Pub Date : 2016-01-01DOI: 10.19112/2413-6174-2016-17-4-11-15
E. Salnikova
{"title":"HUMAN NEEDS FOR ZINC AND ITS SOURCES (REVIEW)","authors":"E. Salnikova","doi":"10.19112/2413-6174-2016-17-4-11-15","DOIUrl":"https://doi.org/10.19112/2413-6174-2016-17-4-11-15","url":null,"abstract":"","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"75 1","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85759204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.19112/2413-6174-2016-17-2-3-9
A. L. Gorbachev
{"title":"MERCURY AS A MOST IMPORTANT ENVIRONMENTAL POLLUTANT: THE BODY LEVELS OF MERCURY AND OTHER TOXIC CHEMICAL ELEMENTS IN INDIGENOUS RESIDENTS OF NORTH-EAST RUSSIA","authors":"A. L. Gorbachev","doi":"10.19112/2413-6174-2016-17-2-3-9","DOIUrl":"https://doi.org/10.19112/2413-6174-2016-17-2-3-9","url":null,"abstract":"","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"67 1","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78903726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.19112/2413-6174-2016-17-2-36-44
K. Kudabayeva, G. Koshmaganbetova, N. Mickuviene, A. Skalny, M. Skalnaya
{"title":"ROLE OF TRACE ELEMENTS IMBALANCE IN DEVELOPMENT OF ENDEMIC GOITRE AMONG SCHOOLCHILDREN IN OIL AND GAS DISTRICTS OF THE WESTERN REGION OF THE REPUBLIC OF KAZAKHSTAN","authors":"K. Kudabayeva, G. Koshmaganbetova, N. Mickuviene, A. Skalny, M. Skalnaya","doi":"10.19112/2413-6174-2016-17-2-36-44","DOIUrl":"https://doi.org/10.19112/2413-6174-2016-17-2-36-44","url":null,"abstract":"","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"38 1","pages":"36-44"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73179674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.19112/2413-6174-2016-17-4-34-38
E. Stepanova, T. Morugova
{"title":"EFFECT OF IODINE DEFICIENCY ON THE HEALTH OF PREGNANT WOMEN AND THEIR CHILDREN IN THE REPUBLIC OF BASHKORTOSTAN","authors":"E. Stepanova, T. Morugova","doi":"10.19112/2413-6174-2016-17-4-34-38","DOIUrl":"https://doi.org/10.19112/2413-6174-2016-17-4-34-38","url":null,"abstract":"","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"54 3","pages":"34-38"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91494079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.19112/2413-6174-2016-17-3-36-40
A. Skalnaya, O. A. Skalnaya, Wu Cheng-Chi, V. Demidov
Accumulation of essential trace elements was studied in hair of women residing in People’s Republic of Bangladesh. Hair samples were taken from vegetarian and non-vegetarian rural women 18-60 y.o. living in Mymensingh district of Bangladesh. Hair essential trace elements (Co, Cr, Cu, Fe, I, Mn, Se, Zn) analysis by ICP-MS was provided and results were compared to Russian women reference ranges. The study has shown that investigated Bangladesh women population has extremely elevated hair Fe and Mn and low I and Cu in comparison to Russians. Also, vegetarianism has no influence on hair essential trace elements level in Bangladesh women, as opposed to Russian.
研究了居住在孟加拉国人民共和国的妇女头发中必需微量元素的积累。头发样本取自孟加拉国Mymensingh地区18-60岁的素食和非素食农村妇女。用ICP-MS对头发必需微量元素(Co, Cr, Cu, Fe, I, Mn, Se, Zn)进行了分析，并与俄罗斯女性参考范围进行了比较。研究表明，与俄罗斯人相比，被调查的孟加拉国妇女的头发铁和锰含量极高，而I和Cu含量较低。此外，与俄罗斯女性相比，素食主义对孟加拉国女性头发必需微量元素水平没有影响。
{"title":"HAIR ESSENTIAL TRACE ELEMENTS IN BANGLADESH WOMEN: INFLUENCE OF VEGETARIANISM","authors":"A. Skalnaya, O. A. Skalnaya, Wu Cheng-Chi, V. Demidov","doi":"10.19112/2413-6174-2016-17-3-36-40","DOIUrl":"https://doi.org/10.19112/2413-6174-2016-17-3-36-40","url":null,"abstract":"Accumulation of essential trace elements was studied in hair of women residing in People’s Republic of Bangladesh. Hair samples were taken from vegetarian and non-vegetarian rural women 18-60 y.o. living in Mymensingh district of Bangladesh. Hair essential trace elements (Co, Cr, Cu, Fe, I, Mn, Se, Zn) analysis by ICP-MS was provided and results were compared to Russian women reference ranges. The study has shown that investigated Bangladesh women population has extremely elevated hair Fe and Mn and low I and Cu in comparison to Russians. Also, vegetarianism has no influence on hair essential trace elements level in Bangladesh women, as opposed to Russian.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"1109 1","pages":"36-40"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76763149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.19112/2413-6174-2016-17-3-14-18
E. Salnikova
{"title":"ENVIRONMENTAL PROBLEMS AND THEIR INFLUENCE ON PUBLIC HEALTH (REVIEW)","authors":"E. Salnikova","doi":"10.19112/2413-6174-2016-17-3-14-18","DOIUrl":"https://doi.org/10.19112/2413-6174-2016-17-3-14-18","url":null,"abstract":"","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"85 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85047926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.19112/2413-6174-2016-17-4-44-48
O. A. Kravchenko, V. Maksin
{"title":"BEHAVIOUR AND ACCUMULATION FEATURES OF ZINC AND COPPER NANOAQUACITRATES IN HYDROECOSYSTEMS","authors":"O. A. Kravchenko, V. Maksin","doi":"10.19112/2413-6174-2016-17-4-44-48","DOIUrl":"https://doi.org/10.19112/2413-6174-2016-17-4-44-48","url":null,"abstract":"","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"11 1","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84690331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Meissner, B. Nebe, R. Beck, R. Guthoff, T. Noack
Background: To prevent posterior capsule opacification (PCO), we followed the hypothesis that calcium channel blockers (antagonists) interfere with integrin signaling and block cell adhesion in lens epithelial cells (LEC). In primary human LEC we found that the T channel antagonist mibefradil induces apoptosis which was accompanied with cell shape changes and loss of cell adhesion. Although T-type calcium channels are substantially present in membranes of freshly dispersed primary cultured hLEC and calcium currents are inhibited by mibefradil at concentrations of 10-8 M, the antiproliferative site of action of this drug remains unclear, since this feature is observed at concentrations 200-fold higher than that for calcium channel blockade. Methods: Epithelial cells of the human lens were dispersed by enzymatic treatment, recordings of membrane currents were performed using patch clamp technique in the whole cell configuration. Westernblot analysis was used for protein detection. Results: Total current elicited on depolarizing voltage steps from a holding potential of-80 mV was composed of inward (calcium) and outward (potassium) current. Outward current could be inhibited mostly by intracellular application of cesium ions. Currents in inward direction were activated fast (< 2 ms) and inactivated during the following 20 ms. They were characterized as calcium currents since the known calcium channel inhibitor nifedipine blocked these currents in a concentration-dependent manner. Using potassium in the pipette (145 mM) as main charge carrier, additionally a noninactivating potassium current and a voltage- and time-dependent potassium current which slowly inactivated (Kv) were observed (control). Adding mibefradil in concentrations from 10-6 M - 10-5 M to the bath solution, the inwardly directed and the non-inactivating current component were inhibited concentration-dependent. The Kv component was affected in a similar way, however, this component showed an increased inactivation behavior after application of mibefradil in the named concentrations. Conclusion: The total effects of mibefradil are significant for the calcium homeostasis since calcium current itself is inhibited but, moreover, the membrane is permanently depolarized up to 20 mV by the drug. Both effects may contribute to the observed reduced cell adhesion during mibefradil treatment. (Less)
{"title":"Importance of calcium and potassium currents in human lens epithelial cells (hLEC) and the effect of the calcium channel blocker mibefradil","authors":"A. Meissner, B. Nebe, R. Beck, R. Guthoff, T. Noack","doi":"10.5414/TEP24228","DOIUrl":"https://doi.org/10.5414/TEP24228","url":null,"abstract":"Background: To prevent posterior capsule opacification (PCO), we followed the hypothesis that calcium channel blockers (antagonists) interfere with integrin signaling and block cell adhesion in lens epithelial cells (LEC). In primary human LEC we found that the T channel antagonist mibefradil induces apoptosis which was accompanied with cell shape changes and loss of cell adhesion. Although T-type calcium channels are substantially present in membranes of freshly dispersed primary cultured hLEC and calcium currents are inhibited by mibefradil at concentrations of 10-8 M, the antiproliferative site of action of this drug remains unclear, since this feature is observed at concentrations 200-fold higher than that for calcium channel blockade. Methods: Epithelial cells of the human lens were dispersed by enzymatic treatment, recordings of membrane currents were performed using patch clamp technique in the whole cell configuration. Westernblot analysis was used for protein detection. Results: Total current elicited on depolarizing voltage steps from a holding potential of-80 mV was composed of inward (calcium) and outward (potassium) current. Outward current could be inhibited mostly by intracellular application of cesium ions. Currents in inward direction were activated fast (< 2 ms) and inactivated during the following 20 ms. They were characterized as calcium currents since the known calcium channel inhibitor nifedipine blocked these currents in a concentration-dependent manner. Using potassium in the pipette (145 mM) as main charge carrier, additionally a noninactivating potassium current and a voltage- and time-dependent potassium current which slowly inactivated (Kv) were observed (control). Adding mibefradil in concentrations from 10-6 M - 10-5 M to the bath solution, the inwardly directed and the non-inactivating current component were inhibited concentration-dependent. The Kv component was affected in a similar way, however, this component showed an increased inactivation behavior after application of mibefradil in the named concentrations. Conclusion: The total effects of mibefradil are significant for the calcium homeostasis since calcium current itself is inhibited but, moreover, the membrane is permanently depolarized up to 20 mV by the drug. Both effects may contribute to the observed reduced cell adhesion during mibefradil treatment. (Less)","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"25 1","pages":"228-234"},"PeriodicalIF":0.0,"publicationDate":"2007-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78232417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The activity of the enzyme glutathione peroxidase (SeGSHPx) has been suggested as an indicator of selenium status. The purpose of this study was to measure the activity of this enzyme in a large sample of healthy, free-living Canadians to determine normal distributions and the effects of age, smoking, and drinking habits, exercise, and the use of oral contraceptives (OCs) or estrogen replacement therapy. The population consisted of 386 self-selected subjects between the ages of 24 and 75. Erythrocyte SeGSHPx activity was 21.5 +or- 7 (Mean +or- SD) and 33.6 +or- 8U/g Hb and plasma activity was 226 +or- 31 and 214 +or- 38 U/L for males (n=239) and females (n=147), respectively. Erythrocyte activity was significantly higher in females and males (p0.01). The Se form of GSHPx accounted for 76% and 54% of total activity in plasma and erythrocytes, respectively. No differences due to age were seen in males, although plasma SeGSHPx, non-SeGSHPx, and total GSHPx activities were elevated in females 65 years of age and older. Cigarette smoking significantly elevated erythrocyte SeGSHPx and total activity in male subjects. This elevation did not vary with the amount smoked and was not seen in ex-smokers. Drinking elevated erythrocyte non-SeGSHPx and total activity in male subjects with the highest activity seen in drinkers who also smoked. No significant differences were seen with level of exercise except for a slight elevation with vigorous exercise. Estrogen use significantly elevated erythrocyte SeGSHPx, non-SeGSHPx, and total activities in both pre- and postmenopausal women. These data suggest that some lifestyle factors can have small but significant effects of GSHPx activity and must be controlled for when population-based surveys are being conducted.
{"title":"Glutathione peroxidase activity in a healthy Canadian population. Effects of age, smoking and drinking habits, exercise and oral contraceptive use.","authors":"M R L'abbe, M W Collins, K D Trick, P J Laffey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The activity of the enzyme glutathione peroxidase (SeGSHPx) has been suggested as an indicator of selenium status. The purpose of this study was to measure the activity of this enzyme in a large sample of healthy, free-living Canadians to determine normal distributions and the effects of age, smoking, and drinking habits, exercise, and the use of oral contraceptives (OCs) or estrogen replacement therapy. The population consisted of 386 self-selected subjects between the ages of 24 and 75. Erythrocyte SeGSHPx activity was 21.5 +or- 7 (Mean +or- SD) and 33.6 +or- 8U/g Hb and plasma activity was 226 +or- 31 and 214 +or- 38 U/L for males (n=239) and females (n=147), respectively. Erythrocyte activity was significantly higher in females and males (p0.01). The Se form of GSHPx accounted for 76% and 54% of total activity in plasma and erythrocytes, respectively. No differences due to age were seen in males, although plasma SeGSHPx, non-SeGSHPx, and total GSHPx activities were elevated in females 65 years of age and older. Cigarette smoking significantly elevated erythrocyte SeGSHPx and total activity in male subjects. This elevation did not vary with the amount smoked and was not seen in ex-smokers. Drinking elevated erythrocyte non-SeGSHPx and total activity in male subjects with the highest activity seen in drinkers who also smoked. No significant differences were seen with level of exercise except for a slight elevation with vigorous exercise. Estrogen use significantly elevated erythrocyte SeGSHPx, non-SeGSHPx, and total activities in both pre- and postmenopausal women. These data suggest that some lifestyle factors can have small but significant effects of GSHPx activity and must be controlled for when population-based surveys are being conducted.</p>","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"9 1","pages":"45-53"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22014500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Zinc depletion and menorrhagia in Nigerians using copper T-200 intrauterine device.","authors":"E A Wright, M M Kapu, U P Isichei","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"6 4","pages":"147-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22035969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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