{"title":"Abnormal Expression of lncRNA SNHG7 in Dry Eye Disease and Its Effect on Human Conjunctival Epithelial Cells.","authors":"Shuang Liu, Guang Yang, Qingnan Li, Shaohua Tang","doi":"10.1620/tjem.2024.J134","DOIUrl":"https://doi.org/10.1620/tjem.2024.J134","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kangli Lu, Yujiao Huang, Zhicai Chen, Kuncheng Cai
{"title":"Effects of Neurotrophic Tyrosine Kinase Receptor Type I NTRK1 Polymorphism on Epidural Analgesia with Hydromorphone during Labor.","authors":"Kangli Lu, Yujiao Huang, Zhicai Chen, Kuncheng Cai","doi":"10.1620/tjem.2024.J135","DOIUrl":"https://doi.org/10.1620/tjem.2024.J135","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Light chain proximal tubulopathy (LCPT) is a rare type of paraprotein-related disease (PRDs) characterized by monoclonal free light chain (FLC) deposition in proximal tubular epithelial cells (PTECs). A diagnosis of LCPT requires identification of FLC deposition in PTECs; however, FLC luminescence defects in immunofluorescence staining using frozen tissue (IF-F), regarded as "masked LCPT", are occasionally encountered. We describe two cases of focal masked LCPT in monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM) diagnosed by IF in formalin-fixed, paraffin-embedded tissue sections following pronase digestion (IF-P) rather than by IF-F. Case 1 was a 66-year-old woman who exhibited renal dysfunction with IgG-λ monoclonal proteinemia, and Case 2 was a 69-year-old man who exhibited renal dysfunction with IgG-κ type monoclonal proteinemia. In both cases, renal pathology showed focal tubular damage consisted of swelling and desquamation of PTECs. FLC deposition in PTECs was detectable by IF-P but not by IF-F. Consequently, an appropriate diagnosis by IF-P led the patients to receive chemotherapy immediately. These two cases indicate that LCPT can be present even if tubular injury is focal and PRD is not severe. According to a literature review of 33 cases, including our 2 cases, focal LCPT complicated by MGUS/SMM is relative rare. In PRD, evaluation with IF-P is desirable for assessing LCPT when FLC deposition is undetected by IF-F despite characteristic degenerative PTECs. We consider that early and definitive diagnosis of LCPT by IF-P rather than IF-F might result in favorite outcome since physicians could smoothly decide treatment strategy.
{"title":"Focal Light Chain Proximal Tubulopathy Complicated by Monoclonal Gammopathy of Undetermined Significance/Smoldering Multiple Myeloma Successfully Diagnosed by Immunofluorescence on Pronase-Digested Paraffin Section: Reports of Two Cases and Review of the Literature.","authors":"Tetsuya Abe, Yukihiro Wada, Kazuhiro Takeuchi, Ryota Uchitsubo, Shun Sakurabayashi, Sayumi Kawamura, Mariko Kamata, Shokichi Naito, Togo Aoyama, Akira Shimizu, Yasuo Takeuchi","doi":"10.1620/tjem.2024.J047","DOIUrl":"10.1620/tjem.2024.J047","url":null,"abstract":"<p><p>Light chain proximal tubulopathy (LCPT) is a rare type of paraprotein-related disease (PRDs) characterized by monoclonal free light chain (FLC) deposition in proximal tubular epithelial cells (PTECs). A diagnosis of LCPT requires identification of FLC deposition in PTECs; however, FLC luminescence defects in immunofluorescence staining using frozen tissue (IF-F), regarded as \"masked LCPT\", are occasionally encountered. We describe two cases of focal masked LCPT in monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM) diagnosed by IF in formalin-fixed, paraffin-embedded tissue sections following pronase digestion (IF-P) rather than by IF-F. Case 1 was a 66-year-old woman who exhibited renal dysfunction with IgG-λ monoclonal proteinemia, and Case 2 was a 69-year-old man who exhibited renal dysfunction with IgG-κ type monoclonal proteinemia. In both cases, renal pathology showed focal tubular damage consisted of swelling and desquamation of PTECs. FLC deposition in PTECs was detectable by IF-P but not by IF-F. Consequently, an appropriate diagnosis by IF-P led the patients to receive chemotherapy immediately. These two cases indicate that LCPT can be present even if tubular injury is focal and PRD is not severe. According to a literature review of 33 cases, including our 2 cases, focal LCPT complicated by MGUS/SMM is relative rare. In PRD, evaluation with IF-P is desirable for assessing LCPT when FLC deposition is undetected by IF-F despite characteristic degenerative PTECs. We consider that early and definitive diagnosis of LCPT by IF-P rather than IF-F might result in favorite outcome since physicians could smoothly decide treatment strategy.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"53-60"},"PeriodicalIF":1.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The 2024 Noto Peninsula Earthquake, which reached a maximum intensity of 7, led to the deterioration of critical services including electricity, water, communication, and roads, resulting in 241 fatalities. The medical response of pharmacists during disasters has gained attention since the 2011 Great East Japan Earthquake. However, few studies have evaluated the challenges that hospital pharmacy departments face during disasters. T.T., the author, supported the hospital pharmacy department of the Anamizu General Hospital from February 2 to 4, 2024. He handled medication dispensing for inpatients, provided medication and instructions to outpatients, and reported to the local coordination headquarters. Furthermore, he stayed overnight in the department to handle on-call activities. Daily tasks included reporting and information sharing with the coordination headquarters. Regarding pharmacist support activities in medical facilities, challenges arose from the malfunctioning of automated tablet dispensing machines after the earthquake, worsening dispensing conditions and pharmaceutical supply issues. To avoid these problems, pharmacists should provide swift and continuous medical support until automated tablet dispensing machines' systems are restored after an earthquake. Additionally, it is considered beneficial for medical institutions to include in their business continuity plans a stockpile of medicines that can last for 7 days, as preparation for coping with earthquakes and similar emergencies. The findings of this report could be useful to all countries facing the possibility of disasters.
{"title":"Disaster Pharmacists' Support and Challenges Faced by Hospital Pharmacy Departments in the Disaster Response for the 2024 Noto Peninsula Earthquake.","authors":"Tatsuya Tai, Masahiro Watanabe, Sayaka Yamashita, Takahiro Motoki, Kazunori Yamaguchi, Hiroaki Tanaka, Shinji Kosaka","doi":"10.1620/tjem.2024.J046","DOIUrl":"10.1620/tjem.2024.J046","url":null,"abstract":"<p><p>The 2024 Noto Peninsula Earthquake, which reached a maximum intensity of 7, led to the deterioration of critical services including electricity, water, communication, and roads, resulting in 241 fatalities. The medical response of pharmacists during disasters has gained attention since the 2011 Great East Japan Earthquake. However, few studies have evaluated the challenges that hospital pharmacy departments face during disasters. T.T., the author, supported the hospital pharmacy department of the Anamizu General Hospital from February 2 to 4, 2024. He handled medication dispensing for inpatients, provided medication and instructions to outpatients, and reported to the local coordination headquarters. Furthermore, he stayed overnight in the department to handle on-call activities. Daily tasks included reporting and information sharing with the coordination headquarters. Regarding pharmacist support activities in medical facilities, challenges arose from the malfunctioning of automated tablet dispensing machines after the earthquake, worsening dispensing conditions and pharmaceutical supply issues. To avoid these problems, pharmacists should provide swift and continuous medical support until automated tablet dispensing machines' systems are restored after an earthquake. Additionally, it is considered beneficial for medical institutions to include in their business continuity plans a stockpile of medicines that can last for 7 days, as preparation for coping with earthquakes and similar emergencies. The findings of this report could be useful to all countries facing the possibility of disasters.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"49-52"},"PeriodicalIF":16.4,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of 15 Years of Continuous Treatment with Bisphosphonate on Japanese Postmenopausal Osteoporosis Patients: An Observational Study","authors":"Kousuke Iba, Megumi Hanaka, Makoto Emori, Kenichi Takashima, Atsushi Teramoto, Junichi Takada","doi":"10.1620/tjem.2024.J124","DOIUrl":"10.1620/tjem.2024.J124","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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