Pub Date : 2024-11-03eCollection Date: 2024-11-12DOI: 10.1021/acsomega.4c07463
Zhongyi Zhang, Yunliang He, Mei Zhao, Xin He, Zubing Zhou, Yuanyuan Yue, Tao Shen, Juncheng Liu, Gan Zhang, Yong Zhang
Background: Qinglian Hongqu decoction (QLHQD), a traditional Chinese herbal remedy, shows potential in alleviating metabolic issues related to nonalcoholic fatty liver disease (NAFLD). However, its precise mode of action remains uncertain. Objective: This study aims to evaluate the efficacy and mechanisms of QLHQD in treating NAFLD. Methods: This study utilized a NAFLD mouse model to assess the effects of QLHQD on lipid metabolism, including blood lipids and hepatic steatosis, as well as glucose metabolism, including blood glucose levels, OGTT results, and serum insulin. Network pharmacology, bioinformatics, and molecular docking were used to explore how QLHQD may improve NAFLD treatment. Key proteins involved in these mechanisms were validated via WB and immunohistochemistry. Additionally, the expression of downstream pathway targets was examined to further validate the insulin resistance mechanism by which QLHQD improves NAFLD. Results: Animal studies demonstrated that QLHQD alleviated lipid abnormalities, hepatic steatosis, blood glucose levels, the insulin resistance index, and the OGTT results in NAFLD mice (P < 0.05 or 0.01). Network pharmacology and bioinformatics analyses indicated that the effects of QLHQD on NAFLD might involve bile acid secretion pathways. Subsequent validation through Western blotting, immunohistochemistry, and qPCR demonstrated that QLHQD may influence fat metabolism and insulin sensitivity in NAFLD mice via the FXR/TGR5/GLP-1 signaling pathway. Conclusion: QLHQD significantly alleviates glucose and lipid metabolism disorders in a high-fat diet-induced NAFLD mouse model. Its mechanism of action may involve the activation of the FXR/TGR5/GLP-1 signaling pathway in the gut, which reduces lipid accumulation and insulin resistance.
{"title":"Qinlian Hongqu Decoction Modulates FXR/TGR5/GLP-1 Pathway to Improve Insulin Resistance in NAFLD Mice: Bioinformatics and Experimental Study.","authors":"Zhongyi Zhang, Yunliang He, Mei Zhao, Xin He, Zubing Zhou, Yuanyuan Yue, Tao Shen, Juncheng Liu, Gan Zhang, Yong Zhang","doi":"10.1021/acsomega.4c07463","DOIUrl":"10.1021/acsomega.4c07463","url":null,"abstract":"<p><p><b>Background:</b> Qinglian Hongqu decoction (QLHQD), a traditional Chinese herbal remedy, shows potential in alleviating metabolic issues related to nonalcoholic fatty liver disease (NAFLD). However, its precise mode of action remains uncertain. <b>Objective:</b> This study aims to evaluate the efficacy and mechanisms of QLHQD in treating NAFLD. <b>Methods:</b> This study utilized a NAFLD mouse model to assess the effects of QLHQD on lipid metabolism, including blood lipids and hepatic steatosis, as well as glucose metabolism, including blood glucose levels, OGTT results, and serum insulin. Network pharmacology, bioinformatics, and molecular docking were used to explore how QLHQD may improve NAFLD treatment. Key proteins involved in these mechanisms were validated via WB and immunohistochemistry. Additionally, the expression of downstream pathway targets was examined to further validate the insulin resistance mechanism by which QLHQD improves NAFLD. <b>Results:</b> Animal studies demonstrated that QLHQD alleviated lipid abnormalities, hepatic steatosis, blood glucose levels, the insulin resistance index, and the OGTT results in NAFLD mice (<i>P</i> < 0.05 or 0.01). Network pharmacology and bioinformatics analyses indicated that the effects of QLHQD on NAFLD might involve bile acid secretion pathways. Subsequent validation through Western blotting, immunohistochemistry, and qPCR demonstrated that QLHQD may influence fat metabolism and insulin sensitivity in NAFLD mice via the FXR/TGR5/GLP-1 signaling pathway. <b>Conclusion:</b> QLHQD significantly alleviates glucose and lipid metabolism disorders in a high-fat diet-induced NAFLD mouse model. Its mechanism of action may involve the activation of the FXR/TGR5/GLP-1 signaling pathway in the gut, which reduces lipid accumulation and insulin resistance.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 45","pages":"45447-45466"},"PeriodicalIF":3.7,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bauxite residue (or red mud) is a highly alkaline waste generated during the extraction of alumina. As a result of the substantial accumulation of bauxite residue in tailings facilities, there is a growing interest in exploring the potential for reusing this material for other purposes. The main objective of this study is to evaluate the use of activated bauxite residue (ABR) for remediating oil sands process-affected water (OSPW) and as a supplement to municipal wastewater treatment through bench-scale, proof-of-concept studies. The ABR is produced through a reduction roasting process that alters the physicochemical properties of bauxite residue, resulting in the generation of potentially effective adsorbent media. The treatment performance via chemical and biological activity removals (cytotoxicity, estrogenicity, and mutagenicity) was also assessed. For OSPW, ABR treatment resulted in the effective removal of recalcitrant acid-extractable organics (AEOs), with kinetics following the pseudo-second-order and comparable adsorption capacity to other waste materials (e.g., petroleum coke). ABR also effectively reduced the estrogenicity and mutagenicity of OSPW, albeit cytotoxicity increased at higher dosages, possibly due to some components leaching out of the material (e.g., metals). For municipal wastewater, ABR treatment reduced fecal coliform concentrations (>99%), total phosphorus (up to 98%), total ammonia-nitrogen (63%), estrogenicity (nondetectable), and mutagenicity (nondetectable), especially in the primary effluent. The ultimate end use of ABR is for the recovery of valuable metals (especially iron) and as a construction material, but additional work is needed to optimize the dosage (currently in the g/L range) and maximize the use of ABR as an adsorbent prior to its subsequent uses.
{"title":"Treating Waste with Waste: Activated Bauxite Residue (ABR) as a Potential Wastewater Treatment.","authors":"Fei Cheng, Jingya Pang, Scott Berggren, Himanshu Tanvar, Brajendra Mishra, Maricor J Arlos","doi":"10.1021/acsomega.4c06699","DOIUrl":"10.1021/acsomega.4c06699","url":null,"abstract":"<p><p>Bauxite residue (or red mud) is a highly alkaline waste generated during the extraction of alumina. As a result of the substantial accumulation of bauxite residue in tailings facilities, there is a growing interest in exploring the potential for reusing this material for other purposes. The main objective of this study is to evaluate the use of activated bauxite residue (ABR) for remediating oil sands process-affected water (OSPW) and as a supplement to municipal wastewater treatment through bench-scale, proof-of-concept studies. The ABR is produced through a reduction roasting process that alters the physicochemical properties of bauxite residue, resulting in the generation of potentially effective adsorbent media. The treatment performance via chemical and biological activity removals (cytotoxicity, estrogenicity, and mutagenicity) was also assessed. For OSPW, ABR treatment resulted in the effective removal of recalcitrant acid-extractable organics (AEOs), with kinetics following the pseudo-second-order and comparable adsorption capacity to other waste materials (e.g., petroleum coke). ABR also effectively reduced the estrogenicity and mutagenicity of OSPW, albeit cytotoxicity increased at higher dosages, possibly due to some components leaching out of the material (e.g., metals). For municipal wastewater, ABR treatment reduced fecal coliform concentrations (>99%), total phosphorus (up to 98%), total ammonia-nitrogen (63%), estrogenicity (nondetectable), and mutagenicity (nondetectable), especially in the primary effluent. The ultimate end use of ABR is for the recovery of valuable metals (especially iron) and as a construction material, but additional work is needed to optimize the dosage (currently in the g/L range) and maximize the use of ABR as an adsorbent prior to its subsequent uses.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 45","pages":"45251-45262"},"PeriodicalIF":3.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p><p>X-ray structural elucidation, supramolecular self-assembly, and energetics of existential noncovalent interactions for a triad comprising α-diketone, α-ketoimine, and an imidorhenium complex are highlighted in this report. Molecular packing reveals a self-assembled 2D network stabilized by the C-H···O H-bonds for the α-diketone (benzil), and the first structural report of Brown and Sadanaga stressing on the prevalence of <i>only the van der Waals forces</i> seems to be an oversimplified conjecture. In the α-ketoimine, the imine nitrogen atom undergoes intramolecular N···H interaction to render itself inert toward intermolecular C-H···N interaction and exhibits two types of C-H···O H-bonds in consequence to generate a self-assembled 2D molecular architecture. The imidorhenium complex features a self-aggregated 3D packing engendered by the interplay of C-H···Cl H-bonds along with the ancillary C-H···π, C···C, and C···Cl contacts. To the best of our knowledge, in rhenium chemistry, this imidorhenium complex unravels the first example of self-associated 3D molecular packing constructed by the directional hydrogen bonds of C-H···Cl type. The presence of characteristic supramolecular synthons, viz., R<sub>2</sub> <sup>2</sup>(12), R<sub>2</sub> <sup>2</sup>(16), and R<sub>2</sub> <sup>2</sup>(14), in the α-diketone, α-ketoimine, and imidorhenium complex, respectively, has prompted us to delve into the energetics of noncovalent interactions. Symmetry-adapted perturbation theory analysis has authenticated a stability order: R<sub>2</sub> <sup>2</sup>(14) > R<sub>2</sub> <sup>2</sup>(12) > R<sub>2</sub> <sup>2</sup>(16) based on the interaction energy values of -25.97, -9.93, and -4.98 kcal/mol, respectively. The respective average contributions of the long-range dispersion, electrostatic, and induction forces are 58.5, 32.8, and 8.7%, respectively, for the intermolecular C-H···O interactions. The C-H···Cl interactions experience comparable contribution from the dispersion force (57.9% on average), although the electrostatic and induction forces contribute much less, 28.0 and 14.1%, respectively, on average. The natural energy decomposition analysis has further attested that the short-range, interfragment charge transfer occurring via the lp(O/Cl) → σ*(C-H) routes contributes 17-25% of the total attractive force for the C-H···O and C-H···Cl interactions. Quantum theory of atoms in molecules analysis unfolds a first-order exponential decay relation (<i>y</i> = 8.1043<i>e</i> <sup>-<i>x</i>/0.4095</sup>) between the electron density at the bond critical point and the distance of noncovalent interactions. The distances of noncovalent interactions in the lattices are internally governed by the individual packing patterns rather than the chemical nature of the H-bond donors and acceptors. Intrinsic bond strength index analysis shows promise to correlate the electron density at BCP with the SAPT-derived interaction energy for the noncovalent interactions.
{"title":"Diverse Self-Assembled Molecular Architectures Promoted by C-H···O and C-H···Cl Hydrogen Bonds in a Triad of α-Diketone, α-Ketoimine, and an Imidorhenium Complex: A Unified Analysis Based on XRD, NEDA, SAPT, QTAIM, and IBSI Studies.","authors":"Ankita Sinha, Suphal Sen, Tejender Singh, Aniruddha Ghosh, Satyen Saha, Krishanu Bandyopadhyay, Arindam Dey, Suparna Banerjee, Jaydip Gangopadhyay","doi":"10.1021/acsomega.4c07702","DOIUrl":"10.1021/acsomega.4c07702","url":null,"abstract":"<p><p>X-ray structural elucidation, supramolecular self-assembly, and energetics of existential noncovalent interactions for a triad comprising α-diketone, α-ketoimine, and an imidorhenium complex are highlighted in this report. Molecular packing reveals a self-assembled 2D network stabilized by the C-H···O H-bonds for the α-diketone (benzil), and the first structural report of Brown and Sadanaga stressing on the prevalence of <i>only the van der Waals forces</i> seems to be an oversimplified conjecture. In the α-ketoimine, the imine nitrogen atom undergoes intramolecular N···H interaction to render itself inert toward intermolecular C-H···N interaction and exhibits two types of C-H···O H-bonds in consequence to generate a self-assembled 2D molecular architecture. The imidorhenium complex features a self-aggregated 3D packing engendered by the interplay of C-H···Cl H-bonds along with the ancillary C-H···π, C···C, and C···Cl contacts. To the best of our knowledge, in rhenium chemistry, this imidorhenium complex unravels the first example of self-associated 3D molecular packing constructed by the directional hydrogen bonds of C-H···Cl type. The presence of characteristic supramolecular synthons, viz., R<sub>2</sub> <sup>2</sup>(12), R<sub>2</sub> <sup>2</sup>(16), and R<sub>2</sub> <sup>2</sup>(14), in the α-diketone, α-ketoimine, and imidorhenium complex, respectively, has prompted us to delve into the energetics of noncovalent interactions. Symmetry-adapted perturbation theory analysis has authenticated a stability order: R<sub>2</sub> <sup>2</sup>(14) > R<sub>2</sub> <sup>2</sup>(12) > R<sub>2</sub> <sup>2</sup>(16) based on the interaction energy values of -25.97, -9.93, and -4.98 kcal/mol, respectively. The respective average contributions of the long-range dispersion, electrostatic, and induction forces are 58.5, 32.8, and 8.7%, respectively, for the intermolecular C-H···O interactions. The C-H···Cl interactions experience comparable contribution from the dispersion force (57.9% on average), although the electrostatic and induction forces contribute much less, 28.0 and 14.1%, respectively, on average. The natural energy decomposition analysis has further attested that the short-range, interfragment charge transfer occurring via the lp(O/Cl) → σ*(C-H) routes contributes 17-25% of the total attractive force for the C-H···O and C-H···Cl interactions. Quantum theory of atoms in molecules analysis unfolds a first-order exponential decay relation (<i>y</i> = 8.1043<i>e</i> <sup>-<i>x</i>/0.4095</sup>) between the electron density at the bond critical point and the distance of noncovalent interactions. The distances of noncovalent interactions in the lattices are internally governed by the individual packing patterns rather than the chemical nature of the H-bond donors and acceptors. Intrinsic bond strength index analysis shows promise to correlate the electron density at BCP with the SAPT-derived interaction energy for the noncovalent interactions.","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"9 45","pages":"45518-45536"},"PeriodicalIF":3.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1001/jamainternmed.2024.4435
A Parker Ruhl, Matthew M Hsieh, Elizabeth A Stuart
{"title":"Charting the Waters of Sickle Cell Disease With Target Trial Emulation.","authors":"A Parker Ruhl, Matthew M Hsieh, Elizabeth A Stuart","doi":"10.1001/jamainternmed.2024.4435","DOIUrl":"10.1001/jamainternmed.2024.4435","url":null,"abstract":"","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":" ","pages":"1372-1373"},"PeriodicalIF":22.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1001/jamainternmed.2024.4320
Timothy S Anderson, Deborah Grady
{"title":"Glucagon-Like Peptide-1 Receptor Agonists and Suicidality-Two Important Pieces of Data but an Incomplete Puzzle.","authors":"Timothy S Anderson, Deborah Grady","doi":"10.1001/jamainternmed.2024.4320","DOIUrl":"10.1001/jamainternmed.2024.4320","url":null,"abstract":"","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":" ","pages":"1312-1313"},"PeriodicalIF":22.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1001/jamainternmed.2024.4739
Katie Fitzgerald Jones, Kelly Stolzmann, Jolie Wormwood, Jacquelyn Pendergast, Christopher J Miller, Michael Still, Barbara G Bokhour, Joseph Hanlon, Steven R Simon, Amy K Rosen, Amy M Linsky
Importance: Patient-directed educational materials are a promising implementation strategy to expand deprescribing reach and adoption, but little is known about the impact across medication groups with potentially different perceived risks.
Objective: To examine the impact of a patient-directed education intervention on clinician deprescribing of potentially low-benefit (proton pump inhibitors) or high-risk medications (high-dose gabapentin, diabetes agents with hypoglycemia risks).
Design, setting, and participants: This pragmatic multisite nonrandomized clinical trial took place at 3 geographically distinct US Veterans Affairs (VA) medical centers from April 2021 to October 2022. The total study sample was composed of the intervention cohort and the historical control cohort cared for by 103 primary care practitioners (PCPs).
Intervention: The primary intervention component was a medication-specific brochure, mailed during the intervention time frame to all eligible patients 2 to 3 weeks prior to upcoming primary care appointments. Patients seen by the same PCPs at the same sites 1 year prior to the study intervention served as controls.
Main outcome and measures: The primary binary outcome variable was deprescribing 6 months after the intervention, defined as complete cessation or any dose reduction of the target medication using VA pharmacy dispensing data.
Results: The total study sample included 5071 patients. The overall rate of deprescribing among the intervention cohort (n = 2539) was 29.5% compared with 25.8% among the controls (n = 2532). In an unadjusted model, the intervention cohort was statistically significantly more likely to have deprescribing (odds ratio [OR], 1.17 [95% CI, 1.03-1.33]; P = .02). In a multivariable logistic regression model nesting patients within PCPs within sites and controlling for patient and PCP characteristics, the odds of deprescribing in the intervention cohort were 1.21 times that of the control cohort (95% CI, 1.05-1.38; P = .008). The difference in deprescribing prevalence between the intervention and control cohorts (proton pump inhibitors: 29.4% vs 25.4%; gabapentin: 40.2% vs 36.2%; hypoglycemia risk: 27.3% vs 25.1%) did not statistically significantly differ by medication group (P = .90).
Conclusion and relevance: This nonrandomized clinical trial found that patient-directed educational materials provided prior to scheduled primary care appointments can effectively promote deprescribing for potentially low-benefit and high-risk medication groups.
{"title":"Patient-Directed Education to Promote Deprescribing: A Nonrandomized Clinical Trial.","authors":"Katie Fitzgerald Jones, Kelly Stolzmann, Jolie Wormwood, Jacquelyn Pendergast, Christopher J Miller, Michael Still, Barbara G Bokhour, Joseph Hanlon, Steven R Simon, Amy K Rosen, Amy M Linsky","doi":"10.1001/jamainternmed.2024.4739","DOIUrl":"10.1001/jamainternmed.2024.4739","url":null,"abstract":"<p><strong>Importance: </strong>Patient-directed educational materials are a promising implementation strategy to expand deprescribing reach and adoption, but little is known about the impact across medication groups with potentially different perceived risks.</p><p><strong>Objective: </strong>To examine the impact of a patient-directed education intervention on clinician deprescribing of potentially low-benefit (proton pump inhibitors) or high-risk medications (high-dose gabapentin, diabetes agents with hypoglycemia risks).</p><p><strong>Design, setting, and participants: </strong>This pragmatic multisite nonrandomized clinical trial took place at 3 geographically distinct US Veterans Affairs (VA) medical centers from April 2021 to October 2022. The total study sample was composed of the intervention cohort and the historical control cohort cared for by 103 primary care practitioners (PCPs).</p><p><strong>Intervention: </strong>The primary intervention component was a medication-specific brochure, mailed during the intervention time frame to all eligible patients 2 to 3 weeks prior to upcoming primary care appointments. Patients seen by the same PCPs at the same sites 1 year prior to the study intervention served as controls.</p><p><strong>Main outcome and measures: </strong>The primary binary outcome variable was deprescribing 6 months after the intervention, defined as complete cessation or any dose reduction of the target medication using VA pharmacy dispensing data.</p><p><strong>Results: </strong>The total study sample included 5071 patients. The overall rate of deprescribing among the intervention cohort (n = 2539) was 29.5% compared with 25.8% among the controls (n = 2532). In an unadjusted model, the intervention cohort was statistically significantly more likely to have deprescribing (odds ratio [OR], 1.17 [95% CI, 1.03-1.33]; P = .02). In a multivariable logistic regression model nesting patients within PCPs within sites and controlling for patient and PCP characteristics, the odds of deprescribing in the intervention cohort were 1.21 times that of the control cohort (95% CI, 1.05-1.38; P = .008). The difference in deprescribing prevalence between the intervention and control cohorts (proton pump inhibitors: 29.4% vs 25.4%; gabapentin: 40.2% vs 36.2%; hypoglycemia risk: 27.3% vs 25.1%) did not statistically significantly differ by medication group (P = .90).</p><p><strong>Conclusion and relevance: </strong>This nonrandomized clinical trial found that patient-directed educational materials provided prior to scheduled primary care appointments can effectively promote deprescribing for potentially low-benefit and high-risk medication groups.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT0429490.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":" ","pages":"1339-1346"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1001/jamainternmed.2024.4846
Christopher L Cai, Aaron S Kesselheim, Benjamin N Rome
{"title":"Estimated Savings Under the Medicare High-Value Drug List Model.","authors":"Christopher L Cai, Aaron S Kesselheim, Benjamin N Rome","doi":"10.1001/jamainternmed.2024.4846","DOIUrl":"10.1001/jamainternmed.2024.4846","url":null,"abstract":"","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":" ","pages":"1390-1392"},"PeriodicalIF":22.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1001/jamainternmed.2024.3586
Cynthia C Harper, Katherine Brown, Kavita Shah Arora
{"title":"Contraceptive Access in the US Post-Dobbs.","authors":"Cynthia C Harper, Katherine Brown, Kavita Shah Arora","doi":"10.1001/jamainternmed.2024.3586","DOIUrl":"10.1001/jamainternmed.2024.3586","url":null,"abstract":"","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":" ","pages":"1279-1280"},"PeriodicalIF":22.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1001/jamapsychiatry.2024.2862
Toshi A Furukawa, Pim Cuijpers
{"title":"Informant Effect on Placebo Response in Mental Disorders.","authors":"Toshi A Furukawa, Pim Cuijpers","doi":"10.1001/jamapsychiatry.2024.2862","DOIUrl":"10.1001/jamapsychiatry.2024.2862","url":null,"abstract":"","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":" ","pages":"1159"},"PeriodicalIF":22.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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