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An appraisal of routine Antenatal laboratory parameters at booking in Bowen University Teaching Hospital, Ogbomoso, Oyo State Nigeria 对尼日利亚奥约州Ogbomoso的Bowen大学教学医院常规产前实验室参数的评估
Pub Date : 2022-06-03 DOI: 10.4314/tjhc.v29i1.2
Y. Bakare, O. Ogunlaja, T. Bobo, I. Ogunlaja, A. Olasinde, S. Akinola
Antenatal care (ANC) involves a planned and coordinated medical and psychosocial support that optimally begins before conception and extends throughout the antepartum period. Routine laboratory tests at booking are part of this range of evidence-based interventions to ensure healthy mothers and infants.  The usual recommended routine ANC laboratory tests in low resource countries include; packed Cell Volume (PCV), Blood/Rhesus group, Hemoglobin genotype, Venereal Disease Research Laboratory (VDRL), Human Immunodeficiency Virus (HIV), Hepatitis B surface antigen (HBsAg) and urinalysis. A review of Antenatal booking investigation results of consecutive presenting pregnant women at Bowen University Teaching Hospital (BUTH), Ogbomoso between January 1, 2019 and June 30, 2021 were analyzed alongside with other relevant information such as age, parity, occupation, level of education, year of last childbirth. Eight hundred and fifty-two pregnant women participated in the study, out of which 522 (61.3%) were <30 years while 312 (36.6%) and 18 (2.1%) were 30-39 years and ≥40 years respectively. Most of the women were age 20 – 29 years (60.6%) and only 2 (0.7%) were teenagers. Majority of the participants had parity of 1-4 (94.7%) while only 33 were grand multiparous. A total of 387 (45.4) women had normal PCV while 465 (54.6) had a PCV in the range of mild to moderate anaemia. None was severely anaemic.  The commonest blood group was ‘O’ 390 (45.7%). Most of the mothers 771 (90.4%) were Rhesus D positive while 81 (9.6%) of them were negative. Only three women were positive for HIV while 6 and 78 women had a positive VDRL and HbSAg test results respectively. Most of the women are young (<40 years), have blood group O rhesus D positive and were anaemic at booking. Most of the participants are non-reactive to VDRL, HIV and HBsAg tests. The high percentage of anaemic cases in this study have justified the critical role of routine ANC laboratory tests in providing prompt detection and thus modification or management of pre-existing conditions or risk factors that may influence the course and outcome of pregnancy and labour.
产前保健包括有计划和协调的医疗和社会心理支助,这种支助最好在怀孕前开始,并贯穿整个产前期。预约时的常规实验室检查是确保母亲和婴儿健康的一系列循证干预措施的一部分。在资源匮乏的国家,通常建议的常规ANC实验室检测包括;包装细胞体积(PCV),血液/恒河鼠组,血红蛋白基因型,性病研究实验室(VDRL),人类免疫缺陷病毒(HIV),乙型肝炎表面抗原(HBsAg)和尿液分析。回顾性分析2019年1月1日至2021年6月30日在Ogbomoso博文大学教学医院(BUTH)连续就诊的孕妇产前预约调查结果,并结合年龄、胎次、职业、教育程度、最后一次分娩年份等相关信息进行分析。852名孕妇参与了这项研究,其中<30岁的522名(61.3%),30-39岁的312名(36.6%),≥40岁的18名(2.1%)。大多数女性年龄在20 - 29岁之间(60.6%),只有2名(0.7%)是青少年。大多数参与者的胎次为1-4次(94.7%),而只有33例是大产。共有387(45.4)名妇女的PCV正常,而465(54.6)名妇女的PCV在轻度至中度贫血范围内。没有人严重贫血。最常见的血型为' O ' 390(45.7%)。771例(90.4%)母亲rh阳性,81例(9.6%)母亲rh阴性。只有3名女性HIV阳性,而VDRL和HbSAg检测结果分别为6和78名女性阳性。大多数女性年轻(<40岁),O型血rh阳性,预约时贫血。大多数参与者对VDRL、HIV和HBsAg检测无反应。在这项研究中,贫血病例的高比例证明了常规ANC实验室检查在及时发现并因此改变或管理可能影响妊娠和分娩过程和结果的已有疾病或风险因素方面的关键作用。
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引用次数: 1
Rehospitalization rate and predictors of rehospitalization in heart failure patients in North Central Nigeria 尼日利亚中北部心力衰竭患者再住院率及再住院预测因素
Pub Date : 2022-06-03 DOI: 10.4314/tjhc.v29i1.7
J. Ogunmodede, P. Kolo, B. Dele-Ojo, I. Yusuf, I.L. Salau, I. Katibi, A. Omotoso
Abstract Heart failure (HF) is a major cause of morbidity and mortality worldwide. Despite the advancement in its treatment the rate of rehospitalization of patients after treatment for HF is still high around the world. Studies assessing rehospitalization rates of HF patients are few in Nigeria. The objective of the study was to determine the 180-day rehospitalization rate and predictors of rehospitalization in acute HF patients managed in our Centre. The study was a retrospective cohort study of 148 patients with acute HF. The 180-day rehospitalization rate in our patients was 16.2%. The median time to rehospitalization was 61days. Serum urea (p=0.016), serum creatinine (p=0.033), admission eGFR < 60mls/min/1.73m2 (p=0.007), LVEF (p=0.045) were associated with rehospitalization. eGFR < 60mls/min/1.73m2 was an independent predictor of 180-day rehospitalization OR 5.4, (CI 1.701-7.690), p=0.014 suggesting 5 times greater likelihood of rehospitalization than patients with higher eGFR. The Kaplan-Meier survival curve for 180-day rehospitalization was plotted. In conclusion, the 180-day rehospitalization rate among our patients varies from other reported rates in our environment. Acute HF patients with renal dysfunction have a high likelihood of medium term rehospitalization and hence constitute an at-risk group for targeted intervention during admission.
心力衰竭(HF)是世界范围内发病率和死亡率的主要原因。尽管在治疗方面取得了进步,但在世界范围内,心衰患者治疗后的再住院率仍然很高。评估心衰患者再住院率的研究在尼日利亚很少。本研究的目的是确定本中心管理的急性心衰患者180天再住院率和再住院预测因素。该研究是一项148例急性心衰患者的回顾性队列研究。180天再住院率为16.2%。再住院的中位时间为61天。血清尿素(p=0.016)、血清肌酐(p=0.033)、入院时eGFR < 60ml /min/1.73m2 (p=0.007)、LVEF (p=0.045)与再次住院相关。eGFR < 60mls/min/1.73m2是180天再住院的独立预测因子OR 5.4, (CI 1.701-7.690), p=0.014,提示再住院的可能性是eGFR较高患者的5倍。绘制180天再住院期Kaplan-Meier生存曲线。总之,我们的患者180天再住院率与我们环境中其他报告的率不同。伴有肾功能不全的急性心力衰竭患者中期再住院的可能性较大,因此是入院时进行针对性干预的高危人群。
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引用次数: 0
Prenatal maternal prevalence and new-born vertical transmission of Human Papillomavirus (HPV) at the University of Ilorin Teaching Hospital, Ilorin, Nigeria 在尼日利亚伊洛林的伊洛林大学教学医院,产前产妇流行率和新生儿人乳头瘤病毒(HPV)垂直传播
Pub Date : 2022-05-31 DOI: 10.4314/tjhc.v29i1.1
A. Nyamngee, F.O. Onoriasakpobare, O. Agbede, A. Akanbi II, M. K. Sulaiman
Vertical transmission of Human Papillomavirus (HPV) infection can occur as demonstrated by the established association between a maternal history of genital warts and the development of laryngeal papillomas in children less than 2 years of age. Also there has been reported cases of infants who had genital warts present at the time of delivery. The prevalence and transmission rates of HPV at birth not known.  This study determined the prevalence of HPV DNA in the cord blood of the baby at delivery and the maternal cervical sample, and the concordance between the prevalence in the cord blood and in the cervical sample using the Polymerase Chain Reaction (PCR). Cord blood samples were collected at from 113 participating pregnant women, from whom their cervical swab samples had been taken in antenatal clinic. The specimens were analysed for HPV DNA using the PCR with the consensus primers MY09/MY11. HPV DNA was detected in 54 cord blood and 11 cervical samples. There were 9 positive concordances for both the cord blood and the cervical sample. The prevalence of HPV DNA in the cord blood was 47.92% and in the maternal cervical sample was 9.7% and the difference was statistically significant. The typing on the positive HPV DNA shows 50.77% positive for HPV 16 and 16.92% positive for HPV 18. The detection of HPV DNA in the cord blood and the type specific genotypes concordance in the cervical suggests that the mother is the most probable source of HPV positive in the new born. Therefore, this should be a compulsory procedure at the point of delivery for early detection and treatment of HPV infections among the newborn babies.
人类乳头状瘤病毒(HPV)感染的垂直传播可以发生,这是由母体生殖器疣史与2岁以下儿童喉部乳头状瘤发展之间的既定关联所证明的。也有报告说,婴儿在分娩时就有生殖器疣。出生时HPV的患病率和传播率尚不清楚。本研究利用聚合酶链式反应(PCR)测定了分娩时婴儿脐带血和产妇宫颈样本中HPV DNA的患病率,以及脐带血和宫颈样本中HPV DNA患病率的一致性。从113名参与研究的孕妇中采集脐带血样本,并在产前诊所采集宫颈拭子样本。采用引物MY09/MY11对标本进行HPV DNA PCR分析。在54份脐带血和11份宫颈样本中检测到HPV DNA。脐带血和宫颈样本均有9例阳性吻合。脐带血HPV DNA检出率为47.92%,宫颈样本检出率为9.7%,差异有统计学意义。HPV DNA阳性分型显示HPV 16阳性50.77%,HPV 18阳性16.92%。脐带血中HPV DNA的检测和子宫颈特定基因型的一致性表明,母亲是新生儿中HPV阳性的最可能来源。因此,这应该是一个强制性的程序,在分娩点的早期发现和治疗HPV感染的新生儿。
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引用次数: 0
Evaluation of household medication use at Uselu area Edo State, Nigeria 尼日利亚埃多州乌塞卢地区家庭用药情况评价
Pub Date : 2019-07-26 DOI: 10.4314/TJHC.V26I3
J. S. Soni, A. C. Oparah, S. Usifoh, F. Oseji, P. C. Nwobodo
The presence of medicines in the households is a risk factor for irrational drug use; which may expose patients to adverse effects and treatment failures. This study determined common chronic disease/s in the households, storage of medications and sources through which households obtained medications, knowledge of medication use and methods of handling their left-over and expired medicines. A descriptive, cross-sectional household survey was conducted. Questionnaires were used based on the methods contained in the WHO manual. Data on the extent of storage, sources of medicines and their current status among others were collected and were entered in to Excel. Of the 126 participants surveyed, 58 (46.03%) attained a tertiary education, 40 (31.75%) had member/s of the family working in a health sector. Only 38 (30.16%) of households had at least one person suffering from chronic disease/s, 25 (65.79%) were hypertensive, 73 (57.94%) of the study participants sometimes had left-over medication/s. forty eight (13.48%) of the medications were supplements, 215(61.08%) of the medicines were prescribed by a doctor, 156 (42.05%) of them were purchased from a pharmacy, 151(42.90%) of drugs were stored in a basket/carts, 344 (97.72%) of drugs were in good storage conditions, 332 (94.32%) had valid (present) expiration dates and 289 (82.10%) of the drugs did not have  correct duration. In this survey, hypertension, diabetes and arthritis were the most common chronic disease conditions. Most of the medicines were purchased from community pharmacies, methods of storage and disposal of medications were in basket/carts and in trash bins/ thrown away respectively. However, these medicines found were in good conditions, though, poorly labeled and participants had poor knowledge on how long to use their medications. Keywords: Household, irrational treatment, left-over medication/s, storage
家庭中药品的存在是不合理用药的一个风险因素;这可能会使患者面临不良反应和治疗失败。这项研究确定了家庭中常见的慢性疾病、药物的储存和获得药物的来源、药物使用知识以及处理剩余和过期药物的方法。进行了一项描述性横断面家庭调查。根据世卫组织手册所载的方法使用了问卷。收集了储存范围、药品来源及其现状等数据,并将其输入到Excel中。在接受调查的126名参与者中,58人(46.03%)接受过高等教育,40人(31.75%)有家庭成员在卫生部门工作。只有38户(30.16%)家庭至少有一人患有慢性疾病,25户(65.79%)患有高血压,73户(57.94%)的研究参与者有时有剩余药物。其中,补品48种(13.48%),医生处方药品215种(61.08%),药店购买药品156种(42.05%),篮/推车储存药品151种(42.90%),储存条件良好的药品344种(97.72%),有效(目前)有效期药品332种(94.32%),有效期不正确的药品289种(82.10%)。在这项调查中,高血压、糖尿病和关节炎是最常见的慢性疾病。大部分药物从社区药房购买,药物的储存和处置方法分别为篮子/推车和垃圾桶/扔掉。然而,这些被发现的药物状况良好,但标签很差,参与者对药物的使用时间知之甚少。关键词:家庭;不合理治疗;剩余药品/s
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引用次数: 1
Practice of routine medical check-ups and screening for cardiovascular risk factors in Delta State, south-south Nigeria: a population-based study 尼日利亚南南三角洲州例行体检和心血管危险因素筛查的做法:一项基于人口的研究
Pub Date : 2019-07-01 DOI: 10.4314/TJHC.V26I2
E. Umuerri
Disease prevention is an effective strategy to decrease morbidity and mortality across a wide range of diseases and routine medical screening is a cost-effective method of improving population health and life expectancy. The aim of this study was to determine the practices of apparently healthy adults towards routine medical check-ups and screening for cardiovascular risk factors. This was done using a cross-sectional questionnaire-based study design. The study population was drawn from among adult residents of a rural (Jesse) and an urban (Warri) community in Delta State, South-South Nigeria.A total of 866 respondents were studied, 44% were rural dwellers. Their mean age was 42.5(±16.05) years. Two-thirds (242/358) of the respondents who had completed secondary education were urban dwellers. A third of the respondents practiced routine medical screening and this was significantly higher among the urban dwellers (40.0% vs. 22.2% p<0.001). Among respondents who do not practice routine medical screening, 48.5% had no apparent reason and 70.1% were urban dwellers.Majority of the respondents had no health care provider. The typical healthcare providers were doctors (25.7 %), pharmacist/dispenser (9.2%) and nurses (4.3%). Among respondents who had doctors as the typical healthcare provider, 26.9% have had education on cardiovascular risk factor prevention. This was significantly higher among urban dwellers.Majority of the respondents have never had their blood pressure (56.0%), blood glucose (65.8%) and cholesterol (94.6%) checked, significantly higher among rural dwellers.In conclusion, routine medical check-ups and screening for cardiovascular risk factors were poor in this study. There is a need for increased public health promotion and education among Nigerians. Keywords: Cardiovascular risk factors, medical check-up, adult
预防疾病是降低各种疾病发病率和死亡率的有效战略,常规医疗检查是改善人口健康和延长预期寿命的一种成本效益高的方法。本研究的目的是确定表面上健康的成年人对常规体检和心血管危险因素筛查的做法。这项研究采用了基于横断面问卷的研究设计。研究人群来自尼日利亚南南三角洲州农村(Jesse)和城市(Warri)社区的成年居民。调查对象共866人,其中44%为农村居民。平均年龄42.5(±16.05)岁。完成中等教育的受访者中有三分之二(242/358)是城市居民。三分之一的受访者进行常规医疗筛查,这在城市居民中明显更高(40.0%对22.2% p<0.001)。在不进行常规体检的受访者中,48.5%没有明显原因,70.1%为城市居民。大多数答复者没有保健服务提供者。典型的医疗服务提供者是医生(25.7%)、药剂师/配药员(9.2%)和护士(4.3%)。在以医生为典型医疗服务提供者的受访者中,26.9%的人接受过心血管危险因素预防的教育。城市居民的这一比例要高得多。绝大多数调查对象从未检测过血压(56.0%)、血糖(65.8%)和胆固醇(94.6%),其中农村居民比例较高。总之,在本研究中,常规体检和心血管危险因素筛查较差。有必要加强对尼日利亚人的公共卫生宣传和教育。关键词:心血管危险因素,体检,成人
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引用次数: 1
Attributed Causes of Diabetes among Literate Adults in Lagos State, Nigeria: Implications to Health Workers 尼日利亚拉各斯州识字成年人中糖尿病的归因:对卫生工作者的影响
Pub Date : 2019-02-22 DOI: 10.4314/tjhc.v26i1
A. Odebode
This study investigated the attributed causes of diabetes among literate adults in Lagos State, Nigeria and examined the influence of certain variables such as:  gender, religious affiliation and age on the respondents’ views. Descriptive survey design was adopted for the study. A researcher-developed instrument entitled “Attributed Causes of Diabetes  Questionnaire (ACDQ)” was used to collect data from 600 respondents in Lagos State, who were selected using purposive and simple random sampling techniques. The three formulated null hypotheses were tested and analyzed using t-test and Analysis of Variance at 0.05 alpha level.The finding of this study revealed poor economic status, high intake of sugary diet, lack of medical check-up, lack of functional insulin in the body, lack of physical exercise, illiteracy as the attributed causes of diabetes among literate adults in Lagos State. Results also showed that there were no gender, educational level and age significant differences in the attributed causes of diabetes among the respondents. By implication, health workers should gather up to date information to debunk wrong attribution of causes of diabetes and to further educate the entire populace on the causes of diabetes. Keywords: Attribution, Causes, Diabetes, Literate Adults, Health Workers.
本研究调查了尼日利亚拉各斯州有文化的成年人中糖尿病的归因,并检查了某些变量的影响,如:性别、宗教信仰和年龄对受访者观点的影响。本研究采用描述性调查设计。研究人员开发了一种名为“糖尿病归因问卷(ACDQ)”的工具,用于从拉各斯州的600名受访者中收集数据,这些受访者是通过有目的和简单的随机抽样技术选择的。采用0.05 α水平的t检验和方差分析对三个制定的零假设进行检验和分析。这项研究的结果表明,拉各斯州有文化的成年人患糖尿病的原因包括经济状况差、高糖饮食摄入、缺乏医疗检查、体内缺乏功能性胰岛素、缺乏体育锻炼和文盲。结果还显示,受访者在糖尿病的归因上没有性别、教育程度和年龄的显著差异。由此可见,卫生工作者应收集最新信息,以揭穿对糖尿病病因的错误归因,并进一步教育全体民众了解糖尿病的病因。关键词:归因,原因,糖尿病,有文化的成年人,卫生工作者
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引用次数: 1
Compliance to use of surgical checklist among private medical practitioners 私家医生使用手术核对表的依从性
Pub Date : 2019-01-01 DOI: 10.4314/TJHC.V26I4
O. Olakulehin, O. Akanbi, O. Habeeb, M. Adeoti, D. Onilede, T. Akinloye, O. Olanipekun
Surgery put patients at appreciable risk of adverse outcomes and death. Operative Surgical Checklists serves as an aid-memoire to ensure patients’ and health care personnel safety during the perioperative period. A cross-sectional survey of private medical practitioners (PMP) was conducted to find out about the awareness and compliance of general medical practitioners in Nigeria on the use of WHO Surgical Checklists. Relevant data were obtained through a pre-tested paper based questionnaire. One hundred and nineteen questionnaires were analysed. The mean age of the respondents was 58.20 (±4.761) years. The mean duration of time from post qualification was 31.083 (±4.387) years. Twenty-four (20.16%) of the respondents have additional qualifications in various clinical and non clinical specialties. Forty-seven (39.49%) of the respondents had heard about surgical checklist mainly from the internet. Only 5 (10.63%) of them use it, and in less than 25% of the occasions. Use of checklist shows no significant statistical difference between those with additional qualifications to those without (p= .6970).  About 96% of the respondents believed that surgical checklist is beneficial. The most barrier to use of surgical checklist was unavailability of the checklists. Surgical checklist is poorly utilized by the private medical practitioners.  We suggest the need to further emphasize the use of surgical checklists at various levels of our practices.Keywords: Surgical checklist, World health organization, private medical practitioners and Operation
手术使患者面临明显的不良后果和死亡风险。手术检查表作为辅助备忘录,确保围手术期患者和医护人员的安全。对私人医生进行了一项横断面调查,以了解尼日利亚全科医生对使用世卫组织手术清单的认识和遵守情况。相关数据通过预测的纸质问卷获得。对119份问卷进行了分析。受访者平均年龄58.20(±4.761)岁。平均离岗时间为31.083(±4.387)年。24名(20.16%)受访者在各种临床和非临床专业拥有额外资格。47名(39.49%)受访者主要通过网络了解手术清单。只有5人(10.63%)使用手机,而且使用频率不到25%。使用检查表显示,有额外资格的人员与没有额外资格的人员之间没有显著的统计学差异(p= .6970)。96%的受访者认为手术核对表是有益的。使用手术检查清单的最大障碍是无法获得检查清单。私人医生对手术检查表的利用程度较差。我们建议有必要进一步强调在我们实践的各个层面使用手术检查清单。关键词:外科检查表;世界卫生组织;私人医生
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引用次数: 0
Attitude of working-class nursing mothers towards exclusive breastfeeding in Lokoja Metropolis, Nigeria: implications to counselling practice 尼日利亚Lokoja大都会工人阶级哺乳母亲对纯母乳喂养的态度:对咨询实践的影响
Pub Date : 2018-05-29 DOI: 10.4314/tjhc.v25i2
A. Odebode, F. Okesina, E. K. Ola-Alani
Many working-class nursing women put up questionable attitude when it comes to exclusively breastfeeding their babies. The purpose of this study therefore, is to investigate the attitude of working-class nursing mothers in Lokoja Metropolis towards exclusive breastfeeding. Variables such as age, type of occupation and educational attainment were also examined if they would affect the respondents’ expressions. Descriptive survey method was adopted for the study. A total of 200 respondents who were selected using a two-stage sampling procedure participated in the study. An instrument entitled ‘Attitude towards Exclusive Breastfeeding Questionnaire’ was used to collect data for the study. The instrument was validated by five experts in the 5 experts in the Departments of Counsellor Education and Adult & Primary Education, University of Ilorin, Nigeria. The reliability of the instrument was ascertained through test re-test reliability method with a reliability co-efficient of 0.83. ANOVA statistical method was used to test the formulated hypotheses at 0.05 alpha level. Result showed that the attitude of working-class nursing mothers in Lokoja Metropolis towards exclusive breastfeeding is positive. There was no significant difference in the attitude of working-class nursing mothers towards exclusive breastfeeding in Lokoja Metropolis based on age but there were significant differences on the bases of type of occupation and educational attainment. It was concluded that counsellors should encourage and counsel working-class mothers to adopt benefitting coping strategies so that they can maintain their positive attitude towards exclusive breastfeeding of their babies. Keywords: Attitude, Working Class, Nursing Mothers, Exclusive Breastfeeding, Lokoja Metropolis
许多工人阶级的哺乳妇女对纯母乳喂养婴儿持怀疑态度。因此,本研究的目的是调查Lokoja大都会工人阶级哺乳母亲对纯母乳喂养的态度。年龄、职业类型和受教育程度等变量也会影响受访者的表达。本研究采用描述性调查方法。采用两阶段抽样程序选出的总共200名受访者参与了研究。一项名为“对纯母乳喂养的态度问卷”的工具被用于收集研究数据。该工具由尼日利亚伊洛林大学辅导员教育系和成人与初等教育系的5名专家中的5名专家进行了验证。通过重测信度法确定仪器的信度,信度系数为0.83。采用方差分析(ANOVA)统计方法在0.05 α水平上检验所提出的假设。结果表明,洛科佳市工薪阶层哺乳母亲对纯母乳喂养的态度是积极的。洛科佳市工人阶级哺乳母亲对纯母乳喂养的态度在年龄上没有显著差异,但在职业类型和受教育程度上存在显著差异。结论是,辅导员应鼓励和指导工人阶级母亲采取有益的应对策略,使她们能够对婴儿的纯母乳喂养保持积极的态度。关键词:态度;工人阶级;哺乳母亲
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引用次数: 1
Haematological effects of aqueous extract of Vernonia amygdalina and a known immunostimulant In Wistar Rats 苦杏仁水提物和已知免疫刺激剂对Wistar大鼠血液学的影响
Pub Date : 2018-02-09 DOI: 10.4314/TJHC.V25I1
R. Kadir, A. Ibrahim, I. M. Bamtefa, B. A. Ibrahim, M. K. Ogunfemi, S. Gwadabe, R. Jaji-Sulaimon, F. Adigun, M. Ajao
Plants have provided sources of drugs which have made contribution to health. The use of plant extracts for the treatment of diseases is being practiced widely. Vernonia amygdalina (VA), otherwise known as bitter leaf is a shrub that grows commonly in tropical Africa and consumed as vegetable. People have considered bitter leaf as a traditional medicine, as its being used for the treatment of various illnesses such as fever, diarrhea, malaria, etc. However, its haematological effects are to be explored in this study.Thirty adult male wistar rats weighing averagely 150g were studied. They were housed, fed and cared under humane conditions in the animal house. They were divided into six groups of 5 each, with groups I and II being controls while the others were experimental. Prednisone was administered for two weeks, then blood samples were taken following which the treatments were given for specified periods. The animals were thereafter sacrificed and blood samples for CD4 and haematologic parameters taken, as well as splenic organ for histology.The results show weight increase across all groups. There was no appreciable difference in the CD4 and red blood cell count in the bitter leaf groups while the levamisole had significant decrease in these parameters. Bitter leaf was associated with significant decrease in haemoglobin level. The photomicrographs of the spleen showed decrease dimension in the white pulp and marginal zone. Levamisole and Vernonia amygdalina were associated with decreased haematological parameters.Keyowrds: Vernonia amygdalina, Levamisole, Haematological parameters, Wistar rats
植物提供了对健康有贡献的药物的来源。利用植物提取物治疗疾病正在得到广泛应用。扁桃苦叶(VA),也被称为苦叶,是一种灌木,通常生长在热带非洲,作为蔬菜食用。人们认为苦叶子是一种传统药物,因为它被用来治疗各种疾病,如发烧、腹泻、疟疾等。然而,其血液学作用尚待研究。以30只平均体重150g的成年雄性wistar大鼠为研究对象。它们在动物饲养场的人道条件下被饲养、喂养和照顾。他们被分成六组,每组5人,第一组和第二组是对照组,其他组是实验组。泼尼松给药两周,然后采集血液样本,然后在指定的时间内给予治疗。随后处死动物,采集血液CD4和血液学指标,并对脾器官进行组织学检查。结果显示,所有人群的体重都有所增加。苦叶组小鼠CD4和红细胞计数无明显差异,左旋咪唑组小鼠CD4和红细胞计数有显著降低。苦叶与血红蛋白水平显著降低有关。脾脏的显微照片显示白色髓质和边缘区尺寸减小。左旋咪唑和扁桃仁与血液参数下降有关。关键词:苦杏仁;左旋咪唑;血液学参数
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引用次数: 1
Improving the Alignment of Measles Notification in Nigeria with Response Activities (Measles Immunization): An Overview from 2012-2016 改进尼日利亚麻疹通报与应对活动(麻疹免疫)的一致性:2012-2016年概述
Pub Date : 2018-01-01 DOI: 10.4314/tjhc.v25i4
S. Bello, A. Saka, M. Adeboye, A. Ojuawo
Immunization is a proven tool for controlling and eliminating life-threatening infectious diseases and is estimated to avert between 2 and 3 million deaths each year globally. Measles is one of the viral diseases preventable with adequate measles routine immunization (MRI). WHO has the mandate that by the end of 2020, at least five WHO regions amongst which is Africa should have eliminated measles. This study examined improving the alignment of measles notification with response activities (measles immunization) retrospectively in Nigeria from 2012-2016.This is a 5 year retrospective MRI data from 2012-2016 collected from the National Primary Health Care Development Agency (NPHCDA), the agency responsible for immunization in the country with the permission of the Chief Executive Officer (CEO). This was examined to ascertain the extent of MRI coverage in Nigeria for five years. Also, measles data from the Integrated Disease Surveillance and Response (IDSR) collected from the Nigeria Centre for Disease Control (NCDC) was examined for the same period of time (2012-2016). The collected data were analyzed to see if MRI and measles cases are synergistic and aligned to eliminating measles. The MRI coverage for the observed years appeared relatively high, yet the measles cases were also relatively high; suggesting that MRI coverage did not have significant effect in reducing the number of measles cases in the observed. Specifically, the number of measles cases in the North zones was relatively higher than the South zones despite apparent increase in MRI coverage in the North (2012-2016). The South zones showed inconsistencies in MRI coverage. From this study, there is need for NCDC and NPHCDA to brainstorm and collaborate to consider strategies to harmoniously combat measles and key into the principles of the measles 2nd dose vaccination (MCV2) if Nigeria is to progress to the elimination phase of measles infection.Keywords: Measles vaccine, Infectious disease, measles elimination, Nigeria,
免疫接种是一种经过验证的控制和消除威胁生命的传染病的工具,估计每年可在全球避免200万至300万人死亡。麻疹是一种可通过充分的麻疹常规免疫(MRI)预防的病毒性疾病。世卫组织的任务是,到2020年底,世卫组织至少有五个区域(其中包括非洲)应消除麻疹。本研究回顾性调查了尼日利亚2012-2016年麻疹通报与应对活动(麻疹免疫接种)的一致性改善情况。这是从国家初级卫生保健发展机构(NPHCDA)收集的2012-2016年5年回顾性MRI数据,该机构在首席执行官(CEO)的许可下负责该国的免疫工作。对这一情况进行了检查,以确定尼日利亚五年的MRI覆盖范围。此外,还对同期(2012-2016年)从尼日利亚疾病控制中心(NCDC)收集的来自疾病综合监测和应对(IDSR)的麻疹数据进行了检查。对收集的数据进行分析,以确定MRI和麻疹病例是否具有协同作用,并与消除麻疹相一致。观察年份的MRI覆盖率相对较高,麻疹病例也相对较高;这表明MRI覆盖在减少观察到的麻疹病例数量方面没有显着效果。具体而言,尽管北部MRI覆盖率明显增加(2012-2016年),但北部地区的麻疹病例数相对高于南部地区。南部区MRI覆盖范围不一致。根据这项研究,如果尼日利亚要进入消除麻疹感染的阶段,NCDC和NPHCDA需要集思广益并开展合作,以考虑协调防治麻疹的战略,并将麻疹第二剂疫苗接种(MCV2)的原则纳入其中。关键词:麻疹疫苗,传染病,麻疹消除,尼日利亚,
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