I Abdel-Karim","doi":"10.2174/1875933501805010016","DOIUrl":"https://doi.org/10.2174/1875933501805010016","url":null,"abstract":"Despite the widespread application of zinc oxide nanoparticles in biomedicine, their use is still a controversial issue. Zinc oxide nanoparticles were reported to have therapeutic benefits. However, they were reported to have toxicological hazards as well. Several studies reported the antibacterial, anticancer, antioxidant, and immunomodulatory effects of zinc oxide nanoparticles. Additionally, zinc oxide nanoparticles were used in sunscreens. Furthermore, the ability to use zinc oxide nanoparticles as an adjuvant treatment to alleviate the toxic effects of chemotherapeutic drugs has been reported. However, zinc oxide nanoparticles were shown to induce toxic effects in different body organs and systems. The affected organs included liver, spleen, kidney, stomach, pancreas, heart and lung. In addition, zinc oxide nanoparticles were reported to adversely affect the neurological system, lymphatic system, hematological indices, sex hormones levels, and fetal development. The toxic effects of zinc oxide nanoparticles were based on their concentration, their dose, the route of their administration, and the time of exposure to those particles. Thus, it is crucial to assess their efficacy and safety to determine their toxicological risks and therapeutic benefits.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80654837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-30DOI: 10.2174/1875933501805010001
R. Tiwari, G. Tiwari, P. Wal, A. Wal, P. Maurya
Received: November 30, 2017 Revised: April 5, 2018 Accepted: April 16, 2018 Abstract: Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good watersolubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which may deliver these drugs to targeted site more efficiently than marketed gel preparation of DAP and also overcome the problems related with oral administration of CLXS.
{"title":"Development, Characterization and Transdermal Delivery of Dapsone and an Antibiotic Entrapped in Ethanolic Liposomal Gel for the Treatment of Lapromatous Leprosy","authors":"R. Tiwari, G. Tiwari, P. Wal, A. Wal, P. Maurya","doi":"10.2174/1875933501805010001","DOIUrl":"https://doi.org/10.2174/1875933501805010001","url":null,"abstract":"Received: November 30, 2017 Revised: April 5, 2018 Accepted: April 16, 2018 Abstract: Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good watersolubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which may deliver these drugs to targeted site more efficiently than marketed gel preparation of DAP and also overcome the problems related with oral administration of CLXS.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"82 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2018-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76781960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.2174/1875933501704010030
S. Debnath, S. Srinivasan, M. Debnath
{"title":"Development of Dry Powder Inhaler Containing Prothionamide-PLGA Nanoparticles Optimized Through Statistical Design: In-vivo Study","authors":"S. Debnath, S. Srinivasan, M. Debnath","doi":"10.2174/1875933501704010030","DOIUrl":"https://doi.org/10.2174/1875933501704010030","url":null,"abstract":"","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"1 1","pages":"30-40"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83294082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-31DOI: 10.2174/1875933501704010017
Sukhwinder Singh, S. Kamal, A. Sharma, Daljit Kaur, Manoj Kumar Katual, R. Kumar
{"title":"Formulation and Evaluation of Solid Lipid Nanoparticles Containing Levosulpiride","authors":"Sukhwinder Singh, S. Kamal, A. Sharma, Daljit Kaur, Manoj Kumar Katual, R. Kumar","doi":"10.2174/1875933501704010017","DOIUrl":"https://doi.org/10.2174/1875933501704010017","url":null,"abstract":"","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"1 1","pages":"17-29"},"PeriodicalIF":0.0,"publicationDate":"2017-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76152805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-09-30DOI: 10.2174/1875933501704010001
S. Halbandge, Supriya P. Mortale, S. Karuppayil
Received: April 27, 2017 Revised: July 27, 2017 Accepted: August 10, 2017 Abstract: Background: Biofilm formation by Candida albicans is a significant clinical challenge. Fungal biofilms are resistant to most of the currently available antifungal agents. Amphotericin-B (AmB) is an antifungal agent used for the treatment of systematic fungal infections but it is well known for its toxicities and side-effects. Novel approaches are needed to treat these infections that can reduce its toxicities.
摘要:背景:白色念珠菌形成生物膜是一项重大的临床挑战。真菌生物膜对目前大多数可用的抗真菌药物具有耐药性。两性霉素- b (AmB)是一种用于治疗系统性真菌感染的抗真菌药物，但其毒性和副作用是众所周知的。需要新的方法来治疗这些感染，以减少其毒性。
{"title":"Biofabricated Silver Nanoparticles Synergistically Activate Amphotericin B Against Mature Biofilm Forms of","authors":"S. Halbandge, Supriya P. Mortale, S. Karuppayil","doi":"10.2174/1875933501704010001","DOIUrl":"https://doi.org/10.2174/1875933501704010001","url":null,"abstract":"Received: April 27, 2017 Revised: July 27, 2017 Accepted: August 10, 2017 Abstract: Background: Biofilm formation by Candida albicans is a significant clinical challenge. Fungal biofilms are resistant to most of the currently available antifungal agents. Amphotericin-B (AmB) is an antifungal agent used for the treatment of systematic fungal infections but it is well known for its toxicities and side-effects. Novel approaches are needed to treat these infections that can reduce its toxicities.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"8 1","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2017-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84537888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-05-25DOI: 10.2174/1875933501103010002
M. F. J. C. Rubio, Arturo Vera Hernánde, L. L. Salas, E. Ávila-Navarro, E. Navarro
Hyperthermia also called thermal therapy or thermotherapy is a type of cancer treatment in which body tissue is exposed to high temperatures. Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. Otherwise, ablation or high temperature hyperthermia, including lasers and the use of radiofrequency, microwaves, and high-intensity focused ultrasound, are gaining attention as an alternative to standard sur- gical therapies. The electromagnetic microwave irradiation applied to the tumor tissue causes water molecules to vibrate and rotate, resulting in tissue heating and subsequently cell death via thermal-induced protein denaturation. The effective- ness of this technique is related to the temperature achieved during the therapy, as well as the length time of treatment and cell and tissue characteristics. Numerical electromagnetic and thermal simulations are used to optimize the antenna design and predict heating patterns. A computer modeling of a double slot antenna for interstitial hyperthermia was designed us- ing two different numerical methods, the Finite Element Method and a Finite-Difference Time-Domain. The aim of this work is to analyze both numerical methods and finally experiments results are compared to the simulated results generated by a thermal model. Our results show that normalized SAR patterns using FEM and FDTD look broadly similar. Further- more, the computed 60 °C isotherm using FEM and the measured lesion diameter in ex vivo tissue results agree very well.
{"title":"Coaxial Slot Antenna Design for Microwave Hyperthermia using Finite-Difference Time-Domain and Finite Element Method","authors":"M. F. J. C. Rubio, Arturo Vera Hernánde, L. L. Salas, E. Ávila-Navarro, E. Navarro","doi":"10.2174/1875933501103010002","DOIUrl":"https://doi.org/10.2174/1875933501103010002","url":null,"abstract":"Hyperthermia also called thermal therapy or thermotherapy is a type of cancer treatment in which body tissue is exposed to high temperatures. Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. Otherwise, ablation or high temperature hyperthermia, including lasers and the use of radiofrequency, microwaves, and high-intensity focused ultrasound, are gaining attention as an alternative to standard sur- gical therapies. The electromagnetic microwave irradiation applied to the tumor tissue causes water molecules to vibrate and rotate, resulting in tissue heating and subsequently cell death via thermal-induced protein denaturation. The effective- ness of this technique is related to the temperature achieved during the therapy, as well as the length time of treatment and cell and tissue characteristics. Numerical electromagnetic and thermal simulations are used to optimize the antenna design and predict heating patterns. A computer modeling of a double slot antenna for interstitial hyperthermia was designed us- ing two different numerical methods, the Finite Element Method and a Finite-Difference Time-Domain. The aim of this work is to analyze both numerical methods and finally experiments results are compared to the simulated results generated by a thermal model. Our results show that normalized SAR patterns using FEM and FDTD look broadly similar. Further- more, the computed 60 °C isotherm using FEM and the measured lesion diameter in ex vivo tissue results agree very well.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"3 1","pages":"2-9"},"PeriodicalIF":0.0,"publicationDate":"2011-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82097057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-05-25DOI: 10.2174/1875933501103010024
N. Levi-Polyachenko, J. Stewart
The aim of this review is to introduce the reader to the potential clinical utility for the delivery of chemotherapy in the context of nanoparticles. We will present traditional methods of hyperthermia and then focus on the clinical technique for using intraperitoneal hyperthermic chemoperfusion for the treatment of peritoneal surface dissemination of colorectal cancer. Cellular mechanisms of hyperthermia as well as clinically effective chemotherapeutic agents are discussed. In the past decade carbon and metal nanoparticles have been explored for their ability to induce hyperthermia; however, many of these studies examine nanoparticles for tumor ablation at high temperatures. There are currently few studies that evaluate mild hyperthermia (below 43°C) generated by nanoparticles to enhance the delivery of chemotherapeutic agents. The fundamentals for generation of hyperthermia from carbon and metal nanoparticles is discussed as are the limitations and benefits of specific nanoparticles with chemotherapeutic agents. This review will show that there is significant potential for the use of nanoparticles to induce hyperthermia and increase the delivery of chemotherapeutic agents for treatment of colorectal cancer and other peritoneal disease.
{"title":"Clinical Relevance of Nanoparticle Induced Hyperthermia for Drug Delivery and Treatment of Abdominal Cancers","authors":"N. Levi-Polyachenko, J. Stewart","doi":"10.2174/1875933501103010024","DOIUrl":"https://doi.org/10.2174/1875933501103010024","url":null,"abstract":"The aim of this review is to introduce the reader to the potential clinical utility for the delivery of chemotherapy in the context of nanoparticles. We will present traditional methods of hyperthermia and then focus on the clinical technique for using intraperitoneal hyperthermic chemoperfusion for the treatment of peritoneal surface dissemination of colorectal cancer. Cellular mechanisms of hyperthermia as well as clinically effective chemotherapeutic agents are discussed. In the past decade carbon and metal nanoparticles have been explored for their ability to induce hyperthermia; however, many of these studies examine nanoparticles for tumor ablation at high temperatures. There are currently few studies that evaluate mild hyperthermia (below 43°C) generated by nanoparticles to enhance the delivery of chemotherapeutic agents. The fundamentals for generation of hyperthermia from carbon and metal nanoparticles is discussed as are the limitations and benefits of specific nanoparticles with chemotherapeutic agents. This review will show that there is significant potential for the use of nanoparticles to induce hyperthermia and increase the delivery of chemotherapeutic agents for treatment of colorectal cancer and other peritoneal disease.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"45 1","pages":"24-37"},"PeriodicalIF":0.0,"publicationDate":"2011-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86828274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-05-25DOI: 10.2174/1875933501103010010
R. Sharma, A. Sharma, Ching-Jen Chen
Heating tumors by nanoparticles and resistance in tumor cells to a high temperature is emerging as an effective tool as nanomedicine tool in cancer therapy. The art of thermal mapping in a tumor at various locations is emerging as the selective approach of hyperthermia to monitor temperature and treat the tumor. However, thermometry and tumor cell interaction with nanoparticles may monitor and evaluate the tumor cell survival after exposure to high physiological temperatures but show cytotoxicity. The design and application of 10-100 nano meter sized nanoparticles in tumor hyperthermia has emerged as an effective technology in hyperthermia imaging and treatment. The temperature and nanoparticle magnetic moment relationship is specific. Furthermore, there are two main issues that are unsolved as of yet. First issue is the relationship of tumor energy changes due to tumor magnetization by different nanoparticles. The second issue is the heat transfer behavior of the nanoparticle inside the tumor combined with hyperthermia and efficacy of combined modality on the tumor tissue temperature rise. In present study, we highlight that in vivo imaging such as MR thermometry, photoacuastic mapping of different tumor locations solve these issues to some extent. The art of combined use of hyperthermia by nanoparticles with hypoxia sensitive nitroimidazole radiosensitizers with chemotherapeutic drugs is highlighted to have a great impact on public health as alternative therapeutic oncology and monitoring therapy.
{"title":"State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting","authors":"R. Sharma, A. Sharma, Ching-Jen Chen","doi":"10.2174/1875933501103010010","DOIUrl":"https://doi.org/10.2174/1875933501103010010","url":null,"abstract":"Heating tumors by nanoparticles and resistance in tumor cells to a high temperature is emerging as an effective tool as nanomedicine tool in cancer therapy. The art of thermal mapping in a tumor at various locations is emerging as the selective approach of hyperthermia to monitor temperature and treat the tumor. However, thermometry and tumor cell interaction with nanoparticles may monitor and evaluate the tumor cell survival after exposure to high physiological temperatures but show cytotoxicity. The design and application of 10-100 nano meter sized nanoparticles in tumor hyperthermia has emerged as an effective technology in hyperthermia imaging and treatment. The temperature and nanoparticle magnetic moment relationship is specific. Furthermore, there are two main issues that are unsolved as of yet. First issue is the relationship of tumor energy changes due to tumor magnetization by different nanoparticles. The second issue is the heat transfer behavior of the nanoparticle inside the tumor combined with hyperthermia and efficacy of combined modality on the tumor tissue temperature rise. In present study, we highlight that in vivo imaging such as MR thermometry, photoacuastic mapping of different tumor locations solve these issues to some extent. The art of combined use of hyperthermia by nanoparticles with hypoxia sensitive nitroimidazole radiosensitizers with chemotherapeutic drugs is highlighted to have a great impact on public health as alternative therapeutic oncology and monitoring therapy.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"76 7 1","pages":"10-23"},"PeriodicalIF":0.0,"publicationDate":"2011-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87866269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-01-01DOI: 10.2174/1875933501103010038
Chelsea D Landon, Ji-Young Park, David Needham, Mark W Dewhirst
The overall objective of liposomal drug delivery is to selectively target drug delivery to diseased tissue, while minimizing drug delivery to critical normal tissues. The purpose of this review is to provide an overview of temperature-sensitive liposomes in general and the Low Temperature-Sensitive Liposome (LTSL) in particular. We give a brief description of the material design of LTSL and highlight the likely mechanism behind temperature-triggered drug release. A complete review of the progress and results of the latest preclinical and clinical studies that demonstrate enhanced drug delivery with the combined treatment of hyperthermia and liposomes is provided as well as a clinical perspective on cancers that would benefit from hyperthermia as an adjuvant treatment for temperature-triggered chemotherapeutics. This review discusses the ideas, goals, and processes behind temperature-sensitive liposome development in the laboratory to the current use in preclinical and clinical settings.
{"title":"Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.","authors":"Chelsea D Landon, Ji-Young Park, David Needham, Mark W Dewhirst","doi":"10.2174/1875933501103010038","DOIUrl":"https://doi.org/10.2174/1875933501103010038","url":null,"abstract":"<p><p>The overall objective of liposomal drug delivery is to selectively target drug delivery to diseased tissue, while minimizing drug delivery to critical normal tissues. The purpose of this review is to provide an overview of temperature-sensitive liposomes in general and the Low Temperature-Sensitive Liposome (LTSL) in particular. We give a brief description of the material design of LTSL and highlight the likely mechanism behind temperature-triggered drug release. A complete review of the progress and results of the latest preclinical and clinical studies that demonstrate enhanced drug delivery with the combined treatment of hyperthermia and liposomes is provided as well as a clinical perspective on cancers that would benefit from hyperthermia as an adjuvant treatment for temperature-triggered chemotherapeutics. This review discusses the ideas, goals, and processes behind temperature-sensitive liposome development in the laboratory to the current use in preclinical and clinical settings.</p>","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"3 ","pages":"38-64"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1875933501103010038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31540084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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