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Transactions of the American Clinical and Climatological Association最新文献

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LEARNING TO PIVOT: DEVELOPING TALENT AND A CHAMPIONSHIP TEAM. 学习转向：培养人才和一支冠军球队。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2023-01-01
W Kimryn Rathmell

Developing the future leaders of biomedical science is fundamentally the most important role that we play in academic medicine. Similar to the path to elite championship athletics, the path begins early: engaging young minds to find excitement in science, enlightening medical students on the importance of curiosity, challenging faculty to achieve milestones and mature as leaders. Coaching strategies are critical and are different at each developmental stage. It may seem that it is becoming harder to entice young talent to pursue a career in biomedical research, or that the perpetually leaky pipeline is corroding to the point of hemorrhage. This perspective will explore the factors contributing to this loss, with flow further compromised by low input volume and high demand, and survey the coaching strategies that inspire the drive to pursue biomedical inquiry and the range of skills that must be developed to enable our workforce to thrive.

从根本上说，培养生物医学科学的未来领导者是我们在学术医学中发挥的最重要作用。与精英锦标赛田径之路类似，这条路很早就开始了：让年轻人在科学中找到激情，启发医学生好奇心的重要性，挑战教师实现里程碑并成为成熟的领导者。指导策略至关重要，在每个发展阶段都有所不同。吸引年轻人才从事生物医学研究似乎越来越困难，或者永远泄漏的管道正在腐蚀到出血的地步。这一观点将探讨造成这种损失的因素，低投入量和高需求会进一步影响流量，并调查激励人们进行生物医学研究的指导策略，以及必须培养的技能范围，以使我们的员工能够茁壮成长。
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引用次数: 0
PRESENT MEMBERS. 现任成员。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2023-01-01
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引用次数: 0
THE GORDON WILSON LECTURE: RAPID COVID-19 VACCINE DEVELOPMENT AND THE FUTURE OF VACCINOLOGY. 戈登·威尔森演讲：新冠肺炎疫苗的快速发展和疫苗技术的未来。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2023-01-01
Barney S Graham
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引用次数: 0
THE JEREMIAH METZGER LECTURE: TURNING GENES INTO MEDICINES: HIGHLIGHTS AND HURDLES IN THE DEVELOPMENT OF GENE THERAPY FOR GENETIC DISEASE. jeremiahmetzger讲座：将基因转化为药物：遗传病基因治疗发展的亮点和障碍。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2023-01-01
Katherine A High

The journey from in vitro transfer of genes into mammalian cells to approved gene therapy products has spanned decades. This manuscript summarizes hurdles encountered and obstacles overcome in the development of successful adeno-associated viral (AAV) vectors for hemophilia B and for an inherited retinal dystrophy caused by mutations in the RPE65 gene. In the case of hemophilia B, careful analysis of the first unsuccessful attempts led to the realization that the human immune response to AAV vectors was preventing durable expression; elucidation of the response to the recombinant virion led to strategies that enabled successful long-lasting gene transfer. For RPE65 deficiency, a key to success was development and validation of a novel clinical endpoint for a disease that previously lacked a pharmacologic treatment.

从将基因体外转移到哺乳动物细胞，到获得批准的基因治疗产品，这一过程已经跨越了几十年。本文总结了在开发成功的腺相关病毒（AAV）载体治疗血友病B和由RPE65基因突变引起的遗传性视网膜营养不良过程中遇到的障碍和克服的障碍。在血友病B的情况下，对第一次失败尝试的仔细分析导致人们意识到，人类对AAV载体的免疫反应正在阻止持久表达；对重组病毒粒子反应的阐明导致了能够成功进行长期基因转移的策略。对于RPE65缺乏症，成功的关键是开发和验证一种以前缺乏药物治疗的疾病的新临床终点。
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引用次数: 0
THE GORDON WILSON MEMORIAL LECTURE. 戈登·威尔逊纪念演讲。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2022-01-01
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引用次数: 0
THE THEODORE E. WOODWARD AWARD. 西奥多·伍德沃德奖。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2022-01-01
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引用次数: 0
CHARLES C. J. CARPENTER, MD: 1931 - 2020. 查尔斯·c·j·卡朋特，马里兰州:1931 - 2020。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2022-01-01
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引用次数: 0
CHEVES MCCORD SMYTHE, MD: 1924 - 2020. Cheves McCord smythe，马里兰州:1924 - 2020。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2022-01-01
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引用次数: 0
OFFICERS AND COUNCIL SPRING 2022. 官员和理事会2022年春季。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2022-01-01
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引用次数: 0
ALFRED F. PARISI, MD, FASE: 1937 - 2020. Alfred f. parisi, md, fase: 1937 - 2020。
Q2 Medicine
Transactions of the American Clinical and Climatological Association
Pub Date : 2022-01-01
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引用次数: 0
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