Pub Date : 2026-01-22Epub Date: 2025-06-05DOI: 10.1620/tjem.2025.J067
Anıl Orhan, Süleyman Demiryas, Engin Hatipoğlu, Karolin Yanar, Nuray Kepil, Salih Pekmezci
The potential hemostatic effects of cyanoacrylate are well-known, but the histopathological effects on application sites are not clearly established. This study aims to understand the histopathological and biochemical parameters of cyanoacrylate application during the early periods of liver traumas. For this purpose, Wistar albino rats weighing 250-300 g were divided into five groups, and liver lacerations on liver lobes were created in study groups. During the study, hematocrit levels during the pre-operative phase and before sacrification, duration of bleeding, post-operative adhesions of intraabdominal compartments, levels of biochemical markers such as hydroxyproline, collagen, matrix metalloproteinase, and histopathological evaluation of liver regeneration were taken into consideration. Results revealed fibrin sealant and cyanoacrylate managed to achieve better hemostasis compared to mechanical compression and regenerated cellulose. Peritoneal Adhesion Scores of regenerated cellulose and cyanoacrylate were higher compared to mechanical compression and fibrin sealant. Histopathologically, all groups had similar levels of fibrosis, only slightly lesser in the mechanical compression group. Biochemical evaluations showed regenerated cellulose and cyanoacrylate had elevated levels of hydroxyproline, collagen I and III. In conclusion, our study demonstrated that cyanoacrylate was as effective as other tissue sealants in achieving hemostasis, and did not increase fibrosis in the early stages of liver regeneration.
{"title":"Cyanoacrylate is still an Effective Surgical Strategy for Homeostasis: A Rodent Model of Liver Trauma and Evaluation of Early Wound Healing.","authors":"Anıl Orhan, Süleyman Demiryas, Engin Hatipoğlu, Karolin Yanar, Nuray Kepil, Salih Pekmezci","doi":"10.1620/tjem.2025.J067","DOIUrl":"10.1620/tjem.2025.J067","url":null,"abstract":"<p><p>The potential hemostatic effects of cyanoacrylate are well-known, but the histopathological effects on application sites are not clearly established. This study aims to understand the histopathological and biochemical parameters of cyanoacrylate application during the early periods of liver traumas. For this purpose, Wistar albino rats weighing 250-300 g were divided into five groups, and liver lacerations on liver lobes were created in study groups. During the study, hematocrit levels during the pre-operative phase and before sacrification, duration of bleeding, post-operative adhesions of intraabdominal compartments, levels of biochemical markers such as hydroxyproline, collagen, matrix metalloproteinase, and histopathological evaluation of liver regeneration were taken into consideration. Results revealed fibrin sealant and cyanoacrylate managed to achieve better hemostasis compared to mechanical compression and regenerated cellulose. Peritoneal Adhesion Scores of regenerated cellulose and cyanoacrylate were higher compared to mechanical compression and fibrin sealant. Histopathologically, all groups had similar levels of fibrosis, only slightly lesser in the mechanical compression group. Biochemical evaluations showed regenerated cellulose and cyanoacrylate had elevated levels of hydroxyproline, collagen I and III. In conclusion, our study demonstrated that cyanoacrylate was as effective as other tissue sealants in achieving hemostasis, and did not increase fibrosis in the early stages of liver regeneration.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"9-17"},"PeriodicalIF":1.6,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cimetidine is effective for treating periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome, primarily in children, and is covered by public insurance in Japan. However, as demand for gastric ulcer treatment declines, cimetidine production has been restricted, raising concerns about supply for pediatric patients. We analyzed Japanese prescription trends in adults and children using publicly available data. Specifically, national reimbursement data were used to assess annual cimetidine prescription volumes by age group and pediatric share. Chronological changes were examined based on original formulation supply. In the database, 11 and 6 cimetidine products (including discontinued stock) were available for outpatient and in-hospital dispensing, respectively. Annually, 1.01 million and 80,000 cimetidine tablets (200-mg equivalents) were dispensed for patients under 15 years in outpatient and in-hospital settings, respectively. No inpatient prescriptions were recorded. Pediatric prescriptions peaked at ages 5-9 years, differing from adult trends, and accounted for 2.5% of total prescriptions. Although overall dispensing volumes are declining, pediatric prescriptions are increasing. Despite overall demand decreasing, approximately 1 million 200-mg cimetidine tablets are needed annually for use in children, and pediatric demand is increasing. Therefore, securing production of this new indication is essential.
{"title":"Cimetidine for Pediatric Use in Japan: Rising Prescriptions for a New Indication.","authors":"Karin Oshima, Eisuke Inage, Shun Toriumi, Kenji Oishi, Hiromichi Yamada, Yosuke Baba, Takahiro Kudo, Yoshikazu Ohtsuka, Ryuta Nishikomori, Hidefumi Nakamura, Nobuaki Michihata, Hiromichi Shoji","doi":"10.1620/tjem.2025.J075","DOIUrl":"10.1620/tjem.2025.J075","url":null,"abstract":"<p><p>Cimetidine is effective for treating periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome, primarily in children, and is covered by public insurance in Japan. However, as demand for gastric ulcer treatment declines, cimetidine production has been restricted, raising concerns about supply for pediatric patients. We analyzed Japanese prescription trends in adults and children using publicly available data. Specifically, national reimbursement data were used to assess annual cimetidine prescription volumes by age group and pediatric share. Chronological changes were examined based on original formulation supply. In the database, 11 and 6 cimetidine products (including discontinued stock) were available for outpatient and in-hospital dispensing, respectively. Annually, 1.01 million and 80,000 cimetidine tablets (200-mg equivalents) were dispensed for patients under 15 years in outpatient and in-hospital settings, respectively. No inpatient prescriptions were recorded. Pediatric prescriptions peaked at ages 5-9 years, differing from adult trends, and accounted for 2.5% of total prescriptions. Although overall dispensing volumes are declining, pediatric prescriptions are increasing. Despite overall demand decreasing, approximately 1 million 200-mg cimetidine tablets are needed annually for use in children, and pediatric demand is increasing. Therefore, securing production of this new indication is essential.</p>","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":"3-8"},"PeriodicalIF":1.6,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of MALAT1 in the Progression of ACLF via the miR-141-3p/TGFB2 Axis and Its Association with Patient Prognosis.","authors":"Yan Qiao, Di Wu, Hua Jiang, Yuan Li, Defu Zhang","doi":"10.1620/tjem.2025.J144","DOIUrl":"https://doi.org/10.1620/tjem.2025.J144","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Diagnostic Value of miR-142-3p in Pediatric Acute Respiratory Distress Syndromes and Its Effects on Human Lung Epithelial Cells.","authors":"Wenjing Yan, Jianzhu He, Yangping Zhou, Jian Zhu","doi":"10.1620/tjem.2025.J142","DOIUrl":"https://doi.org/10.1620/tjem.2025.J142","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Comprehensive High-Quality Nursing on Pulmonary Function and Neurological Function in Patients with Stroke Combined with Lung Infection: A Randomized Controlled Trial.","authors":"Yanfei Xu, Xuejing Jin","doi":"10.1620/tjem.2025.J153","DOIUrl":"https://doi.org/10.1620/tjem.2025.J153","url":null,"abstract":"","PeriodicalId":23187,"journal":{"name":"Tohoku Journal of Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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