Pub Date : 2019-09-17DOI: 10.1201/9780203735398-75
Bert Volger
Introductory information Name of the submitting Party/observer Crop Life International (CLI) on behalf of Makhteshim Agan Industries (MAI) Contact details (name, telephone, e-mail) of the submitting Party/observer Bert Volger, Consultant for Makhteshim Agan Industries (MAI) 1087 Heartsease Drive West Chester, PA 19382 bertvolger@comcast.net Chemical name (as used by the POPs Review Committee) Endosulfan
介绍信息提交方/观察员代表Makhteshim Agan Industries (MAI)的Crop Life International (CLI)提交方/观察员的联系方式(姓名，电话，电子邮件)Bert Volger, Makhteshim Agan Industries (MAI) 1087 Heartsease Drive West Chester, PA 19382 bertvolger@comcast.net化学名称(由POPs审查委员会使用)硫丹
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In 1994, the MAK value for ethylene glycol monoethyl ether acetate was established at 5 ml/m3 by analogy to the MAK value for ethylene glycol monoethyl ether. Since the MAK value for ethylene glycol monoethyl ether was re-evaluated in 2007, a review of the MAK value for ethylene glycol monoethyl ether acetate has also become necessary. In humans, ethylene glycol monoethyl ether acetate is deacetylated to ethylene glycol monoethyl ether with a half-life of 8 to 11 minutes (see documentation “2Ethoxyethanol, 2-Ethoxyethyl acetate” 1998, a translation of the 1994 German) and metabolized further to form the critical metabolite ethoxyacetic acid, which accumulates in the human body and is considered to be responsible for the haematotoxicity and reproductive toxicity. The profile of ethylene glycol monoethyl ether acetate is similar to that of ethylene glycol monoethyl ether; only the irritation potential to the skin and eyes is somewhat lower. It is therefore justified to assess the data of ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate together. For this reason, the data for ethylene glycol monoethyl ether acetate were documented together with those for ethylene glycol monoethyl ether in the supplement “ethylene glycol monoethyl ether” (documentation “Ethylene glycol monoethyl ether” 2008).
{"title":"Ethylene Glycol Monoethyl Ether Acetate","authors":"R. Ryan","doi":"10.2307/3433415","DOIUrl":"https://doi.org/10.2307/3433415","url":null,"abstract":"In 1994, the MAK value for ethylene glycol monoethyl ether acetate was established at 5 ml/m3 by analogy to the MAK value for ethylene glycol monoethyl ether. Since the MAK value for ethylene glycol monoethyl ether was re-evaluated in 2007, a review of the MAK value for ethylene glycol monoethyl ether acetate has also become necessary. In humans, ethylene glycol monoethyl ether acetate is deacetylated to ethylene glycol monoethyl ether with a half-life of 8 to 11 minutes (see documentation “2Ethoxyethanol, 2-Ethoxyethyl acetate” 1998, a translation of the 1994 German) and metabolized further to form the critical metabolite ethoxyacetic acid, which accumulates in the human body and is considered to be responsible for the haematotoxicity and reproductive toxicity. The profile of ethylene glycol monoethyl ether acetate is similar to that of ethylene glycol monoethyl ether; only the irritation potential to the skin and eyes is somewhat lower. It is therefore justified to assess the data of ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate together. For this reason, the data for ethylene glycol monoethyl ether acetate were documented together with those for ethylene glycol monoethyl ether in the supplement “ethylene glycol monoethyl ether” (documentation “Ethylene glycol monoethyl ether” 2008).","PeriodicalId":23188,"journal":{"name":"Toxicology Desk Reference","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85457084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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