Pub Date : 1933-04-01DOI: 10.1001/ARCHINTE.1933.00150230086003
H. M. Thomas
Hypertrophic pulmonary osteo-arthropathy, as the syndrome is commonly designated in this country, has recently been observed under circumstances different from any heretofore described. A patient whose history I shall give in some detail returned to the clinic following an operation of subtotal thyroidectomy, presenting most exaggerated clubbed fingers and swelling of the lower part of the legs. Roentgenographic studies of the bones revealed a remarkable picture of subperiosteal new bone formation, involving most of the long bones of the skeleton, but showing a change in the bones of the hands which had not been seen by the clinicians or the roentgenologists at the Johns Hopkins Hospital. Since finding in an article by Holthusen 1 the print of an x-ray picture of a hand showing similar changes, I have come across quite a number of articles, particularly in the German literature, which discuss this condition at great length. The cause of
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Pub Date : 1932-12-03DOI: 10.1001/JAMA.1932.02740750008003
G. Minot
Pernicious anemia has been demonstrated by Castle and his associates 1 to be a disorder which they have considered a "conditioned deficiency" disease, to indicate that the deficiency syndrome is the result not of a deficient diet but of a deficient utilization of a normal diet owing to a specific defect in the afflicted individual. They have shown that these patients in relapse lack an "intrinsic factor" secreted by the normal stomach, which when properly brought in contact with an "extrinsic factor," namely, appropriate food, causes material to be formed which is necessary for normal blood production. Like all deficiency disorders, whether due to a lack of a hormone, a vitamin, a mineral or other sustances, treatment must consist in supplying the deficient factor on a quantitative basis. In pernicious anemia the degree of deficiency will vary according to: The degree of deficiency of the intrinsic factor (complete or partial).
{"title":"The Importance of the Treatment of Pernicious Anemia on a Quantitative Basis.","authors":"G. Minot","doi":"10.1001/JAMA.1932.02740750008003","DOIUrl":"https://doi.org/10.1001/JAMA.1932.02740750008003","url":null,"abstract":"Pernicious anemia has been demonstrated by Castle and his associates 1 to be a disorder which they have considered a \"conditioned deficiency\" disease, to indicate that the deficiency syndrome is the result not of a deficient diet but of a deficient utilization of a normal diet owing to a specific defect in the afflicted individual. They have shown that these patients in relapse lack an \"intrinsic factor\" secreted by the normal stomach, which when properly brought in contact with an \"extrinsic factor,\" namely, appropriate food, causes material to be formed which is necessary for normal blood production. Like all deficiency disorders, whether due to a lack of a hormone, a vitamin, a mineral or other sustances, treatment must consist in supplying the deficient factor on a quantitative basis. In pernicious anemia the degree of deficiency will vary according to: The degree of deficiency of the intrinsic factor (complete or partial).","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"15 10","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"1932-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91513892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Importance of the Treatment of Pernicious Anemia on a Quantitative Basis.","authors":"G R Minot","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"48 ","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"1932-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194434/pdf/tacca200001-0082.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29743849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Osteomalacia-Report of a Case.","authors":"R R Snowden","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"48 ","pages":"54-61"},"PeriodicalIF":0.0,"publicationDate":"1932-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194439/pdf/tacca200001-0105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29743851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Some Little Appreciated Aspects of Malignant Lymphoma.","authors":"H Jackson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"48 ","pages":"126-37"},"PeriodicalIF":0.0,"publicationDate":"1932-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194446/pdf/tacca200001-0177.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29745615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unroofing of Pulmonary Tuberculous Cavities.","authors":"E H Bruns, J Casper","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"48 ","pages":"185-207"},"PeriodicalIF":0.0,"publicationDate":"1932-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194429/pdf/tacca200001-0236.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29745621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adherent Pericardium and Pick's Syndrome. An Autopsy Study.","authors":"H B Sprague, H A Burch, P D White","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"48 ","pages":"260-75"},"PeriodicalIF":0.0,"publicationDate":"1932-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194444/pdf/tacca200001-0311.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29745626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dextrocardia: A Report of Six Cases, Four Presenting Pulmonary Complications, Two of Which Present Marked Bronchiectasis.","authors":"J J Lloyd","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"48 ","pages":"138-46"},"PeriodicalIF":0.0,"publicationDate":"1932-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194447/pdf/tacca200001-0189.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29745616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accessory Lobes of the Human Lungs.","authors":"W B Soper","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"48 ","pages":"160-8"},"PeriodicalIF":0.0,"publicationDate":"1932-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194448/pdf/tacca200001-0211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29745618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acropachy, or Secondary Subperiosteal New-Bone Formation.","authors":"H M Thomas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23190,"journal":{"name":"Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association","volume":"48 ","pages":"208-28"},"PeriodicalIF":0.0,"publicationDate":"1932-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194451/pdf/tacca200001-0259.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29745622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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