Thrombosis research最新文献

{"title":"Comparative outcomes of ultrasound-assisted catheter-directed thrombolysis between patients with acute and acute-on-chronic pulmonary embolism","authors":"Riccardo M. Fumagalli ,&nbsp;Conrad von Stempel ,&nbsp;William Pleming ,&nbsp;Frederikus A. Klok ,&nbsp;Stavros V. Konstantinides ,&nbsp;Nils Kucher ,&nbsp;Bhavin Rawal ,&nbsp;Luca Valerio ,&nbsp;Stefano Barco","doi":"10.1016/j.thromres.2025.109552","DOIUrl":"10.1016/j.thromres.2025.109552","url":null,"abstract":"<div><h3>Background</h3><div>Radiologic signs of chronic thrombi are present in approximately 20 % of patients with acute pulmonary embolism (PE). We assessed the effectiveness of ultrasound-assisted catheter-directed thrombolysis (USAT) in patients with acute PE with or without signs of chronic PE and the accuracy of radiologic parameters predicting chronic thromboembolic pulmonary hypertension (CTEPH).</div></div><div><h3>Methods</h3><div>Index CT scans of patients who underwent USAT for acute PE with right ventricular strain were reviewed by three radiologists blinded to clinical and hemodynamic outcomes. At least 3 validated radiological criteria of chronic thromboembolism defined acute-on-chronic PE. Changes in mean pulmonary arterial pressure (mPAP) 20 h after USAT and presence of post-PE impairment (PPEI) or CTEPH at 3–6 months were compared between patients with and without acute-on-chronic PE.</div></div><div><h3>Results</h3><div>Among 180 consecutive patients (median age 65 years), 31 (17 %) had acute-on-chronic PE. Absolute mPAP reduction was 11 (Q1-Q3: 5–17) mmHg in acute vs. 10 (Q1-Q3: 5–17) mmHg in acute-on-chronic PE from similar baseline mPAP. PPEI or CTEPH were recorded in 2.0 % of patients in the acute group vs. 13 % in the acute-on-chronic group (odds ratio 7.0, 95 %C.I. 1.4–40). Of 3 (1.7 %) patients diagnosed with CTEPH, all presented with ≥3 radiological criteria suggesting pre-existing CTEPH at index CT scan.</div></div><div><h3>Conclusions</h3><div>CT signs of chronic thromboembolism at the time of acute PE did not appear to influence the immediate hemodynamic response to USAT in most patients but may raise the suspicion of pre-existing CTEPH if ≥3 validated radiological criteria are present.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109552"},"PeriodicalIF":3.4,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absolute time-dependent risk of hospital-acquired venous thromboembolism in children","authors":"Maya K. Raad,&nbsp;Stephanie Prozora,&nbsp;E. Vincent S. Faustino","doi":"10.1016/j.thromres.2025.109553","DOIUrl":"10.1016/j.thromres.2025.109553","url":null,"abstract":"<div><h3>Background</h3><div>Absolute time-dependent risk of hospital-acquired venous thromboembolism (HA-VTE) is essential to evaluate the net clinical benefit of pharmacologic thromboprophylaxis. The multicenter Children's Hospital Acquired Thrombosis (CHAT) risk assessment model (RAM) identified risk factors for pediatric HA-VTE but was not designed to predict this risk. We aimed to predict the absolute time-dependent risk of HA-VTE in hospitalized children.</div></div><div><h3>Methods</h3><div>We conducted a single center case-cohort study of children ≤18 years old admitted from 2013 to 2022. Children with radiologically confirmed, symptomatic HA-VTE were considered cases. A 5 % random sample of eligible admissions formed the subcohort. Using Kaplan-Meier estimates and Cox regression with risk factors from the CHAT RAM and time to HA-VTE as outcome, we calculated the absolute time-dependent risk of HA-VTE of each child. Performance was assessed using area under the receiver operating characteristic curve (AUROC), calibration plot, and area under the precision-recall curve (AUPRC).</div></div><div><h3>Results</h3><div>We identified 81 children with HA-VTE from 23,287 admissions. Adolescent age, slightly limited mobility, and central venous catheter were associated with time to HA-VTE. Median absolute time-dependent risk of HA-VTE was 1.7 % (IQR: 1.0 %, 2.1 %) by day 12 of admission when the revised RAM performed best. AUROC by day 12 was 0.81 (95 % confidence interval, CI: 0.70, 0.93) with calibration slope of 1.13 (95 % CI: 0.38, 1.87), calibration intercept of 0.004 (95 % CI: −0.64, 0.65), and AUPRC of 0.04 (95 % CI: 0.004, 0.07).</div></div><div><h3>Conclusions</h3><div>We accurately predicted the absolute time-dependent risk of HA-VTE. Similar predictions should be developed for bleeding.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109553"},"PeriodicalIF":3.4,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FVIIa-AT complexes in patients with acute ischemic stroke: Impact on clinical outcomes","authors":"Marek Kachnic ,&nbsp;Martyna Matysiewicz ,&nbsp;Joanna Natorska ,&nbsp;Jan P. Bembenek ,&nbsp;Elżbieta Szczygieł-Pilut ,&nbsp;Anetta Undas","doi":"10.1016/j.thromres.2025.109551","DOIUrl":"10.1016/j.thromres.2025.109551","url":null,"abstract":"<div><h3>Background</h3><div>Plasma levels of activated factor VII-antithrombin complexes (FVIIa-AT) reflect indirectly tissue factor (TF)-FVII interaction. We investigated FVIIa-AT in acute ischemic stroke (AIS) and its prognostic value.</div></div><div><h3>Methods</h3><div>We prospectively studied 88 AIS patients (median age 75 years), of whom 67 (76.1 %) received thrombolysis. Plasma FVIIa-AT levels, fibrin clot properties, i.e. clot lysis time (CLT), fibrin clot permeability (Ks), and protein carbonyl (PC) levels were measured on admission, at 24 h, and at 3 months. Stroke-related mortality and functional outcomes (modified Rankin Scale, mRS) were assessed at 3 months.</div></div><div><h3>Results</h3><div>Baseline FVIIa-AT (median 134.7 (IQR, 118.2–149.8 pM)), correlated with age (<em>r</em> = 0.51; <em>p</em> &lt; 0.001), NIHSS (<em>r</em> = 0.54; <em>p</em> &lt; 0.001), Ks (<em>r</em> = 0.32; <em>p</em> = 0.002), CLT (<em>r</em> = 0.34; <em>p</em> = 0.001), PC (<em>r</em> = 0.36; <em>p</em> &lt; 0.001), and mRS at 3 months (<em>r</em> = 0.51; p &lt; 0.001). After 24 h, FVIIa-AT increased by 8.3 % (<em>p</em> &lt; 0.001) and correlated with NIHSS (<em>r</em> = 0.52; p &lt; 0.001), PC (<em>r</em> = 0.35; <em>p</em> = 0.001), and mRS (<em>r</em> = 0.59; p &lt; 0.001). At 24 h, thrombolysis had no impact on FVIIa-AT. After 3 months, FVIIa-AT decreased by 20.9 % compared to baseline (<em>p</em> &lt; 0.0001). Baseline and 24-hour FVIIa-AT levels increased the odds of hemorrhagic transformation at 48 h (OR = 1.62, 95 %CI 1.09–2.42 and OR = 1.46, 95 %CI 1.04–2.03) and mRS &gt; 2 at 3 months (OR = 1.48, 95 %CI 1.12–1.95 and OR = 1.61, 95 %CI 1.23–2.10, respectively). Stroke-related mortality was associated with FVIIa-AT solely at 24 h (OR = 1.59, 95 %CI 1.18–2.14).</div></div><div><h3>Conclusions</h3><div>FVIIa-AT levels are linked to acute stroke severity and worse clinical outcomes, in association with prothrombotic fibrin clot properties and enhanced protein carbonylation.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109551"},"PeriodicalIF":3.4,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Activation of the pentose phosphate pathway mitigates platelet storage lesions and improves platelet preservation quality” [Thromb. Res. 252 (2025) 109377]","authors":"Liujun Guo ,&nbsp;Chengrui Qian ,&nbsp;Chengyan Gao ,&nbsp;Hasiyati Heililahong ,&nbsp;Min Xin ,&nbsp;Lei Hang ,&nbsp;Can Lou ,&nbsp;Jiaming Li ,&nbsp;Xuefeng Wang ,&nbsp;Jing Dai ,&nbsp;Xuemei Fan ,&nbsp;Xiaohong Cai","doi":"10.1016/j.thromres.2025.109539","DOIUrl":"10.1016/j.thromres.2025.109539","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109539"},"PeriodicalIF":3.4,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombocytopenia in antiphospholipid syndrome: predictors, prognostic implications, and thrombotic risk in a large cohort study","authors":"David Galarza ,&nbsp;Massimo Radin ,&nbsp;Irene Cecchi ,&nbsp;Alessandro Morotti ,&nbsp;Isabella Russo ,&nbsp;Sofia Camerlo ,&nbsp;Alice Barinotti ,&nbsp;Roberta Fenoglio ,&nbsp;Savino Sciascia","doi":"10.1016/j.thromres.2025.109544","DOIUrl":"10.1016/j.thromres.2025.109544","url":null,"abstract":"<div><h3>Background</h3><div>Antiphospholipid syndrome (APS) is a multifaceted autoimmune disorder associated with thrombosis and pregnancy morbidity. Thrombocytopenia, a frequent manifestation of APS, presents unique clinical challenges due to its dual association with thrombotic and hemorrhagic risks. This study investigates the incidence, characteristics, and predictors of thrombocytopenia in a large cohort of antiphospholipid antibodies (aPL)-positive patients and its association with other clinical manifestations.</div></div><div><h3>Methods</h3><div>We conducted a multicenter retrospective cohort study from 2014 to 2024 involving 211 aPL-positive patients at San Giovanni Bosco and San Luigi Gonzaga Hospital, Turin, Italy. Data on demographic, laboratory, and clinical features were collected every six months or at the occurrence of new clinical events. Thrombocytopenia definitions excluded other etiologies. Laboratory and clinical evaluations included thrombosis risk factors, autoantibody profiles, and treatment regimens.</div></div><div><h3>Results</h3><div>Thrombocytopenia occurred in 42 patients (20 %), with varying severity: mild (33 %), moderate (38 %), and severe (29 %). Severe cases primarily exhibited platelet counts below 20 × 10^9/L. Patients with thrombocytopenia demonstrated higher rates of thrombotic events, venous recurrences, deep vein thrombosis, pulmonary embolism, and catastrophic APS (CAPS). Renal involvement was more frequent, while inflammatory manifestations (pericarditis, pleuritis, and arthralgia) were less common. Patients with thrombocytopenia showed higher frequency of anti-β2 glycoprotein I antibodies IgG positivity and leukopenia. Therapeutic interventions included increased use of steroids, intravenous immunoglobulins, mycophenolate, and rituximab. Thrombocytopenia was more prevalent in systemic APS diagnoses (21 % vs. 3 %).</div></div><div><h3>Conclusion</h3><div>Thrombocytopenia in APS patients, particularly in severe cases, correlates with heightened thrombotic risk and systemic manifestations. These findings highlight the importance of customized strategies that balance thrombosis prevention with bleeding risk, especially in complex cases.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109544"},"PeriodicalIF":3.4,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of patient-related outcome measures used for patients surviving a pulmonary embolism: A systematic review","authors":"Stian Ingemann-Molden ,&nbsp;Christina Krogner Caspersen ,&nbsp;Nanna Rolving ,&nbsp;Anette Arbjerg Højen ,&nbsp;Frederikus A. Klok ,&nbsp;Erik Lerkevang Grove ,&nbsp;Jane Andreasen","doi":"10.1016/j.thromres.2025.109543","DOIUrl":"10.1016/j.thromres.2025.109543","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Patients who survive a pulmonary embolism (PE) often suffer several negative long-term physical and mental consequences, limiting their ability to stay physically- and socially active ultimately deteriorating their quality of life. Patients with PE therefore need evidence-based rehabilitation, targeting what is important to each individual patient. Valid and reliable patient-reported outcome measures (PROMs) are crucial to help clinicians plan and track rehabilitation outcomes in a reliable manner.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;A systematic review to generate an overview over psychometric properties (reliability, validity, responsiveness, floor/ceiling effect and accessibility) of 34 PROMs used to assess PE, identified in a previous review by the research group.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A literature search was performed in PUBMED, CINAHL and EMBASE from inception to September 2024 and included psychometric studies of 34 specific PROMs. The evidence for each psychometric property was evaluated according to the COSMIN criteria for good measurement properties and graded according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach for systematic reviews. Methodological quality was assessed using the COSMIN Risk of Bias checklist for PROMs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The literature search yielded 3.801 records after removal of duplicates; 3.778 records were excluded based on title and abstract and further 10 articles were excluded during full-text reading leaving 13 articles evaluating the psychometric properties of PROMs. The Pulmonary Embolism Quality of life Questionnaire (PEmb-QoL) was assessed in 10 studies, showing very good internal consistency, reliability, criterion validity, construct validity, responsiveness and floor/ceiling effects. Structural validity for the PEmb-QoL was considered inadequate. One study found moderate evidence for the EQ-5D-5l showing adequate convergent construct validity. EQ-5D-5L also showed very good divergent construct validity, as well as good floor/ceiling effects and acceptability but inadequate structural validity. Low evidence for Perception of anticoagulation treatment questionnaire (PACT-Q) showed very good construct validity and internal consistency as well as adequate structural validity. Structural validity for the PACT-Q was acceptable, while content validity was doubtful and poor floor/ceiling effects. Finally moderate to high evidence for the Post-VTE functional status scale (PVFS) showing very good construct validity but inadequate structural validity and doubtful content validity.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Some aspects of psychometric properties has been assessed in four out of the 34 PROMs used to assess patients with PE. Future studies should strive towards assessing all psychometric properties of PROMs used both clinically and in research.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Implications&lt;/h3&gt;&lt;div&gt;The r","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109543"},"PeriodicalIF":3.4,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemostatic changes following ECMO circuit replacement in adult patients with COVID-19: An exploratory retrospective study","authors":"Bernhard Nagler ,&nbsp;Sabrina Thurner ,&nbsp;Peter Schellongowski ,&nbsp;Oliver Robak ,&nbsp;Alexander Hermann ,&nbsp;Thomas Staudinger ,&nbsp;Nina Buchtele","doi":"10.1016/j.thromres.2025.109542","DOIUrl":"10.1016/j.thromres.2025.109542","url":null,"abstract":"<div><h3>Background</h3><div>Extracorporeal membrane oxygenation (ECMO) is an important intervention for severe respiratory failure, yet coagulation abnormalities and circuit thrombosis remain significant challenges. Circuit exchanges are frequently performed to restore oxygenator function and mitigate ECMO-related coagulopathies, but optimal criteria for their indication remain unclear.</div></div><div><h3>Methods</h3><div>This retrospective analysis included adult patients with coronavirus disease 2019 associated acute respiratory distress syndrome (ARDS) receiving venovenous (VV) ECMO at a tertiary hospital between January 2020 and April 2023. The primary endpoint was the change in d-dimer level on the third day after a circuit exchange compared to the last value before the circuit exchange. Secondary analyses included parameters such as fibrinogen, platelet count, LDH, post‑oxygenator pO₂ and transmembrane pressure. Statistical comparisons were made using Wilcoxon-signed-rank tests and linear mixed models.</div></div><div><h3>Results</h3><div>Among 48 patients, 37 (77.1 %) underwent at least one coagulation-related circuit exchange, totalling 96 exchanges. D-dimer levels significantly decreased from 19 μg/ml (IQR 11–25) before exchange to 4 μg/ml (IQR 2–7) after exchange (<em>p</em> &lt; 0.001). Platelet counts increased significantly (<em>p</em> = 0.024), while LDH levels decreased (<em>p</em> = 0.001). No significant changes were observed in fibrinogen levels. A sharp increase in d-dimer prior to exchange correlated with subsequent decreases post-exchange (<em>R</em> = −0.66, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>ECMO circuit exchanges are associated with significant improvements in coagulation parameters, particularly d-dimer reduction, suggesting that d-dimer trends may serve as a key indicator for elective circuit replacement. Future prospective studies should refine exchange criteria to optimize patient outcomes while minimizing unnecessary interventions.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109542"},"PeriodicalIF":3.4,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet Thromboxane B2 overproduction associated with liver fibrosis severity in patients with MASLD","authors":"Francesco Baratta ,&nbsp;Nicholas Cocomello ,&nbsp;Guido Carpino ,&nbsp;Alessandra Colantoni ,&nbsp;Vittoria Cammisotto ,&nbsp;Simona Bartimoccia ,&nbsp;Valentina Castellani ,&nbsp;Diletta Overi ,&nbsp;Pierleone Lucatelli ,&nbsp;Evaristo Ettorre ,&nbsp;Roberto Carnevale ,&nbsp;Pasquale Pignatelli ,&nbsp;Daniele Pastori ,&nbsp;Maria Del Ben ,&nbsp;Eugenio Gaudio ,&nbsp;Giovambattista Desideri ,&nbsp;Francesco Violi","doi":"10.1016/j.thromres.2025.109540","DOIUrl":"10.1016/j.thromres.2025.109540","url":null,"abstract":"<div><h3>Background and aims</h3><div>Experimental study demonstrated that platelet cyclooxygenase-1 (COX-1) activation is implicated in the pathogenesis of metabolic dysfunction-associated steatosis liver disease (MASLD). However, the relationship between COX-1 activation and MASLD severity is still unclear. This study aimed to investigate platelet COX-1 activation in patients with MASLD.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study involving patients with biopsy-proven MASLD. Serum Thromboxane B₂ (TxB₂) levels was measured as a biomarker of ex vivo COX-1 activation potential and plasma sP-selectin as in vivo marker of platelet activation. Oxidative stress biomarkers included serum NOX2-derived peptide (sNOX2-dp) and hydrogen peroxide breakdown activity (HBA).</div></div><div><h3>Results</h3><div>TxB₂ serum levels increased progressively from MASLD simple steatosis (MASLD-SS) to steatohepatitis (MASH) (<em>p</em> = 0.017) and cirrhosis (<em>p</em> = 0.012). Serum TxB₂ (rS = 0.467, <em>p</em> &lt; 0.001) and sNOX2-dp (rS = 0.476, <em>p</em> &lt; 0.001) levels were positively correlated with fibrosis stage and inversely correlated with HBA (rS = −0.506, <em>p</em> &lt; 0.001). In addition, serum TxB₂ correlated with sP-selectin (rS = 0.428, <em>p</em> &lt; 0.001). Multivariate linear regression analysis revealed that TxB₂ associated with liver fibrosis stage (<em>p</em> = 0.007) and sNOX2-dp (<em>p</em> = 0.018).</div></div><div><h3>Conclusions</h3><div>This study provides evidence of platelet TxB₂ overproduction, which increases progressively from MASLD-SS to MASH and cirrhosis and is significantly associated with the degree of liver fibrosis. These findings support the hypothesis that platelet COX-1 activation is involved in the pathogenesis of MASLD.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109540"},"PeriodicalIF":3.4,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring anti-Xa activity and its correlation with C-Reactive Protein in Intensive Care Unit patients receiving a therapeutic dosage of nadroparin","authors":"Chaja N. Klein ,&nbsp;Freek van Gorp ,&nbsp;Matthieu C.J. Bosman ,&nbsp;Frederikus A. Klok ,&nbsp;Lenneke E.M. Haas","doi":"10.1016/j.thromres.2025.109541","DOIUrl":"10.1016/j.thromres.2025.109541","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"257 ","pages":"Article 109541"},"PeriodicalIF":3.4,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"von Willebrand factor and fibrin monomer - induced septic shock coagulation typing: Clinical comparison between thrombotic thrombocytopenic purpura - like syndrome and sepsis - induced coagulopathy with prognostic implications","authors":"Yi Liu ,&nbsp;Weili Zhao ,&nbsp;Qingqing Huang ,&nbsp;Xiaohong Wan ,&nbsp;Zongfang Ren ,&nbsp;Jinxi Yue ,&nbsp;Jin Yang ,&nbsp;Chen Han ,&nbsp;Bangting Zhang ,&nbsp;Haoling Zhang ,&nbsp;Wangzheqi Zhang ,&nbsp;Jingjing Zhang","doi":"10.1016/j.thromres.2025.109536","DOIUrl":"10.1016/j.thromres.2025.109536","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to investigate the pathological mechanisms, clinical features, and prognostic differences between thrombotic thrombocytopenic purpura-like syndrome (TTP-like syndrome) and sepsis-induced coagulopathy (SIC) in patients experiencing septic shock. The findings will provide a basis for subtype-guided diagnosis and treatment of coagulation disorders.</div></div><div><h3>Methods</h3><div>In this single-center retrospective cohort, 250 septic shock patients were divided into TTP-like syndrome (<em>n</em> = 101), SIC (<em>n</em> = 113), and control (<em>n</em> = 36) groups. Platelet count, vWF, FM, Sequential Organ Failure Assessment (SOFA) scores, and 28-day mortality were analyzed to compare coagulation phenotypes and outcomes.</div></div><div><h3>Results</h3><div>The TTP-like syndrome group was characterized by thrombocytopenia, with a median platelet (PLT) decline rate of 49.10 %. This group also exhibited markedly elevated vWF antigen levels, averaging 334.66 ± 80.04 %. Additionally, all patients in this group presented with multiple organ dysfunction syndrome (MODS) at a rate of 100 %. In contrast, the SIC group demonstrated more severe platelet consumption, with a median PLT of 42 × 10⁹/L, elevated fibrinogen degradation product (FM) levels (median 9.22 μg/mL), and a significantly higher 28-day mortality rate (35.40 % vs. 11.88 % in the TTP-like group). The patterns of organ injury varied between the two groups; the SIC group displayed more pronounced liver (SOFA 1.43 ± 1.08) and renal (SOFA 1.41 ± 1.47) involvement, while the TTP-like syndrome group predominantly exhibited circulatory (SOFA 2.46 ± 1.45) and respiratory (SOFA 2.53 ± 0.76) dysfunction. vWF and FM had some predictive value for 28-day mortality, with area under the curve values of 0.59 and 0.60, respectively.</div></div><div><h3>Conclusion</h3><div>TTP-like syndrome and SIC represent heterogeneous coagulation phenotypes in septic shock, with differences in biomarkers, organ injury, and prognosis. A vWF- and FM-guided subtype classification may improve individualized treatment strategies and prognostic management.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"256 ","pages":"Article 109536"},"PeriodicalIF":3.4,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145517454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}