Pub Date : 2024-12-12Print Date: 2024-12-17DOI: 10.4045/tidsskr.24.0480
Guttorm Raknes
{"title":"Protonpumpehemmarar mot spiserørskreft – til nytte eller skade?","authors":"Guttorm Raknes","doi":"10.4045/tidsskr.24.0480","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0480","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 15","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-11Print Date: 2024-12-17DOI: 10.4045/tidsskr.24.0383
Sigrid Anna Aalberg Vikjord, Even Hovig Fyllingen, Michael Krauss-Schilling
{"title":"Anatomisk variant i bronkialtreet.","authors":"Sigrid Anna Aalberg Vikjord, Even Hovig Fyllingen, Michael Krauss-Schilling","doi":"10.4045/tidsskr.24.0383","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0383","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 15","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-11Print Date: 2025-01-21DOI: 10.4045/tidsskr.24.0597
Hans Høegh
{"title":"Overlegen.","authors":"Hans Høegh","doi":"10.4045/tidsskr.24.0597","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0597","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-10Print Date: 2024-12-17DOI: 10.4045/tidsskr.24.0603
Åslaug Helland
{"title":"Nobelpris for bittesmå RNA-fragmenter.","authors":"Åslaug Helland","doi":"10.4045/tidsskr.24.0603","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0603","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 15","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-10Print Date: 2024-12-17DOI: 10.4045/tidsskr.24.0592
Knut Mork Skagen, Signe Flottorp
{"title":"Fredsprisen til overlevende etter atombomben.","authors":"Knut Mork Skagen, Signe Flottorp","doi":"10.4045/tidsskr.24.0592","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0592","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 15","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-10Print Date: 2024-12-17DOI: 10.4045/tidsskr.24.0319
Jostein Wågen Hauge, Cora Mjeldheim Wærp, Dag Hofsø, Sadollah Abedini
Background: Isolated central hypothyroidism, although rare, has been documented in case reports in patients with chronic kidney disease (CKD) treated with roxadustat, a novel agent in the treatment of renal anaemia.
Case presentation: A woman in her sixties with CKD stage 5 (not in dialysis) and no prior thyroid disease, was started on treatment with roxadustat 70 mg x 3 weekly for renal anaemia. During treatment, the patient developed classic signs of hypothyroidism (fatigue, dry skin, constipation, difficulty concentrating), with blood samples consistent with isolated central hypothyroidism. Roxadustat was discontinued awaiting further investigation. One month later the patient's symptoms had resolved, and six weeks later thyroid hormones had normalised. The patient was subsequently started on a regular erythropoiesis-stimulating agent.
Interpretation: This example highlights the importance of routine monitoring of thyroid function in patients with CKD receiving roxadustat. Importantly, the condition resolved upon discontinuation of the medication.
背景：孤立的中枢性甲状腺功能减退症，虽然罕见，但在慢性肾病（CKD）患者中已经有病例报告，这些患者使用罗沙司他（一种治疗肾性贫血的新药）治疗。病例介绍：一名60多岁的女性，CKD 5期（未透析），既往无甲状腺疾病，开始使用罗沙司他70mg x 3周治疗肾性贫血。治疗期间，患者出现甲状腺功能减退的典型症状（疲劳、皮肤干燥、便秘、注意力难以集中），血液样本符合孤立性中央性甲状腺功能减退。罗沙司他已停止生产，等待进一步调查。一个月后，患者症状消退，六周后甲状腺激素恢复正常。患者随后开始使用常规促红细胞生成素。解释：本例强调了接受罗沙司他治疗的CKD患者常规监测甲状腺功能的重要性。重要的是，这种情况在停药后就消失了。
{"title":"Central hypothyroidism caused by roxadustat.","authors":"Jostein Wågen Hauge, Cora Mjeldheim Wærp, Dag Hofsø, Sadollah Abedini","doi":"10.4045/tidsskr.24.0319","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0319","url":null,"abstract":"<p><strong>Background: </strong>Isolated central hypothyroidism, although rare, has been documented in case reports in patients with chronic kidney disease (CKD) treated with roxadustat, a novel agent in the treatment of renal anaemia.</p><p><strong>Case presentation: </strong>A woman in her sixties with CKD stage 5 (not in dialysis) and no prior thyroid disease, was started on treatment with roxadustat 70 mg x 3 weekly for renal anaemia. During treatment, the patient developed classic signs of hypothyroidism (fatigue, dry skin, constipation, difficulty concentrating), with blood samples consistent with isolated central hypothyroidism. Roxadustat was discontinued awaiting further investigation. One month later the patient's symptoms had resolved, and six weeks later thyroid hormones had normalised. The patient was subsequently started on a regular erythropoiesis-stimulating agent.</p><p><strong>Interpretation: </strong>This example highlights the importance of routine monitoring of thyroid function in patients with CKD receiving roxadustat. Importantly, the condition resolved upon discontinuation of the medication.</p>","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 15","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-06Print Date: 2024-12-07DOI: 10.4045/tidsskr.24.0639
Jeanette Varpen Unhjem
{"title":"Consequences of sexual boundary violations.","authors":"Jeanette Varpen Unhjem","doi":"10.4045/tidsskr.24.0639","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0639","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05Print Date: 2025-01-21DOI: 10.4045/tidsskr.24.0636
Trine Hessevik Paulsen, Elina Seppälä
{"title":"Mycoplasma pneumoniae – kompleks og gåtefull.","authors":"Trine Hessevik Paulsen, Elina Seppälä","doi":"10.4045/tidsskr.24.0636","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0636","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05Print Date: 2024-12-17DOI: 10.4045/tidsskr.24.0376
Anne Kveim Lie, Mekdes Gebremariam, Hanne Ochieng Lichtwarck, Elia Mmbaga, Andrea Solnes Miltenburg
{"title":"Kortvarig hospitering må planlegges nøye.","authors":"Anne Kveim Lie, Mekdes Gebremariam, Hanne Ochieng Lichtwarck, Elia Mmbaga, Andrea Solnes Miltenburg","doi":"10.4045/tidsskr.24.0376","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0376","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 15","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05Print Date: 2024-12-17DOI: 10.4045/tidsskr.24.0474
Gudrun Maria Waaler Bjørnelv, Yvonne Anne Michel
{"title":"Kostnadseffektivitetsanalyser – hvordan beregnes helsegevinster?","authors":"Gudrun Maria Waaler Bjørnelv, Yvonne Anne Michel","doi":"10.4045/tidsskr.24.0474","DOIUrl":"https://doi.org/10.4045/tidsskr.24.0474","url":null,"abstract":"","PeriodicalId":23123,"journal":{"name":"Tidsskrift for Den Norske Laegeforening","volume":"144 15","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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