{"title":"Clinical Profile and Outcome of Young Patients with Extrahepatic Biliary Obstruction at A High-Volume Tertiary Care Centre in Northern India","authors":"Ravikant Thakur","doi":"10.7869/tg.616","DOIUrl":"https://doi.org/10.7869/tg.616","url":null,"abstract":"","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90825031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Gastroparesis with its varied etiology is one of the major health issues in India. Poor correlation between delayed gastric emptying and its symptoms is well-known. This study was planned to evaluate the proportion of confirmed gastroparesis by scintigraphy among patients with suggestive clinical features, their underlying aetiologies and clinical profiling in a real-world setting in India. Settings and Design : Patients clinically diagnosed with gastroparesis, presenting varyingdegreesofsymptoms for at least 12-weeks, were enrolled in this multic-entric,cross-sectional, clinico-epidemiological study. Results : Overall, 196/201 enrolled patients underwent gastric scintigraphy; 88 (45%) were found to be scintigraphically positive and 108 (55%) patients were only clinically positive. Underlying etiologies of gastroparesis were idiopathic (51.2%), type-2 diabetes (44.8%), type-1 diabetes (2.5%) and psychological conditions (1.5%). Most patients presented symptoms like postprandial fullness (75.6%), bloating (50.7%), abdominal pain (45.3%), nausea (41.3%), abdominal discomfort (40.3%), early satiety (37.8%) and vomiting (17.9%) of moderate severity. Common dietary risk factors were fatty diet (66.7%), fiber-rich food (57.7%) and carbonated drinks (18.9%). Weight loss (6.5%), esophagitis (5.5%) and electrolyte disturbances (0.5%) were the associated complications. About 89.8% were on proton-pump inhibitors, followed by prokinetics (51.8%) and antiemetics (8.4%). The mean PAGI-QoL score was 3.6 ± 0.94, suggesting a moderate effect of gastroparesis on QoL. Conclusion : Poor correlation exists between gastric scintigraphy and gastrointestinal symptoms, thus reiterating the significance of the clinical diagnosis of gastroparesis, especially in diabetes. Only about half of the patients were prescribed prokinetics, emphasizing the need for appropriate pharmacotherapy using prokinetics for holistic management of gastroparesis.
{"title":"Correlation of Gastric Scintigraphy and Clinical Symptoms in the Diagnosis of Gastroparesis and its Impact on Quality of Life: A Pan India Real World Study","authors":"R. R","doi":"10.7869/tg.618","DOIUrl":"https://doi.org/10.7869/tg.618","url":null,"abstract":"Background : Gastroparesis with its varied etiology is one of the major health issues in India. Poor correlation between delayed gastric emptying and its symptoms is well-known. This study was planned to evaluate the proportion of confirmed gastroparesis by scintigraphy among patients with suggestive clinical features, their underlying aetiologies and clinical profiling in a real-world setting in India. Settings and Design : Patients clinically diagnosed with gastroparesis, presenting varyingdegreesofsymptoms for at least 12-weeks, were enrolled in this multic-entric,cross-sectional, clinico-epidemiological study. Results : Overall, 196/201 enrolled patients underwent gastric scintigraphy; 88 (45%) were found to be scintigraphically positive and 108 (55%) patients were only clinically positive. Underlying etiologies of gastroparesis were idiopathic (51.2%), type-2 diabetes (44.8%), type-1 diabetes (2.5%) and psychological conditions (1.5%). Most patients presented symptoms like postprandial fullness (75.6%), bloating (50.7%), abdominal pain (45.3%), nausea (41.3%), abdominal discomfort (40.3%), early satiety (37.8%) and vomiting (17.9%) of moderate severity. Common dietary risk factors were fatty diet (66.7%), fiber-rich food (57.7%) and carbonated drinks (18.9%). Weight loss (6.5%), esophagitis (5.5%) and electrolyte disturbances (0.5%) were the associated complications. About 89.8% were on proton-pump inhibitors, followed by prokinetics (51.8%) and antiemetics (8.4%). The mean PAGI-QoL score was 3.6 ± 0.94, suggesting a moderate effect of gastroparesis on QoL. Conclusion : Poor correlation exists between gastric scintigraphy and gastrointestinal symptoms, thus reiterating the significance of the clinical diagnosis of gastroparesis, especially in diabetes. Only about half of the patients were prescribed prokinetics, emphasizing the need for appropriate pharmacotherapy using prokinetics for holistic management of gastroparesis.","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87900549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dizygotic Twins with Irritable Bowel Syndrome and Interleukin-6 Promoter Polymorphism (-174 G/C)","authors":"S. Acharyya","doi":"10.7869/tg.624","DOIUrl":"https://doi.org/10.7869/tg.624","url":null,"abstract":"","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87727183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seroprevalence of Hepatitis C Virus in Liver Disease Patients and Blood Donors from Northern India","authors":"Deepak Kumar","doi":"10.7869/tg.617","DOIUrl":"https://doi.org/10.7869/tg.617","url":null,"abstract":"","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75829300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Management of Chylothorax in Cirrhosis of the Liver using Trans-jugular Intrahepatic Portosystemic Shunt (TIPS)","authors":"Ajay Jain","doi":"10.7869/tg.621","DOIUrl":"https://doi.org/10.7869/tg.621","url":null,"abstract":"","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84750881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Irreducible Rectal Prolapse in a Patient with Anorectal Malformation: Arduous to Reduce","authors":"H. Bhattacharjee","doi":"10.7869/tg.622","DOIUrl":"https://doi.org/10.7869/tg.622","url":null,"abstract":"","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88414346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Histopathological Study of Congenital Pouch Colon and its Impact on Management","authors":"S. Acharya","doi":"10.7869/tg.619","DOIUrl":"https://doi.org/10.7869/tg.619","url":null,"abstract":"","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88277685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Balekuduru, Athish Shetty, G. Ramachandraiah, S. Subbaraj
Mucormycosis (zygomycosis) is a mould infection caused by a group of ubiquitous fungi (Mucorales). Rhizopus oryzae is the most common cause of mucormycosis1. The risk factors for the development of invasive mucormycosis are diabetes mellitus, particularly with ketoacidosis, corticosteroid use, neutropenic states in organ/stem cell transplantation or hematologic malignancies, malnourished states in renal failure, low birth infants, human immunodeficiency virus (HIV) infection and states of iron overload or treatment with desferoxamine. Nosocomial outbreaks may occur by transmission through contaminated bandages, tongue depressors and intravenous catheters1.
{"title":"Invasive Gastrointestinal Mucormycosis Presenting as Pneumonia","authors":"A. Balekuduru, Athish Shetty, G. Ramachandraiah, S. Subbaraj","doi":"10.7869/TG.589","DOIUrl":"https://doi.org/10.7869/TG.589","url":null,"abstract":"Mucormycosis (zygomycosis) is a mould infection caused by a group of ubiquitous fungi (Mucorales). Rhizopus oryzae is the most common cause of mucormycosis1. The risk factors for the development of invasive mucormycosis are diabetes mellitus, particularly with ketoacidosis, corticosteroid use, neutropenic states in organ/stem cell transplantation or hematologic malignancies, malnourished states in renal failure, low birth infants, human immunodeficiency virus (HIV) infection and states of iron overload or treatment with desferoxamine. Nosocomial outbreaks may occur by transmission through contaminated bandages, tongue depressors and intravenous catheters1.","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91280996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-steroidal Anti-inflammatory Drug Induced Duodenal Diaphragm Managed with Endoscopic Dilation","authors":"Ankur Gupta, D. Sonkar, A. Shukla","doi":"10.7869/TG.591","DOIUrl":"https://doi.org/10.7869/TG.591","url":null,"abstract":"","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82639059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anju Mullath, A. Koshy, Roy j. Mukkada, A. Chettupuzha, S. Paul, P. Mathew, P. Mahadevan, Murali Krishna
Tropical Gastroenterology 96 The duration of antifungal treatment is guided by the resolution of clinical and radiological features which may take 6 to 8 weeks. The recommended therapeutic drug level of posaconazole is a trough concentration of 1 μg/mL or higher4. Delayed presentation with inability to remove the infected intestinal segment and use of parenteral antifungal therapy alone in an immunocompromised patient might have led to fatality in our case. Therefore, a high degree of clinical suspicion, early diagnosis and prompt surgical debridement with anti -fungal therapy might improve survival.
{"title":"Intra-Biliary Colorectal Metastasis in Lynch Syndrome: Fifteen Years After the Index Cancer","authors":"Anju Mullath, A. Koshy, Roy j. Mukkada, A. Chettupuzha, S. Paul, P. Mathew, P. Mahadevan, Murali Krishna","doi":"10.7869/TG.590","DOIUrl":"https://doi.org/10.7869/TG.590","url":null,"abstract":"Tropical Gastroenterology 96 The duration of antifungal treatment is guided by the resolution of clinical and radiological features which may take 6 to 8 weeks. The recommended therapeutic drug level of posaconazole is a trough concentration of 1 μg/mL or higher4. Delayed presentation with inability to remove the infected intestinal segment and use of parenteral antifungal therapy alone in an immunocompromised patient might have led to fatality in our case. Therefore, a high degree of clinical suspicion, early diagnosis and prompt surgical debridement with anti -fungal therapy might improve survival.","PeriodicalId":23281,"journal":{"name":"Tropical gastroenterology : official journal of the Digestive Diseases Foundation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76996024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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